@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYJ0: (2018-01-09 )
MMMKKQIITIAGGGSTYTPGIVQAILNNEKRLPLSEIRLYDIDEERNMDMYLIVKFMLKRKGFSNIRIRATDDPKLAFTGCDFVFSQIRVGGLEMREKDEKIPLKHGLVGQETCGLGGFAYGMRSIKGLLEIVDHIQDYAPKAWILNYTNPESIVSEAVRRKYPNVKMINACDMTISIEETIAVNYGYDRKNWIVTYYGLNHFGWYTSIYDKELQREIMPEIIEKLITKEMQVADFNIGDKTWQKTFQMMSVITKNFPSNIPNNYLEYYLYPDMVVEHTDKEYTRANMVMDGREKNTKEMADKIRRGIVEEVLNFNFGEHGQYIVDIAISLLNDDRRRFMLIVPNQGAIPNLRSDAVVEIPAYVGATGVEPITLRKPISDFHKGLMEAQVAVEKLLVDAYFEGSYQKALQAFTLNQTVPNARVAKKILDEMIKVNKKYWPALK
Atome Classification :
(20 SA)
.........10.....-...20......-..30.--.......40..-.--....--.-50.........60--.........70........80.....-------...90------.........100.....----.---.----110.......120...---....130.......140.......150.......160--..-.....170....--...----180-....----..-.---190--........200--.----.---......-210.........220.....-----.-.230..-.-...-.------.240....------------.-..250..----.....260----------..------.-------......270.-..----....280------.........290..---..-..-.300.....------.---.310..-------------.----...-----.-320--------.........330----.......340..-.....350.......360.......370....-...380........390.......400.......410.......-420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MM
M
K
K
Q
I
I
T
I
AGGGST-Y
T
P
G
I
V
Q
A
I
LN-NEKRL--
P
L
S
E
I
R
L
Y
DID-E--ERN
M
--
D
-
M
-
Y
L
I
V
K
F
M
L
K
R---KGFS
N
I
R
I
R
ATDDP
K
L
A
F
T
G
C
D
F
V
F
S
-------
Q
I
RV-------GGLEMREKDEKIPLKHG----L---V----GQETCGL
G
G
F
A
Y
G
M
R
S
---
I
K
G
L
L
E
I
V
D
H
I
Q
DYAP
K
A
W
I
L
NYT
N
P
E
S
I
V
S
E
A
V
R
R
K--YP-N
V
K
M
I
N
AC
D
M
T
I
--
S
I
E
----
E
T
I
-
A
V
NY----GY-D---R-
K
--
N
W
I
V
T
Y
YGLN---H----F---G
W
Y
T
S
I
-
Y
--
D
K
E
L
Q
R
E
I
M
P
E
I
I
E
K
L
I
-----
T
-
K
EM-
Q
V
-A-DFN-I------G
D
K
T
W
Q
K
T
------------
F
-
Q
M
M
S
V
I
T
----KNFPSN------------I
P
------
N
-------
N
Y
L
E
Y
YLYP
D
-
M
V
----VEHTD--------KEYTRANMVMDGRE---K
N
-
T
K
-
E
M
A
D
K
I
R
R
G
------
I
---
V
E
E
V
LN-------------F----NFG-----E-H----------GQ
Y
I
V
D
I
A
I
S
L
L----NDDR
R
R
F
M
L
I
VP-NQGAIPNLRSD
A
V
V
EIPAYVGATGV
E
P
I
T
LRK-
P
I
S
D
-
F
H
K
G
L
M
E
A
Q
V
A
V
E
K
L
L
V
D
A
YFE
G
S
Y
Q
K
A
L
Q
A
F
TLNQTVP-
N
A
R
V
A
K
K
I
L
D
E
M
I
K
V
N
K
K
YWPALK
22
HHSearch
90.29
46%
-43
- C4 -
-
1U8X
2
GLVA_BACSU
X:
[26-465]
--
K
K
S
F
S
I
V
I
A
G
G
G
S
T
-
F
T
P
G
I
V
L
M
L
L
D
-
H
L
E
E
F
--
P
I
R
K
L
K
L
Y
D
N
D
-
K
--
E
R
Q
D
--
R
-
I
-
A
G
A
C
D
V
F
I
R
E
---
K
A
P
-
D
I
E
F
A
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
-------
H
I
R
V
-------
G
K
Y
A
M
R
A
L
D
E
Q
I
P
L
K
Y
G
----
V
---
V
----
G
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
---
I
G
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
L
--
R
P
-
N
S
K
I
L
N
I
C
D
M
P
V
--
G
I
E
----
D
R
M
-
A
Q
I
L
----
G
L
-
S
---
S
R
K
--
E
M
K
V
R
Y
Y
G
L
N
---
H
----
F
---
G
W
W
T
S
I
-
Q
--
D
Q
-
E
G
N
D
L
M
P
K
L
K
E
H
V
S
-----
Q
-
Y
G
Y
-
I
P
K
T
---------------
S
W
N
D
T
------------
F
-
A
K
A
R
D
V
Q
----
A
A
D
P
D
T
------------
L
P
------
N
-------
T
Y
L
Q
Y
Y
L
F
P
D
-
D
M
----
V
K
K
S
N
--------
P
N
H
T
R
A
N
E
V
M
E
G
R
E
---
A
F
I
F
S
-
Q
C
-
D
M
I
-------------
T
R
E
Q
S
S
-------------
E
NSEI
K
I
D
-----
D
-
H
----------
A
S
Y
I
V
D
L
A
R
A
I
A
----
Y
N
T
G
E
R
M
L
L
I
V
E
-
N
N
G
A
I
A
N
F
D
P
T
A
M
V
E
V
P
C
I
V
G
S
N
G
P
E
P
I
T
V
G
--
T
I
P
Q
-
F
Q
K
G
L
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
-
N
A
R
V
A
R
L
I
L
E
D
L
V
E
A
N
K
D
F
W
P
E
L
D
1
PsiBlast_PDB
88.14
45%
-34
- C4 -
-
1U8X
2
GLVA_BACSU
X:
[31-464]
-------
I
V
I
A
G
G
G
S
T
-
F
T
P
G
I
V
L
M
L
L
D
-
H
L
E
E
F
--
P
I
R
K
L
K
L
Y
D
N
D
-
K
--
E
R
Q
D
--
R
-
I
-
A
G
A
C
D
V
F
I
R
E
---
K
A
-
P
D
I
E
F
A
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
-------
H
I
R
V
-------
G
K
Y
A
M
R
A
L
D
E
Q
I
P
L
K
Y
G
----
V
---
V
----
G
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
---
I
G
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
L
--
R
P
-
N
S
K
I
L
N
I
C
D
M
P
V
--
G
I
E
----
D
R
M
-
A
Q
I
L
----
G
L
S
S
---
R
-
K
--
E
M
K
V
R
Y
Y
G
L
N
---
H
----
F
---
G
W
W
T
S
I
-
Q
--
D
Q
E
-
G
N
D
L
M
P
K
L
K
E
H
V
S
-----
Q
Y
G
Y
I
-
P
K
-
T
---------------
S
W
N
D
T
------------
F
-
A
K
A
R
D
V
Q
----
A
A
D
P
D
T
------------
L
P
------
N
-------
T
Y
L
Q
Y
Y
L
F
P
D
-
D
M
----
V
K
K
S
N
--------
P
N
H
T
R
A
N
E
V
M
E
G
R
E
---
A
F
-
I
F
-
S
Q
C
D
M
I
T
R
E
------
Q
---
S
S
E
N
S
E
-------------
I
----
K
I
D
-----
D
-
H
----------
A
S
Y
I
V
D
L
A
R
A
I
A
----
Y
N
T
G
E
R
M
L
L
I
V
E
-
N
N
G
A
I
A
N
F
D
P
T
A
M
V
E
V
P
C
I
V
G
S
N
G
P
E
P
I
T
V
G
T
--
I
P
Q
-
F
Q
K
G
L
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
-
N
A
R
V
A
R
L
I
L
E
D
L
V
E
A
N
K
D
F
W
P
E
L
-
26
HHSearch
79.10
29%
-76
- C4 -
-
1UP7
2
BGLT_THEMA
F:
[3-416]
-----
M
R
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
-
I
S
E
D
V
--
R
I
D
E
V
I
F
Y
D
I
D
-
E
--
E
K
Q
K
--
I
-
V
-
V
D
F
V
K
R
L
V
K
D
-------
R
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
-------
Q
F
R
P
-------
G
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
----
L
---
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
---
F
P
I
V
E
E
Y
V
D
T
V
R
K
T
-
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
--
L
E
-
Y
E
K
F
I
G
L
C
N
V
P
I
--
N
F
I
----
R
E
I
-
A
E
M
F
----
S
A
-
R
---
L
-
E
--
D
V
F
L
K
Y
Y
G
L
N
---
H
----
L
---
S
F
I
E
K
V
-
F
--
V
--
K
G
E
D
V
T
E
K
V
F
E
N
L
K
-----
L
-
K
-------------------
P
D
E
D
F
P
-------------------
T
W
F
Y
----
D
S
V
R
-
L
------------
I
V
------
N
-------
P
Y
L
R
Y
Y
L
M
E
K
-
K
M
----
F
K
K
I
S
--------
T
H
E
L
R
A
R
E
V
M
K
I
E
K
---
E
L
-
F
E
-
K
Y
R
T
A
---------------
V
E
I
P
E
-------------
E
LTKR
G
G
S
-----
M
-
Y
----------
S
T
A
A
A
H
L
I
R
D
L
E
----
T
D
E
G
K
I
H
I
V
N
T
R
-
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
--
K
G
D
H
-
F
A
L
S
F
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
Y
V
K
L
--
25
HHSearch
77.36
29%
-76
- C4 -
-
1UP7
2
BGLT_THEMA
A:
[1-416]
---
R
H
M
R
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
-
I
S
E
D
V
--
R
I
D
E
V
I
F
Y
D
I
D
-
E
--
E
K
Q
K
--
I
-
V
-
V
D
F
V
K
R
L
V
K
D
-------
R
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
-------
Q
F
R
P
-------
G
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
----
L
---
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
---
F
P
I
V
E
E
Y
V
D
T
V
R
K
T
-
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
--
L
E
-
Y
E
K
F
I
G
L
C
N
V
P
I
--
N
F
I
----
R
E
I
-
A
E
M
F
----
S
A
-
R
---
L
-
E
--
D
V
F
L
K
Y
Y
G
L
N
---
H
----
L
---
S
F
I
E
K
V
-
F
--
V
--
K
G
E
D
V
T
E
K
V
F
E
N
L
K
-----
L
-
K
------------
I
------
P
D
E
D
F
P
-------------------
T
W
F
Y
----
D
S
V
R
-
L
------------
I
V
------
N
-------
P
Y
L
R
Y
Y
L
M
E
K
-
K
M
----
F
K
K
I
S
--------
T
H
E
L
R
A
R
E
V
M
K
I
E
K
---
E
L
-
F
E
-
K
Y
R
T
A
---------------
V
E
I
P
E
-------------
E
LTKR
G
G
S
-----
M
-
Y
----------
S
T
A
A
A
H
L
I
R
D
L
E
----
T
D
E
G
K
I
H
I
V
N
T
R
-
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
--
K
G
D
H
-
F
A
L
S
F
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
Y
V
K
L
--
6
PsiBlast_PDB
74.21
29%
-46
- C4 -
-
1UP4
-
BGLT_THEMA
A:
[3-411]
-------
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
-
I
S
E
D
V
--
R
I
D
E
V
I
F
Y
D
I
D
-
E
--
E
K
Q
K
--
I
-
V
-
V
D
F
V
K
R
L
V
K
D
---
R
----
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
-------
Q
F
R
P
-------
G
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
----
L
---
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
---
F
P
I
V
E
E
Y
V
D
T
V
R
K
-
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
--
L
E
-
Y
E
K
F
I
G
L
C
N
V
P
I
--
N
F
I
----
R
E
I
-
A
E
M
F
----
S
A
-
R
---
L
-
E
--
D
V
F
L
K
Y
Y
G
L
N
---
H
----
L
---
S
F
--------------------
I
E
K
V
F
-----
V
-
K
-------------------
G
E
D
V
T
E
K
V
------------
F
-
E
N
L
K
L
K
---------
D
E
DFP
T
W
F
Y
D
S
VRL
I
V
------
N
-------
P
Y
L
R
Y
Y
L
M
E
K
-
K
M
----
F
K
K
I
S
--------
T
H
E
L
R
A
R
E
V
M
-------
K
I
-
E
K
-
E
L
F
E
K
Y
R
T
A
VE----
I
---
P
E
E
L
T
K
-------------
R
----
G
G
S
-----
M
-
Y
----------
S
T
A
A
A
H
L
I
R
D
L
E
----
T
D
E
G
K
I
H
I
V
N
T
R
-
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
-
D
H
-
F
A
L
S
F
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
Y
-----
5
PsiBlast_PDB
73.18
29%
-48
- C4 -
-
1UP6
2
BGLT_THEMA
A:
[4-412]
-------
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
-
I
S
E
D
V
--
R
I
D
E
V
I
F
Y
D
I
D
-
E
--
E
K
Q
K
--
I
-
V
-
V
D
F
V
K
R
L
V
K
D
---
R
----
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
-------
Q
F
R
P
-------
G
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
----
L
---
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
---
F
P
I
V
E
E
Y
V
D
T
V
R
K
-
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
--
L
E
-
Y
E
K
F
I
G
L
C
N
V
P
I
--
N
F
I
----
R
E
I
-
A
E
M
F
----
S
A
-
R
---
L
-
E
--
D
V
F
L
K
Y
Y
G
L
N
---
H
----
L
---
S
F
--------------------
I
E
K
V
F
-----
V
-
K
-------------------
G
E
D
V
T
E
K
V
------------
F
-
E
N
L
K
L
K
L
-------
P
D
E
DFP
T
W
F
Y
D
S
VRL
I
V
------
N
-------
P
Y
L
R
Y
Y
L
M
E
K
-
K
M
----
F
K
K
I
S
--------
T
H
E
L
R
A
R
E
V
M
-------
K
I
-
E
K
-
E
L
F
E
K
Y
R
T
A
VE----
I
---
P
E
E
L
T
K
-------------
R
----
G
G
S
-----
M
-
Y
----------
S
T
A
A
A
H
L
I
R
D
L
E
----
T
D
E
G
K
I
H
I
V
N
T
R
-
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
-
D
H
-
F
A
L
S
F
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
Y
-----
4
PsiBlast_PDB
72.84
29%
-49
- C4 -
-
1UP7
2
BGLT_THEMA
A:
[5-413]
-------
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
-
I
S
E
D
V
--
R
I
D
E
V
I
F
Y
D
I
D
-
E
--
E
K
Q
K
--
I
-
V
-
V
D
F
V
K
R
L
V
K
D
---
R
----
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
-------
Q
F
R
P
-------
G
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
----
L
---
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
---
F
P
I
V
E
E
Y
V
D
T
V
R
K
-
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
--
L
E
-
Y
E
K
F
I
G
L
C
N
V
P
I
--
N
F
I
----
R
E
I
-
A
E
M
F
----
S
A
-
R
---
L
-
E
--
D
V
F
L
K
Y
Y
G
L
N
---
H
----
L
---
S
F
--------------------
I
E
K
V
F
-----
V
-
K
-------------------
G
E
D
V
T
E
K
V
------------
F
-
E
N
L
K
L
K
-------
I
P
D
E
DFP
T
W
F
Y
D
S
VRL
I
V
------
N
-------
P
Y
L
R
Y
Y
L
M
E
K
-
K
M
----
F
K
K
I
S
--------
T
H
E
L
R
A
R
E
V
M
-------
K
I
-
E
K
-
E
L
F
E
K
Y
R
T
A
VE----
I
---
P
E
E
L
T
K
-------------
R
----
G
G
S
-----
M
-
Y
----------
S
T
A
A
A
H
L
I
R
D
L
E
----
T
D
E
G
K
I
H
I
V
N
T
R
-
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
-
D
H
-
F
A
L
S
F
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
Y
-----
24
HHSearch
70.43
32%
-9
- C4 -
-
1S6Y
-
?
A:
[4-440]
----
R
L
K
I
A
T
I
G
G
G
S
S
-
Y
T
P
E
L
V
E
G
L
I
K
-
R
Y
H
E
L
--
P
V
G
E
L
W
L
V
D
I
P
-
E
G
K
E
K
L
E
--
I
-
V
-
G
A
L
A
K
R
M
V
E
K
---
A
G
V
-
P
I
E
I
H
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
-------
Q
F
R
V
-------
G
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
----
V
---
I
----
G
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
---
I
P
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
---
Y
T
K
Q
E
K
V
V
G
L
C
N
V
P
I
--
G
M
R
----
M
G
V
-
A
K
L
L
----
G
V
-
D
---
A
-
D
--
R
V
H
I
D
F
A
G
L
N
---
H
----
M
---
V
F
G
L
H
V
-
Y
--
L
--
D
G
V
E
V
T
E
K
V
I
D
L
V
A
-----
H
-
P
---------------------
L
G
W
E
-------------------
P
D
F
L
----
K
G
L
K
-
V
------------
L
P
------
C
-------
P
Y
H
R
Y
Y
F
Q
T
D
-
K
M
----
L
A
E
E
L
E
A
A
K
----
T
K
G
T
R
A
E
V
V
Q
Q
L
E
K
---
E
L
-
F
E
-
L
Y
K
D
P
---------------------------------
R
----
G
G
A
-----
Y
-
Y
----------
S
D
A
A
C
S
L
I
S
S
I
Y
----
N
D
K
R
D
I
Q
P
V
N
T
R
-
N
N
G
A
I
A
S
I
S
A
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
--
D
L
P
V
-
A
V
R
G
L
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
I
L
D
E
M
L
E
A
H
K
E
Y
L
P
Q
F
-
2
PsiBlast_PDB
70.31
32%
-2
- C4 -
-
5C3M
-
?
A:
[5-435]
-----
L
K
M
A
T
I
G
G
G
S
S
-
Y
T
P
E
L
V
E
G
L
I
K
-
R
Y
H
E
L
--
P
V
G
E
L
W
L
V
D
I
P
-
E
G
K
E
K
L
E
--
I
-
V
-
G
A
L
A
K
R
M
V
E
K
---
A
G
V
P
-
I
E
I
H
L
T
L
D
R
R
R
A
L
E
G
A
D
F
V
T
T
-------
Q
F
R
V
-------
G
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
----
V
---
I
----
G
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
---
I
P
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
Y
--
T
K
-
Q
E
K
V
V
G
L
C
N
V
P
I
--
G
M
R
----
M
G
V
-
A
K
L
L
----
G
V
-
D
---
A
-
D
--
R
V
H
I
D
F
A
G
L
N
---
H
----
M
---
V
F
G
L
H
V
-
Y
--
L
D
G
V
------
E
V
T
E
K
V
I
D
L
V
A
H
P
-----------------------
L
G
W
E
P
D
------------
F
L
K
G
L
K
V
------------------------
L
P
------
C
-------
P
Y
H
R
Y
Y
Y
Q
T
D
-
K
M
L
A
E
E
L
E
A
A
K
--------
T
K
G
T
R
A
E
V
V
Q
Q
-
L
E
---
K
E
-
L
F
-
E
L
Y
K
D
P
-----------------------------------------------
G
----------
G
A
Y
Y
S
D
A
A
C
S
L
I
S
S
I
Y
N
D
K
R
D
I
Q
P
V
N
T
R
-
N
N
G
A
I
A
S
I
P
P
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
D
L
P
V
A
---
V
R
G
L
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
M
L
D
E
M
L
E
A
H
K
E
H
L
P
---
3
PsiBlast_PDB
68.77
32%
-10
- C4 -
-
1S6Y
-
?
A:
[4-438]
----
R
L
K
I
A
T
I
G
G
G
S
S
-
Y
T
P
E
L
V
E
G
L
I
K
-
R
Y
H
E
L
--
P
V
G
E
L
W
L
V
D
I
P
-
E
--
G
K
----
E
-
K
-
L
E
I
V
G
A
L
A
K
R
M
V
E
K
A
G
V
P
I
E
I
H
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
-------
Q
F
R
V
-------
G
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
----
V
---
I
----
G
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
---
I
P
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
Y
--
T
K
-
Q
E
K
V
V
G
L
C
N
V
P
I
--
G
M
R
----
M
G
V
-
A
K
L
L
----
G
V
-
D
---
A
-
D
--
R
V
H
I
D
F
A
G
L
N
---
H
MV--
F
---
G
L
H
V
Y
L
-
D
--
G
V
E
V
T
E
K
V
I
D
L
V
A
H
--------
P
-----------------------
L
G
W
E
P
D
------------
F
L
K
G
L
K
V
------------------------
L
P
------
C
-------
P
Y
H
R
Y
Y
F
Q
T
D
-
K
M
L
A
E
E
L
E
A
A
K
--------
T
K
G
T
R
A
E
V
V
Q
Q
-
L
E
---
K
E
-
L
F
-
E
L
Y
K
D
P
---------------------------------------------
R
-
G
----------
G
A
Y
Y
S
D
A
A
C
S
L
I
S
S
I
Y
N
D
K
R
D
I
Q
P
V
N
T
R
-
N
N
G
A
I
A
S
I
S
A
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
D
L
P
V
A
---
V
R
G
L
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
I
L
D
E
M
L
E
A
H
K
E
Y
L
P
---
45
Fugue
67.27
31%
-1
- C4 -
-
5C3M
-
?
B:
[5-438]
----
L
K
M
A
T
I
-
G
G
G
S
S
-
Y
T
P
E
L
V
E
G
L
I
K
-
R
Y
H
E
L
--
P
V
G
E
L
W
L
V
D
I
P
-
E
--
G
K
E
K
LE
I
-
V
-
G
A
L
A
K
R
M
V
E
K
---
A
G
V
P
-
I
E
I
H
L
T
L
D
R
R
R
A
L
E
G
A
D
F
V
T
T
-------
Q
F
R
V
-------
G
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
----
V
---
I
----
G
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
---
I
P
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
Y
--
T
K
-
Q
E
K
V
V
G
L
C
N
V
P
I
--
G
M
R
----
M
G
V
-
A
K
L
L
----
G
V
-
D
---
A
-
D
--
R
V
H
I
D
F
A
G
L
N
---
H
----
M
---
V
F
G
L
H
V
-
Y
LD
G
V
E
V
T
E
K
V
I
D
L
V
A
H
P
L
G
-----
W
-
E
P
D
-
F
L
-
K
-
G
L
K
-
V
---------------------------------------------------------
L
P
------
C
-------
P
Y
H
R
Y
Y
Y
--------------
Q
--------
T
D
K
M
L
A
E
E
L
E
A
A
K
T
---
K
G
-
T
R
A
E
V
V
Q
Q
L
E
K
E
------
L
---
F
E
L
Y
K
D
-------------
P
----
R
G
G
-----
A
-
Y
----------
Y
S
D
A
A
C
S
L
I
S
S
I
----
Y
N
D
K
R
D
I
Q
P
V
N
T
R
N
N
G
A
I
A
S
I
P
P
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
D
--
L
P
V
-
A
V
R
G
L
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
M
L
D
E
M
L
E
A
H
K
E
H
L
P
Q
F
F
27
HHSearch
64.19
24%
-6
- C4 -
-
3FEF
-
LPLD_BACSU
D:
[3-436]
--
L
D
Q
I
K
I
A
Y
I
G
G
G
S
Q
G
W
A
R
S
L
M
S
D
L
S
I
-
D
-
E
R
M
---
S
G
T
V
A
L
Y
D
L
D
-
F
--
E
A
A
Q
--
K
-
N
-
E
V
I
G
N
H
S
-
G
-----
N
G
-
R
W
R
Y
E
A
V
S
T
L
K
K
A
L
S
A
A
D
I
V
I
I
-------
S
I
L
P
-------
G
S
L
D
D
M
E
V
D
V
H
L
P
E
R
C
G
----
I
---
Y
QS--
V
G
D
T
V
G
P
G
G
I
I
R
G
L
R
A
---
V
P
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
V
--
F
P
-
G
I
K
A
I
G
C
C
H
E
V
F
--
G
T
Q
----
K
L
L
-
A
E
M
V
TERL
G
I
-
E
VPR
R
-
E
--
D
I
R
V
N
V
L
G
I
N
---
H
----
F
---
T
W
I
T
K
A
-
S
--
Y
--
R
H
I
D
L
L
P
I
F
R
E
F
S
A
-----
H
-
Y
G
E
S
G
Y
-
E
L
E
G
E
C
W
RDSVFC
S
A
H
R
V
A
-------------------
F
D
L
F
----
E
T
Y
G
-
A
------------
I
P
------
A
AGDRHLA
E
F
L
P
G
P
Y
L
K
Q
P
E
V
----
W
K
F
H
L
TPISF---
R
K
Q
D
R
A
E
K
R
Q
E
T
E
R
---
L
I
-
V
Q
-
Q
R
G
-------------------
V
--------------------
A
E
K
-----
A
-
S
----------
G
E
E
G
V
N
I
I
A
A
L
L
----
G
L
G
E
L
V
T
N
V
N
M
P
-
N
Q
G
Q
V
L
N
L
P
I
Q
A
I
V
E
T
N
A
F
I
T
R
N
R
V
Q
P
I
L
S
G
--
A
L
P
K
-
G
V
E
M
L
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
L
N
D
P
L
V
Q
I
D
R
S
D
A
E
Q
L
F
N
D
M
L
-----------
7
PsiBlast_PDB
61.69
24%
-19
- C4 -
-
3FEF
-
LPLD_BACSU
A:
[8-415]
-------
I
A
Y
I
G
G
G
S
Q
-
G
W
A
R
S
L
M
S
D
L
S
-
I
D
E
R
M
--
S
-
G
T
V
A
L
Y
D
L
D
-
F
--
E
A
A
Q
--
K
-
N
-
E
V
I
G
N
----
H
---
S
G
N
G
R
W
R
Y
E
A
V
S
T
L
K
K
A
L
S
A
A
D
I
V
I
I
-------
S
I
L
P
-------
G
S
L
D
D
M
E
V
D
V
H
L
P
E
R
C
G
----
I
YQS
V
----
G
-
D
T
V
G
P
G
G
I
I
R
G
L
R
A
---
V
P
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
V
--
F
P
-
G
I
K
A
I
G
C
C
H
E
V
F
--
G
T
Q
K
L
L
A
E
M
V
-
T
E
R
L
----
G
I
-
E
VPR
R
-
E
--
D
I
R
V
N
V
L
G
I
N
---
H
----
F
---
T
W
I
T
K
A
-
S
--
Y
R
H
I
--
D
L
L
P
--
I
F
R
E
F
-----
S
-
A
H
Y
-
G
E
-
S
-
G
Y
E
-
L
------
E
G
E
C
W
R
D
S
VFCSAH
R
V
A
F
D
L
F
-
E
T
Y
G
A
I
P
A
A
G
D
R
H
L
A
E
F
------------
L
P
------
G
-------
P
Y
L
K
---
Q
P
E
-
V
W
----
K
F
H
L
T
--------
P
I
S
F
R
K
Q
D
R
A
E
K
R
Q
---
E
T
-
E
R
-
L
I
V
Q
Q
--
R
G
------
V
---
A
E
K
A
---------------------
S
G
-----
E
-
E
----------
G
---
V
N
I
I
A
A
L
L
----
G
L
G
E
L
V
T
N
V
N
M
P
-
N
Q
G
Q
V
L
N
L
P
I
Q
A
I
V
E
T
N
A
F
I
T
R
N
R
V
Q
P
I
-
L
S
G
-
A
L
P
K
-
G
V
E
M
L
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
--------------------------------
28
HHSearch
59.80
19%
23
- C4 -
-
3U95
-
?
F:
[1-458]
-----
M
K
I
S
I
V
G
A
G
S
V
R
F
A
L
Q
L
V
E
D
I
A
Q
-
T
-
D
E
L
SR
E
D
T
H
I
Y
L
M
D
V
H
-
E
--
R
R
L
N
--
A
-
S
-
Y
I
L
A
R
K
Y
V
E
E
---
L
N
S
-
P
V
K
V
V
K
T
E
S
L
D
E
A
I
E
G
A
D
F
I
I
N
-------
T
A
Y
P
YDPRYHD
S
G
S
Q
R
W
D
E
V
T
K
V
G
E
K
H
G
----
Y
---
Y
RGID
S
Q
E
L
N
M
V
S
T
Y
T
Y
V
L
S
S
YPD
V
K
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
---
W
T
-
G
A
N
I
I
G
F
C
H
G
V
A
--
G
V
Y
-----
E
V
-
F
E
R
L
----
G
L
-
D
---
P
-
E
--
E
V
D
W
Q
V
A
G
V
N
---
H
----
G
---
I
W
L
N
R
F
-
R
--
Y
--
R
G
K
D
A
Y
P
L
L
D
E
W
I
E
-----
K
-
E
L
S
-
K
W
-
E
-
P
K
N
P
W
------
D
-
T
Q
M
S
P
A
----------------
A
M
D
M
Y
----
R
F
Y
G
-
M
------------
L
P
------
I
GDTVRN-
G
--
T
W
K
Y
H
Y
N
-
L
E
----
T
K
K
K
W
FRRFGGID
N
E
V
E
R
P
K
F
H
E
H
L
R
R
ARE
R
L
-
I
K
-
L
A
E
E
V
Q
E
N
P
------
H
LKI
T
E
K
H
P
E
-------------
I
FP--
K
G
R
-----
L
-
S
----------
G
E
Q
H
I
P
F
I
N
A
I
A
----
N
N
K
R
V
R
L
F
L
N
V
E
-
N
Q
G
A
L
K
D
F
P
D
D
L
V
M
E
L
P
V
W
V
D
S
S
G
I
H
R
E
K
V
E
P
-
D
L
T
H
R
I
K
I
F
Y
L
W
P
R
I
L
R
T
E
W
N
L
E
A
F
I
S
R
D
R
K
V
L
E
E
I
L
I
R
D
P
R
T
K
-
S
Y
E
Q
V
V
K
V
L
D
E
I
L
S
L
P
--------
8
PsiBlast_PDB
55.03
22%
21
- C4 -
-
3U95
-
?
A:
[3-391]
-------
I
S
I
V
G
A
G
S
V
R
F
A
L
Q
L
V
E
D
I
A
Q
T
D
E
L
S
R
--
E
D
T
H
I
Y
L
M
D
V
H
-
E
--
R
R
L
N
--
A
-
S
-
Y
I
L
A
R
K
Y
V
E
E
---
L
N
-
S
P
V
K
V
V
K
T
E
S
L
D
E
A
I
E
G
A
D
F
I
I
N
T
A
Y
P
Y
D
P
R
Y
H
D
-------
S
G
S
Q
R
W
D
E
V
T
K
V
G
E
K
H
G
YYRG
I
---
D
----
S
Q
E
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
V
K
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
---
W
T
-
G
A
N
I
I
G
F
C
H
G
V
A
--
G
V
Y
----
E
V
F
-
E
-
R
L
----
G
L
-
D
---
P
-
E
EV
D
W
Q
V
A
--
G
V
N
---
H
----
G
---
I
W
L
N
R
F
R
Y
--
R
G
K
D
A
Y
P
L
L
D
E
W
I
E
K
E
L
-----
S
-
K
W
E
-
P
----------------
K
N
P
W
D
T
Q
------------
M
-
S
P
A
A
M
D
M
----
Y
R
F
Y
G
M
------------
L
P
I
G
DTVR
N
-------
G
T
W
K
Y
H
Y
N
L
E
----------
T
K
--------
K
K
W
F
R
R
F
G
G
I
D
N
E
V
---
E
R
-
P
K
--
F
H
E
H
L
R
R
A
R
E
R
L
I
K
L
---
A
E
E
V
Q
E
N
PHLKITEKHPEI
F
----
P
K
G
-----
R
L
S
----------
G
E
Q
H
I
P
F
I
N
A
I
A
----
N
N
K
R
V
R
L
F
L
N
V
E
-
N
Q
G
A
L
K
D
F
P
D
D
L
V
M
E
L
P
V
W
V
D
S
S
G
I
-----------------------------------------------------------------------------
9
PsiBlast_PDB
51.65
22%
3
- C4 -
-
1VJT
1
?
A:
[15-403]
-------
I
S
I
I
G
A
G
S
V
R
F
A
L
Q
L
V
G
D
I
A
Q
-
T
E
E
-
L
--
S
R
E
D
T
H
I
Y
M
M
D
V
H
--
E
R
R
L
--
N
-
A
-
S
Y
I
L
A
R
K
Y
V
E
---
E
L
N
S
P
V
K
I
V
K
T
S
S
L
D
E
A
I
D
G
A
D
F
I
I
N
T
A
Y
P
Y
D
P
R
Y
H
D
-------
S
G
S
Q
R
W
D
E
V
T
K
V
G
E
K
H
G
YYRG
I
---
D
----
S
Q
E
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
M
K
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
---
W
T
-
G
A
N
I
V
G
F
C
H
G
V
A
--
G
V
Y
----
E
V
F
E
K
L
D
L
----
D
P
-
E
---
E
-
V
--
D
W
Q
V
A
--
G
V
N
---
H
----
G
---
I
W
L
N
R
F
R
Y
--
R
G
E
D
A
Y
P
L
L
D
E
W
I
E
K
K
L
-----
P
--
E
W
-
E
P
-
K
-
N
-------------
P
W
D
T
Q
------------
M
-
S
P
A
A
M
D
M
----
Y
K
F
Y
G
M
------------
L
P
I
G
DTVR
N
-------
G
S
W
K
Y
H
-----
Y
N
----
L
E
T
K
K
--------
K
W
F
G
K
F
G
G
I
D
N
E
V
E
---
R
---
P
-
K
F
H
E
Q
L
R
R
A
R
E
R
L
I
K
L
---
A
E
E
V
Q
Q
------------------
N
P
G
MKLTE
E
-
H
PEIFPKGKLS
G
E
Q
H
I
P
F
I
N
A
I
A
----
N
N
K
R
V
R
L
F
L
N
V
E
-
N
Q
G
T
L
K
D
F
P
D
D
V
V
M
E
L
P
V
W
V
D
C
C
G
I
-----------------------------------------------------------------------------
42
HHSearch
47.19
18%
-57
- C4 -
-
4PLZ
2
LDH_PLAFD
A:
[4-304]
----
K
A
K
I
V
L
V
G
S
G
M
I
--
G
G
V
M
A
T
L
I
V
Q
-
K
--
N
----
L
G
D
V
V
L
F
D
I
V
-
K
--
N
M
P
H
--
G
K
A
-
L
D
T
S
H
T
N
V
M
A
----
Y
S
-
N
C
K
V
S
G
S
N
T
Y
-
D
D
L
A
G
A
D
V
V
I
V
-------
T
A
G
F
---------------------------------------------
R
D
D
L
L
P
L
N
---
N
K
I
M
I
E
I
G
G
H
I
K
K
N
C
P
N
A
F
I
I
V
V
T
N
P
V
D
V
M
V
Q
L
L
H
Q
H
S
G
V
P
-
K
N
K
I
I
G
L
G
G
V
L
D
T
S
R
L
K
----
Y
Y
I
-
S
Q
K
L
----
N
V
-
C
---
P
-
R
--
D
V
N
A
H
I
V
G
A
H
GNK
M
----
V
---
L
L
K
R
Y
I
-
T
--
V
--
G
G
I
P
L
Q
E
F
I
N
N
K
L
I
---------------------------
S
-
D
A
E
L
-------------------
E
A
I
F
----
D
R
T
V
------------------------------------------------
N
---------------
T
A
-------
L
---
E
I
-
V
N
-
L
-
H
-----
A
----------
S
---
P
--------------------
Y
V
-----
A
-
P
----------
A
A
A
I
I
E
M
A
E
S
Y
L
----
K
D
L
K
K
V
L
I
C
S
T
L
-
L
E
G
Q
-
Y
G
H
S
-
D
I
F
G
G
T
P
V
V
L
G
A
N
G
V
E
Q
V
I
E
L
--
Q
L
N
S
-
E
E
K
A
K
F
D
E
--------------------------------------------------------
30
HHSearch
47.05
18%
-34
- C4 -
-
3P7M
-
?
A:
[3-306]
--
M
A
R
K
K
I
T
L
V
G
A
G
N
I
--
G
G
T
L
A
H
L
A
L
I
-
K
--
Q
----
L
G
D
V
V
L
F
D
I
A
-
Q
--
G
M
P
N
--
G
-
K
A
L
D
L
L
Q
T
C
P
-
I
---
E
G
V
-
D
F
K
V
R
G
T
N
D
Y
-
K
D
L
E
N
S
D
V
V
I
V
-------
T
A
G
V
-------
P
R
K
P
G
M
S
R
D
D
L
L
-------------------------------
G
I
N
---
I
K
V
M
Q
T
V
G
E
G
I
K
H
N
C
P
N
A
F
V
I
C
I
T
N
P
L
D
I
M
V
N
M
L
Q
K
F
S
G
V
P
-
D
N
K
I
V
G
M
A
G
V
L
D
S
A
R
F
R
----
T
F
L
-
A
D
E
L
----
N
V
-
S
---
V
-
Q
--
Q
V
Q
A
Y
V
M
G
-
G
---
H
----
G
DT
M
V
P
L
T
K
M
-
S
--
N
V
-
A
G
V
S
L
E
Q
L
V
------------------------------------------------------------------
K
E
G
-
K
------------
L
K
------
Q
-------
E
R
L
D
-------
A
I
----
V
S
R
-------------
T
R
-----
S
G
G
G
---
E
I
-
V
A
-
L
L
K
T
----
G
----------
S
---
A
--------------------
Y
Y
-----
A
-
P
----------
A
A
A
G
I
Q
M
A
E
S
F
L
----
K
D
K
K
M
I
L
P
C
A
A
K
-
V
K
A
G
M
Y
G
L
D
E
D
L
F
V
G
V
P
T
E
I
S
A
N
G
V
R
P
I
E
V
---
E
I
S
D
-
K
E
R
E
Q
L
Q
V
S
I
N
-----------------------------------------------------
29
HHSearch
46.73
18%
-32
- C4 -
-
3P7M
-
?
B:
[2-306]
-
A
M
A
R
K
K
I
T
L
V
G
A
G
N
I
--
G
G
T
L
A
H
L
A
L
I
-
K
--
Q
----
L
G
D
V
V
L
F
D
I
A
-
Q
--
G
M
P
N
--
G
-
K
A
L
D
L
L
Q
T
C
P
-
I
---
E
G
V
-
D
F
K
V
R
G
T
N
D
Y
-
K
D
L
E
N
S
D
V
V
I
V
-------
T
A
G
V
-------
P
R
K
P
G
M
S
R
D
D
L
L
-------------------------------
G
I
N
---
I
K
V
M
Q
T
V
G
E
G
I
K
H
N
C
P
N
A
F
V
I
C
I
T
N
P
L
D
I
M
V
N
M
L
Q
K
F
S
G
V
P
-
D
N
K
I
V
G
M
A
G
V
L
D
S
A
R
F
R
----
T
F
L
-
A
D
E
L
----
N
V
-
S
---
V
-
Q
--
Q
V
Q
A
Y
V
M
G
-
G
---
H
----
G
DT
M
V
P
L
T
K
M
-
S
--
N
V
-
A
G
V
S
L
E
Q
L
V
------------------------------------------------------------------
K
E
G
-
K
------------
L
K
------
Q
-------
E
R
L
D
-------
A
I
----
V
S
R
-------------
T
R
-----
S
G
G
G
---
E
I
-
V
A
-
L
L
K
T
----
G
----------
S
---
A
--------------------
Y
Y
-----
A
-
P
----------
A
A
A
G
I
Q
M
A
E
S
F
L
----
K
D
K
K
M
I
L
P
C
A
A
K
-
V
K
A
G
M
Y
G
L
D
E
D
L
F
V
G
V
P
T
E
I
S
A
N
G
V
R
P
I
E
V
---
E
I
S
D
-
K
E
R
E
Q
L
Q
V
S
I
N
-----------------------------------------------------
43
HHSearch
45.84
15%
-64
- C4 -
-
3PQE
-
LDH_BACSU
D:
[2-313]
-
N
K
H
V
N
K
V
A
L
I
G
A
G
F
V
--
G
S
S
Y
A
F
A
L
I
N
-
Q
--
G
I
---
T
D
E
L
V
V
I
D
V
N
-
K
--
E
K
A
M
--
G
-----
D
V
M
D
L
N
H
G
---
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
-------
C
A
G
A
-------
N
-------------------------------------
R
L
E
L
V
E
K
N
---
L
K
I
F
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
SG
L
P
-
K
E
R
V
I
G
S
G
T
T
L
D
SA
R
F
R
----
F
M
L
-
S
E
Y
F
----
G
A
-
A
---
P
-
Q
--
N
V
C
A
H
I
I
G
-
E
---
H
GDTE
L
---
P
V
W
S
H
A
-
N
--
V
--
G
G
V
P
V
S
E
L
V
E
K
-------------------------------
N
D
-
Y
K
-------------------
Q
E
E
-----------------------------------------------
L
D
-
Q
I
----
V
D
D
V
-----------
K
N
A
A
Y
H
----------
I
-
I
E
-
K
-
K
-----
G
----------
A
-----------------------
T
Y
Y
-----
G
-
V
----------
A
M
S
L
A
R
I
T
K
A
I
L
----
H
N
E
N
S
I
L
T
V
S
T
Y
-
L
D
G
Q
Y
-
G
-
A
D
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
--
N
L
N
E
-
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
H
--------------------------------------------