@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYK5: (2018-01-09 )
MEHYEADAYDVIVVGAGHAGSEAALAAARMGSKTLLLTINLDMVAFMPCNPSVGGPAKGVVVREIDALGGEMGKNIDKTYIQMRMLNTGKGPAVRALRAQADKHAYSTEMKHTIEKEPNLTLRQGIVEELIVEDGVCHGVVTSTGASYRAKAVVITAGTALRGEIIIGELKYSSGPNNSQPSIGLANHLKELGFAIERFKTGTPPRVKSSTIDYSVTEEQPGDKEPNHFSFSTPDSAYKLDQESCWLTYTGETTHQIIRDNLHRAPMFTGIVEGVGARYCPSIEDKIVRFADKPRHQLFLEPEGLNTEEVYVQGLSTSLPEDVQVNMLHSIAGLEKVEMMRTGYAIEYDVVEPHQLRPTLETKVVENLYTAGQTNGTSGYEEAAGQGLIAGINAALKVQGKEPLVIKRSDGYIGVMIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTEMGHRVGLVKEDQYKNYLKKKEAVEQEIKRLMNVRIKPTEEVQDFLATINAAPLKDGVLASDFLRRPEITYAELLRFIPENEELTRKEIEQVEVQIKYEGYIKKAMEKVEKLKRMEAKKIPENIDYAAINGLATEAKQKLQKIQPETIAQASRISGVNPADLSILMVYIEQGKIAKVSEPA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-.......130.......140.......150.......160.......170....-...180.-......190.......200.......210.......220.......230.-...-----...240--.........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.....--..480....----...490.....----..500.---......510.......520.......530--...------.-....--.540........550.......560.......570.......580.......590.......600.......610.......620.......630.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEHYEADA
Y
D
V
I
V
V
GAGHAG
S
E
A
A
L
A
A
A
RMGS
K
T
L
L
L
T
I
NL
D
M
V
A
F
MPCNPSVGGPAK
G
V
V
V
R
E
I
D
A
LGGEMGKN
I
D
K
T
Y
I
Q
M
R
M
LNTGK
G
P
A
V
R
A
L
R
A
Q
ADKH
A
Y
S
T
E
M
K
H
T
IEKEPN
L
T
L
-
R
Q
G
I
V
E
E
L
I
V
EDGVCH
G
V
VTSTGAS
Y
R
A
K
A
V
V
I
TAGT
A
L
R
G
E
I
I
I
G
E
L
K
YSSGP-NNSQPSI-
G
L
A
N
H
L
K
E
L
G
F
A
I
E
R
FKTGTPPRVKSSTI
D
Y
SVTEEQPGDKEPNHFSFST-PDS-----
A
Y
KL----DQE
S
C
W
L
T
YTG
E
T
T
H
Q
I
I
R
DNLHRA
P
M
F
T
G
I
V
E
G
VGARYCP
S
I
E
D
K
I
V
R
F
ADKPR
H
Q
L
F
LEPEGL
N
T
E
E
V
Y
V
QGLSTSLPE
D
V
Q
V
N
M
L
H
S
I
A
G
L
E
K
V
E
M
M
RTG
Y
A
I
E
Y
DVV
E
P
H
QLRP
T
L
E
T
K
V
V
E
N
L
Y
TAGQTNGTSG
Y
E
E
AAGQ
G
L
I
A
GI
N
A
A
L
K
VQGKE
P
L
V
I
KRSD
G
Y
I
G
V
M
I
D
D
L
V
TKGTN
E
P
Y
R
L
L
TSRA
E
Y
R
L
L
L
R
HDNA
D
L
R
L
TEMGHRVGLV
K
E
D
Q
Y
K
N
Y
L
K
K
K
E
A
V
E
--
Q
E
I
K
R
L
M
NV----RIK
P
T
E
E
V
Q
D
F
----
L
A
TINA---APLKDG
V
L
A
S
D
F
LRRPEI
T
Y
A
E
L
L
R
FI----PEN------
E
-
E
L
T
R
--
K
E
-
I
E
Q
V
E
V
Q
I
K
Y
E
G
Y
I
K
K
A
M
E
K
V
E
K
L
K
R
M
E
A
K
KIPENI
D
Y
A
A
IN
G
L
A
T
E
A
K
Q
K
L
Q
KI
Q
P
E
T
I
A
Q
A
S
RISGV
N
P
A
D
L
S
I
L
M
V
Y
IEQGKIAKVSEPA
23
PsiBlast_CBE
70.48
50%
-12
- C6 -
-
3CP8
1
MNMG_CHLTE
B:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
R
M
S
C
N
P
A
I
G
G
V
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
-
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
-
T
S
V
-----
A
N
R
-----
N
L
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
R
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
----
L
H
R
T
E
S
I
I
--
K
R
V
Q
H
C
L
E
V
MKTA
K
V
T
P
A
-
E
I
N
T
L
----
L
M
N
K
G
L
---
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
LSVR
S
A
A
------
E
-
E
L
C
N
DP
R
V
-
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
22
PsiBlast_CBE
70.48
50%
-13
- C6 -
-
3CP8
1
MNMG_CHLTE
C:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
R
M
S
C
N
P
A
I
G
G
V
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
-
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
-
T
S
V
-----
A
N
R
-----
N
L
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
R
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
----
L
H
R
T
E
S
I
I
--
K
R
V
Q
H
C
L
E
V
MKTA
K
V
T
P
A
-
E
I
N
T
L
----
L
M
N
K
G
L
---
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
LSVR
S
A
A
------
E
-
E
L
C
N
DP
R
V
-
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
3
PsiBlast_PDB
70.27
50%
-11
- C6 -
-
3CP8
1
MNMG_CHLTE
A:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
R
M
S
C
N
P
A
I
G
G
V
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
-
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
-
T
S
V
-----
A
N
R
-----
N
L
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
R
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
----
L
H
R
T
E
S
I
I
--
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
----
L
M
N
K
G
L
---
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
A
------
E
-
E
L
C
N
D
P
R
V
-
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
107
HHSearch
69.88
50%
-6
* C6 *
-
3CP8
1
MNMG_CHLTE
B:
[20-639]
------
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
R
M
S
C
N
P
A
I
G
G
V
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
-
G
L
T
E
S
L
A
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
-
T
S
V
-----
A
-
N
R
----
N
L
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
R
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
E
S
I
I
K
R
V
Q
--
H
C
L
E
V
M
K
T
A
----
K
V
T
P
A
E
I
-
N
T
L
----
L
M
N
K
G
L
---
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
----
L
S
V
RSAAEE
L
-
C
N
D
P
--
R
V
-
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
25
PsiBlast_CBE
67.53
50%
5
- C6 -
-
2ZXI
1
MNMG_AQUAE
C:
[23-633]
---
W
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
G
-----
S
Y
W
F
PKGK
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
----
S
V
A
V
G
--
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
---
T
--
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
------------------------------
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
------------
27
PsiBlast_CBE
67.49
50%
7
- C6 -
-
2ZXH
1
MNMG_AQUAE
B:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
G
-----
S
Y
W
F
PKGK
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
KW
K
E
F
Y
K
S
E
R
V
------------
R
S
Y
SVAT
L
M
T
M
N
Y
---
T
--
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
------------------------------
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
------------
26
PsiBlast_CBE
67.14
50%
8
- C6 -
-
2ZXI
1
MNMG_AQUAE
B:
[23-633]
---
W
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
G
-----
S
Y
W
F
PKGK
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
----
S
V
A
V
G
G
D
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
---
T
--
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
------------------------------
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
------------
24
PsiBlast_CBE
66.88
50%
5
- C6 -
-
2ZXI
1
MNMG_AQUAE
D:
[23-633]
---
W
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
G
-----
S
Y
W
F
PKGK
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
KW
K
E
F
Y
K
S
E
R
V
----
S
V
A
V
G
G
D
T
R
S
Y
SVAT
L
M
T
M
N
Y
---
T
--
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
------------------------------
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
------------
4
PsiBlast_PDB
66.69
50%
7
- C6 -
-
2ZXH
1
MNMG_AQUAE
A:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
G
-----
S
Y
W
F
PKG
K
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
------------
R
S
Y
S
V
A
T
L
M
T
M
N
Y
---
T
--
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
------------------------------
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
------------
21
PsiBlast_CBE
65.77
50%
-13
- C6 -
-
3CP8
1
MNMG_CHLTE
D:
[22-580]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
R
M
S
C
N
P
A
I
G
G
V
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
-
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
-
T
S
V
-----
A
N
R
-----
N
L
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
R
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
----
L
H
R
T
E
S
I
I
--
K
R
V
Q
H
C
L
E
V
MKTA
K
V
T
P
A
-
E
I
N
T
L
----
L
M
N
K
G
L
---
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
LSVR
S
A
A
------
E
-
E
L
C
N
DP
R
V
-
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
-----------------------------------------------------------------------
108
HHSearch
64.22
50%
41
- C6 -
-
2ZXI
1
MNMG_AQUAE
D:
[22-635]
--
A
W
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
-
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
-
E
P
V
GSYWF
P
K
G
K
----
E
Q
V
N
C
W
I
T
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
V
K
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
--
K
W
K
E
F
Y
K
S
E
----
R
V
S
V
A
V
-------------
G
G
-----
D
T
R
S
Y
S
V
A
T
L
M
T
-
M
N
Y
T
L
D
D
V
K
E
K
F
----
G
Y
E
------
V
-
P
Q
H
P
--
Y
V
-
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
----------
5
PsiBlast_PDB
63.43
51%
-52
- C6 -
-
3G05
-
MNMG_ECO57
A:
[28-576]
---
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
-
P
L
S
R
R
L
R
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
-----
Q
H
P
-----
Q
Q
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
M
R
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
N
I
E
--
R
E
R
Q
R
L
K
S
T
----
W
V
T
P
S
A
E
A
A
-------
A
E
V
N
A
HLT
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
----
P
F
A
------
P
-
A
L
T
D
--
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
---------------------------------------------------------------------------------
110
HHSearch
63.19
51%
-60
- C6 -
-
3G05
-
MNMG_ECO57
A:
[27-576]
--
S
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
-
P
L
S
R
R
L
R
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
------
Q
H
P
----
Q
Q
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
M
R
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
N
I
E
--
R
E
R
Q
R
L
K
S
T
----
W
V
T
P
S
A
E
A
A
A
E
----
V
N
A
H
L
T
---
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
----
P
F
A
------
P
A
L
T
D
E
--
Q
A
-
A
E
Q
V
E
I
Q
V
K
Y
E
G
---------------------------------------------------------------------------------
1
PsiBlast_PDB
62.31
50%
-55
- C6 -
-
3CP2
-
MNMG_ECOLI
A:
[22-573]
---
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
-----------------------
I
-
P
L
S
R
R
L
R
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
-----
Q
H
P
-----
Q
Q
V
P
C
Y
I
T
H
T
N
----------------------------------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
N
I
E
--
R
E
R
Q
R
L
K
S
T
----
W
V
T
P
S
A
E
A
A
-------
A
E
V
N
A
HLT
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
----
P
F
A
------
P
-
A
L
T
D
--
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
------------------------------------------------------------------------------
2
PsiBlast_PDB
61.51
50%
-55
- C- -
-
3CES
-
MNMG_ECOLI
A:
[2-550]
---
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
-
P
L
S
R
R
L
R
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
-----
Q
H
P
-----
Q
Q
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
M
R
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
N
I
E
--
R
E
R
Q
R
L
K
S
T
----
W
V
T
P
S
A
E
A
A
-------
A
E
V
N
A
H
LT
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
----
P
F
A
------
P
-
A
L
T
D
--
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
---------------------------------------------------------------------------------
106
HHSearch
61.22
50%
-65
- C- -
-
3CES
-
MNMG_ECOLI
B:
[1-550]
--
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
-
P
L
S
R
R
L
R
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
------
Q
H
P
----
Q
Q
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
S
N
L
-------------------
S
I
E
D
K
V
M
R
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
N
I
E
--
R
E
R
Q
R
L
K
S
T
----
W
V
T
P
S
A
E
A
A
A
E
----
V
N
A
H
L
T
---
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
----
P
F
A
------
P
A
L
T
D
E
--
Q
A
-
A
E
Q
V
E
I
Q
V
K
Y
E
G
---------------------------------------------------------------------------------
20
PsiBlast_PDB
41.38
48%
-237
- C5 -
-
5MIP
2
?
A:
[24-53]
-------
K
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
41.11
48%
-230
- C5 -
-
5MIR
2
?
A:
[24-53]
-------
K
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
40.77
48%
-224
- C5 -
-
5MIQ
2
?
A:
[24-53]
-------
K
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
40.43
48%
-224
- C5 -
-
5MH4
2
?
A:
[24-53]
-------
K
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------