@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYF8: (2018-01-09 )
MIIKSERISLKHLLTVEALTDQEVMGLIRRGQEFKQGANWTPQKRQYFATNLFFENSTRTHKSFDVAEKKLGLEVIEFEASTSSVQKGETLYDTVLTMSALGVDVAVIRHGDENYYDELIQSKTIQCSIINGGDGSGQHPTQCLLDLMTIYEEFGHFEGLKVAIVGDITHSRVAKSNMQMLKRLGAQVFFSGPREWYDDEFEVYGHYMPLDELLDQVDVMMMLRVQHERHDGKESFSKEGYHQEHGLTVERAKKLQKHAIIMHPAPVNRDVELADSLVEGLQSRIVQQMSNGVFVRMAILEAVLNGKA
Atome Classification :
(76 SA)
.........10........20........30........40..--......50........60........70.......-.--80........90........100..-.....110.-......120.......130.......140.......150.......160.......170.......180..-.....190.---------------.---------.....-200---....--.....210.......220.......230........240.......250.......260.......270.......280.......290.......300......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIIKSERI
S
L
K
H
L
L
T
V
E
AL
T
D
Q
E
V
M
G
L
I
RR
G
Q
E
F
KQGANW
T
P
Q
--
K
R
Q
Y
F
A
T
N
L
F
FENSTRTHKS
F
D
V
A
E
K
KLG
L
E
V
I
E
F
-E--ASTSSVQKG
E
T
L
Y
D
T
V
L
T
M
S
ALG
V
D
-
V
A
V
I
RHGD
E
-
N
Y
Y
D
E
L
I
QSK
T
I
Q
C
S
I
INGGDGSGQ
H
P
T
Q
C
L
L
D
L
M
T
I
Y
E
E
FGHFEG
L
K
V
A
I
V
GDI
T
H
S
R
V
A
K
S
N
M
Q
M
L
K
R
L-GA
Q
V
F
FSG
P
---------------
R
---------EWYDD-
E
-----
F
E
V
Y--GHYM
P
L
D
E
L
L
D
Q
V
D
V
M
M
M
L
R
V
Q
H
ERH-DGKESFSKEGYHQEHG
L
T
V
E
R
A
K
K
L
Q
K
H
A
I
I
MHPAPVN
R
D
V
E
L
A
D
S
L
V
E
G
L
Q
S
R
I
V
Q
Q
MSNG
V
F
V
R
M
A
I
L
E
A
V
LNGKA
3
PsiBlast_PDB
97.89
55%
-96
- C10 -
-
3R7F
1
PYRB_BACSU
A:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
27
PsiBlast_CBE
97.02
55%
-102
- C10 -
-
3R7F
3
PYRB_BACSU
B:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
26
PsiBlast_CBE
96.95
55%
-98
- C10 -
-
3R7F
1
PYRB_BACSU
C:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
2
PsiBlast_PDB
96.24
55%
-103
- C10 -
-
3R7D
-
PYRB_BACSU
A:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
23
PsiBlast_CBE
94.72
55%
-93
- C10 -
-
3R7L
2
PYRB_BACSU
D:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
25
PsiBlast_CBE
94.24
55%
-93
- C10 -
-
3R7L
2
PYRB_BACSU
B:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
22
PsiBlast_CBE
94.24
55%
-91
- C10 -
-
3R7L
2
PYRB_BACSU
E:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
4
PsiBlast_PDB
93.41
55%
-92
- C10 -
-
3R7L
2
PYRB_BACSU
A:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
24
PsiBlast_CBE
93.27
55%
-90
- C10 -
-
3R7L
2
PYRB_BACSU
C:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
21
PsiBlast_CBE
92.81
55%
-91
- C10 -
-
3R7L
2
PYRB_BACSU
F:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
----
138
HHSearch
87.87
55%
-51
- C10 -
-
3R7F
1
PYRB_BACSU
A:
[1-291]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
-
T
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
--
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
E
N
T----
F
G
-----
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
-
Q
S
A
--
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
--
1
PsiBlast_PDB
83.36
55%
-
- C10 -
-
2AT2
-
PYRB_BACSU
A:
[1-289]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
-
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
--
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
-
E
------
N
T
F
--
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
---
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
----
137
HHSearch
82.79
55%
-
- C10 -
-
2AT2
-
PYRB_BACSU
C:
[1-292]
---------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
-
T
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
-
V
C
V
I
R
H
S
E
D
-
E
--
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
---------------
S
---------
E
W
Q
D
E
E
N
T----
F
G
-----
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
-
Q
S
A
--
V
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
T
N
-
12
PsiBlast_PDB
69.82
34%
-78
- C10 -
-
5G1P
1
PYR1_HUMAN
A:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
--
E
A
T
S
S
V
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
PSLRMP
P
T
V
R
A
F
V
A
S----------
G
T
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
--------------
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
142
HHSearch
67.84
37%
-11
- C10 -
-
3D6N
-
PYRB_AQUAE
B:
[1-290]
---------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
--
K
E
E
T
--
I
-
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
-
Y
V
V
F
R
V
P
F
V
F
F
--
P
Y
K
E
I
V
K
S
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
---------------
K
---------
T
L
I
P
R
-
D
VEVFK
V
D
-----
V
F
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
-
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
---
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
----
38
PsiBlast_CBE
67.74
34%
-69
- C10 -
-
5G1O
2
PYR1_HUMAN
C:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-----------
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
PSLRMP
P
T
V
R
A
F
V
A
S
R
---------
G
T
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
------------
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
40
PsiBlast_CBE
67.14
34%
-35
- C10 -
-
5G1N
3
F:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
--
E
A
T
S
S
V
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
PSLRMPPTVRAFVAS
R
---------
G
T
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
-
G
S
T
Q
E
Y
--
E
A
C
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
10
PsiBlast_PDB
66.58
34%
-45
- C10 -
-
5G1N
2
PYR1_HUMAN
A:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
--
E
A
T
S
S
V
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
PSLRMP
P
T
V
R
A
F
V
A
S
R
---------
G
T
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
-
G
S
T
Q
E
Y
--
E
A
C
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
33
PsiBlast_CBE
66.26
34%
-61
- C10 -
-
5G1P
2
PYR1_HUMAN
D:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
--
E
A
T
S
S
V
---
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
P
S
M
PPTVRAF
V
A
S
--
R
---------
G
-
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
----------
E
A
C
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
44
PsiBlast_CBE
66.17
34%
-38
- C10 -
-
5G1N
2
PYR1_HUMAN
B:
[56-311]
----------------------------------------------------
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
--
E
A
T
S
S
V
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
A
-
D
-
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
--
L
A
A
K
H
C
R
R
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
-
R
V
S
L
R
Y
V
A
P
PSLRMP
P
T
V
R
A
F
V
A
S
R
---------
G
T
K
Q
E
-
E
-----
F
E
--------
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
-
G
S
T
Q
E
Y
--
E
A
C
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
----
143
HHSearch
66.11
36%
-14
- C10 -
-
4BJH
10
PYRB_AQUAE
B:
[32-321]
---------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
--
K
E
E
T
--
I
-
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
-
Y
V
V
F
R
V
P
F
V
F
F
--
P
Y
K
E
I
V
K
S
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
---------------
K
---------
T
L
I
P
R
-
D
VEVFK
V
D
-----
V
F
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
-
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
---
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
----
6
PsiBlast_PDB
64.36
36%
-16
- C10 -
-
4BJH
10
PYRB_AQUAE
B:
[32-316]
---------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
E
T
I
K
--
A
S
---
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
-
F
P
Y
K
E
I
V
--
K
S
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
---------------
K
---------
T
L
I
P
R
-
D
-----
V
E
V
F
K
V
D
V
F
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
-
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
---------
113
PsiBlast_CBE
62.25
33%
20
- C10 -
-
3AT1
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
102
PsiBlast_CBE
62.13
33%
24
- C10 -
-
1TUG
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
103
PsiBlast_CBE
61.60
33%
22
- C10 -
-
1TU0
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
61
PsiBlast_CBE
60.82
33%
27
- C10 -
-
4KGV
1
?
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
82
PsiBlast_CBE
60.78
33%
22
- C10 -
-
1R0C
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
73
PsiBlast_CBE
60.67
33%
19
- C10 -
-
2FZG
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
68
PsiBlast_CBE
60.67
33%
25
- C10 -
-
2IPO
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
104
PsiBlast_CBE
60.62
33%
18
- C10 -
-
1TU0
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
79
PsiBlast_CBE
60.57
33%
22
- C10 -
-
1ZA2
2
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
51
PsiBlast_CBE
60.49
33%
24
- C10 -
-
1EKX
2
PYRB_ECOLI
B:
[8-306]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
114
PsiBlast_CBE
60.42
33%
21
- C10 -
-
3AT1
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
70
PsiBlast_CBE
60.41
33%
27
- C10 -
-
2H3E
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
101
PsiBlast_CBE
60.40
33%
22
- C10 -
-
1TUG
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
119
PsiBlast_CBE
60.37
33%
26
- C10 -
-
1AT1
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
59
PsiBlast_CBE
60.30
33%
26
- C10 -
-
4KGX
1
?
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
122
PsiBlast_CBE
60.23
33%
24
- C10 -
-
1XJW
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
A
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
105
PsiBlast_CBE
60.21
33%
26
- C10 -
-
1TTH
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
55
PsiBlast_CBE
60.15
33%
28
- C10 -
-
4KH0
1
?
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
81
PsiBlast_CBE
60.14
33%
22
- C10 -
-
1R0C
1
PYRB_ECOLI
G:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
76
PsiBlast_CBE
60.12
33%
23
- C10 -
-
2FZC
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
121
PsiBlast_CBE
60.10
33%
25
- C10 -
-
1XJW
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
A
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
53
PsiBlast_CBE
60.08
33%
27
- C10 -
-
4KH1
1
?
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
126
PsiBlast_CBE
59.97
33%
25
- C10 -
-
1F1B
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
--
P
L
A
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
67
PsiBlast_CBE
59.89
33%
27
- C10 -
-
2IPO
4
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
107
PsiBlast_CBE
59.86
33%
27
- C10 -
-
8ATC
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
100
PsiBlast_CBE
59.81
33%
27
- C10 -
-
1D09
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
75
PsiBlast_CBE
59.81
33%
23
- C10 -
-
2FZC
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
64
PsiBlast_CBE
59.81
33%
28
- C10 -
-
4F04
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
110
PsiBlast_CBE
59.79
33%
24
- C10 -
-
8AT1
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
71
PsiBlast_CBE
59.74
33%
21
- C10 -
-
2FZK
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
77
PsiBlast_CBE
59.71
33%
23
- C10 -
-
2AIR
2
PYRB_ECOLI
G:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
72
PsiBlast_CBE
59.70
33%
23
- C10 -
-
2FZK
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
108
PsiBlast_CBE
59.65
33%
26
- C10 -
-
8ATC
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
78
PsiBlast_CBE
59.59
33%
21
- C10 -
-
2AIR
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
115
PsiBlast_CBE
59.57
33%
28
- C10 -
-
2AT1
2
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
106
PsiBlast_CBE
59.56
33%
32
- C10 -
-
1TTH
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
125
PsiBlast_CBE
59.49
33%
31
- C10 -
-
1F1B
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
--
P
L
A
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
16
PsiBlast_PDB
59.40
33%
27
- C10 -
-
1EKX
2
PYRB_ECOLI
A:
[8-306]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
50
PsiBlast_CBE
59.36
33%
27
- C10 -
-
1EKX
2
PYRB_ECOLI
C:
[8-306]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
60
PsiBlast_CBE
59.35
33%
28
- C10 -
-
4KGV
1
?
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
120
PsiBlast_CBE
59.33
33%
23
- C10 -
-
1AT1
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
80
PsiBlast_CBE
59.31
33%
23
- C10 -
-
1ZA2
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
74
PsiBlast_CBE
59.18
33%
27
- C10 -
-
2FZG
1
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
Q
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
116
PsiBlast_CBE
59.17
33%
23
- C10 -
-
2AT1
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
63
PsiBlast_CBE
59.00
33%
26
- C10 -
-
4F04
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
58
PsiBlast_CBE
58.89
33%
26
- C10 -
-
4KGX
1
?
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
13
PsiBlast_PDB
58.66
36%
8
- C10 -
-
1ML4
1
PYRB_PYRAB
A:
[28-305]
----------------------------
R
L
E
R
E
L
K
E
K
G
Q
L
E
Y
A
--
K
G
K
I
L
A
T
-
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
--
A
S
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
-
V
I
V
I
R
H
P
K
E
-
G
A
A
R
--
L
A
A
E
V
A
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
ELLRMP
R
H
I
V
-----
E
---------
E
L
R
E
K
-
G
-----
M
K
V
V
---
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
A
K
D
E
L
R
---
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
----
112
PsiBlast_CBE
58.64
33%
31
- C10 -
-
7AT1
2
PYRB_ECOLI
A:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMP
E
Y
I
L
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
54
PsiBlast_CBE
58.63
33%
26
- C10 -
-
4KH0
1
?
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
52
PsiBlast_CBE
58.46
33%
27
- C10 -
-
4KH1
1
?
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
99
PsiBlast_CBE
58.03
33%
29
- C10 -
-
1D09
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
111
PsiBlast_CBE
57.97
33%
30
- C10 -
-
7AT1
2
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
69
PsiBlast_CBE
57.96
33%
27
- C10 -
-
2H3E
1
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPQYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---
109
PsiBlast_CBE
57.89
33%
30
- C10 -
-
8AT1
2
PYRB_ECOLI
C:
[7-305]
----------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
--
A
N
P
Q
P
E
LL
K
H
K
V
I
A
S
-
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
-
A
I
V
M
R
H
P
Q
E
-
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
---------------
D
ALAMPEYIL
D
M
L
D
E
-
K
-----
G
I
A
W
--
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
-
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
---
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
---