@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYF3: (2018-01-09 )
MNENPLAVKLPGLELKNPIMPASGCFGFGKEYGKYYDLNQLGSIMVKATTPNARFGNPTPRVAETPSGMLNAIGLQNPGLDVVMHKLLPELEEYNELPIIANVAGACEEDYVEVCSKIGEAPNVKAIELNISCPNVKHGGIAFGTDSDVAFQLTQAVKKVSSVPVYVKLSPNVTDIVPIAQAIEAGGADGFTMINTLLGMRIDLKTRKPILANQTGGLSGPAIKPVAIRLIHQVASISSLPIIGMGGVQTVDDVLEMFMAGASAVAIGTANFTDPYICPKLIKELPVRMSELGIESLERLIKEVREERER
Atome Classification :
(22 SA)
-.........10........20.....-...30........40........50..-......60......-..70........80........-90..-....--..100.......110.......120-...---.---...--..130.....--..140.......150.......160.......170.--......180.-..-..----..190.....----..-200.......210-.--...--....220.......230....--.-.-.240--........250.......260.......270...-.....280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MNEN
P
L
A
V
KLPGLELKNPIMPAS
G
C
F
-
G
F
G
K
E
YGKYY
D
L
N
Q
L
G
S
I
M
V
K
ATTPNA-RFGNPTPRVAETPS-
G
M
L
N
AIGLQNP
G
L
D
V
V
M
H
K
L
L
P
-
E
L
E
E
-YNEL--
P
I
I
A
N
V
AGA
C
E
E
D
Y
V
E
V
C
S
KIGE---AP
N
---
V
---
K
A
I
--
E
L
N
ISCPNVK--HG
G
I
A
FGTD
S
D
V
A
F
Q
L
T
Q
A
V
K
K
VSSV
P
V
Y
V
K
LSPN
V
--
T
D
I
V
P
I
A
Q
A
I
-EA-GG----AD
G
F
T
M
I
N
T
L
----LG-
M
R
I
D
LKTRK
P
I
L--A--NQT--GGLSGPA
I
K
P
V
A
I
R
L
I
H
Q
V
A
S--I-S-SL
P
---
I
IGMGG
V
Q
T
V
D
D
V
L
E
M
F
MAGA
S
A
V
A
I
GTA-NFTD-P
Y
I
C
P
K
L
I
K
EL
P
V
R
M
S
EL
G
I
E
S
L
E
R
L
I
K
E
V
R
E
E
RER
4
PsiBlast_PDB
90.70
74%
-50
- C1 -
-
1EP3
2
PYRDB_LACLM
A:
[5-311]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
I
G
L
Q
N
P
G
L
E
V
I
M
T
E
K
L
P
-
W
L
N
E
N
F
P
E
L
--
P
I
I
A
N
V
A
G
S
E
E
A
D
Y
V
A
V
C
A
K
I
G
D
---
A
A
N
---
V
---
K
A
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
Q
P
I
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
D
-
V
-
D
I
P
---
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
K
-
2
PsiBlast_PDB
90.48
74%
-45
- C1 -
-
1EP1
2
PYRDB_LACLM
A:
[5-311]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
I
G
L
Q
N
P
G
L
E
V
I
M
T
E
K
L
P
-
W
L
N
E
N
F
P
E
L
--
P
I
I
A
N
V
A
G
S
E
E
A
D
Y
V
A
V
C
A
K
I
G
D
---
A
A
N
---
V
---
K
A
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
Q
P
I
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
D
-
V
-
D
I
P
---
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
K
-
1
PsiBlast_PDB
90.11
73%
-47
- C1 -
-
5KSW
2
PYRDB_LACLA
A:
[1-306]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
D
G
L
Q
N
P
G
L
E
V
I
M
A
E
K
L
P
-
W
L
N
E
N
F
P
D
L
--
P
I
I
A
N
V
A
G
S
E
E
D
D
Y
V
A
V
C
A
K
I
G
D
---
A
P
N
---
V
---
K
V
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
D
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
K
P
V
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
V
-
V
-
D
I
P
---
I
I
G
M
G
G
V
E
S
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
E
K
L
P
E
V
M
D
Q
Y
G
I
D
S
L
E
N
L
I
Q
E
V
K
N
S
K
--
3
PsiBlast_PDB
88.28
74%
-46
- C1 -
-
1EP2
3
PYRDB_LACLM
A:
[5-311]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
I
G
L
Q
N
P
G
L
E
V
I
M
T
E
K
L
P
-
W
L
N
E
N
F
P
E
L
--
P
I
I
A
N
V
A
G
S
E
E
A
D
Y
V
A
V
C
A
K
I
G
D
---
A
A
N
---
V
---
K
A
I
--
E
L
N
I
S
C
P
N
------
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
Q
P
I
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
D
-
V
-
D
I
P
---
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
K
-
21
PsiBlast_CBE
88.03
73%
-42
- C1 -
-
5KSW
2
PYRDB_LACLA
C:
[1-305]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
D
G
L
Q
N
P
G
L
E
V
I
M
A
E
K
L
P
-
W
L
N
E
N
F
P
D
L
--
P
I
I
A
N
V
A
G
S
E
E
D
D
Y
V
A
V
C
A
K
I
G
D
---
A
P
N
---
V
---
K
V
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
D
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
K
P
V
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
V
-
V
-
D
I
P
---
I
I
G
M
G
G
V
E
S
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
E
K
L
P
E
V
M
D
Q
Y
G
I
D
S
L
E
N
L
I
Q
E
V
K
N
S
---
70
HHSearch
85.51
75%
-18
- C1 -
-
1EP3
2
PYRDB_LACLM
A:
[3-306]
--
E
N
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
I
G
L
Q
N
P
G
L
E
V
I
M
T
E
K
L
P
-
W
L
N
E
N
F
P
E
L
--
P
I
I
A
N
V
A
G
S
E
E
A
D
Y
V
A
V
C
A
K
I
G
D
A--
A
-
N
---
V
---
K
A
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
Q
P
I
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
D
-
V
-
D
I
P
---
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
------
66
HHSearch
84.88
74%
-22
- C1 -
-
5KSW
2
PYRDB_LACLA
A:
[1-303]
----
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
-
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
P
-
R
F
G
N
P
T
P
R
V
A
E
T
A
S
-
G
M
L
N
A
D
G
L
Q
N
P
G
L
E
V
I
M
A
E
K
L
P
-
W
L
N
E
N
F
P
D
L
--
P
I
I
A
N
V
A
G
S
E
E
D
D
Y
V
A
V
C
A
K
I
G
D
A--
P
-
N
---
V
---
K
V
I
--
E
L
N
I
S
C
P
N
V
K
--
H
G
G
Q
A
F
G
T
D
P
D
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
--
T
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
G
-
V
R
F
D
L
K
T
R
K
P
V
L
--
A
--
N
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
V
-
V
-
D
I
P
---
I
I
G
M
G
G
V
E
S
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
D
-
P
F
V
C
P
K
I
I
E
K
L
P
E
V
M
D
Q
Y
G
I
D
S
L
E
N
L
I
Q
E
V
K
-----
55
Fugue
80.20
72%
-4
- C1 -
-
1EP3
2
PYRDB_LACLM
A:
[1-311]
M
T
E
N
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
G
-
C
F
G
F
G
E
E
Y
A
K
Y
Y
D
L
N
K
L
G
S
I
M
V
K
A
T
T
L
H
-P
R
F
G
N
P
T
P
R
V
A
E
T
A
-S
G
M
L
N
A
I
G
L
Q
N
P
G
L
E
V
I
M
T
E
K
L
P
-
W
L
N
E
-
N
F
P
-E
L
P
I
I
A
N
V
A
G
S
E
E
A
D
Y
V
A
V
C
A
K
I
G
D
---
A
A
N
---
V
---
K
A
I
--
E
L
N
I
S
C
P
N
V
K
HG--
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
V
P
L
Y
V
K
L
S
P
N
V
T--
D
I
V
P
I
A
K
A
V
-
E
A
-
A
G
----
A
D
G
L
T
M
I
N
T
L
----
M
-
G
V
R
F
D
L
K
T
R
Q
P
I
L
AN----
I
T
--
G
G
L
S
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
--
D
V
D
--
I
P
---
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
A
G
A
S
A
V
A
V
G
T
A
-
N
F
A
-D
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
K
-
34
PsiBlast_CBE
64.21
31%
-43
- C1 -
-
3C61
5
?
D:
[4-311]
------
L
Q
V
D
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
S
T
T
E
D
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
R
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
R
K
--
P
L
F
L
S
M
S
G
L
S
V
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
EFPQ
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
GF
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
V
N
--
A
F
--
Y
-
R
-
R
C
P
GKL
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
H
E
E
G
P
A
I
F
E
R
L
T
A
E
L
L
D
V
M
A
K
K
G
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
35
PsiBlast_CBE
64.12
31%
-42
- C1 -
-
3C61
2
?
C:
[4-311]
------
L
Q
V
D
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
S
T
T
E
D
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
R
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
R
K
--
P
L
F
L
S
M
S
G
L
S
V
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
EFPQ
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
GF
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
V
N
--
A
F
--
Y
-
R
-
R
C
P
GKL
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
H
E
E
G
P
A
I
F
E
R
L
T
A
E
L
L
D
V
M
A
K
K
G
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
36
PsiBlast_CBE
63.81
31%
-40
- C1 -
-
3C61
3
?
B:
[4-311]
------
L
Q
V
D
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
S
T
T
E
D
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
R
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
R
K
--
P
L
F
L
S
M
S
G
L
S
V
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
EFPQ
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
GF
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
V
N
--
A
F
--
Y
-
R
-
R
C
P
GKL
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
H
E
E
G
P
A
I
F
E
R
L
T
A
E
L
L
D
V
M
A
K
K
G
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
71
HHSearch
62.75
30%
-39
- C1 -
-
4EF8
6
?
A:
[34-345]
---
S
M
S
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
A
Y
A
A
E
-
Q
H
D
--
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
-
A
T
E
K
G
---
V
I
L
--
E
L
N
L
S
C
P
N
V
P
--
G
K
-
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
D
F
A
H
F
D
A
A
A
E
I
L
-
N
E
F
P
K
----
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
PK
Q
G
F
--
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
A
F
Y
R
--
R
-
C
P
G
K
L
---
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
Q
E
E
G
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
T
----
17
PsiBlast_PDB
62.51
31%
-43
- C1 -
-
3C61
3
?
A:
[4-311]
------
L
Q
V
D
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
S
T
T
E
D
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
R
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
R
K
--
P
L
F
L
S
M
S
G
L
S
V
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
I
L
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
E
F
PQ
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
G
F
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
V
N
--
A
F
--
Y
-
R
-
R
C
P
G
K
L
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
H
E
E
G
P
A
I
F
E
R
L
T
A
E
L
L
D
V
M
A
K
K
G
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
74
HHSearch
61.52
30%
-39
- C1 -
-
3TQ0
4
?
B:
[34-344]
---
S
M
S
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
A
Y
A
A
E
-
Q
H
D
--
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
-
A
---
T
EKG
V
I
L
--
E
L
N
L
S
C
P
N
V
P
--
G
K
-
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
DF
A
H
F
D
A
A
A
E
I
L
-
N
E
F
P
K
----
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
PK
Q
G
F
--
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
A
F
Y
R
--
R
-
C
P
G
K
L
---
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
Q
E
E
G
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
48
PsiBlast_CBE
61.48
31%
-39
- C1 -
-
4EF9
4
?
A:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
I
L
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
E
F
PK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
G
F
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
G
K
L
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
68
HHSearch
61.45
27%
-42
- C1 -
-
3W88
22
PYRD_TRYCC
A:
[1-310]
---
S
M
C
L
K
L
N
L
L
D
H
V
F
A
N
P
F
M
N
A
A
G
V
L
-
C
S
T
E
E
D
L
R
C
M
T
A
S
S
S
G
A
L
V
S
K
S
C
T
S
A
P
-
R
D
G
N
P
E
P
R
Y
M
A
F
P
L
-
G
S
I
N
S
M
G
L
P
N
L
G
F
D
F
Y
L
K
Y
A
S
D
-
L
H
D
--
Y
S
K
K
--
P
L
F
L
S
I
S
G
L
S
V
E
E
N
V
A
M
V
R
R
L
A
P
V
A
Q
E
-
K
---
G
---
V
L
L
--
E
L
N
L
S
C
P
N
V
P
--
G
K
-
P
Q
V
A
Y
D
F
E
A
M
R
T
Y
L
Q
Q
V
S
L
A
Y
G
L
P
F
G
V
K
M
P
P
Y
F
D
I
A
H
F
D
T
A
A
A
V
L
N
E
F
-
P
L
----
V
K
F
V
T
C
V
N
S
V
G---
N
G
-
L
V
I
D
A
E
S
E
S
V
V
I
--
K
PK
Q
G
F
--
G
G
L
G
G
K
Y
I
L
P
T
A
L
A
N
V
N
A
F
Y
R
--
R
-
C
P
D
K
L
---
V
F
G
C
G
G
V
Y
S
G
E
D
A
F
L
H
I
L
A
G
A
S
M
V
Q
V
G
T
A
-
L
Q
E
E
G
P
G
I
F
T
R
L
E
D
E
L
L
E
I
M
A
R
K
G
Y
R
T
L
E
E
F
R
G
R
V
------
49
PsiBlast_CBE
61.35
31%
-41
- C1 -
-
4EF8
6
?
B:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
E
F
PK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
G
F
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
G
K
L
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
42
PsiBlast_CBE
61.12
31%
-38
- C1 -
-
3TQ0
4
?
A:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
E
F
PK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
G
F
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
G
K
L
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
47
PsiBlast_CBE
61.09
31%
-41
- C1 -
-
4EF9
4
?
B:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
EFPK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
GF
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
GKL
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
50
PsiBlast_CBE
61.01
31%
-40
- C1 -
-
4EF8
6
?
A:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
E
F
PK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
G
F
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
G
K
L
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
41
PsiBlast_CBE
60.05
31%
-38
- C1 -
-
3TQ0
4
?
B:
[37-344]
------
L
Q
V
N
L
L
N
N
T
F
A
N
P
F
M
N
A
A
G
V
M
-
C
T
T
T
E
E
L
V
A
M
T
E
S
A
S
G
S
L
V
S
K
S
C
T
P
A
L
-
R
E
G
N
P
T
P
R
Y
Q
A
L
P
L
-
G
S
I
N
S
M
G
L
P
N
N
G
F
D
F
Y
L
-
A
Y
A
A
-
E
Q
H
D
-
Y
G
K
K
--
P
L
F
L
S
M
S
G
L
S
M
R
E
N
V
E
M
C
K
R
L
A
A
---
V
A
T
---
E
---
K
G
V
IL
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
V
A
Y
D
F
D
A
M
R
Q
C
L
T
A
V
S
E
V
Y
P
H
S
F
G
V
K
M
P
P
Y
F
---
D
F
A
H
F
D
A
A
A
-
E
I
-
L
N
EFPK
V
Q
F
I
T
C
I
N
S
I
G---
N
G
-
L
V
I
D
A
E
T
E
S
V
V
I
--
K
--
P
K
Q
GF
G
G
L
G
G
R
Y
V
L
P
T
A
L
A
N
I
N
--
A
F
--
Y
-
R
-
R
C
P
GKL
I
F
G
C
G
G
V
Y
T
G
E
D
A
F
L
H
V
L
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
-
P
S
I
F
E
R
L
T
S
E
L
L
G
V
M
A
K
K
R
Y
Q
T
L
D
E
F
R
G
K
V
R
-----
12
PsiBlast_PDB
49.73
30%
-29
- C1 -
-
1JUE
6
PYRDA_LACLM
A:
[10-301]
--------------
K
F
A
N
P
F
M
N
A
S
G
V
H
-
C
M
T
I
E
D
L
E
E
L
K
A
S
Q
A
G
A
Y
I
T
K
S
S
T
L
E
K
-
R
E
G
N
P
L
P
R
Y
V
D
L
E
L
-
G
S
I
N
S
M
G
L
P
N
L
G
F
D
Y
Y
L
D
Y
V
L
K
N
Q
K
E
N
-
A
Q
E
G
--
P
I
F
F
S
I
A
G
M
S
A
A
E
N
I
A
M
L
K
K
I
Q
E
---
S
D
F
---
S
---
G
I
T
--
E
L
N
L
S
C
P
N
V
P
---
G
K
P
Q
L
A
Y
D
F
E
A
T
E
K
L
L
K
E
V
F
T
F
F
T
K
P
L
G
V
K
L
P
P
Y
F
---
D
L
V
H
F
D
I
M
A
-
E
I
-
L
N
----
Q
F
P
L
T
Y
V
N
S
V
NSIG
N
G
-
L
F
I
D
P
E
A
E
S
V
V
I
KP
K
--
D
G
F
--
G
G
I
G
G
A
Y
I
K
P
T
A
L
A
N
V
R
A
F
Y
T
R
L
K
-
P
-
E
I
Q
---
I
I
G
T
G
G
I
E
T
G
Q
D
A
F
E
H
L
L
C
G
A
T
M
L
Q
I
G
T
A
-
L
H
K
E
G
P
A
I
F
D
R
I
I
K
E
L
E
E
I
M
N
Q
K
G
Y
Q
S
I
-------------