@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XY74: (2018-01-08 )
MQIYDYIVIGGGSGGIASANRAGMHGAKVLLIEANELGGTCVNVGCVPKKVMWQASTILETIERDASSYGIQADLKNVDFAGLVERREKYIDFLHGAYQRGLDSNHVEAIKGYATFIDSQTIEVNGETYRAPKILIATGGRASKMTIPGGEYAIDSNGFFELTELPKRAIVLGAGYIAAELSGVFRGLGSEVMWAYRKERPLRTFDKMLSDNLIQMYQEAGIKTYAHHIAKEITKNNDEYTVLFENGETLTGDCVLFAGGRVPNTEKLGLENTNVELDKKGFIKVDKYQNTTDEHIFAVGDVIGKLDLTPVAIAAGRRLSERLFNGKKDSYLDYKLVPTVVFTHPPIATIGLTEEEALEKYGENELKVYRSRFTPMYFALNDYRQKCEMKLICVGKEERIVGLHAIGVGVDEMLQGFAVAIKMGATKEDFDNTVAIHPTGAEEFVTMR
Atome Classification :
(39 SA)
.........10.....-...20........30.....---------...40........50........60.....-...70.-.....--.--.80........90........100-....-...110......--.--120...-----..---------...130-----.......140--------..---....---..150.........160.......170.......180.....---..190.......200-.......210.......220.......230...------.-..-.-240---..---...------.-.250-------.......260.......270.......280-.......290.......300----..-.-..----.-...310.......320.--......330.......340.......350.......360.......370....--...380----.-..-.-...-390......-.400.......-.410.......420.......430......---.440......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
I
Y
D
Y
I
V
I
GGGSGGI-ASANRAGMHG
A
K
V
L
L
I
EANE---------LG
G
T
C
V
NVGCV
P
K
K
V
M
W
Q
A
S
T
I
L
E
T
I
E
R
D
A
-
S
SYGIQ-ADLKN--V--
D
F
A
G
L
V
E
R
R
E
K
Y
I
D
F
L
H
G
A
Y
QRGL-DS
N
H
-
V
E
A
I
K
G
Y
A
TFID--S--
Q
-
T
I
E
V-----NG---------E
T
Y
RA
P
-----
K
I
L
I
ATGGR---------
A
S
---
K
M
TI---PGG--
E
Y
A
IDSNGF
F
E
L
T
ELPK
R
A
I
V
LG
A
G
Y
I
A
A
E
L
S
G
V
F
R
G
---
L
G
S
E
V
M
W
A
Y
RKERP
L
-
R
T
F
D
K
M
L
S
D
N
L
I
Q
M
Y
Q
EAG
I
K
T
Y
A
H
H
I
A
K
E
I
TK------N-ND-
E
-
Y
T
V
---
L
F
---ENG------E-TLTG-------
D
C
V
L
F
AGGRVPN
T
E
KLGLENTN
V
E
LDKKG
F
-
I
K
V
DKYQNTT
D
E
H
I
F
A
V
G
------
D
V
-I-GK----L-DLT
P
V
A
I
A
A
G
R
R
L
S
E
R
L
--FNGKKDS
Y
L
D
Y
K
L
V
P
T
V
V
FTHPP
I
A
T
IGL
T
E
E
E
A
L
E
KYG
E
N
E
L
K
V
Y
R
S
RFT
P
M
--
Y
F
A
L
N
D
----
Y
-
R
Q
-K-C
E
M
-
K
L
I
C
VGKE
E
-
R
I
V
-
G
L
H
AIGV-
G
V
D
E
M
L
Q
G
F
A
V
A
IKMGATKEDFD
N
T
V
A
IHP---T
G
A
E
E
F
VTMR
119
HHSearch
96.33
57%
-55
- C1 -
-
5VDN
4
?
B:
[15-463]
T
K
H
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
-
P
D
Y
G
F
D
-
T
T
V
N
H
--
F
--
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
N
K
-
V
D
V
I
Q
G
F
A
R
F
V
D
--
A
--
H
-
T
V
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
A
--
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
---
L
G
T
E
T
H
L
F
V
R
K
H
A
P
L
-
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
------
N
A
D
G
-
S
-
L
T
L
---
Q
L
---
E
N
G
------
T
-
E
V
T
V
-------
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
-
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
N
-
T
-
G
V
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
T
A
M
--
Y
S
A
V
T
-----
Q
-
H
R
Q
P
-
C
R
M
-
K
L
V
C
V
G
A
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
101
HHSearch
95.98
56%
-58
- C1 -
-
1GES
2
GSHR_ECOLI
B:
[2-449]
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
-
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
T
D
G
-
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
-----
T
-
H
R
Q
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
-
6
PsiBlast_PDB
95.79
56%
-61
- C1 -
-
1GES
2
GSHR_ECOLI
A:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
-
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
21
PsiBlast_CBE
95.73
58%
-58
- C1 -
-
5VDN
4
?
B:
[18-463]
---
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
-
P
D
Y
G
F
D
-
T
T
V
N
H
--
F
--
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
N
K
-
V
D
V
I
Q
G
F
A
R
F
V
D
--
A
--
H
-
T
V
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
A
--
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
---
L
G
T
E
T
H
L
F
V
R
K
H
A
P
L
-
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
------
N
-
A
D
G
S
-
L
T
L
---
Q
L
---
E
N
G
------
T
-
E
V
T
V
-------
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
-
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
N
-
T
-
G
V
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
T
A
M
--
Y
S
A
V
T
Q
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
A
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
29
PsiBlast_CBE
95.46
56%
-59
- C1 -
-
1GES
2
GSHR_ECOLI
B:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
-
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
107
HHSearch
95.21
57%
-58
- C1 -
-
5V36
1
?
B:
[5-452]
T
K
Q
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
-
A
D
Y
G
F
D
-
V
T
T
Q
A
--
F
--
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
N
G
-
V
E
R
V
Y
G
Y
A
T
F
V
D
--
A
--
H
-
T
V
E
V
-----
A
G
---------
E
H
Y
T
A
P
-----
H
I
L
I
A
T
G
G
H
---------
A
L
---
L
P
D
I
---
P
G
S
--
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
---
L
G
S
E
T
H
L
F
V
R
R
D
R
P
L
-
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
------
N
T
D
N
-
S
-
L
T
L
---
I
L
---
E
N
G
------
E
-
E
Y
T
V
-------
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
-
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
------
D
V
-
N
-
G
K
----
L
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
T
S
M
--
Y
T
A
V
T
-----
S
-
H
R
Q
A
-
C
K
M
-
K
L
V
T
V
G
E
D
E
-
K
I
V
-
G
L
H
G
I
G
Y
-
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
-
24
PsiBlast_CBE
95.15
58%
-58
- C1 -
-
5V36
1
?
B:
[8-453]
---
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
-
A
D
Y
G
F
D
-
V
T
T
Q
A
--
F
--
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
N
G
-
V
E
R
V
Y
G
Y
A
T
F
V
D
--
A
--
H
-
T
V
E
V
-----
A
G
---------
E
H
Y
T
A
P
-----
H
I
L
I
A
T
G
G
H
---------
A
L
---
L
P
D
I
---
P
G
S
--
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
---
L
G
S
E
T
H
L
F
V
R
R
D
R
P
L
-
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
------
N
-
T
D
N
S
-
L
T
L
---
I
L
---
E
N
G
------
E
-
E
Y
T
V
-------
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
-
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
------
D
V
-
N
-
G
K
----
L
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
T
S
M
--
Y
T
A
V
T
S
----
H
-
R
Q
-
A
-
C
K
M
-
K
L
V
T
V
G
E
D
E
-
K
I
V
-
G
L
H
G
I
G
Y
-
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
23
PsiBlast_CBE
94.96
57%
-58
- C1 -
-
1GER
2
GSHR_ECOLI
B:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
---
L
G
A
K
T
H
L
F
V
R
K
H
A
P
L
-
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
1
PsiBlast_PDB
94.87
58%
-57
- C1 -
-
5VDN
4
?
A:
[18-463]
---
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
-
P
D
Y
G
F
D
-
T
T
V
N
H
--
F
--
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
N
K
-
V
D
V
I
Q
G
F
A
R
F
V
D
--
A
--
H
-
T
V
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
A
--
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
---
L
G
T
E
T
H
L
F
V
R
K
H
A
P
L
-
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
------
N
-
A
D
G
S
-
L
T
L
---
Q
L
---
E
N
G
------
T
-
E
V
T
V
-------
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
-
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
N
-
T
-
G
V
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
T
A
M
--
Y
S
A
V
T
Q
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
A
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
3
PsiBlast_PDB
94.67
57%
-60
- C1 -
-
1GET
3
GSHR_ECOLI
A:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
---
L
G
A
K
T
H
L
F
V
R
K
H
A
P
L
-
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
4
PsiBlast_PDB
94.24
58%
-58
- C1 -
-
5V36
3
?
A:
[8-453]
---
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
-
A
D
Y
G
F
D
-
V
T
T
Q
A
--
F
--
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
N
G
-
V
E
R
V
Y
G
Y
A
T
F
V
D
--
A
--
H
-
T
V
E
V
-----
A
G
---------
E
H
Y
T
A
P
-----
H
I
L
I
A
T
G
G
H
---------
A
L
---
L
P
D
I
---
P
G
S
--
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
---
L
G
S
E
T
H
L
F
V
R
R
D
R
P
L
-
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
------
N
-
T
D
N
S
-
L
T
L
---
I
L
---
E
N
G
------
E
-
E
Y
T
V
-------
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
-
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
------
D
V
-
N
-
G
K
----
L
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
T
S
M
--
Y
T
A
V
T
S
----
H
-
R
Q
-
A
-
C
K
M
-
K
L
V
T
V
G
E
D
E
-
K
I
V
-
G
L
H
G
I
G
Y
-
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
22
PsiBlast_CBE
93.89
57%
-59
- C1 -
-
1GET
3
GSHR_ECOLI
B:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
---
L
G
A
K
T
H
L
F
V
R
K
H
A
P
L
-
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
2
PsiBlast_PDB
93.57
57%
-58
- C1 -
-
1GER
2
GSHR_ECOLI
A:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
---
L
G
A
K
T
H
L
F
V
R
K
H
A
P
L
-
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
28
PsiBlast_CBE
92.86
56%
-58
- C1 -
-
1GEU
3
GSHR_ECOLI
B:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
-
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
25
PsiBlast_CBE
92.67
57%
-55
- C1 -
-
5U1O
2
?
D:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
-
E
D
Y
G
F
D
-
V
D
V
K
G
--
F
--
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
N
K
-
V
N
V
I
K
G
F
A
K
F
V
D
--
E
--
K
-
T
V
E
V
-----
N
G
---------
E
H
Y
T
A
D
-----
H
I
L
I
A
V
G
G
R
---------
P
T
---
I
P
N
I
---
P
G
A
--
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
---
L
G
T
E
T
H
L
F
V
R
K
E
S
P
L
-
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
------
E
-
A
D
G
S
-
L
T
L
---
H
L
---
E
N
G
------
E
-
S
Q
N
V
-------
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
-
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
------
D
I
-
M
E
G
G
----
I
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
T
A
M
--
Y
T
A
V
T
K
----
H
-
R
Q
-
P
-
C
K
M
-
K
L
V
C
A
G
E
E
E
-
T
V
V
-
G
L
H
G
I
G
F
-
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
5
PsiBlast_PDB
92.51
57%
-54
- C1 -
-
5U1O
2
?
A:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
-
E
D
Y
G
F
D
-
V
D
V
K
G
--
F
--
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
N
K
-
V
N
V
I
K
G
F
A
K
F
V
D
--
E
--
K
-
T
V
E
V
-----
N
G
---------
E
H
Y
T
A
D
-----
H
I
L
I
A
V
G
G
R
---------
P
T
---
I
P
N
I
---
P
G
A
--
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
---
L
G
T
E
T
H
L
F
V
R
K
E
S
P
L
-
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
------
E
-
A
D
G
S
-
L
T
L
---
H
L
---
E
N
G
------
E
-
S
Q
N
V
-------
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
-
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
------
D
I
-
M
E
G
G
----
I
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
T
A
M
--
Y
T
A
V
T
K
----
H
-
R
Q
-
P
-
C
K
M
-
K
L
V
C
A
G
E
E
E
-
T
V
V
-
G
L
H
G
I
G
F
-
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
27
PsiBlast_CBE
92.25
57%
-53
- C1 -
-
5U1O
2
?
B:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
-
E
D
Y
G
F
D
-
V
D
V
K
G
--
F
--
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
N
K
-
V
N
V
I
K
G
F
A
K
F
V
D
--
E
--
K
-
T
V
E
V
-----
N
G
---------
E
H
Y
T
A
D
-----
H
I
L
I
A
V
G
G
R
---------
P
T
---
I
P
N
I
---
P
G
A
--
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
---
L
G
T
E
T
H
L
F
V
R
K
E
S
P
L
-
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
------
E
-
A
D
G
S
-
L
T
L
---
H
L
---
E
N
G
------
E
-
S
Q
N
V
-------
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
-
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
------
D
I
-
M
E
G
G
----
I
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
T
A
M
--
Y
T
A
V
T
K
----
H
-
R
Q
-
P
-
C
K
M
-
K
L
V
C
A
G
E
E
E
-
T
V
V
-
G
L
H
G
I
G
F
-
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
40
PsiBlast_CBE
92.04
48%
-61
- C1 -
-
2R9Z
2
GASHR_MARGR
B:
[3-448]
-
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
-
P
G
F
G
V
Q
-
A
S
G
-
T
--
L
--
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
--
A
--
H
-
T
I
E
V
-----
E
G
---------
Q
R
L
S
A
D
-----
H
I
V
I
A
T
G
G
R
---------
P
I
---
V
P
R
L
---
P
G
A
--
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
-
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
------
D
-
A
Q
-
G
-
T
T
L
---
V
A
---
Q
D
G
------
T
-
R
L
E
G
F------
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
------
D
I
-
T
-
G
R
----
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
T
P
M
--
R
Y
A
L
N
E
----
H
-
G
P
-
K
-
T
A
M
-
K
L
V
C
A
G
P
E
Q
-
R
V
V
-
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
7
PsiBlast_PDB
92.00
56%
-56
- C1 -
-
1GEU
3
GSHR_ECOLI
A:
[5-450]
---
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
-
P
D
Y
G
F
D
-
T
T
I
N
K
--
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
--
A
--
K
-
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
---------
P
S
---
H
P
D
I
---
P
G
V
--
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
-
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
G
S
-
L
T
L
---
E
L
---
E
D
G
------
R
-
S
E
T
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
----
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
--
Y
T
A
V
T
T
----
H
-
R
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
F
-
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
26
PsiBlast_CBE
91.93
57%
-54
- C1 -
-
5U1O
2
?
C:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
-
E
D
Y
G
F
D
-
V
D
V
K
G
--
F
--
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
N
K
-
V
N
V
I
K
G
F
A
K
F
V
D
--
E
--
K
-
T
V
E
V
-----
N
G
---------
E
H
Y
T
A
D
-----
H
I
L
I
A
V
G
G
R
---------
P
T
---
I
P
N
I
---
P
G
A
--
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
---
L
G
T
E
T
H
L
F
V
R
K
E
S
P
L
-
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
------
E
-
A
D
G
S
-
L
T
L
---
H
L
---
E
N
G
------
E
-
S
Q
N
V
-------
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
-
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
------
D
I
-
M
E
G
G
----
I
-
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
T
A
M
--
Y
T
A
V
T
K
----
H
-
R
Q
-
P
-
C
K
M
-
K
L
V
C
A
G
E
E
E
-
T
V
V
-
G
L
H
G
I
G
F
-
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
104
HHSearch
90.98
49%
-58
- C1 -
-
2R9Z
2
GASHR_MARGR
B:
[2-447]
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
-
P
G
F
G
V
Q
-
A
S
G
-
T
--
L
--
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
--
A
--
H
-
T
I
E
V
-----
E
G
---------
Q
R
L
S
A
D
-----
H
I
V
I
A
T
G
G
R
---------
P
I
---
V
P
R
L
---
P
G
A
--
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
-
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
------
D
-
A
Q
-
G
-
T
T
L
---
V
A
---
Q
D
G
T-----
R
-
L
E
G
F
-------
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
------
D
I
-
T
-
G
R
----
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
T
P
M
--
R
Y
A
L
N
-----
E
-
H
G
P
K
-
T
A
M
-
K
L
V
C
A
G
P
E
Q
-
R
V
V
-
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
-
41
PsiBlast_CBE
90.23
48%
-61
- C1 -
-
2R9Z
2
GASHR_MARGR
A:
[3-448]
-
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
-
P
G
F
G
V
Q
-
A
S
-----
L
--
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
--
A
--
H
-
T
I
E
V
-----
E
G
---------
Q
R
L
S
A
D
-----
H
I
V
I
A
T
G
G
R
---------
P
I
---
V
P
R
L
---
P
G
A
--
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
-
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
------
D
-
A
Q
-
G
-
T
T
L
---
V
A
---
Q
D
G
------
T
-
R
L
E
G
F------
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
------
D
I
-
T
-
G
R
----
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
T
P
M
--
R
Y
A
L
N
E
----
H
-
G
P
-
K
-
T
A
M
-
K
L
V
C
A
G
P
E
Q
-
R
V
V
-
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
102
HHSearch
89.39
49%
-58
- C1 -
-
2R9Z
2
GASHR_MARGR
A:
[2-447]
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
-
P
G
F
G
V
Q
-
A
S
-----
L
--
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
--
A
--
H
-
T
I
E
V
-----
E
G
---------
Q
R
L
S
A
D
-----
H
I
V
I
A
T
G
G
R
---------
P
I
---
V
P
R
L
---
P
G
A
--
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
-
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
------
D
-
A
Q
-
G
-
T
T
L
---
V
A
---
Q
D
G
T
-----
R
-
L
E
G
F
-------
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
------
D
I
-
T
-
G
R
----
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
T
P
M
--
R
Y
A
L
N
-----
E
-
H
G
P
K
-
T
A
M
-
K
L
V
C
A
G
P
E
Q
-
R
V
V
-
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
-
103
HHSearch
82.97
51%
-15
- C1 -
-
3DK9
1
GSHR_HUMAN
A:
[19-478]
-
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
--
D
PK
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
---
T
P
H
E
SQI
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
S
M
V
T
A
---
V
P
G
R
L
P
V
M
T
M
-
I
P
D
V
-------
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
-----
K
-
R
K
T
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
37
PsiBlast_CBE
82.14
49%
-15
- C1 -
-
3DJJ
10
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
DP
K
--
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
T
P
H
E
S
Q
I
---
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
---
S
M
---
V
T
A
V
PGR
L
-
P
-
V
M
T
M
I
P
DV---
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
K
----
R
-
K
T
-
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
35
PsiBlast_CBE
82.10
49%
-14
- C1 -
-
3DK8
5
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
DP
K
--
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
T
P
H
E
S
Q
I
---
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
---
S
M
---
V
T
A
V
PGR
L
-
P
-
V
M
T
M
I
P
DV---
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
K
----
R
-
K
T
-
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
38
PsiBlast_CBE
81.79
49%
-13
- C1 -
-
3DJG
2
GSHR_HUMAN
X:
[20-477]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
DP
K
--
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
TPH
E
S
Q
I
---
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
---
S
M
---
V
T
A
VPGRL-
P
-
V
M
T
M
IPDV---
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
K
----
R
-
K
T
-
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
117
HHSearch
79.67
44%
-46
- C1 -
-
1ONF
1
GSHR_PLAFK
A:
[2-495]
--
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
N
A
K
V
A
L
V
E
K
S
R
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
-
E
N
S
-
R
H
Y
G
F
D
-
T
-
K
F
S
--
F
--
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
L
-------------------------------
E
G
R
-----
N
I
L
I
A
V
G
N
K
---------
P
V
---
F
P
P
V
---
K
G
I
--
E
N
T
I
S
S
D
E
F
F
N
I
K
-
E
S
K
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
R
---
L
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
-
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
------
V
S
D
K
-
N
-
L
S
I
---
H
L
---
S
D
G
------
R
I
Y
E
H
F
-------
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
N
-
N
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
------
D
C
-
C
-
M
V
KF
Y
N
V
-
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
L
K
K
-
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
N
V
K
I
Y
E
S
K
F
T
N
L
--
F
F
S
V
Y
D
IE--
P
E
L
K
E
K
-
T
Y
L
-
K
L
V
C
V
G
K
D
E
-
L
I
K
-
G
L
H
I
I
G
L
-
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
-
105
HHSearch
79.04
51%
-14
- C1 -
-
2GRT
1
GSHR_HUMAN
A:
[1-461]
V
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
--
D
P
K
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
---
T
P
H
E
SQI
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
S
M
V
T
A
---
V
P
G
R
L
P
V
M
T
M
-
I
P
D
V
-------
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
-----
K
-
R
K
T
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
42
PsiBlast_CBE
78.43
40%
-53
- C1 -
-
1ONF
1
GSHR_PLAFK
A:
[2-496]
--
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
N
A
K
V
A
L
V
E
K
S
R
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
-
N
S
-
R
H
Y
G
F
D
-
T
K
F
-
S
--
F
--
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
L
-------------------------------
E
G
R
-----
N
I
L
I
A
V
G
N
K
---------
P
V
---
F
P
P
V
---
K
G
I
--
E
N
T
I
S
S
D
E
F
F
N
I
K
E
S
K
K
I
G
I
V
-
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
R
---
L
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
-
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
------
V
-
S
D
-
K
N
L
S
I
---
H
L
---
S
D
G
------
R
-
I
Y
E
H
F------
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
N
-
N
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
DCCMVK---
F
-
Y
N
----
V
-
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
-
L
K
K
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
N
V
K
I
Y
E
S
K
F
T
N
L
--
F
F
S
V
Y
D
IEPE
L
-
K
E
-
K
-
T
Y
L
-
K
L
V
C
V
G
K
D
E
-
L
I
K
-
G
L
H
I
I
G
L
-
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
Q
39
PsiBlast_CBE
78.33
49%
-9
- C1 -
-
2GH5
12
GSHR_HUMAN
B:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
-
A
D
Y
G
F
P
-
S
C
E
G
K
--
F
--
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
DP
K
--
P
-
T
I
E
V
-----
S
G
---------
K
K
Y
T
A
P
-----
H
I
L
I
A
T
G
G
M
---------
P
S
TPH
E
S
Q
I
---
P
G
A
--
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
-
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
------
T
-
L
S
-
G
-
L
E
V
---
S
M
---
V
T
A
VPGRL-
P
-
V
M
T
M
IPDV---
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
------
D
V
-
C
-
G
K
----
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
M
--
Y
H
A
V
T
K
----
R
-
K
T
-
K
-
C
V
M
-
K
M
V
C
A
N
K
E
E
-
K
V
V
-
G
I
H
M
Q
G
L
-
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
124
Fugue
71.87
53%
26
- C1 -
-
1GER
2
GSHR_ECOLI
A:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
-E--------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P-
D
Y
G
F
D
-
T
T
I
--NK
F
--
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
V
D
V
I
K
-
G
F
A
R
F
V
---
D
--
A
K
T
L
E
V
-----
N
G
---------
E
T
I
T
A
D
-----
H
I
L
I
A
T
G
G
R
P
S
H
P
DIPGV-
E
---
Y
G
I
D
--------
S
D
G
F
F
A
L
P
-----
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
-
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
------
N
-
T
D
-
G
-
S
L
T
---
L
E
L
ED-
G
R
------
S
-
E
T
-
V
-------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
------
D
N
-
T
-
G
A
-----V
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
FN--
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
-MY
T
A
V
T
T
H
----
R
--
Q
-
P
-
C
R
M
-
K
L
V
C
V
G
S
E
E
-
K
I
V
-
G
I
H
G
I
G
-F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
--
V
A
I
H
PT-
A
A
E
E
F
V
T
M
R
68
PsiBlast_CBE
66.78
34%
3
- C1 -
-
5EBK
6
?
A:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
-
R
E
S
-
G
G
F
G
W
E
-
M
D
R
E
S
--
L
CP
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
--
A
--
H
-
T
V
V
V
-----
R
K
SEDPHSDVL
E
T
L
D
T
E
-----
Y
I
L
I
A
T
G
S
W
---------
P
T
---
R
L
G
V
---
P
G
D
--
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KP
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
-
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
------
N
-
E
D
G
S
-
N
H
V
---
H
F
---
N
D
G
------
T
-
E
E
D
Y
-------
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
------
D
V
-
T
-
N
R
----
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
T
P
L
--
M
H
N
I
S
G
----
S
-
K
H
-
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
-
E
V
L
-
G
V
H
M
L
G
D
-
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
72
PsiBlast_CBE
65.38
34%
4
- C1 -
-
4ADW
5
?
A:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
-
R
E
S
-
G
G
F
G
W
E
-
M
D
R
E
S
--
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
--
A
--
H
-
T
V
V
V
-----
R
K
SEDPHSDVL
E
T
L
D
T
E
-----
Y
I
L
I
A
T
G
S
W
---------
P
T
---
R
L
G
V
---
P
G
D
--
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KP
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
-
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
------
N
-
E
D
G
S
-
N
H
V
---
H
F
---
N
D
G
------
T
-
E
E
D
Y
-------
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
------
D
V
-
T
-
N
R
----
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
T
P
L
--
M
H
N
I
S
G
----
S
-
K
H
-
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
-
E
V
L
-
G
V
H
M
L
G
D
-
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
67
PsiBlast_CBE
65.03
34%
2
- C1 -
-
5EBK
7
?
B:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
-
R
E
S
-
G
G
F
G
W
E
-
M
D
R
E
S
--
L
CP
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
--
A
--
H
-
T
V
V
V
-----
R
K
SEDPHSDVL
E
T
L
D
T
E
-----
Y
I
L
I
A
T
G
S
W
---------
P
T
---
R
L
G
V
---
P
G
D
--
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KP
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
-
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
------
N
-
E
D
G
S
-
N
H
V
---
H
F
---
N
D
G
------
T
-
E
E
D
Y
-------
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
------
D
V
-
T
-
N
R
----
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
T
P
L
--
M
H
N
I
S
G
----
S
-
K
H
-
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
-
E
V
L
-
G
V
H
M
L
G
D
-
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
71
PsiBlast_CBE
64.81
34%
4
- C1 -
-
4ADW
5
?
B:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
-
R
E
S
-
G
G
F
G
W
E
-
M
D
R
E
S
--
L
CP
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
--
A
--
H
-
T
V
V
V
-----
R
K
SEDPHSDVL
E
T
L
D
T
E
-----
Y
I
L
I
A
T
G
S
W
---------
P
T
---
R
L
G
V
---
P
G
D
--
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
YKP
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
-
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
------
N
-
E
D
G
S
-
N
H
V
---
H
F
---
N
D
G
------
T
-
E
E
D
Y
-------
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
------
D
V
-
T
-
N
R
----
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
T
P
L
--
M
H
N
I
S
G
----
S
-
K
H
-
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
-
E
V
L
-
G
V
H
M
L
G
D
-
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
82
PsiBlast_CBE
64.54
36%
0
- C1 -
-
1ZKQ
1
TRXR2_MOUSE
A:
[31-501]
-
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
L
-
A
C
A
K
E
A
A
Q
L
G
K
K
V
A
V
A
D
Y
V
E
PSPR
G
T
K
W
G
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
A
-
L
L
G
G
M
I
R
D
A
-
H
H
Y
G
W
E
V
A
Q
P
V
Q
--
H
--
N
W
K
T
M
A
E
A
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
V
D
--
E
--
H
-
T
V
R
G
V
D
KG
G
K
A
---------
T
L
L
S
A
E
-----
H
I
V
I
A
T
G
G
R
---------
P
R
---
Y
P
T
Q
---
V
K
G
AL
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
T
G
---
I
G
L
D
T
T
V
M
M
R
-
S
I
P
L
-
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
K
K
L
-----
P
-
T
N
-
Q
-
L
Q
V
---
T
W
---
E
D
H
ASGK
E
-
D
-
T
G
T
F
-------
D
T
V
L
W
A
I
G
R
V
P
E
T
R
T
L
N
L
E
K
A
G
I
S
T
N
P
K
N
Q
K
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
------
D
V
-
A
E
G
R
----
P
-
E
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
--
F
-
G
K
S
S
T
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
H
V
E
V
Y
H
A
Y
Y
K
P
L
--
E
F
T
V
A
D
----
R
D
A
S
-
Q
-
C
Y
I
-
K
M
V
C
M
R
E
P
P
-
Q
L
V
L
G
L
H
F
L
G
P
-
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
---
T
C
S
E
E
V
V
K
L
H
83
PsiBlast_CBE
63.55
36%
0
- C1 -
-
1ZDL
2
TRXR2_MOUSE
A:
[31-501]
-
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
L
-
A
C
A
K
E
A
A
Q
L
G
K
K
V
A
V
A
D
Y
V
E
PSPRG
T
K
W
G
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
A
-
L
L
G
G
M
I
R
D
A
-
H
H
Y
G
W
E
V
A
Q
P
V
Q
--
H
--
N
W
K
T
M
A
E
A
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
V
D
--
E
--
H
-
T
V
R
G
V
D
KG
G
K
A
---------
T
L
L
S
A
E
-----
H
I
V
I
A
T
G
G
R
---------
P
R
---
Y
P
T
Q
---
V
K
G
AL
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
T
G
---
I
G
L
D
T
T
V
M
M
R
-
S
I
P
L
-
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
K
K
L
-----
P
-
T
N
-
Q
-
L
Q
V
---
T
W
---
E
D
H
ASGK
E
-
D
-
T
G
T
F
-------
D
T
V
L
W
A
I
G
R
V
P
E
T
R
T
L
N
L
E
K
A
G
I
S
T
N
P
K
N
Q
K
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
------
D
V
-
A
E
G
R
----
P
-
E
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
--
F
-
G
K
S
S
T
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
H
V
E
V
Y
H
A
Y
Y
K
P
L
--
E
F
T
V
A
D
----
R
D
A
S
-
Q
-
C
Y
I
-
K
M
V
C
M
R
E
P
P
-
Q
L
V
L
G
L
H
F
L
G
P
-
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
---
T
C
S
E
E
V
V
K
L
H
65
PsiBlast_CBE
62.09
36%
10
- C1 -
-
2X8C
5
?
A:
[108-582]
---
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
G
A
K
T
A
V
L
D
Y
V
E
P
T
PI
G
T
T
W
G
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
-
E
H
F
G
W
S
-
L
D
R
S
K
--
I
S
H
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
--
P
--
H
-
E
V
Q
I
-----
T
D
---------
K
N
Q
K
V
S
T
I
T
G
N
K
I
I
L
A
T
G
E
R
---------
P
K
---
Y
P
E
I
---
P
G
A
V-
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
S
---
L
G
G
D
V
T
V
M
V
R
S
I
L
-
L
-
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
-
N
N
-
K
-
P
G
L
---
L
L
---
V
K
G
------
H
-
Y
T
D
G
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
------
D
I
N
A
-
G
K
----
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
-
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
D
I
E
V
Y
H
S
N
F
K
P
L
--
E
W
T
V
A
H
----
R
-
E
D
-
N
V
C
Y
M
-
K
L
V
C
R
K
S
D
N
M
R
V
L
-
G
L
H
V
L
G
P
-
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H