@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYF4: (2018-01-09 )
MKQEMMEIVQQKQLAPKIFEMTLKGDLVKEMQQPGQFLHILVPRADLLLRRPISLNHIDHETNTCRIIYRVEGEGTRVFSTLSAGDHLDVMGPLGNGFDLSNLHTGDEVFIIGGGIGVPPLYELSKQLVEKGIKPTHFLGFATHEVVYYEKEFNRLGETRIATDDGTYGMHGNVGNLLLGTKTEPTAVFACGSNGLLKTVEQLFSSHQNVQLSLESRMACGIGACYACVCHTPEDETGTKSVKVCDEGPIFKIGEVII
Atome Classification :
(20 SA)
-.........10........20......--..30........40.....-----------------------------...50........60........70-----------.-----------------..--..-...-80.......-.-.90........100.......110.......120.......130--.-.......140.......150....---.-----.--.--160-.---.----..----...170---..--.....--.-----180.-----.......190.......200......----.--.----------------210--------------------.........220.......230.....-----------..240.-......250......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-M
K
Q
E
M
M
E
I
V
Q
Q
KQL
A
P
K
I
F
E
M
T
L
K
G
D
L
--
V
K
E
M
QQPG
Q
F
L
H
I
L
VPR
A
D
-----------------------------
L
L
L
RRPISLNHIDHETN
T
C
R
I
I
Y
R
V-----------E-----------------GE--G
T
-
R
V
F
-
S
-TLSAGD
H
-
L
-
D
V
MGPLGNGFDLSNLHTG
D
E
V
F
I
I
GGGIGVP
P
L
Y
E
L
S
K
Q
L
V
EK---G-IKPT
H
F
L
G
F
A
T
H
E
V
V
Y
Y
E
K
E
F
N
RL---G-----E--
T
--
R
IA-T---D----DG----TYGMH----GN--VG
N
L
L
--L-----G-TK-----TE
P
T
A
V
F
A
CGSN
G
L
L
K
T
V
E
-
Q
L
F
SSH----Q--
N
----------------
V
----------------------
Q
L
S
L
E
SR
M
A
C
G
I
G
A
C
Y
A
C
V
CHTPEDET-----------GT
K
S
V
K
-VCDEGP
I
F
KIGEVII
27
HHSearch
83.18
52%
-27
- C2 -
-
5KSW
2
PYRK_LACLA
D:
[4-262]
--
L
Q
E
M
M
T
I
V
S
Q
R
E
V
A
S
N
I
F
E
M
V
L
K
G
E
L
--
V
E
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
A
S
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
V
A
K
T
C
T
I
L
Y
R
I
-----------
G
-----------------
D
E
TS
G
T
-
Y
E
I
-
S
-
K
L
Q
S
G
A
K
-
I
-
D
V
M
G
P
L
G
N
G
F
P
V
D
E
V
V
S
T
D
K
I
L
I
V
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
E
K
---
N
-
C
Q
M
T
I
L
L
G
F
A
S
E
K
V
K
I
L
E
K
E
F
A
E
L
KN-
V
-----
S
--
L
--
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
E
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
E
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
N
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
L
L
1
PsiBlast_PDB
82.91
52%
-32
- C2 -
-
5KSW
2
PYRK_LACLA
B:
[5-255]
---
Q
E
M
M
T
I
V
S
Q
R
E
V
A
S
N
I
F
E
M
V
L
K
G
E
L
--
V
E
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
A
S
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
V
A
K
T
C
T
I
L
Y
R
I
G
D
---------
E
-----------------
T
S
--
G
T
-
Y
E
I
-
S
-
K
L
Q
S
G
A
K
-
I
-
D
V
M
G
P
L
G
N
G
F
P
V
D
E
V
V
S
T
D
K
I
L
I
V
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
E
K
---
N
-
C
Q
M
T
I
L
L
G
F
A
S
E
K
V
K
I
L
E
K
E
F
A
E
L
---
K
-----
N
--
V
S
L
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
E
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
E
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
N
H
A
L
K
-
V
C
E
D
G
P
V
F
-------
21
PsiBlast_CBE
82.03
52%
-31
- C2 -
-
5KSW
2
PYRK_LACLA
D:
[5-255]
---
Q
E
M
M
T
I
V
S
Q
R
E
V
A
S
N
I
F
E
M
V
L
K
G
E
L
--
V
E
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
A
S
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
V
A
K
T
C
T
I
L
Y
R
I
GD---------
E
-----------------
T
S
--
G
T
-
Y
E
I
-
S
-
K
L
Q
S
G
A
K
-
I
-
D
V
M
G
P
L
G
N
G
F
P
V
D
E
V
V
S
T
D
K
I
L
I
V
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
E
K
---
N
-
C
Q
M
T
I
L
L
G
F
A
S
E
K
V
K
I
L
E
K
E
F
A
E
L
---
K
-----
N
--
V
SL
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
E
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
E
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
N
H
A
L
K
-
V
C
E
D
G
P
V
F
-------
22
HHSearch
81.61
51%
-23
- C2 -
-
1EP3
2
PYRK_LACLM
B:
[4-262]
--
L
Q
E
M
M
T
V
V
S
Q
R
E
V
A
Y
N
I
F
E
M
V
L
K
G
T
L
--
V
D
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
G
A
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
A
K
T
C
T
I
L
Y
R
I
-----------
G
-----------------
D
E
TT
G
T
-
Y
K
L
-
S
-
K
L
E
S
G
A
K
-
V
-
D
V
M
G
P
L
G
N
G
F
P
V
A
E
V
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
---
G
-
C
Q
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
S
N
L
KN-
V
-----
T
--
L
--
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
N
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
D
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
2
PsiBlast_PDB
81.18
50%
-28
- C2 -
-
1EP3
2
PYRK_LACLM
B:
[5-255]
---
Q
E
M
M
T
V
V
S
Q
R
E
V
A
Y
N
I
F
E
M
V
L
K
G
T
L
--
V
D
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
G
A
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
A
K
T
C
T
I
L
Y
R
I
G
D
---------
E
-----------------
T
T
--
G
T
-
Y
K
L
-
S
-
K
L
E
S
G
A
K
-
V
-
D
V
M
G
P
L
G
N
G
F
P
V
A
E
V
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
---
G
-
C
Q
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
S
N
L
---
K
-----
N
--
V
T
L
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
N
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
D
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
S
H
A
L
K
-
V
C
E
D
G
P
V
F
-------
3
PsiBlast_PDB
81.01
50%
-38
- C2 -
-
1EP1
2
PYRK_LACLM
B:
[4-254]
---
Q
E
M
M
T
V
V
S
Q
R
E
V
A
Y
N
I
F
E
M
V
L
K
G
T
L
--
V
D
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
G
A
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
A
K
T
C
T
I
L
Y
R
I
G
D
---------
E
-----------------
T
T
--
G
T
-
Y
K
L
-
S
-
K
L
E
S
G
A
K
-
V
-
D
V
M
G
P
L
G
N
G
F
P
V
A
E
V
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
---
G
-
C
Q
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
S
N
L
---
K
-----
N
--
V
T
L
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
N
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
D
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
S
H
A
L
K
-
V
C
E
D
G
P
V
F
-------
42
Fugue
80.92
49%
-12
- C2 -
-
1EP3
2
PYRK_LACLM
B:
[2-262]
S
Q
L
Q
E
M
M
T
V
V
S
Q
R
E
V
A
Y
N
I
F
E
M
V
L
K
G
T
L
--
V
D
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
G
A
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
A
K
T
C
T
I
L
Y
R
I
-----------
G
-----------------
D
E
TT
G
T
-
Y
K
L
-
S
-
K
L
E
S
G
A
K
-
V
-
D
V
M
G
P
L
G
N
G
F
P
V
A
E
V
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
---
G
-
C
Q
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
S
N
L
---
K
N
V
---
T
--
L
--
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
N
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
D
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
--
D
-----------
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
4
PsiBlast_PDB
80.48
50%
-35
- C2 -
-
1EP2
2
PYRK_LACLM
B:
[4-254]
---
Q
E
M
M
T
V
V
S
Q
R
E
V
A
Y
N
I
F
E
M
V
L
K
G
T
L
--
V
D
E
M
D
L
P
G
Q
F
L
H
L
A
V
P
N
G
A
-----------------------------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
A
K
T
C
T
I
L
Y
R
I
G
D
---------
E
-----------------
T
T
--
G
T
-
Y
K
L
-
S
-
K
L
E
S
G
A
K
-
V
-
D
V
M
G
P
L
G
N
G
F
P
V
A
E
V
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
---
G
-
C
Q
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
S
N
L
---
K
-----
N
--
V
T
L
K
I
A
-
T
---
D
----
D
G
----
S
Y
G
T
K
----
G
H
--
V
G
M
L
M
--
N
-----
E
-
I
D
-----
F
E
V
D
A
L
Y
T
C
G
A
P
A
M
L
K
A
V
A
-
K
K
Y
D
Q
L
----
E
--
R
----------------
L
----------------------
Y
I
S
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
-------------
S
H
A
L
K
-
V
C
E
D
G
P
V
F
-------
25
HHSearch
69.82
30%
-50
- C2 -
-
5JCA
3
SUDHB_PYRFU
S:
[6-256]
----
M
M
F
K
I
L
R
K
E
R
L
A
P
G
I
N
L
F
E
I
E
S
P
R
--
I
A
K
H
A
K
P
G
Q
F
V
M
I
R
L
H
E
-------------------------------
K
G
E
R
I
P
L
T
I
A
D
V
D
I
S
K
G
S
I
T
I
V
A
Q
E
-----------
V
-----------------
G
K
--
T
T
-
R
E
L
-
G
-
T
Y
E
A
G
D
Y
I
L
-
D
V
L
G
P
L
G
K
P
S
H
I
D
Y
---
F
G
T
V
V
M
I
G
G
G
V
G
V
A
E
I
Y
P
V
A
K
A
M
K
E
K
---
G
-
N
Y
V
I
S
I
L
G
F
R
T
K
D
L
V
F
W
E
D
K
L
R
S
V
S--
D
-----
E
--
V
--
I
V
T
-
T
---
N
----
D
G
----
S
Y
G
M
K
----
G
F
--
T
T
H
A
L
--
Q
-----
K
-
L
I
EEG--
R
K
I
D
L
V
H
A
V
G
P
A
I
M
M
K
A
V
A
-
E
L
T
K
P
Y
G---
I
--
K
----------------
T
----------------------
V
A
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
V
-
G
G
---------------
E
V
K
F
-
A
C
V
D
G
P
E
F
D
A
H
L
V
D
W
26
HHSearch
69.50
30%
-50
- C2 -
-
5JFC
2
SUDHB_PYRFU
S:
[6-256]
----
M
M
F
K
I
L
R
K
E
R
L
A
P
G
I
N
L
F
E
I
E
S
P
R
--
I
A
K
H
A
K
P
G
Q
F
V
M
I
R
L
H
E
-------------------------------
K
G
E
R
I
P
L
T
I
A
D
V
D
I
S
K
G
S
I
T
I
V
A
Q
E
-----------
V
-----------------
G
K
--
T
T
-
R
E
L
-
G
-
T
Y
E
A
G
D
Y
I
L
-
D
V
L
G
P
L
G
K
P
S
H
I
D
Y
---
F
G
T
V
V
M
I
G
G
G
V
G
V
A
E
I
Y
P
V
A
K
A
M
K
E
K
---
G
-
N
Y
V
I
S
I
L
G
F
R
T
K
D
L
V
F
W
E
D
K
L
R
S
V
S--
D
-----
E
--
V
--
I
V
T
-
T
---
N
----
D
G
----
S
Y
G
M
K
----
G
F
--
T
T
H
A
L
--
Q
-----
K
-
L
I
EEG--
R
K
I
D
L
V
H
A
V
G
P
A
I
M
M
K
A
V
A
-
E
L
T
K
P
Y
G---
I
--
K
----------------
T
----------------------
V
A
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
V
-
G
G
---------------
E
V
K
F
-
A
C
V
D
G
P
E
F
D
A
H
L
V
D
W
7
PsiBlast_PDB
69.25
30%
-66
- C2 -
-
5JCA
3
SUDHB_PYRFU
S:
[7-249]
-----
M
F
K
I
L
R
K
E
R
L
A
P
G
I
N
L
F
E
I
E
S
P
R
--
I
A
K
H
A
K
P
G
Q
F
V
M
I
R
L
H
E
K
G
-------------------------------
E
R
I
P
L
T
I
A
D
V
D
I
S
K
G
S
I
T
I
V
A
Q
E
-----------
V
-----------------
G
K
--
T
T
-
R
E
L
-
G
-
T
Y
E
A
G
D
Y
I
L
-
D
V
L
G
P
L
G
K
P
---
S
H
I
D
Y
F
G
T
V
V
M
I
G
G
G
V
G
V
A
E
I
Y
P
V
A
K
A
M
K
E
K
---
G
-
N
Y
V
I
S
I
L
G
F
R
T
K
D
L
V
F
W
E
D
K
L
R
S
V
---
S
D----
E
--
V
--
I
V
T
-
T
---
N
----
D
G
----
S
Y
G
M
K
----
G
F
--
T
T
H
A
L
--
Q
KLIEE
G
-
R
K
-----
I
D
--
L
V
H
A
V
G
P
A
I
M
M
K
A
V
A
-
E
L
T
K
P
Y
----
G
I-
K
----------------
T
----------------------
V
A
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
-----
T
V
-----------
G
G
E
V
K
F
-
A
C
V
D
G
P
E
F
-------
8
PsiBlast_PDB
69.22
30%
-66
- C2 -
-
5JFC
2
SUDHB_PYRFU
S:
[7-249]
-----
M
F
K
I
L
R
K
E
R
L
A
P
G
I
N
L
F
E
I
E
S
P
R
--
I
A
K
H
A
K
P
G
Q
F
V
M
I
R
L
H
E
K
G
-------------------------------
E
R
I
P
L
T
I
A
D
V
D
I
S
K
G
S
I
T
I
V
A
Q
E
-----------
V
-----------------
G
K
--
T
T
-
R
E
L
-
G
-
T
Y
E
A
G
D
Y
I
L
-
D
V
L
G
P
L
G
K
P
---
S
H
I
D
Y
F
G
T
V
V
M
I
G
G
G
V
G
V
A
E
I
Y
P
V
A
K
A
M
K
E
K
---
G
-
N
Y
V
I
S
I
L
G
F
R
T
K
D
L
V
F
W
E
D
K
L
R
S
V
---
S
D----
E
--
V
--
I
V
T
-
T
---
N
----
D
G
----
S
Y
G
M
K
----
G
F
--
T
T
H
A
L
--
Q
KLIEE
G
-
R
K
-----
I
D
--
L
V
H
A
V
G
P
A
I
M
M
K
A
V
A
-
E
L
T
K
P
Y
----
G
I-
K
----------------
T
----------------------
V
A
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
-----
T
V
-----------
G
G
E
V
K
F
-
A
C
V
D
G
P
E
F
-------
5
PsiBlast_PDB
65.69
29%
-55
- C2 -
-
4YLF
2
PYRKH_THEMA
A:
[8-251]
-------
E
I
V
K
K
V
K
I
A
E
D
V
F
D
F
W
I
H
S
P
S
--
V
S
K
E
A
R
P
G
Q
F
V
V
I
R
L
H
E
K
G
-----------------------------
E
--
R
I
P
L
T
V
A
D
T
K
P
E
E
G
L
F
R
M
V
V
K
V
-----------
V
-----------------
G
K
--
T
T
-
H
E
L
-
S
-
L
K
K
E
G
D
T
I
L
-
D
V
V
G
P
L
G
N
P
S
E
I
E
N
Y
G
N
---
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
---
G
-
N
N
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
K
E
I
---
S
-----
D
--
V
--
L
L
V
-
T
---
D
----
D
G
----
S
A
G
M
K
----
G
V
--
V
T
D
A
M
DK
L
-----
F
-
R
E
-----
R
K
F
D
I
C
W
A
V
G
P
T
I
M
M
K
F
C
T
L
K
A
R
E
F
G
----
V
--
P
----------------
I
----------------------
W
V
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
------
T
-----------
V
S
G
Q
I
K
F
A
C
V
D
G
P
E
F
R
G
E
E
V
--
24
HHSearch
64.16
29%
-50
- C2 -
-
4YLF
2
PYRKH_THEMA
A:
[4-253]
---
T
A
L
N
E
I
V
K
K
V
K
I
A
E
D
V
F
D
F
W
I
H
S
P
S
--
V
S
K
E
A
R
P
G
Q
F
V
V
I
R
L
H
E
-------------------------------
K
G
E
R
I
P
L
T
V
A
D
T
K
P
E
E
G
L
F
R
M
V
V
K
V
-----------
V
-----------------
G
K
--
T
T
-
H
E
L
-
S
-
L
K
K
E
G
D
T
I
L
-
D
V
V
G
P
L
G
N
P
S
E
I
E
N
---
Y
G
N
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
---
G
-
N
N
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
K
E
I
---
S
-----
D
--
V
--
L
L
V
-
T
---
D
----
D
G
----
S
A
G
M
K
----
G
V
--
V
T
D
A
M
--
D
-----
K
-
L
F
RE---
R
K
F
D
I
C
W
A
V
G
P
T
I
M
M
K
F
C
T
-
L
K
A
R
E
F
G---
V
--
P
----------------
I
----------------------
W
V
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
V
-
S
G
---------------
Q
I
K
F
-
A
C
V
D
G
P
E
F
R
G
E
E
V
D
W
6
PsiBlast_PDB
63.59
29%
-44
- C2 -
-
4YRY
3
PYRKH_THEMA
A:
[8-251]
-------
E
I
V
K
K
V
K
I
A
E
D
V
F
D
F
W
I
H
S
P
S
--
V
S
K
E
A
R
P
G
Q
F
V
V
I
R
L
H
E
K
G
-----------------------------
E
--
R
I
P
L
T
V
A
D
T
K
P
E
E
G
L
F
R
M
V
V
K
V
-----------
V
-----------------
G
K
--
T
T
-
H
E
L
-
S
-
L
K
K
E
G
D
T
I
L
-
D
V
V
G
P
L
G
N
P
S
E
I
E
N
Y
G
N
---
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
---
G
-
N
N
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
K
E
I
---
S
-----
D
--
V
--
L
L
V
-
T
---
D
----
D
G
----
S
A
G
M
K
----
G
V
--
V
T
D
A
M
D
K
L
-----
F
-
R
E
-----
R
K
F
D
I
C
W
A
V
G
P
T
I
M
M
K
F
C
T
L
K
A
R
E
F
G
----
V
--
P
----------------
I
----------------------
W
V
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
------
T
-----------
V
S
G
Q
I
K
F
A
C
V
D
G
P
E
F
R
G
E
E
V
--
23
HHSearch
63.06
29%
-47
- C2 -
-
4YLF
3
PYRKH_THEMA
C:
[4-253]
---
T
A
L
N
E
I
V
K
K
V
K
I
A
E
D
V
F
D
F
W
I
H
S
P
S
--
V
S
K
E
A
R
P
G
Q
F
V
V
I
R
L
H
E
-------------------------------
K
G
E
R
I
P
L
T
V
A
D
T
K
P
E
E
G
L
F
R
M
V
V
K
V
-----------
V
-----------------
G
K
--
T
T
-
H
E
L
-
S
-
L
K
K
E
G
D
T
I
L
-
D
V
V
G
P
L
G
N
P
S
E
I
E
N
---
Y
G
N
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
---
G
-
N
N
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
K
E
I
---
S
-----
D
--
V
--
L
L
V
-
T
---
D
----
D
G
----
S
A
G
M
K
----
G
--------------------------
K
F
D
I
C
W
A
V
G
P
T
I
M
M
K
F
C
T
-
L
K
A
R
E
F
G---
V
--
P
----------------
I
----------------------
W
V
S
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
V
-
S
G
---------------
Q
I
K
F
-
A
C
V
D
G
P
E
F
R
G
E
E
V
D
W
28
HHSearch
61.15
22%
-48
- C2 -
-
5VJ7
2
?
B:
[1-258]
-----
M
Y
K
I
L
E
K
K
E
I
A
M
R
N
T
W
Y
K
V
Y
A
P
H
--
V
A
K
K
V
Q
P
G
Q
F
V
I
V
R
A
F
P
-------------------------------
N
G
E
R
I
P
L
T
P
V
M
W
D
R
E
E
G
W
I
V
L
I
V
F
T
-----------
R
-----------------
G
K
--
T
T
-
M
R
M
-
A
V
E
L
K
E
G
D
S
-
L
L
N
V
A
G
P
L
G
T
P
V
P
M
E
K
---
F
G
K
I
L
A
I
G
A
Y
T
G
I
V
E
V
Y
P
I
A
K
A
W
Q
E
I
---
G
-
N
D
V
T
T
L
H
V
T
F
-
E
P
M
V
I
L
K
E
E
L
E
K
A
V--
T
-----
R
--
H
--
I
V
E
-
P
V
PL
N
PN--
Q
D
----
F
L
A
N
-KNVS
Q
R
--
L
K
E
K
V
--
R
-----
E
-
L
L
ES---
E
D
W
D
L
V
F
M
V
G
P
V
G
D
Q
K
Q
V
F
-
E
V
V
K
E
Y
G---
V
--
P
----------------
M
----------------------
K
V
D
L
H
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
V
-
G
G
---------------
E
V
K
F
-
A
C
V
D
G
P
E
F
D
A
Y
Q
V
D
W
29
HHSearch
55.14
22%
-3
- C2 -
-
2PIA
2
PDR_BURCE
A:
[7-313]
--
G
F
L
R
L
K
I
A
S
K
E
K
I
A
R
D
I
W
S
F
E
L
T
D
P
Q
GA
P
L
P
P
F
E
A
G
A
N
L
T
V
A
V
P
N
--------------------------------
G
S
R
R
T
Y
S
L
C
N
D
S
Q
E
R
N
R
Y
V
I
A
V
K
R
-----------
D
SN---------------
G
R
--
G
G
S
I
S
F
I
D
-
D
T
S
E
G
D
A
-
V
-
E
V
S
L
P
R
N
E
-
F
P
L
D
K
R
--
A
K
S
F
I
L
V
A
G
G
I
G
I
T
P
M
L
S
M
A
R
Q
L
R
A
E
---
G
L
R
S
F
R
L
Y
Y
L
T
R
D
P
E
G
T
A
F
F
D
E
L
T
S
D
EWR
S
-----
D
--
V
--
K
I
H
-
H
---
D
----
H
G
----
D
P
--
T
----
K
A
FD
F
W
S
V
F
--
E
-----
K
-
S
------
K
P
A
Q
H
V
Y
C
C
G
P
Q
A
L
M
D
T
V
R
-
D
M
T
G
H
W
PSGT
V
H
F
E
S
FGATNTNAR
E
N
T
P
F
T
V
R
L
SRSG
T
S
F
E
I
P
ANRS
I
L
E
V
L
R
D
A
N
V
R
V
P
S
S
C
E
S
G
T
C
G
S
C
K
T
A
L
C
S
G
E
A
DHRDMVLRDDE
K
G
T
Q
I
M
-
V
C
V
S
R
A
K
--------
41
HHSearch
53.25
22%
1
- C2 -
-
2R6H
1
?
C:
[8-277]
--
K
E
W
E
C
E
V
L
S
N
K
N
V
S
T
F
I
K
E
F
V
V
K
L
P
E
G-
E
T
M
N
F
K
S
G
S
Y
A
Q
I
K
I
P
K
Y
N
I
R
YAD
Y
D
I
Q
DRFR
G
D
W
D
K
M
DAWS
L
T
C
K
N
E
E
E
T
V
R
A
Y
S
M
A
N
Y
P
A
E
G
N
I
I
T
L
N
V
R
I
-----------
A
TPPFDRAANKWK
A
G
I
K
P
G
I
--
S
S
-
S
Y
I
-
F
-
S
L
K
P
G
D
K
-
V
-
M
M
S
G
P
Y
G
D
-
F
H
I
Q
D
T
--
D
A
E
M
L
Y
I
G
G
G
A
G
M
A
P
L
R
A
Q
I
L
H
L
F
R
T
LKT
G
-
R
K
V
S
Y
W
Y
G
A
R
S
K
N
E
I
F
Y
E
E
D
F
R
E
I
E
--
R
E
F
PN
F
K
--
F
--
H
I
A
-
L
---
S
D---
P
Q
PEDN
W
T
G
Y
V
----
G
F
--
I
H
Q
V
I
Y
-
D
-----
N
-
Y
L
KDHDA
P
E
D
I
E
Y
Y
M
C
G
P
G
P
M
A
N
A
V
K
-
G
M
L
E
N
L
-----------------------------------------------------------------------------------------------------------
32
HHSearch
49.72
21%
16
* C2 *
-
4P6V
1
NQRF_VIBCH
F:
[132-394]
---
K
W
E
C
T
V
I
S
N
D
N
K
A
T
F
I
K
E
L
K
L
A
I
P
D
G-
E
S
V
P
F
R
A
G
G
Y
I
Q
I
E
A
P
A
H
H
V
K
YADFDVPEKYR
G
D
W
D
K
F
NLFR
Y
E
S
K
V
D
E
P
I
I
R
A
Y
S
M
A
N
Y
P
E
E
F
G
I
I
M
L
N
V
R
I
ATPPPNNPNVP
P
-----------------
G
Q
--
M
S
-
S
Y
I
-
W
-
S
L
K
A
G
D
K
-
C
-
T
I
S
G
P
F
G
E
F
-
F
A
K
D
T
--
D
A
E
M
V
F
I
G
G
G
A
G
M
A
P
M
R
S
H
I
F
D
Q
L
K
R
LKS
K
-
R
K
M
S
Y
W
Y
G
A
R
S
K
R
E
M
F
Y
V
E
D
F
D
G
L
A
--
A
E
N
D--
N
F
V
W
--
H
C
A
L
S
---
D
PQPE
D
N
----
W
T
G
Y
T
----
G
F
--
I
H
N
V
L
--
Y
-----
E
N
Y
L
KDHEA
P
E
D
C
E
Y
Y
M
C
G
P
P
M
M
N
A
A
V
I
-
N
M
L
K
N
L
-----------------------------------------------------------------------------------------------------------