@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XY78: (2018-01-08 )
MAKQNIVVVGAGYAGVSATKYLAKKLKKEDVAITLIDRHSYHTMMTELHEVAGGRVEPEAIQYDLQHLFARQKNVQLVTDTVIGIDKERKIVKTKLGSYPFDQLILGMGGEPNDFGTPGVKAHGFTLWSFEDSVRIREHIEKTVAKAALEPDDELRKAMLTFVVCGSGFTGIEMIGELIDWKNRLAKDYKLDPNEITLMVVEAMPTILNMLDRNDAAKAERYLRKHNVELLLNAPIVEVAADHIKLKDGRNIPTHTLIWTAGVKGTSDAADFGLESARGQRLIANEYMQAKGYEDKNIYIIGDLVFYEEFPGTPTPQIVQAAEQTGHTAAANIVASIKGGEKHKFKGNYQGFMVSIGAKWGVANLFDKIHLSGFLAIVMKHIVNLKYFFDIRSGYYMFQYLMHEFFHIKDDRNVTRGHSSRYGNVLWSVPLRIFYGLVWFVEASKKIIGNGEVFKPSTWFGEGSWFTGNSVFPWTWEYNVTDVASGASAAGDATTAASGAGASAGEAATQAAHFGLSYAYGEEPMAVIEKSPDWFTKIMQVIMPNNDVAMFFQKFMVFFEIALALALIAGLFTWLCSATTIVLVITFCLSGMFYWVNIWFIFVAFALMNGSGRAIGLDRWVIPWLQRTLGNWWYGRPSSQYGKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.....---..--250.......260.......270.......280.......290.......300.--......310........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAKQ
N
I
V
V
V
GAGYAG
V
S
A
T
K
Y
L
A
K
K
LKKED
V
A
I
T
L
IDRH
S
Y
H
T
M
M
T
E
L
H
E
VAGGRV
E
P
E
A
I
Q
Y
D
L
Q
H
L
F
A
RQKN
V
Q
L
V
T
D
T
V
IGIDKE
R
K
I
V
K
T
KLGSY
P
F
D
Q
L
I
LGMGGEPNDFGTPGVKAH
G
F
T
L
WSFE
D
S
V
R
-
I
R
E
H
I
E
K
T
V
A
K
AALEP
D
D
E
L
R
K
A
M
L
T
F
V
V
CGSG
F
T
G
I
E
M
I
G
E
L
I
D
W
K
N
R
L
A
KDYKLDPN
E
I
T
L
M
V
V
E
A
M
P
T
I
L
N
M
LDRN
D
A
A
K
A
E
R
Y
L
R
KHN
V
E
L
L
LNA
P
I
V
E
VAA
D
H
I
K
LK---DG--RNIP
T
H
T
L
I
W
TAGVKGTS
D
A
A
DFG
L
E
S
ARGQ
R
L
I
A
N
E
Y
M
Q
AKGYEDK
N
I
Y
I
I
G
D
--
L
V
F
YEEF-PGTP
T
P
Q
I
V
Q
A
A
E
QTG
H
T
A
A
A
N
I
V
A
SIKGGEKHKFKGNY
Q
G
F
M
V
S
IGAKW
G
V
A
N
L
F
D
K
I
H
L
S
G
F
L
A
I
V
M
K
H
IVN
L
K
Y
F
F
DIRS
G
Y
Y
M
F
Q
Y
L
M
H
E
F
F
HIKDDRNVTRGHSSRYG
N
V
L
W
S
V
P
L
R
I
F
Y
G
L
V
W
F
V
E
A
S
K
KIIGNG
E
V
FKPSTWFGEGSWFTGNS
V
F
P
W
T
W
EYNVTDVASGASAAGDATTAASGAGASA
G
E
A
A
T
Q
A
A
HFG
L
S
Y
AYGEE
P
M
A
V
IEKS
P
D
W
F
T
K
I
M
Q
V
IMPN
N
D
V
A
M
F
F
Q
K
F
M
V
F
F
E
I
A
L
A
L
A
L
I
A
G
L
F
T
W
L
CS
A
T
T
I
V
L
V
I
T
F
C
L
S
G
M
F
Y
W
V
N
I
W
F
I
F
V
A
F
A
L
MNGSG
R
A
IG
L
D
R
W
V
I
P
W
L
Q
R
T
L
GNWWYGRPSSQYGKK
27
PsiBlast_CBE
94.76
35%
-90
- C1 -
-
4NWZ
1
?
C:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
94.38
35%
-91
- C1 -
-
5KMS
1
?
B:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.99
35%
-91
- C1 -
-
5KMS
1
?
D:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.97
35%
-90
- C1 -
-
5KMS
1
?
C:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.73
35%
-89
- C1 -
-
4NWZ
1
?
A:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
93.46
33%
-101
- C1 -
-
5KMS
1
?
B:
[3-393]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
D
-
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
---
A
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
VDG
E
E
--
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
-
M
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
--
E
N
I
F
I
V
G
D
--
C
A
L
I
I
N
E
E
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
-
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
93.14
35%
-89
- C1 -
-
4NWZ
1
?
B:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.06
35%
-89
- C1 -
-
5KMS
2
?
A:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.26
35%
-88
- C1 -
-
5KMR
1
?
B:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
91.84
35%
-87
- C1 -
-
5KMR
2
?
A:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
90.97
35%
-88
- C1 -
-
5KMR
2
?
C:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
---
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
90.87
35%
-84
- C1 -
-
5KMR
2
?
D:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
N
S
V
R
I
-
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
89.90
31%
-83
- C1 -
-
4XDB
1
Y878_STAA8
B:
[10-404]
-
D
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
K
-
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
A
K
K
V
E
T
N
Q
G
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
-
L
S
R
H
I
E
D
K
F
A
N
Y
A
A
--
S
K
E
K
D
D
N
D
L
S
I
L
V
G
G
A
G
F
T
G
V
E
F
L
G
E
L
T
D
R
I
P
E
L
C
S
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
G
F
V
V
E
V
--
D
G
E
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
S
-
F
E
G
V
K
R
G
R
I
V
T
K
Q
D
L
T
I
N
G
Y
--
D
N
I
F
V
I
G
D
--
C
S
A
F
I
P
A
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
L
N
G
E
S
T
E
E
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
H
D
G
V
G
M
V
F
G
-
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
88.39
31%
-83
- C1 -
-
4XDB
1
Y878_STAA8
A:
[10-404]
-
D
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
K
-
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
A
K
K
V
E
T
N
Q
G
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
-
L
S
R
H
I
E
D
K
F
A
N
Y
A
A
--
S
K
E
K
D
D
N
D
L
S
I
L
V
G
G
A
G
F
T
G
V
E
F
L
G
E
L
T
D
R
I
P
E
L
C
S
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
G
F
V
V
E
V
--
D
G
E
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
S
-
F
E
G
V
K
R
G
R
I
V
T
K
Q
D
L
T
I
N
G
Y
--
D
N
I
F
V
I
G
D
--
C
S
A
F
I
P
A
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
L
N
G
E
S
T
E
E
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
H
D
G
V
G
M
V
F
G
-
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.34
36%
-36
- C1 -
-
5KMQ
1
?
A:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
--
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
E
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
85.20
36%
-32
- C1 -
-
5KMQ
1
?
D:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
N
--
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
E
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.61
35%
-34
- C1 -
-
5KMP
1
?
B:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
E
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.38
35%
-35
- C1 -
-
5KMP
1
?
A:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
E
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V
--
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
--
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.80
36%
-47
- C1 -
-
5KMQ
1
?
C:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
N
--
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
---
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
--------
V
Y
G
H
A
A
S
W
L
K
K
L
E
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
82.36
36%
-37
- C1 -
-
5KMQ
1
?
B:
[3-387]
--
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
-
D
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
E
H
A
F
S
I
N
S
I
-
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
V
V
I
E
V--
D
G
EE
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
S
G
F
E
T
M
R
G
-
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
--
N
I
F
I
V
G
D
CA
L
I
I
N
E
E
N
--
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
M
T
P
F
K
P
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
-
K
V
Y
G
H
A
A
S
W
L
K
K
L
E
D
M
R
Y
L
Y
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------