@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XYV0: (2018-01-10 )
MKKVLVANRGEIAVRVFRACTELGIKTVGIYAEEDEYSVHRFKADEAYLVGQGKKPIDAYLDIEGIISIAKECGADAIHPGYGLLSENLNFAQRCEEEGIIFVGPKLHHLDIFGDKIKAKAAAIEAGIASIPGTDGPIASIDDALEFAKQYGYPIMIKAALGGGGRGMRVAHDEKSAREGYERAKSEAKAAFGSDEVYVEKYIANPKHIEVQILGDTHGNVIHLFERDCSVQRRHQKVVEVAPCVSMNEQQRQKICQAAVQLMKYVGYVNAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITDIDIVTTQLLIAQGLDLHKEIGLPQQEGIKLNGSAIQCRITTEDPLNNFLPDTGKIDTYRSPGGFGVRLDVGNAYAGYVVTPYFDSLLVKVCTHGATFETAIQKMERCLKEFRIRGVKTNIPFMLNVITHPEFQSGNAKTTFIDSTATLFEFPRLRDRGNKTMKYIGEITVNGFPGIESGEKPFYEEPRMPKDLITRTDYVTAKNVLDAKGADALVEWIKGQENLLLTDTTFRDAHQSLLATRVRTKDFKQIARLTGEGLPELFSSEMWGGATFDVAYRFLNEDPWQRLRKIRSLMPNTLLQMLFRGSNAVGYSNYPDNVLVEFVKEAAAQGIDVFRIFDSLNWTPQMEKSIQAVRDTGKIAEAAICYTGDINDPSRAKYNVQYYKDMAKELEQLGAHIIAIKDMAGLLKPQAAYRLISELKETTDLPIHLHTHDTSGNGIITYSAASKAGVDIVDVAMSAMSGNTSQPSMSSLYYALVNGPRLPEITIENAQKLNHYWEDVRMYYKPFENGLNAPETEVYMHEMPGGQYSNLQQQAKAVGLGHRWDEIKQMYHTVNLMFGDIVKVTPSSKVVGDMALFMVQNDLTEEDIYEKGETLSFPESVVTFFQGELGQPVGGFPKKLQKIILKGRPALNERPGLLAESVDFNEVKKELAEKIGYEPKQDEVLSYLMYPQVFLDYQKAYNQFGDVTLLDTPTFFQGIRLGETINVQIERGKTLIIRLDEIGEPDIEGNRVLFFNLNGQRREITIKDNSIISTVQTRLKAEPTNREQIGATMSGSVLDVLVKKGDNVKKGDTLMITEAMKMETAIEARFDGEVAHVYVSSGDTISSGDLLIEVTEK
Atome Classification :
(64 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140..-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270......--.280--.......290.......300.......310.......320..-.--.--..-..330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....-..500........510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.-.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
K
V
L
VANR
G
E
I
A
V
R
V
F
R
A
C
T
ELG
I
K
T
V
G
I
Y
AEEDEY
S
V
H
R
FKADE
A
Y
L
VGQGKK
P
I
D
A
Y
L
D
I
E
G
I
I
S
I
A
K
E
CGADAIHP
G
Y
G
L
L
SEN
L
N
F
A
Q
R
CEEE
G
I
I
F
VGP
K
L
H
H
L
DIFGDK
I
K
A
K
A
A
A
I
E
A
G
I
ASIPGTDGPI
A
S
-
I
D
D
-
A
L
E
F
A
K
QYG
Y
P
I
M
I
K
A
ALGGGGRG
M
R
VAHD
E
K
S
A
R
E
G
Y
E
R
A
K
S
E
A
K
AAFGS
D
E
V
Y
V
E
K
YIANP
K
H
I
E
V
Q
I
L
GDTHG
N
V
I
H
L
FERDC
S
V
Q
R
R
H
Q
K
V
V
EVAPCVSM
N
E
Q
Q
R
Q
K
I
C
Q
A
A
V
Q
L
M
K
Y
VGYVNAG
T
V
E
F
L
V
--EGD
D
--
F
Y
F
I
EVNP
R
V
Q
V
E
H
T
I
T
E
M
I
T
D
I
D
I
V
T
T
Q
L
L
I
A
QGL
D
L
H
-
K
E-I--G--L
P
-
Q
Q
E
G
I
K
LNG
S
A
I
Q
C
R
I
TTED
P
L
N
NFLPDTGKIDTYRSPGG
F
G
V
R
L
DVGNAYA
G
Y
V
V
T
P
Y
F
D
S
L
L
V
K
VCTHG
A
T
F
E
T
A
I
Q
K
M
E
R
C
L
K
E
FRIRGVKTNI
P
F
M
L
N
VITHPEFQSGNA
K
T
T
F
IDS
T
A
T
L
F
EFPRLRDRGNK
T
M
K
Y
I
G
E
I
T
VNGFPGIESGEKPFYEEPRM
P
K
D
L
-
I
TR-TDYV
T
A
K
NVLDAK
G
A
D
A
L
V
E
W
IKGQE
N
L
L
L
TDT
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
F
K
Q
I
A
R
L
TGEG
L
P
E
L
F
SSEMWGG
A
T
F
D
V
A
Y
R
F
LNE
D
P
W
Q
R
L
R
K
I
R
S
L
M
P
N
T
L
L
Q
M
L
F
RGSNAVGYSNY
P
D
N
V
L
V
E
F
V
K
E
A
A
AQG
I
D
V
F
R
I
F
DSLNW
T
P
Q
M
E
K
S
I
Q
A
V
R
DTGKI
A
E
A
A
I
C
Y
TGDINDPSR-
A
K
-
Y
N
V
Q
Y
Y
K
D
M
A
K
E
L
E
Q
LG
A
H
I
I
A
I
K
D
M
A
G
LL
K
P
Q
A
A
Y
R
L
I
S
E
L
K
ETTDL
P
I
H
L
H
THDTSG
N
G
I
I
T
YSAASKAG
V
D
I
V
D
V
A
M
S
AMSGNTSQP
S
M
S
S
L
Y
Y
A
LVNGPRL
P
E
I
T
I
E
N
A
Q
K
L
N
H
Y
W
E
D
V
R
M
Y
Y
K
P
F
ENGLNAPE
T
E
V
Y
M
H
EMPGG
Q
Y
S
N
L
Q
Q
Q
A
K
AVGLGH
R
W
D
E
I
K
Q
M
Y
H
T
V
N
L
M
FG
D
I
V
K
VTPSS
K
V
V
G
D
M
A
L
F
M
VQNDL
T
E
E
D
I
YEKGETLS
F
P
E
S
V
V
T
F
F
Q
GELGQPVG
G
F
P
K
K
L
Q
K
I
I
LKGRPALNERPGLLAESV
D
F
N
E
V
K
K
E
L
A
E
KIGYEP
K
Q
D
E
V
L
S
Y
L
M
Y
P
Q
V
F
L
D
Y
Q
K
A
Y
N
QFG
D
V
T
L
LDT
P
T
F
F
Q
GIRLG
E
T
I
N
V
Q
I
ERG
K
T
L
I
I
R
LDEIGEPDIEG
N
R
V
L
F
F
NLNGQ
R
R
E
I
T
IKDN
S
I
I
S
T
V
Q
T
R
LKAEPT
N
R
E
Q
IGATMS
G
S
V
L
D
V
L
V
KKGDNVKKG
D
T
L
M
I
T
E
A
MK
M
E
T
A
I
E
A
RFDG
E
V
A
H
V
Y
VSSGDTISSG
D
L
L
I
E
VTEK
33
PsiBlast_CBE
67.00
59%
-7
- C3 -
-
3HB9
2
?
D:
[4-1113]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
T
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
------------------------------------------------
A
M
K
M
-----------------------------------
28
PsiBlast_CBE
66.39
59%
-6
- C3 -
-
3HO8
3
?
C:
[4-1061]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
------------------------------------------------------------------
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
29
PsiBlast_CBE
66.08
59%
-5
- C3 -
-
3HO8
3
?
B:
[4-1061]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.04
59%
-7
- C3 -
-
3HO8
2
?
A:
[4-1061]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
-------------------------------------------------------------------
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.65
59%
-7
- C3 -
-
4HNU
1
?
D:
[27-1084]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
E
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
42
PsiBlast_CBE
65.48
59%
-8
- C3 -
-
4HNT
1
?
D:
[27-1084]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
A
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
44
PsiBlast_CBE
64.97
59%
-5
- C3 -
-
4HNT
1
?
B:
[27-1084]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
A
G
V
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L
D
A
G
D
G
F
Q
G
A
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I
S
P
Y
Y
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L
L
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L
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A
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A
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L
R
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R
I
R
G
V
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T
N
I
P
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L
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M
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N
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K
F
T
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D
Y
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T
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P
E
L
F
D
I
Q
P
S
L
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G
T
K
T
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E
Y
I
G
N
V
T
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N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
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A
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P
T
V
S
-
S
S
K
I
A
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F
S
G
T
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L
L
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G
P
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Y
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A
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A
N
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-
S
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A
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A
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A
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A
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N
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L
L
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A
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A
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D
I
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A
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A
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M
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L
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A
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L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.42
69%
-16
- C3 -
-
4QSK
1
?
A:
[5-1144]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
-----------------------------------------------------------------------
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
D
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
A
L
H
-
D
Q
L
V
--
A
--
I
P
-
K
Q
E
D
I
H
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
G
G
F
G
V
R
L
D
A
G
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G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
-
Y
G
S
-
Q
I
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
---
22
PsiBlast_CBE
64.03
69%
-16
- C3 -
-
4QSH
1
?
C:
[6-1145]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
G
S
----------------------------------------------------------------
V
Y
V
E
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
D
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
A
L
H
-
D
Q
L
V
--
A
--
I
P
-
K
Q
E
D
I
H
I
H
G
S
A
I
Q
S
R
I
T
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P
L
N
N
F
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G
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F
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L
L
V
K
L
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T
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G
M
T
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A
T
R
K
M
R
R
N
L
I
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F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
-
Y
G
S
-
Q
I
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
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D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
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D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
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S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
---
23
PsiBlast_CBE
63.97
69%
-16
- C3 -
-
4QSH
1
?
B:
[6-1145]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
----------------------------------------------------------------------
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
D
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
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Y
A
L
H
-
D
Q
L
V
--
A
--
I
P
-
K
Q
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D
I
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I
H
G
S
A
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I
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L
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N
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F
Y
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L
L
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L
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M
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A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
-
Y
G
S
-
Q
I
S
P
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T
K
Q
I
L
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A
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P
E
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V
V
D
W
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K
Q
E
E
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L
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T
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D
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L
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D
I
F
Q
I
A
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A
M
A
H
L
L
P
N
M
F
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F
E
M
W
G
G
A
T
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D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
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F
V
K
Q
S
A
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V
D
V
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R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
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A
K
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A
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G
T
H
I
L
G
I
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A
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L
L
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L
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E
L
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D
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D
V
P
I
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N
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A
A
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D
I
V
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A
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S
A
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G
A
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T
G
L
Y
Y
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L
V
N
G
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T
N
L
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S
Q
I
I
N
H
Y
W
E
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V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
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V
N
Q
M
F
G
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I
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L
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L
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A
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E
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Y
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I
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P
K
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F
L
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Y
Q
E
M
I
N
K
Y
G
D
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T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
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V
I
Y
F
E
L
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P
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I
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D
M
N
V
Q
----
A
R
R
K
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T
T
N
P
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A
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V
I
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K
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K
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L
L
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K
M
E
T
T
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A
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F
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S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
---
21
PsiBlast_CBE
63.83
69%
-17
- C3 -
-
4QSK
1
?
B:
[5-1144]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
-----------------------------------------------------------------------
C
V
M
N
P
K
H
I
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V
Q
I
L
G
D
T
H
G
N
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N
A
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E
L
R
N
R
I
C
D
A
A
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K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
D
D
--
F
Y
F
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V
N
P
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T
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I
G
N
V
T
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F
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G
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H
R
D
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Y
A
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P
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-
Y
G
S
-
Q
I
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Q
E
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L
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A
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N
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D
N
V
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A
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V
D
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W
I
K
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A
A
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D
I
D
D
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-
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Y
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A
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Q
I
I
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Y
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Y
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D
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N
A
L
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T
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Y
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P
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Y
T
N
L
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Q
Q
A
I
A
V
G
L
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D
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W
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V
K
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V
N
Q
M
F
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I
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D
L
A
L
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G
D
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I
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L
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L
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A
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A
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L
K
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K
M
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Y
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P
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Y
I
L
Y
P
K
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F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
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A
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T
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V
I
Y
F
E
L
N
G
Q
P
R
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I
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D
M
N
V
Q
----
A
R
R
K
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T
T
N
P
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A
T
M
T
G
S
V
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Q
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V
V
K
K
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K
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L
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K
M
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S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
---
3
PsiBlast_PDB
63.79
69%
-16
- C3 -
-
4QSH
1
?
A:
[6-1145]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
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S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
-------------------------------------------------------------------------
V
M
N
P
K
H
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V
Q
I
L
G
D
T
H
G
N
I
V
H
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C
N
A
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L
R
N
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A
A
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L
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N
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I
N
A
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T
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L
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--
E
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D
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--
F
Y
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--
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A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
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F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
---
2
PsiBlast_PDB
63.11
69%
-17
- C3 -
-
4QSL
-
?
H:
[4-1060]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
G
S
N
G
P
---------------------------------
R
V
V
E
S
K
E
H
V
K
E
S
F
E
R
A
S
S
E
A
K
A
A
F
G
N
D
E
V
Y
V
E
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
D
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
A
L
H
-
D
Q
L
V
--
A
--
I
P
-
K
Q
E
D
I
H
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
G
G
F
G
V
R
L
D
A
G
N
G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
-
Y
G
S
-
Q
I
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
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L
L
A
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R
V
R
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K
D
I
F
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I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
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M
W
G
G
A
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A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
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F
V
K
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S
A
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V
D
V
F
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V
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L
N
W
I
K
G
M
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V
S
I
D
A
V
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A
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K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
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G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
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N
G
N
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T
N
L
D
A
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N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
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D
F
D
N
A
L
N
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T
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V
Y
I
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M
P
G
G
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Y
T
N
L
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Q
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A
I
A
V
G
L
G
D
R
W
D
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V
K
E
M
Y
T
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V
N
Q
M
F
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V
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V
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D
L
A
L
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L
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G
D
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I
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I
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F
F
M
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I
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P
Y
G
G
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L
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K
L
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L
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R
T
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L
T
D
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P
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A
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M
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P
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N
F
V
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V
K
A
E
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M
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Y
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T
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I
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Y
I
L
Y
P
K
V
F
L
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Y
Q
E
M
I
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K
Y
G
D
V
T
V
L
D
T
P
T
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Y
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G
M
R
L
G
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I
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L
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K
I
L
L
I
K
L
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I
A
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T
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V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
--------------------------------------------------------------------------------------
125
HHSearch
62.83
69%
-1
- C3 -
-
4QSH
1
?
C:
[6-1147]
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
G
S
----------------------------------------------------------------
V
Y
V
E
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
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D
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R
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V
V
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V
A
P
C
N
A
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L
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N
R
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C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
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F
L
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--
E
G
D
D
--
F
Y
F
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I
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L
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A
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Y
A
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--
D
-
Q
--
L
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-
K
Q
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A
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L
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L
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A
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R
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L
I
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I
R
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T
N
I
P
F
L
L
N
V
V
R
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D
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A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
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R
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T
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T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
-
Y
G
S
-
Q
I
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
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A
H
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L
L
A
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R
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D
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I
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A
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A
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L
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N
M
F
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F
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W
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G
A
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A
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N
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D
P
W
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L
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K
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N
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M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
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N
Y
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D
N
V
I
R
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F
V
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S
A
Q
S
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V
D
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V
F
D
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L
N
W
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M
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I
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A
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A
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I
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A
A
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C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
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P
Q
A
A
Y
R
L
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E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
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G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
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A
S
S
A
M
S
G
A
T
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Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
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T
N
L
D
A
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N
S
Q
I
I
N
H
Y
W
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D
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R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
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V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
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K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
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E
E
D
V
Y
E
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G
D
T
I
D
F
P
D
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V
I
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F
F
M
G
E
I
G
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Y
G
G
F
P
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K
L
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K
L
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L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
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V
K
K
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D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
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E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
R
-
4
PsiBlast_PDB
61.43
59%
-8
- C3 -
-
3BG5
4
?
A:
[27-1168]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
-
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
S
F
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N
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Y
I
E
R
Y
I
D
N
P
K
H
I
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V
Q
V
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D
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H
G
N
I
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H
L
F
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D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
---
27
PsiBlast_CBE
61.30
59%
-8
- C3 -
-
3HO8
2
?
D:
[4-1061]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
-----------
L
G
L
G
E
R
F
D
E
V
K
D
M
------------
K
V
T
P
S
S
K
V
V
--------------------------------
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.02
59%
-7
- C3 -
-
3HB9
3
?
A:
[4-1145]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
G
P
I
K
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-
Y
E
L
-
A
K
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A
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A
G
F
P
L
M
I
K
A
T
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-------
R
I
V
R
E
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S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
----
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
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F
L
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--
S
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--
F
F
F
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T
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A
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-
I
--
N
--
M
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-
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A
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Y
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L
L
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L
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K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
---
34
PsiBlast_CBE
60.92
59%
-8
- C3 -
-
3HB9
3
?
C:
[4-1115]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
-
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
G
G
G
G
K
G
M
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
S
F
G
N
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
-
I
--
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
T
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
----------------------------------------------
T
E
A
M
K
M
E
T
---------------------------------
124
HHSearch
60.85
59%
-8
- C3 -
-
3HB9
3
?
A:
[4-1146]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
-
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
----
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
--
G
-
E
EI
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
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C
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I
T
T
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D
P
L
N
D
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M
P
D
T
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T
I
I
A
Y
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S
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G
G
F
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V
R
L
D
A
G
D
G
F
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G
A
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I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
-
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
T
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
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N
A
V
G
Y
K
N
Y
P
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N
V
I
H
K
F
V
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A
K
A
G
I
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F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
S
N
I
-
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
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P
K
A
A
Y
E
L
I
G
E
L
K
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A
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D
L
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L
H
T
H
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G
N
G
L
L
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A
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A
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A
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A
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Y
A
L
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F
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M
E
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L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
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T
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S
K
V
V
G
D
M
A
L
Y
M
V
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N
D
L
D
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Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
--
123
HHSearch
60.74
59%
-14
- C3 -
-
3HBL
3
?
C:
[4-1115]
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
-
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
G
G
G
G
K
G
M
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
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A
E
K
S
F
G
N
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
D
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
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V
T
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I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
--
G
-
E
EI
N
--
M
P
-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
-
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
S
N
I
-
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
A
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
----------------------------------------------
T
E
A
M
K
M
E
T
---------------------------------
20
PsiBlast_PDB
46.81
47%
-99
- C3 -
-
4RZQ
2
ACCC_HAEIN
A:
[22-466]
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
-----
A
K
-
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
----------
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
----------
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
-
F
-----------
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
45.68
47%
-51
- C3 -
-
2VPQ
1
?
B:
[2-447]
-
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
D
G
L
M
K
D
-
V
S
E
-
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
--
D
L
N
D
NK
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
-
D
V
-----------
L
P
Y
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
I
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.54
47%
-49
- C3 -
-
2VPQ
1
?
A:
[2-447]
-
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
D
G
L
M
K
D
-
V
S
E
-
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
--
D
L
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
-
D
V
-----------
L
P
Y
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
I
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
43.69
45%
-30
- C3 -
-
3JZI
1
ACCC_ECOLI
B:
[23-465]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
43.34
45%
-26
- C3 -
-
3JZF
1
ACCC_ECOLI
B:
[23-466]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
43.02
45%
-27
- C3 -
-
2V58
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
42.97
45%
-33
- C3 -
-
2VR1
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
--
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
42.95
45%
-29
- C3 -
-
2W6Z
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
42.95
45%
-28
- C3 -
-
2W70
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
42.87
45%
-28
- C3 -
-
2V59
1
ACCC_ECOLI
A:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
42.54
45%
-28
- C3 -
-
2W6P
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
42.51
45%
-28
- C3 -
-
2W6N
1
ACCC_ECOLI
A:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
42.45
45%
-30
- C3 -
-
2W6Q
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
42.37
45%
-30
- C3 -
-
2W6M
1
ACCC_ECOLI
B:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
42.33
45%
-29
- C3 -
-
2V5A
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
42.31
45%
-28
- C3 -
-
2W71
1
ACCC_ECOLI
C:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
42.30
45%
-29
- C3 -
-
2W6N
1
ACCC_ECOLI
B:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
42.28
45%
-30
- C3 -
-
3RUP
2
ACCC_ECOLI
A:
[5-447]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
42.27
45%
-27
- C3 -
-
2W6M
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
42.27
45%
-30
- C3 -
-
3JZI
1
ACCC_ECOLI
A:
[23-466]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
42.24
45%
-32
- C3 -
-
2W6O
1
ACCC_ECOLI
A:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
42.22
45%
-33
- C3 -
-
3RUP
2
ACCC_ECOLI
B:
[5-449]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
42.16
45%
-29
- C3 -
-
2W71
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
42.09
45%
-32
- C3 -
-
3RV3
2
ACCC_ECOLI
A:
[5-447]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
42.04
45%
-28
- C3 -
-
3RV4
3
ACCC_ECOLI
A:
[5-449]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
E
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
42.02
45%
-28
- C3 -
-
2W6Q
1
ACCC_ECOLI
B:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
41.97
45%
-30
- C3 -
-
2V58
1
ACCC_ECOLI
B:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
41.86
47%
-27
- C3 -
-
4MV4
3
ACCC_HAEIN
A:
[22-465]
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
-
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
G
G
---
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
-
F
-----------
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
41.71
45%
-30
- C3 -
-
2W70
1
ACCC_ECOLI
B:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
41.64
46%
-28
- C3 -
-
3G8C
2
ACCC_ECOLI
B:
[2-441]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
41.60
45%
-33
- C3 -
-
3G8D
1
ACCC_ECOLI
B:
[2-441]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
41.41
45%
-29
- C3 -
-
2J9G
1
ACCC_ECOLI
A:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
--
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
41.31
45%
-27
- C3 -
-
2V59
1
ACCC_ECOLI
B:
[2-445]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
41.23
45%
-26
- C3 -
-
2W6O
1
ACCC_ECOLI
C:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
41.08
45%
-29
- C3 -
-
1DV2
1
ACCC_ECOLI
A:
[5-450]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
41.07
47%
-28
- C3 -
-
4MV3
2
ACCC_HAEIN
A:
[22-465]
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
-
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
------
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
-
F
-----------
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
41.06
45%
-29
- C3 -
-
3RV3
2
ACCC_ECOLI
B:
[5-450]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
40.99
45%
-25
- C3 -
-
1DV2
1
ACCC_ECOLI
B:
[5-450]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
40.74
45%
-30
- C3 -
-
2VQD
1
ACCC_PSEAE
A:
[2-441]
L
E
K
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
C
I
G
P
A
P
A
-
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
V
P
G
S
D
G
P
L
P
E
-
D
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
G
G
G
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
A
A
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
E
V
F
A
R
C
V
Q
A
C
I
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
R
--
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
E
K
L
S
-
I
-----------
R
Q
E
D
V
V
I
R
G
H
A
L
E
C
R
I
N
A
E
D
P
-
K
T
F
M
P
S
P
G
K
V
K
H
F
H
A
P
G
G
N
G
V
R
V
D
-
S
H
L
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
Y
G
A
D
R
D
E
A
L
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
40.53
47%
-30
- C3 -
-
4MV1
3
ACCC_HAEIN
A:
[22-464]
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
-
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
------
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
--------
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
-
F
-----------
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
40.25
46%
-30
- C3 -
-
3G8C
2
ACCC_ECOLI
A:
[2-441]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
39.79
45%
-34
- C3 -
-
2J9G
1
ACCC_ECOLI
B:
[2-446]
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
-
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
--
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
---
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
-
I
-----------
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
39.75
47%
-30
- C3 -
-
4MV8
1
ACCC_HAEIN
A:
[22-466]
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
-
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
-----
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
----------
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
G
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
-
F
-----------
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
35.65
37%
-48
- C3 -
-
3VA7
5
?
A:
[34-478]
---
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
-
H
G
R
T
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
V
P
--------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
DE
Q
R
D
E
--
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
D
-
F
D
-----------
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
F
P
S
--
W
A
R
V
D
T
W
-
V
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------