@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYJ8: (2018-01-09 )
MSNWETKFTKKGFTFDDVLLIPAESHVLPNEVDMSVQLAKNIKLNIPIISASMDTVTDSKMAIAMARQGGLGVIHKNMTISQQADEVRKVKRSESGVIIDPFFLTPQHLVADAEELMSKYRISGVPIVETLENRKLVGIITNRDMRFVTDYHMPIADVMTKDNLVTAPVGTSLKDAEKILQKHKIEKLPIVDNEGRLSGLITIKDIEKVIEFPNAAKDEHGRLLVAAAVGVTSDTFERANALLEAGADAIIIDTAHGHSAGVIRKIQEIRSTFADATLIAGNVATAEATKALYDAGVDVVKVGIGPGSICTTRVVAGVGVPQLTAIYDAASVARQYGKAIIADGGIKYSGDIVKALAAGGHAVMLGSMLAGTDESPGEFEIFQGRRFKTYRGMGSLGAMEKGSKDRYFQGSVNEANKLVPEGIEGRVAYKGSVADIIFQMIGGLRSGMGYVGAANLQQLRDEAQFIQMSGSGLKESHPHDVQITKEAPNYSVES
Atome Classification :
(50 SA)
-------------.........10-.........20......-..30........40-........50........60........70........80........90........100.......110.......120.......130-.......140.......150.......160-.--.-......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......---340.......350.......360.......370.......380.......390.......400.......410....-...420.......430.......440.......450.......460.......470.......480.......490..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------MSNWETKFTK--KGFTF
D
D
V
L
L
IPAESHV-LPNEV
D
M
S
V
Q
L
AKN-
I
K
L
N
I
P
I
I
SASMDTVTDSK
M
A
I
A
M
ARQGG
L
G
V
I
HKNMTI
S
Q
Q
A
D
E
V
R
K
V
KRSES
G
V
I
I
D
P
F
FL
T
P
Q
H
L
V
A
D
A
E
E
L
M
S
KYRISGV
P
I
V
E
TLE-NR
K
L
V
G
I
ITNR
D
M
R
F
V
T
DYHM
P
I
A
D
V
MT-K-D--N-
L
V
TAPVGT
S
L
K
D
A
E
K
I
L
Q
KHKIEKLPIVDNEG
R
L
S
G
L
I
T
I
K
D
I
E
K
V
IEFPNAAKDEHG
R
L
L
V
A
A
AVGVT
S
D
T
F
E
R
A
N
A
L
L
EAGA
D
A
I
I
I
DTAHGH
S
A
G
V
I
R
K
I
Q
E
I
R
S
T
FAD
A
T
L
IAGNVA
T
A
E
A
T
K
A
L
Y
DAG
V
D
V
V
K
VGIGPG
S
I
C
T
T
R
V
V
AGVGV
P
Q
L
T
A
I
Y
D
A
A
S
V
A
R
Q
YG
K
A
---
I
IADGGIKYS
G
D
I
V
K
A
L
AAGG
H
A
V
M
L
G
S
M
LAGTDESPGE
F
E
IFQGRRF
K
T
YRGMGSLGAMEKGSKD
R
Y
F
QGSVN
E
A
N
-
K
LVPEGIEG
R
V
A
YKG
S
V
A
D
I
I
F
Q
M
I
G
G
L
R
SGMGYVG
A
A
N
L
Q
Q
L
R
D
E
A
Q
F
I
Q
MSGSGLKESHPH
D
V
Q
I
TKEAPNYSVES
1
PsiBlast_PDB
88.29
77%
-94
- C2 -
-
1ZFJ
1
IMDH_STRPY
A:
[1-490]
--------------
S
N
W
D
T
K
F
L
K
--
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
-
L
P
N
E
V
D
L
K
T
K
L
A
D
N
-
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
-
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
P
I
S
E
H
M
T
-
S
-
E
--
H
-
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
T
---
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
--------------
N
-
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
---
2
PsiBlast_PDB
86.72
72%
-81
- C2 -
-
3TSB
-
?
A:
[26-510]
----------------
W
E
S
K
F
V
K
--
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
-
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
--
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G
S
K
D
R
Y
F
Q
----
E
G
N
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
---
3
PsiBlast_PDB
84.80
72%
-103
- C2 -
-
3TSD
1
?
A:
[26-497]
----------------
W
E
S
K
F
V
K
--
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
-
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
--
K
-
E
--
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
--------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
----------------
4
PsiBlast_PDB
83.77
69%
-111
- C2 -
-
3USB
3
?
A:
[26-493]
----------------
W
E
S
K
F
V
K
--
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
-
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
--
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
--------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
--------------------
114
HHSearch
83.15
81%
-56
- C2 -
-
1ZFJ
1
IMDH_STRPY
A:
[1-490]
--------------
S
N
W
D
T
K
F
L
K
--
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
-
L
P
N
E
V
D
L
K
T
K
L
A
D
N
-
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
-
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
P
I
S
E
H
M
T
---
S
--
E
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
T
---
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
--------------
N
-
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
---
6
PsiBlast_PDB
77.12
55%
-54
- C2 -
-
4FXS
2
?
A:
[5-486]
-------------------
R
I
A
K
--
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
--
T
E
-
N
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
L
T
K
S
V
A
A
V
M
T
P
K
-
E
--
R
-
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
S
S
D
R
Y
F
Q
-
T
---
A
D
-
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
123
HHSearch
75.66
73%
-89
- C2 -
-
5UPX
2
?
A:
[4-384]
---------------
M
W
E
T
K
F
A
K
--
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
N
D
V
D
L
S
V
E
M
A
P
S
-
L
K
L
N
V
P
I
W
S
A
G
M
D
T
I
T
E
A
K
M
A
I
A
I
A
R
Q
G
G
I
G
V
V
H
K
N
M
S
I
E
Q
Q
A
E
E
I
E
K
V
K
R
S
E
------
S
G
G
------------------------
I
K
D
------------------------------------------------
K
V
-----------
I
E
F
P
N
S
A
K
------------------------
D
K
H
G
R
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
Y
D
C
A
T
V
A
R
E
F
G
K
T
---
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
E
H
G
--
D
R
Y
F
Q
A
D
---
A
K
-
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
E
A
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
---
116
HHSearch
74.34
57%
-23
- C2 -
-
4FXS
2
?
A:
[4-486]
------------------
L
R
I
A
K
--
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
E
---
N
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
L
T
K
S
V
A
A
V
M
T
---
P
KE
R
-
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
S
S
D
R
Y
F
Q
T
----
A
D
-
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
129
HHSearch
73.91
56%
-101
- C2 -
-
5UQG
3
?
E:
[25-403]
------------------
M
K
I
V
K
--
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
-
L
P
K
E
V
K
I
H
T
K
L
T
K
N
-
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
------
S
---------------------------------------------------------------------------
K
E
Y
P
--
D
---
A
N
-
K
D
N
F
G
R
-----------------------------------
L
R
V
G
A
A
I
G
--
V
G
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
F
G
V
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
K
-----------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
R
A
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
--
124
HHSearch
73.44
60%
-105
- C2 -
-
5UZC
7
?
C:
[5-360]
------------------
A
R
I
L
K
--
T
A
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
-
L
P
N
E
V
S
L
K
T
Q
L
T
K
K
-
I
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
N
M
T
I
E
D
Q
A
R
---------------------------
E
V
D
R
V
K
R
S
----------------------------------------------------------------------------------------------------------
G
G
L
L
C
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
L
T
A
V
M
D
C
A
E
E
G
K
K
L
G
I
P
---
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
L
G
A
M
A
------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
N
A
N
F
V
V
Q
T
S
A
G
F
R
E
S
H
P
H
D
I
N
I
T
K
E
A
P
N
Y
S
---
9
PsiBlast_PDB
72.89
54%
-59
- C2 -
-
4DQW
4
?
A:
[23-486]
-------------------
R
I
S
Q
--
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
Q
G
E
----
L
V
G
I
V
T
G
R
D
L
R
V
K
P
N
A
G
D
T
V
A
A
I
M
T
P
K
-
D
--
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
T
G
V
P
---
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
--------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
------------------------
134
HHSearch
72.75
56%
-95
- C2 -
-
4MZ1
4
?
C:
[4-382]
------------------
M
K
I
V
K
--
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
-
L
P
K
E
V
K
I
H
T
K
L
T
K
N
-
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
------
S
E
S
G
G
-----------------------
I
-
K
-------------------------------
K
---
R
--
K
-
E
---
Y
P
------------------
D
A
N
K
D
N
--------------------------
F
G
R
L
R
V
G
A
A
I
--
G
V
G
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
F
G
V
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
K
-----------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
R
A
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
--
125
HHSearch
72.28
60%
-101
- C2 -
-
5UZS
9
?
C:
[2-360]
---------------
N
A
M
A
R
I
L
K
--
T
A
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
-
L
P
N
E
V
S
L
K
T
Q
L
T
K
K
-
I
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
N
M
T
I
E
D
Q
A
R
---------------------------
E
V
D
R
V
K
R
S
----------------------------------------------------------------------------------------------------------
G
G
L
L
C
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
L
T
A
V
M
D
C
A
E
E
G
K
-
L
G
I
P
---
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
L
G
A
M
A
K
-----------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
N
A
N
F
V
V
Q
T
S
A
G
F
R
E
S
H
P
H
D
I
N
I
T
K
E
A
P
N
Y
S
---
133
HHSearch
71.92
61%
-95
- C2 -
-
4X3Z
3
?
A:
[7-363]
------------------
L
R
I
A
K
--
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
---------------------------
V
H
Q
V
K
I
---------------------------------------------------------------------
S
--
G
G
L
-----------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
132
HHSearch
71.59
61%
-94
- C2 -
-
4FO4
2
?
A:
[7-366]
------------------
L
R
I
A
K
--
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
---------------------------
V
H
Q
V
K
I
---------------------------------------------------------------------
S
--
G
G
L
-----------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
G
-
128
HHSearch
71.25
60%
-101
- C2 -
-
4FEZ
5
?
B:
[8-366]
-------------------
R
I
A
K
--
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
------------------------
S
--------------------------------------------------------------------------
K
P
---------------
N
A
C
---------
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
-----------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
-----------------------
21
PsiBlast_CBE
71.01
54%
-64
- C2 -
-
4DQW
3
?
B:
[23-486]
-------------------
R
I
S
Q
--
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
Q
G
E
----
L
V
G
I
V
T
G
R
D
L
R
V
-----
D
T
V
A
A
I
M
T
P
K
-
D
--
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
T
G
V
P
---
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
--------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
------------------------
119
HHSearch
70.12
51%
-88
- C2 -
-
2CU0
1
IMDH_PYRHO
A:
[9-480]
-------------------
E
K
A
I
--
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
-
E
P
K
D
V
D
V
S
T
R
I
T
P
N
-
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
N
G
E
L
L
V
A
--
A
A
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
-
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
--
L
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
G
L
Y
---
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
----------
Y
M
K
T
R
-
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
-----
126
HHSearch
70.05
57%
-96
- C2 -
-
5AHM
1
?
A:
[21-398]
-----------------
M
L
R
I
S
Q
--
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
---
H
--------------------
E
T
A
-
K
A
K
T
Y
P
L
A
S
K
-------------------------------------------------------------------
D
E
--------------------------
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
T
G
V
P
---
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
-----------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
---
135
HHSearch
69.83
56%
-90
- C2 -
-
4QJ1
7
?
D:
[6-360]
------------------
T
K
N
I
G
--
K
G
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
-
L
P
R
E
V
S
L
E
T
K
L
T
K
N
-
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N
M
D
M
E
S
Q
V
N
E
---
V
L
K
--------------------
V
----
K
----------
N
S
-------------------------------------------------------------
G
G
L
--------
R
V
G
A
---------------------------
A
I
G
V
--
N
E
I
E
R
A
K
L
L
V
E
A
G
V
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
I
E
K
C
S
S
V
A
S
K
F
G
I
P
---
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
I
G
D
T
V
Y
K
Y
Y
R
G
M
G
S
V
G
A
M
K
S
--------------
N
-
K
M
V
P
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
S
S
Y
V
E
I
T
T
S
G
L
R
E
S
H
V
H
D
V
E
I
V
K
E
V
M
N
Y
S
---
113
HHSearch
69.77
54%
-114
- C2 -
-
5AHN
1
?
A:
[3-467]
-------------------
R
I
S
Q
--
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
---------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
T
G
V
P
---
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
-----------------------
10
PsiBlast_PDB
69.77
54%
-114
- C2 -
-
5AHN
1
?
A:
[3-467]
-------------------
R
I
S
Q
--
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
---------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
T
G
V
P
---
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
-----------------------
12
PsiBlast_PDB
68.12
61%
-80
- C2 -
-
5UPX
2
?
A:
[1-384]
----------------------------------------------------------------------------------------------------
S
N
A
M
W
E
T
K
F
A
K
E
G
L
T
F
D
D
V
L
L
V
P
----
A
K
S
D
V
L
P
N
D
V
D
L
S
----
V
E
M
A
P
-
S
L
K
L
N
V
P
I
W
S
A
G
M
D
T
I
T
E
A
K
M
A
I
A
I
A
R
Q
-----------
G
G
I
G
V
V
H
K
N
M
S
I
E
Q
Q
A
E
E
I
E
K
V
K
R
S
E
S
G
G
-------
I
K
D
--
K
V
I
E
F
P
N
S
A
K
D
K
H
G
R
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
Y
D
C
A
T
V
A
R
E
F
G
K
T
---
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
E
H
G
--
D
R
Y
F
Q
A
---
D
A
K
-
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
E
A
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
---
93
PsiBlast_CBE
63.37
42%
-120
- C2 -
-
1B3O
2
IMDH2_HUMAN
A:
[29-480]
--------------------------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
-----------------------------------------------------------------------------------------------------------------------------
D
Y
P
L
A
S
K
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
-------------
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
F
G
V
P
---
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
---------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
----------------------------------
13
PsiBlast_PDB
62.56
77%
-111
- C2 -
-
5UPY
7
?
A:
[95-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
Y
D
C
A
T
V
A
R
E
F
G
K
T
---
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
E
H
G
---------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
E
A
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
---
15
PsiBlast_PDB
60.29
71%
-106
- C2 -
-
4MY8
9
?
A:
[116-367]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G
S
K
--------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
-------------------
70
PsiBlast_CBE
60.12
71%
-109
- C2 -
-
4MYA
3
?
B:
[116-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
----------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
----
62
PsiBlast_CBE
59.34
71%
-108
- C2 -
-
4QM1
3
?
B:
[116-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
----------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
---
80
PsiBlast_CBE
59.24
71%
-109
- C2 -
-
4MY8
7
?
B:
[116-366]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
-----------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
--------------------
79
PsiBlast_CBE
58.98
71%
-111
- C2 -
-
4MY8
4
?
C:
[116-366]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
----------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
--------------------
17
PsiBlast_PDB
58.19
71%
-93
- C2 -
-
4MYA
4
?
A:
[116-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
---------------K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
----
20
PsiBlast_PDB
58.04
71%
-110
- C2 -
-
4QM1
3
?
A:
[116-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
----------
61
PsiBlast_CBE
57.91
71%
-112
- C2 -
-
4QM1
3
?
C:
[116-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
-----------
94
PsiBlast_CBE
57.47
63%
-95
- C2 -
-
4X3Z
2
?
B:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
104
PsiBlast_CBE
56.90
63%
-96
- C2 -
-
4FO4
2
?
A:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
60
PsiBlast_CBE
56.90
71%
-109
- C2 -
-
4QM1
3
?
D:
[116-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
P
---
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
----------
99
PsiBlast_CBE
56.88
63%
-101
- C2 -
-
4IX2
1
?
D:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
---------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
103
PsiBlast_CBE
56.77
63%
-96
- C2 -
-
4FO4
2
?
B:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
95
PsiBlast_CBE
55.92
63%
-93
- C2 -
-
4X3Z
3
?
A:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
100
PsiBlast_CBE
55.88
63%
-97
- C2 -
-
4IX2
1
?
C:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
---------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
102
PsiBlast_CBE
55.73
63%
-99
- C2 -
-
4IX2
1
?
A:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
---------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
101
PsiBlast_CBE
55.65
63%
-97
- C2 -
-
4IX2
1
?
B:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
---------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
89
PsiBlast_CBE
55.13
42%
-42
- C2 -
-
1NFB
2
IMDH2_HUMAN
A:
[29-480]
--------------------------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
F
G
V
P
---
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
----------------------------------
88
PsiBlast_CBE
55.01
42%
-41
- C2 -
-
1NFB
2
IMDH2_HUMAN
B:
[29-480]
--------------------------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
F
G
V
P
---
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
----------------------------------
98
PsiBlast_CBE
54.93
63%
-91
- C2 -
-
4QNE
2
?
A:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
97
PsiBlast_CBE
54.23
63%
-95
- C2 -
-
4QNE
2
?
B:
[95-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
----
11
PsiBlast_PDB
54.18
50%
14
- C2 -
-
2CU0
1
IMDH_PYRHO
A:
[3-480]
---------------
K
F
V
E
K
L
E
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
-
E
P
K
D
V
D
V
S
T
R
I
T
P
N
-
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
N
G
E
L
L
V
A
A
A
V
--
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
-
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
T
F
A
--
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
G
L
Y
---
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
----------
Y
M
K
T
R
-
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
-----
96
PsiBlast_CBE
54.02
63%
-119
- C2 -
-
4QQ3
1
?
A:
[95-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
I
P
---
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
--------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
-----------------------
92
PsiBlast_CBE
53.69
42%
-20
- C2 -
-
1B3O
2
IMDH2_HUMAN
B:
[29-480]
--------------------------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
D
R
V
R
-----------
C
G
I
P
I
T
D
T
G
R
M
G
S
R
L
V
G
I
I
-----------------
I
M
T
-
K
R
E
--
D
-
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
F
G
V
P
---
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
---------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
----------------------------------
137
Fugue
47.36
41%
-1
- C2 -
-
1B3O
2
IMDH2_HUMAN
A:
[10-498]
TSYVPDDGLT
A
Q
Q
L
F
N
C
-----
G
--
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
-F
T
A
D
Q
V
D
L
T
S
A
L
T
K
-K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
D
-----------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
-------------
S
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
F
---G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
---------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
----------
G
E
L
K
F
E
K
R
T
S
S
A
Q
------