@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXZ2: (2018-01-06 )
MLTVHVDNQKYDIHIEKGALEQAGSWLQTIWRPQKVAVITDTNVAPLYAEKIMFQLRQANFEPVLSIVPAGETSKSLEQAAELYDFLADNDFTRSDGILALGGGMVGDLAAFVASTFMRGIHFVQIPTTLLAQVDSSIGGKTAVNTNKAKNLVGTFSQPAGVLIDPEVLKTLPVRRLREGIAEIIKSAAIADATLWKQLNELKDEKDLLEHAVPIITATLEIKRKVVEEDVFDQGNRLILNFGHTIGHAIENTAGYGVVSHGEGVAIGMVAITSHAEKIGLSPTGSTAALERILQKFHLPITYDLSHPDELFHAITHDKKARGSQLNIILLEKIGQAKIVPVPTETFKDYLGGL
Atome Classification :
(39 SA)
.......--..10........20.-...-....30........40........50.--.......60------..------...----..----.70........80........90--...-.....-100.......110.......120.......130.......140.......150.......160.......170.......180.......190....--....200--------..---.-----.---------.-.----------------..210.--------..---....220.......230.......240.......250.......260.......270.......280.......290...-....300.--.-.-.-----------.-----------..310---------.......-..320-----.......330.-......340-.-----........350..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
T
V
H
VD--N
Q
K
Y
D
I
H
IEKG
A
L
E
Q
-
A
G
S
-
W
L
Q
T
IWRP
Q
K
V
A
V
I
TDTNV
A
P
L
Y
A
E
K
I
--
M
F
Q
L
R
QANF------EP------
V
L
S
----IV----PAGE
T
S
K
S
L
E
Q
A
A
E
L
Y
D
F
L
ADND--FTR-SDG
I
L
-
A
LGG
G
M
V
G
D
L
A
A
F
V
A
S
T
F
MRG
I
H
F
V
Q
I
P
T
T
L
L
A
Q
V
D
S
SIGGKTAVNT
N
K
A
K
N
L
V
GTFSQPA
G
V
L
I
D
P
E
V
L
K
TL
P
V
R
R
L
R
E
G
I
A
E
I
I
K
S
AAI
A
-
D
A
T
L
--
W
K
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N
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--------LK---
D
-----
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---------
K
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L
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I
T
A
T
L
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V
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FDQG
N
R
L
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L
NFG
H
T
I
G
H
A
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ENTAGY
G
V
VSHGE
G
V
A
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M
V
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ITS
H
A
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KIGLSPTG
S
T
A
A
L
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I
L
Q
-
K
FHL
P
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Y--D-L-S-----------
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-----------
P
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L
F
H
A
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TH-DKKAR-----GSQ
L
N
I
I
L
L
EK-IGQ
A
K
I
V---P-----V
P
T
E
T
F
K
D
Y
LGGL
50
HHSearch
95.78
37%
-86
- C4 -
-
3OKF
1
AROB_VIBCH
A:
[33-386]
-
I
T
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N
L
G
--
E
R
S
Y
P
I
S
I
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A
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L
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P
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M
-----------
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-----------
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K
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V
V
K
--
G
-----
V
P
E
A
V
I
A
Q
A
I
E
Y
-
47
HHSearch
94.96
37%
-81
- C4 -
-
5EKS
1
?
A:
[11-364]
T
L
H
V
E
L
G
--
E
R
R
Y
P
I
F
I
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Q
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L
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L
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----
P
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--
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-
D
C
T
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L
-
A
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G
G
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A
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A
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Y
F
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P
T
T
L
L
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Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
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R
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L
S
A
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L
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K
Y
A
L
L
G
-
D
E
D
F
--
L
V
W
L
E
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E
--------
N
M
---
D
-----
G
---------
L
-
V
A
R--------------
D
A
D
L
L
A
--------
E
A
---
V
Y
R
S
C
A
H
K
A
R
I
V
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N
D
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K
E
---
R
A
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L
N
L
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F
G
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A
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A
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A
N
L
P
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--
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Q
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-----------
P
-----------
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-----------
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L
G
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M
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--------
Q
L
R
L
V
L
L
K
Q
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Q
A
V
I
T
K--
D
-----
F
D
V
E
L
M
K
Q
A
I
L
A
-
2
PsiBlast_PDB
92.75
38%
-83
- C4 -
-
3OKF
1
AROB_VIBCH
A:
[33-372]
-
I
T
V
N
L
G
--
E
R
S
Y
P
I
S
I
G
A
G
L
F
---
A
N
P
-
A
L
L
S
L
S
A
K
Q
K
V
V
I
V
T
N
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T
V
A
P
L
Y
A
P
A
I
--
I
S
L
L
D
H
I
G
C
------
Q
H
------
A
L
L
----
E
L
----
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
I
-
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
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K
N
M
I
G
A
F
Y
Q
P
K
A
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D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
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M
A
E
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I
K
Y
G
I
I
Y
-
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S
A
F
--
F
D
W
L
E
A
Q
--------
M
E
---
A
-----
L
---------
Y
-
A
----------------
L
D
E
Q
A
L
--------
T
Y
A
--
I
A
R
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C
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I
K
A
E
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V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
I
D
A
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Q
F
E
R
I
L
A
I
L
K
-
K
A
H
L
P
V
R
T
PE
N
-
M
-
T
-----------
F
-----------
A
D
F
-----------
M
Q
H
-
M
M
R
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D
K
K
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L
-----
A
G
E
L
R
L
V
L
P
T
S
-
I
G
T
S
A
V
V
----------------------
49
HHSearch
92.02
37%
-87
- C4 -
-
3OKF
1
AROB_VIBCH
B:
[33-386]
-
I
T
V
N
L
G
--
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
N
--
P
A
-
L
L
S
L
S
-
A
K
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
--
I
S
L
L
D
H
I
G
C
------
Q
H
------
A
L
L
----
E
L
----
P
D
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Q
Y
K
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F
N
T
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M
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F
L
L
E
H
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--
Y
S
R
-
D
V
V
V
I
-
A
L
G
G
G
V
I
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D
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V
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A
A
A
C
Y
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G
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I
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I
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T
T
L
L
S
Q
V
D
S
S
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G
G
K
T
A
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N
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P
L
G
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N
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A
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A
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A
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--------
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M
---
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---------
L
-
Y
A
L--------------
D
E
Q
A
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--------
Y
A
---
I
A
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C
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F
G
H
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M
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R
----------------
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K--
G
-----
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A
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Y
-
52
HHSearch
86.55
35%
-45
- C4 -
-
5HVN
1
AROB_FRATT
A:
[15-361]
---------
S
P
S
Y
N
I
I
V
D
S
V
L
--
D
-
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H
-
I
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---
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-----
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I
-
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K--------------
D
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I
--------
E
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S
21
PsiBlast_CBE
84.04
39%
-24
- C4 -
-
5EKS
1
?
B:
[9-349]
M
Q
T
L
H
V
E
L--
R
R
Y
P
I
F
I
--
G
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D
-
P
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L
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S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
G
-
D
E
D
F
--
L
V
W
L
E
-
E
--------
N
M
---
D
G
L
V
A
R
D
---------
A
-
D
----------------
L
L
A
E
A
V
--------
Y
R
---
S
C
A
H
---
K
A
R
I
V
A
N
D
E
----
E
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
Y
G
T
W
L
H
G
E
A
V
A
T
G
M
V
M
A
A
D
L
S
Q
R
L
G
W
I
S
N
E
D
V
A
R
T
K
K
I
I
Q
-
R
A
N
L
P
I
S
C
--
P
-
Q
-
I
-----------
P
-----------
L
D
D
-----------
F
L
G
Y
M
A
H
-
D
K
K
V
-------
G
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
A
V
I
-----------------------
44
HHSearch
83.63
31%
-77
- C4 -
-
1XAG
2
AROB_STAAR
A:
[3-348]
-
L
Q
T
T
Y
P
--
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
-
Y
L
N
Q
---
F
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
D
I
L
S
Y
E
N
--------
V
------
H
K
V
----
I
I
----
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
-
G
E
S
A
--
T
Q
D
I
E
-
Q
--------
H
F
---
K
-----
D
---------
R
E
I
L
Q
--------------
S
L
N
G
M
D
--------
K
Y
---
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
--
H
-
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
-
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
-
Q
L
G
Y
P
L
D
M
--
I
T
D
-
L
-----------
D
-----------
F
E
T
-----------
L
Y
Q
Y
M
L
S
-
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
Q
---
H
-----
V
D
Q
L
T
L
Q
H
A
C
E
Q
-
46
HHSearch
82.82
34%
-26
- C4 -
-
3ZOK
2
DHQS_ACTCH
D:
[19-374]
---
V
D
L
G
--
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
-
L
Q
R
H
V
-
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
--
V
G
A
L
T
N
E
N
P
NV----
S
V
------
E
S
V
----
I
L
----
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
--
F
E
W
Q
E
-
K
--------
N
M
---
P
-----
A
---------
L
-
M
AR--------------
D
P
S
A
L
A
--------
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
-
Q
A
K
L
P
T
A
P
--
P
-
E
T
M
-----------
T
-----------
V
E
M
-----------
F
K
S
V
M
A
V
-
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
K
G
P
L
G
N
C
V
F
T
G--
D
-----
Y
D
R
K
A
L
D
E
T
L
H
A
-
1
PsiBlast_PDB
82.70
39%
-23
- C4 -
-
5EKS
1
?
A:
[9-349]
M
Q
T
L
H
V
E
L
G
E
R
R
Y
P
I
F
I
--
G
S
Q
L
D
-
P
K
Q
-
L
L
E
P
Y
I
H
G
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
--
Q
E
A
L
E
S
L
G
K
------
T
V
------
A
T
C
----
I
L
----
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
-
D
C
T
V
L
-
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
G
-
D
E
D
F
--
L
V
W
L
E
-
E
--------
N
M
---
D
G
L
V
A
R
D
---------
A
-
D
----------------
L
L
A
E
A
V
--------
Y
R
---
S
C
A
H
---
K
A
R
I
V
A
N
D
E
K
E
---
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
Y
G
T
W
L
H
G
E
A
V
A
T
G
M
V
M
A
A
D
L
S
Q
R
L
G
W
I
S
N
E
D
V
A
R
T
K
K
I
I
Q
-
R
A
N
L
P
I
S
C
--
P
-
Q
-
I
-----------
P
-----------
L
D
D
-----------
F
L
G
Y
M
A
H
-
D
K
K
V
--------
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
A
V
I
-----------------------
41
HHSearch
82.43
31%
-69
* C4 *
-
3QBE
-
AROB_MYCTU
A:
[19-365]
-----
A
V
--
D
P
P
Y
P
V
V
I
G
T
G
L
L
D
E
-
L
E
D
-
L
L
A
D
---
R
H
K
V
A
V
V
H
Q
P
G
L
A
E
-
T
A
E
E
I
--
R
K
R
L
A
G
K
G
V
------
D
A
------
H
R
I
----
E
I
----
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
V
-
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
-
D
P
V
I
--
L
D
L
I
E
-
A
--------
D
P
---
Q
-----
A
---------
A
-
L
DP--------------
A
G
D
V
L
P
--------
E
L
---
I
R
R
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
-
R
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
-
S
L
G
L
P
V
S
Y
--
D
-
P
-
D
-----------
A
-----------
L
P
Q
-----------
L
L
E
I
M
A
G
-
D
K
K
T
R
-----
A
G
V
L
R
F
V
V
L
D
G
-
L
A
K
P
G
R
M
V
--
G
-----
P
D
P
G
L
L
V
T
A
Y
A
G
V
36
PsiBlast_CBE
80.98
32%
-86
- C4 -
-
1XAI
2
AROB_STAAR
B:
[9-330]
---------
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
-
Y
L
N
Q
F
---
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
D
I
L
S
Y
E
N
V
------
H
K
------
V
------
I
I
----
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
-
G
E
S
A
--
T
Q
D
I
E
-
Q
--------
H
F
---
K
-----
D
---------
R
-
E
----------------
I
L
Q
S
L
N
--------
G
M
DKY
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
T
--
D
-
L
-
D
-----------
F
------------
E
T
-----------
L
Y
Q
Y
M
L
S
-
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
---------------------------
15
PsiBlast_PDB
80.66
32%
-86
- C4 -
-
1XAI
2
AROB_STAAR
A:
[9-330]
---------
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
-
Y
L
N
Q
F
---
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
D
I
L
S
Y
E
N
V
------
H
K
------
V
------
I
I
----
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
-
G
E
S
A
--
T
Q
D
I
E
-
Q
--------
H
F
---
K
-----
D
---------
R
-
E
----------------
I
L
Q
S
L
N
--------
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
T
--
D
-
L
-
D
-----------
F
------------
E
T
-----------
L
Y
Q
Y
M
L
S
-
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
---------------------------
14
PsiBlast_PDB
80.55
32%
-82
- C4 -
-
1XAG
2
AROB_STAAR
A:
[9-330]
---------
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
-
Y
L
N
Q
F
---
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
D
I
L
S
Y
E
N
V
------
H
K
------
V
------
I
I
----
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
-
G
E
S
A
--
T
Q
D
I
E
-
Q
--------
H
F
---
K
-----
D
---------
R
-
E
----------------
I
L
Q
S
L
N
--------
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
T
--
D
-
L
-
D
-----------
F
------------
E
T
-----------
L
Y
Q
Y
M
L
S
-
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
---------------------------
55
HHSearch
80.42
36%
5
- C4 -
-
1NVB
1
ARO1_EMENI
B:
[8-392]
-----
S
I
--
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
D
L
I
S
D
C
-
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
E
A
F
R
K
R
A
A
EITPSP
R
L
------
L
I
Y
----
N
R
----
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
--------
N
A
---
E
-----
T
---------
I
-
L
KAVRREVTPGEHRFEG
T
E
E
I
L
K
--------
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
RIRKLTAGKHC
S
-----------
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
RAS
V
-----
V
A
N
E
D
I
R
V
V
L
A
--
42
HHSearch
80.38
26%
-72
- C4 -
-
2GRU
5
DOIS_BACCI
A:
[4-366]
-
K
Q
I
C
F
A
--
D
R
C
F
N
F
A
F
G
E
H
V
L
E
S
-
V
E
S
-
Y
I
P
R
D
-
E
F
D
Q
Y
I
M
I
S
D
S
G
V
P
D
S
I
V
H
Y
A
--
A
E
Y
F
G
K
L
-
A
------
P
V
------
H
I
L
----
R
F
----
Q
G
G
E
E
Y
K
T
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
-
R
T
A
I
V
-
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
A
A
S
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
L
-
E
N
D
N
--
K
E
F
T
E
-
D
--------
D
L
NSA
N
-----
V
---------
Y
------------------
S
P
K
Q
L
E
--------
T
F
---
I
N
F
C
I
S
A
K
M
S
V
L
S
E
D
I
Y
E
K
K
K
G
L
I
F
E
Y
G
H
T
I
G
H
A
I
E
L
A
E
Q
G
-
G
I
T
H
G
E
A
I
A
V
G
M
I
Y
A
A
K
I
A
N
R
M
N
L
M
P
E
H
D
V
S
A
H
Y
W
L
L
N
-
K
I
G
A
L
Q
D
I
--
P
L
K
-
S
-----------
D
-----------
P
D
S
-----------
I
F
H
Y
L
I
H
-
D
N
K
R
G
YIKLD
E
D
N
L
G
M
I
L
L
S
G
-
V
G
K
P
A
M
Y
N--
Q
TL
L
T
P
V
R
K
T
L
I
K
E
V
I
R
E
-
45
HHSearch
80.09
31%
-91
- C4 -
-
1XAH
1
AROB_STAAR
B:
[3-348]
-
L
Q
T
T
Y
P
--
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
-
Y
L
N
Q
---
F
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
------
N
--------
V
------
H
K
V
----
I
I
----
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
-
G
E
S
A
--
T
Q
D
I
E
-
Q
--------
H
F
---
K
-----
D
---------
R
E
I
LQ--------------
S
L
N
G
M
D
--------
K
Y
---
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
--
H
-
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
-
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
-
Q
L
G
Y
P
L
D
---------------------------------
T
-----------
L
Y
Q
Y
M
L
--------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
Q
---
H
-----
V
D
Q
L
T
L
Q
H
A
C
E
Q
-
64
Fugue
78.73
35%
-2
- C4 -
-
1DQS
3
ARO1_EMENI
A:
[4-391]
P
T
K
I
S
I
L
--
G
-
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
-
D
L
I
S
D
C
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
E
A
F
R
K
R
A
A
------
E
I
TP
S
P
R
L
L
I
Y
----
N
R
----
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
--------
N
A
---
E
-----
T
I
L
K
A
V
R
RRF
E
-
G
----------------
T
E
E
I
L
K
--------
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
-
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
-----------
I
R
K
L
TAGKHCS
V
D
Q
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
---
R
-----
A
S
V
V
A
N
E
D
I
R
V
V
L
24
PsiBlast_CBE
78.18
37%
-33
- C4 -
-
3ZOK
6
DHQS_ACTCH
B:
[16-351]
I
V
D
V
D
L
G
--
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
-
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
--
V
G
A
L
T
N
E
N
--------
P
------
N
V
S
VESV
I
L
----
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
FE
W
Q
E
K
N
-
M
PAL-----
M
A
---
R
-----
D
---------
P
-
S
----------------
A
L
A
Y
A
--------------
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
-
Q
A
K
L
P
T
A
P
--
P
-
E
-
T
-----------
M
-----------
T
V
E
-----------
M
F
K
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
K
-------------------------------
23
PsiBlast_CBE
78.03
37%
-34
- C4 -
-
3ZOK
3
DHQS_ACTCH
C:
[16-351]
I
V
D
V
D
L
G
--
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
-
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
--
V
G
A
L
T
N
E
N
--------
P
------
N
V
S
VESV
I
L
----
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
FE
W
Q
E
K
N
-
M
PAL-----
M
A
---
R
-----
D
---------
P
-
S
----------------
A
L
A
Y
A
--------------
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
-
Q
A
K
L
P
T
A
P
--
P
-
E
-
T
-----------
M
-----------
T
V
E
-----------
M
F
K
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
K
-------------------------------
22
PsiBlast_CBE
77.39
37%
-34
- C4 -
-
3ZOK
2
DHQS_ACTCH
D:
[16-351]
I
V
D
V
D
L
G
--
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
-
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
--
V
G
A
L
T
N
E
N
--------
P
------
N
V
S
VESV
I
L
----
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
FE
W
Q
E
K
N
-
M
PAL-----
M
A
---
R
-----
D
---------
P
-
S
----------------
A
L
A
Y
A
--------------
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
-
Q
A
K
L
P
T
A
P
--
P
-
E
-
T
-----------
M
-----------
T
V
E
-----------
M
F
K
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
K
-------------------------------
56
HHSearch
77.30
36%
-8
- C4 -
-
1SG6
1
ARO1_EMENI
B:
[8-392]
-----
S
I
--
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
D
L
I
S
D
C
-
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
E
A
F
R
K
R
A
A
E
I
TP
S
P
R
L
------
L
I
Y
----
N
R
----
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
--------
N
A
---
E
-----
T
---------
I
-
L
K
A
V
R
R
E
V
T
PGEHRFEG
T
E
E
I
L
K
--------
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
R
I
R
K
L
T
AG
K
H
C
S
-----------
V
D
Q
-----------
L
M
F
N
M
A
L
--------------
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
R
A
S
V
-----
V
A
N
E
D
I
R
V
V
L
A
--
29
PsiBlast_CBE
74.33
37%
-2
- C4 -
-
1NVD
2
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
------------------------------------------
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
4
PsiBlast_PDB
74.11
38%
-48
- C4 -
-
5HVN
1
AROB_FRATT
A:
[38-342]
-------------------------------------
K
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
--
L
A
A
L
V
D
-
D
L
------
D
V
------
R
T
C
----
I
L
----
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
-
N
S
T
V
L
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
K
D
F
Y
L
--
W
L
D
S
N
-
R
D
K
I
L
----
A
K
---
D
-----
S
---------
V
-
T
----------------
L
I
E
------------
M
---
V
K
R
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
R
G
L
K
H
G
E
A
V
G
V
G
M
A
Q
A
I
D
F
S
H
Y
L
G
L
I
S
Q
Q
Q
A
K
D
F
N
D
F
I
V
-
S
F
G
I
S
I
D
F
PN
D
-
I
-
C
-----------
Q
-----------
K
-
E
-----------
F
L
E
A
M
L
L
-
D
---------
N
K
E
L
K
F
I
L
I
E
N
-
I
G
---------------------------
11
PsiBlast_PDB
73.31
37%
4
- C4 -
-
1NVD
2
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
----------------------
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
A
G
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
26
PsiBlast_CBE
73.07
37%
6
- C4 -
-
1NVF
2
ARO1_EMENI
C:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
EE
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
IYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
NAETILKA
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGTEEILK
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
IRKLTAGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
10
PsiBlast_PDB
72.78
37%
3
- C4 -
-
1NVB
2
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
5
PsiBlast_PDB
72.77
37%
3
- C4 -
-
1DQS
3
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
--------------------------------------
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
TAGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
34
PsiBlast_CBE
72.32
37%
5
- C4 -
-
1NR5
2
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
30
PsiBlast_CBE
72.24
37%
3
- C4 -
-
1NVB
1
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
EE
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
IYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
NAETILKA
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGTEEILK
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
IRKLTAGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
6
PsiBlast_PDB
72.21
37%
7
- C4 -
-
1NR5
2
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
35
PsiBlast_CBE
72.15
37%
4
- C4 -
-
1DQS
3
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
----------------------------------------T
E
E
I
L
K
--
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
27
PsiBlast_CBE
71.77
37%
9
- C4 -
-
1NVF
3
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
EE
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
IYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
NAETILKA
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGTEEILK
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
IRKLTAGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
12
PsiBlast_PDB
71.28
37%
9
- C4 -
-
1NVF
3
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
A
G
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
31
PsiBlast_CBE
71.25
37%
-2
- C4 -
-
1NVA
1
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
A
G
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
--------
G
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
25
PsiBlast_CBE
71.13
37%
-17
- C4 -
-
1SG6
1
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
--------------
K
K
I
V
L
L
S
A
-
I
G
---------------------------
33
PsiBlast_CBE
70.50
37%
-12
- C4 -
-
1NRX
1
ARO1_EMENI
B:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
13
PsiBlast_PDB
70.39
37%
-8
- C4 -
-
1SG6
1
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-----
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AGKHCS
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
K
K
------------
I
V
L
L
S
A
-
I
G
---------------------------
7
PsiBlast_PDB
70.34
37%
-12
- C4 -
-
1NRX
1
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
-
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------
9
PsiBlast_PDB
69.04
37%
-9
- C4 -
-
1NVA
1
ARO1_EMENI
A:
[41-372]
-----------------------------------------
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
E
I
------
T
P
------
S
P
R
----
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
-
S
E
E
E
--
F
T
A
L
E
-
E
N
A
E
T
I
L
K
A
V
R
---
R
-----
E
---------
V
-
T
----------------
P
G
E
H
R
F
EGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
Q
I
L
-
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
-
A
Y
G
L
P
T
S
L
--
K
-
D
-
A
-----------
R
I
R
K
L
T
A
G
K
H
C
S
V
D
Q
-----------
L
M
F
N
M
A
L
-
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
---------------------------