@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYJ6: (2018-01-09 )
MTQDSKRATEKRRRINLTSKEISELLAEGIITIILLLLLNVSILVVISSVINSSPSLTNAIWDSKNIFAERLNTDLFWNGRNFIIPFFFLLDIGVLYWRLIRRYRQMQLRHIISELHYIANGNYDHRIPFELSGDLSRVVTSINGLVDSTVAAIEDERKIEKSKDELITNVSHDIRTPLTSIIGYLGLIEDGQYHSEEDLLKYTHTAYIKAKQMKSLVDDLFEYTKVRQPAVPVNFSAFDMIQLIEQLAADFELEASKKNIQILVQSKVDSLIMDGDTEKLVRVFNNLLTNALKYGKGATKIVIEVERIGSEVVATVKNNGAMIPQQAIDNLFDRFYRVEESRSQATGGTGLGLAIAQSIVALHGGYIYAKSDKQWTSFIMHLPIKKNEKLPIDTQEVIDES
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.----------......110.......120.......130.......140.......150....----------------------------------------------------------------------------------------------------------------...160.......170.......180.......190...-....200-.......-----210.......220.......230.......240.......250..-----.....260---.........-270....-...280.......290.....--..300---.........310.......320.......330.......340.......350.......360-.......370.-.-..-....380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQ
D
S
K
R
A
T
E
K
R
RRINL
T
S
K
E
I
S
E
L
L
A
E
G
I
I
T
I
I
L
L
L
L
L
N
V
S
I
L
V
V
I
S
S
V
INSSPS
L
T
N
A
IWDS
K
N
I
F
A
E
RLNT
D
L
F
WNG
R
N
F
I
I
P
F
F
F
L
L
D
I
G
V
L
Y
W
R
L
I
R
R
----------
Y
R
Q
M
Q
L
R
H
I
I
S
E
L
H
Y
I
ANGNYDHRI
P
F
ELSG
D
L
S
R
V
V
T
S
I
N
G
L
V
D
S
T
V
A
A
I
E
D
----------------------------------------------------------------------------------------------------------------
E
R
K
I
E
K
S
K
D
E
L
I
T
NVS
H
D
I
R
T
P
L
T
S
I
I
G
Y
L
GLIEDGQYH-
S
E
E
D
L
L
K
-
Y
T
H
T
A
Y
I
-----
K
A
K
Q
M
K
S
L
V
D
D
L
F
E
Y
T
KVRQPAVPVN
F
S
A
F
D
M
I
Q
L
I
E
Q
L
A
AD
F
E
L-----EASKK
N
-----
I
Q
I
L
V
QSK
V
-
D
S
LIMDG-
D
T
E
K
L
V
R
V
F
N
N
L
L
T
N
A
L
K
YGK--G
A
T
-----
K
I
V
I
E
V
E
RIG
S
E
V
V
A
T
VKNNGAMI
P
Q
Q
A
I
D
N
L
F
D
R
F
Y
R
V
E
ESRSQATGGT
G
L
G
L
A
I
A
Q
S
I
V
A
-LHG
G
Y
I
Y
A
K-S-D-K
Q
-
W
T
S
F
I
MHLPIKKNEKLPI
D
T
Q
E
V
IDES
30
HHSearch
84.38
27%
-
- C1 -
-
4I5S
-
?
B:
[33-434]
----------------------------------------------------------------------------------------------------
R
E
Y
----------
K
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
MT
D
G
V
L
A
T
D
RSGKITVIN
D
M
A
Q
K
Q
L
NVT
R
E
Q
A
L
E
CNILDILDDDSY
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
RRDEYD
E
F
I
T
L
R
I
R
F
A
L
N
R
R
ESGFIS
G
L
I
A
V
L
H
DA
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
--
T
E
S
V
A
P
S
-
F
I
K
V
S
L
D
-----
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
I
D
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
-----
I
Q
S
Q
Q
-------
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
-
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
--
D
G
G
-----
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
------
T
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
-
S
-
E
-
E
G
E
G
S
T
F
T
I
V
L
P
Y
E
----------------
53
Fugue
67.78
22%
-
* C2 *
-
4I5S
-
?
A:
[37-432]
--
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
NILDILDDDS
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
----------------------------------------------------------------------------------------------------------------
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
--
T
E
S
V
A
P
S
-
F
I
K
V
S
L
D
-----
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
L
D
V
E
L
T
N
-----
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
-----
I
Q
S
Q
Q
S
-----
T
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
-
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
--
D
G
G
-----
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
-
S
E
E
-
G
E
-
G
S
T
F
T
I
V
L
P
------------------
18
PsiBlast_PDB
60.87
26%
-104
- C1 -
-
4BIU
-
CPXA_ECOLI
A:
[70-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
-----------------------------------
17
PsiBlast_PDB
60.60
25%
-79
- C1 -
-
5LFK
2
?
A:
[67-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
V
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
-
P
-
L
G
-
G
L
R
L
V
I
W
L
P
L
Y
K
---------------
15
PsiBlast_PDB
60.39
25%
-93
- C1 -
-
4BIX
1
CPXA_ECOLI
A:
[67-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
V
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
-
P
-
L
G
-
G
L
R
L
V
I
W
L
P
L
Y
K
---------------
54
Fugue
60.29
23%
-110
- C1 -
-
1ID0
1
A:
[1-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
H
P
V
A
P
L
L
D
N
L
T
S
A
L
N
K
-----
V
Y
Q
R
K
G
-----
V
N
I
S
L
D
I
S
--
P
E
I
S
F
V
G
-
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
L
----
E
-----
F
V
E
I
S
A
R
Q
T
D
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
L
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
-
Q
Y
E
G
K
I
V
A
G
-
E
S
M
-
L
G
-
G
A
R
M
E
V
I
F
G
R
Q
H
---------------
16
PsiBlast_PDB
57.05
25%
-97
- C1 -
-
4BIY
1
CPXA_ECOLI
A:
[67-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
V
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
-
P
-
L
G
-
G
L
R
L
V
I
W
L
P
L
Y
K
---------------
14
PsiBlast_PDB
56.31
25%
-71
- C1 -
-
4BIW
2
CPXA_ECOLI
A:
[67-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
V
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
-
P
-
L
G
-
G
L
R
L
V
I
W
L
P
L
Y
K
---------------
12
PsiBlast_PDB
55.92
28%
-105
- C1 -
-
3A0R
-
?
A:
[134-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
-
H
L
D
-
D
P
E
T
L
K
K
-
Y
I
N
I
I
T
N
-----
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
-
V
---
L
E
F
T
E
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
-----
K
I
R
K
M
N
-----
I
D
F
C
F
E
T
D
N
-
E
D
L
R
V
E
A
-
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
--
E
N
G
-----
K
I
K
I
T
S
E
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
------
T
T
------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
-
N
-
R
-
E
N
-
G
V
V
F
I
F
E
I
P
------------------
32
HHSearch
54.65
23%
-99
- C1 -
-
4BIX
-
CPXA_ECOLI
B:
[64-296]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
N
Q
V
V
T
A
L
E
R
M
-----------------------------------------------------------------------------------------------------------------------
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
------
S
K
-
E
L
E
R
I
E
T
-----
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
-------
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
-
D
-
S
-
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
---------------
19
PsiBlast_PDB
54.05
25%
-91
- C1 -
-
4BIV
2
CPXA_ECOLI
A:
[67-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
M
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
-----------------------------------
34
HHSearch
53.83
26%
-5
- C1 -
-
5C93
1
?
A:
[10-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
-
F
L
K
V
T
Q
E
-----
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
-----
I
L
K
K
D
D
NPA
K
Y
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
-
S
-
V
-
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
----------------
5
PsiBlast_PDB
53.46
25%
3
- C1 -
-
5C93
1
?
A:
[3-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
----------------------------------------------------------------------------------------------------------------
Q
Q
K
I
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
-
F
L
K
V
T
Q
E
-----
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
KD
D
N
P
A
K
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
-
S
V
E
-
G
K
-
G
S
T
F
Y
I
S
L
P
Y
E
----------------
35
HHSearch
52.21
26%
-1
- C1 -
-
4U7O
1
?
A:
[32-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
-
F
L
K
V
T
Q
E
-----
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
-----
I
L
K
K
D
D
NPA
K
Y
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
-
S
-
V
-
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
----------------
20
PsiBlast_PDB
52.05
25%
-84
- C1 -
-
4CB0
2
CPXA_ECOLI
A:
[67-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
M
V
T
A
L
E
-------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
--
L
E
-
R
I
E
T
--------
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-----
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
-
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
K
I
-----
E
V
G
F
A
V
D
K
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
-----------------------------------
39
HHSearch
51.81
30%
35
- C1 -
-
4JAV
1
?
A:
[17-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
-
F
L
E
V
I
I
D
-----
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-----
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
--
K
D
A
P
D
K
--
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
-
S
-
E
-
V
G
K
G
S
R
F
F
V
W
I
P
K
D
----------------
10
PsiBlast_PDB
50.74
31%
26
- C1 -
-
4JAV
1
?
A:
[14-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
----
Y
N
-
S
L
G
E
L
D
L
-
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-----
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
-
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
--
K
D
A
P
D
K
Y
V
K
V
I
L
D
-
E
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
-
S
-
E
V
G
K
-
G
S
R
F
F
V
W
I
P
------------------
6
PsiBlast_PDB
50.40
31%
28
- C1 -
-
4JAS
1
?
A:
[14-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
-
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
-----
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-----
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
-
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
--
K
D
A
P
D
K
Y
V
K
V
I
L
D
-
E
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
-
S
-
E
V
G
K
-
G
S
R
F
F
V
W
I
P
------------------
3
PsiBlast_PDB
50.27
26%
16
- C1 -
-
4U7O
1
?
A:
[25-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------V
T
E
-------------------------------------------------------------------------------------------------------------
Q
Q
K
I
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
-
F
L
K
V
T
Q
E
-----
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
KKD
D
N
P
A
K
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
-
S
V
E
-
G
K
-
G
S
T
F
Y
I
S
L
P
Y
E
----------------
21
PsiBlast_CBE
50.26
31%
22
- C1 -
-
4JAV
1
?
B:
[14-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
----
Y
N
-
S
L
G
E
L
D
L
-
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-----
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
-
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
--
K
D
A
P
D
K
Y
V
K
V
I
L
D
-
E
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
-
S
-
E
V
G
K
-
G
S
R
F
F
V
W
I
P
------------------
13
PsiBlast_PDB
26.00
38%
10
- C1 -
-
3SL2
1
A:
[40-153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
EG
G
H
V
-----
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
-
S
I
E
-
G
K
-
G
T
T
I
T
F
T
L
P
Y
K
E
---------------