@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZ28: (2018-01-12 )
MVRVKGLNIGSGRPKICAPLIGAVREEVLREAVLAREAGADLVEWRVDHYREVFSFDEVAETLVLIHEMLDGLPLLFTFRTLAEGGEQDISIRQYRDLYEHVIHTGLVDMVDIELFKVESLGKRLIEEIKSLNIPLIISSHDFKETPADPVLLYRLNVMEHFGADIGKLAVTPNNERDVLRLMELTRRANAFVSMPIITMSMGNLGKISRLVGGTTGSVMTFGSLSSDSTSAPGQLPVKALKQIIQLLNEPL
Atome Classification :
(55 SA)
--.........10........20........30........40........50........60.......-.70........80........90........100-.....-..110.......120.......130----.......140.......150.......160.......170.......180....-...-190-........200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--
M
V
R
V
K
G
L
NIGSGRP
K
I
C
A
P
L
I
G
A
V
R
E
E
V
L
R
E
A
V
L
A
R
EAGA
D
L
V
E
W
R
V
D
H
Y
R
E
V
F
S
F
D
E
V
A
E
T
L
V
L
I
H
E
-
M
LDGL
P
L
L
F
T
F
R
T
L
AEGGEQD
I
S
I
R
Q
Y
R
D
L
Y
E
H
V
-
I
H
TGL-
V
D
M
V
D
I
E
L
F
K
V
E
S
L
G
K
R
L
I
E
E
I
K
SL----NI
P
L
I
I
SSHDFKETPAD
P
V
L
L
Y
R
L
N
V
M
E
H
FGADI
G
K
L
A
VTPNN
E
R
D
V
L
R
L
M
E
L
T
-
R
RA-N-
A
-
F
V
SM
P
I
I
T
MSMG
N
L
G
K
I
S
R
L
VGGTTG
S
V
M
T
F
GSLSSDSTSAPGQL
P
V
K
A
L
K
Q
I
I
Q
L
LNEPL
6
PsiBlast_PDB
86.87
42%
-92
- C5 -
-
4GUI
1
AROD_SALTY
A:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
45
PsiBlast_CBE
86.83
41%
-92
- C5 -
-
3NNT
1
AROD_SALTY
B:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
38
PsiBlast_CBE
86.64
42%
-89
- C5 -
-
3S42
5
AROD_SALTY
B:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
35
PsiBlast_CBE
86.52
42%
-91
- C5 -
-
3M7W
4
AROD_SALTY
D:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
9
PsiBlast_PDB
86.51
42%
-87
- C5 -
-
3LB0
2
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
37
PsiBlast_CBE
86.47
42%
-93
- C5 -
-
3M7W
4
AROD_SALTY
B:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
27
PsiBlast_CBE
86.34
42%
-92
- C5 -
-
4GUJ
1
AROD_SALTY
B:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
8
PsiBlast_PDB
86.25
42%
-100
- C5 -
-
3L2I
-
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
-----
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
4
PsiBlast_PDB
86.16
42%
-91
- C5 -
-
3OEX
-
AROD_SALTY
A:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
51
PsiBlast_CBE
86.15
40%
-103
- C5 -
-
4CNP
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
16
PsiBlast_PDB
86.15
41%
-93
- C5 -
-
3NNT
1
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
44
PsiBlast_CBE
86.13
41%
-90
- C5 -
-
4IUO
1
AROD_SALTY
B:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
7
PsiBlast_PDB
86.08
42%
-92
- C5 -
-
4GUJ
1
AROD_SALTY
A:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
33
PsiBlast_CBE
86.05
42%
-90
- C5 -
-
3M7W
5
AROD_SALTY
F:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
15
PsiBlast_PDB
86.03
41%
-90
- C5 -
-
3O1N
-
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
A
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
29
PsiBlast_CBE
85.99
42%
-94
- C5 -
-
4GFS
1
AROD_SALTY
B:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
-----
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
23
PsiBlast_CBE
85.76
42%
-51
- C5 -
-
4H3D
2
AROD_PEPD6
B:
[8-257]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
I
14
PsiBlast_PDB
85.76
41%
-92
- C5 -
-
4GUH
1
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
28
PsiBlast_CBE
85.65
42%
-92
- C5 -
-
4GUI
1
AROD_SALTY
B:
[7-254]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
40
PsiBlast_CBE
85.64
41%
-90
- C5 -
-
4GUH
1
AROD_SALTY
B:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
17
PsiBlast_PDB
85.56
41%
-93
- C5 -
-
4IUO
1
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
13
PsiBlast_PDB
85.48
41%
-100
- C5 -
-
4GUG
1
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
52
PsiBlast_CBE
85.46
40%
-97
- C5 -
-
4CNP
1
AROD_SALTI
A:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
50
PsiBlast_CBE
85.21
40%
-97
- C5 -
-
4UIO
1
AROD_SALTI
A:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
25
PsiBlast_CBE
85.21
42%
-48
- C5 -
-
3JS3
1
AROD_PEPD6
C:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
AHKK
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
59
PsiBlast_CBE
85.20
40%
-97
- C5 -
-
4CLM
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
21
PsiBlast_CBE
85.02
42%
-50
- C5 -
-
4H3D
1
AROD_PEPD6
D:
[8-257]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
AHKK
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
--
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
I
1
PsiBlast_PDB
84.83
42%
-47
- C5 -
-
3JS3
1
AROD_PEPD6
A:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
48
PsiBlast_CBE
84.77
40%
-98
- C5 -
-
1L9W
1
AROD_SALTI
C:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
49
PsiBlast_CBE
84.76
40%
-95
- C5 -
-
1L9W
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
10
PsiBlast_PDB
84.71
42%
-83
- C5 -
-
3S42
6
AROD_SALTY
A:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
-
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
57
PsiBlast_CBE
84.51
40%
-104
- C5 -
-
4CNN
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
24
PsiBlast_CBE
84.51
42%
-50
- C5 -
-
3JS3
1
AROD_PEPD6
D:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
AHKK
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
22
PsiBlast_CBE
84.48
42%
-49
- C5 -
-
4H3D
2
AROD_PEPD6
C:
[8-257]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
AHKK
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
I
18
PsiBlast_PDB
84.26
40%
-96
- C5 -
-
1QFE
1
AROD_SALTI
A:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
53
PsiBlast_CBE
84.10
40%
-103
- C5 -
-
4CNO
1
AROD_SALTI
D:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
46
PsiBlast_CBE
83.99
40%
-96
- C5 -
-
1QFE
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
41
PsiBlast_CBE
83.89
41%
-98
- C5 -
-
4GUG
1
AROD_SALTY
B:
[28-275]
---
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
-
I
I
T
D
K
P
L
L
F
T
F
R
S
A
----
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
-
V
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
T
V
G
Y
A
H
Q
H
----
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
-
E
-
R
-
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
19
PsiBlast_PDB
83.70
40%
-90
- C5 -
-
1L9W
1
AROD_SALTI
A:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
47
PsiBlast_CBE
83.64
40%
-96
- C5 -
-
1L9W
1
AROD_SALTI
D:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
--
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
26
PsiBlast_CBE
83.54
42%
-48
- C5 -
-
3JS3
1
AROD_PEPD6
B:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
AHKK
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
54
PsiBlast_CBE
83.46
40%
-96
- C5 -
-
4CNO
1
AROD_SALTI
C:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
2
PsiBlast_PDB
83.43
42%
-47
- C5 -
-
4H3D
3
AROD_PEPD6
A:
[8-257]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
-
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
T
G
L
-
V
D
L
I
D
V
E
L
F
----
M
G
D
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
F
K
-
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
--
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
I
55
PsiBlast_CBE
83.38
40%
-98
- C5 -
-
4CNO
1
AROD_SALTI
B:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
56
PsiBlast_CBE
83.28
40%
-100
- C5 -
-
4CNO
1
AROD_SALTI
A:
[4-250]
---
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
-
Q
-
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
68
HHSearch
81.78
42%
-44
- C5 -
-
4H3D
2
AROD_PEPD6
B:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
-
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
-
S
N
-
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
D
E
V
V
N
F
A
H
K
K
----
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
-
N
E
M
-
F
K
I
-
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
--
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
67
HHSearch
78.26
41%
-45
* C5 *
-
1QFE
1
AROD_SALTI
B:
[3-251]
--
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
-
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
-
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
-
L
E
M
-
Q
Q
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
--
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
--
66
HHSearch
78.22
41%
-53
- C5 -
-
4CNN
1
AROD_SALTI
B:
[3-251]
--
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
-
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
-
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
-
L
E
M
-
Q
Q
H
-
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
------
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
--
87
Fugue
77.91
40%
-10
- C5 -
-
1QFE
1
AROD_SALTI
A:
[1-252]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
-
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
-
I
D
S
G
L
-
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
----
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
-
L
E
M
-
Q
-
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
--
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
A
-
79
HHSearch
70.36
32%
-98
- C5 -
-
2O7Q
1
DHQSD_ARATH
A:
[2-250]
------------
K
N
P
S
L
I
C
A
P
V
M
A
D
S
I
D
K
M
V
I
E
T
S
K
A
H
E
L
G
A
D
L
V
E
I
R
L
D
W
L
K
D
F
N
P
L
----
E
D
L
K
T
I
I
K
-
K
S
P
-
L
P
T
L
F
T
Y
R
P
K
W
E
G
G
Q
Y
E
G
D
E
N
E
R
R
D
V
L
R
L
A
-
M
E
-
L
G
-
A
D
Y
I
D
V
E
L
Q
V
A
S
E
F
I
K
S
I
D
-
G
K
K
P
G
----
K
F
K
V
I
V
S
S
H
N
Y
Q
N
T
P
S
V
E
D
L
D
G
L
V
A
R
I
Q
Q
T
G
A
D
I
V
K
I
A
T
T
A
V
D
I
A
D
V
A
R
M
F
H
I
T
-
S
K
-------
A
Q
V
P
T
I
G
L
V
M
G
E
R
G
L
M
S
R
I
L
C
S
K
F
G
G
Y
L
T
F
G
T
L
D
S
S
K
V
S
A
P
G
Q
P
T
I
K
D
L
L
D
L
Y
N
F
R
----
78
HHSearch
70.06
32%
-101
- C5 -
-
2O7S
1
DHQSD_ARATH
A:
[2-251]
------------
K
N
P
S
L
I
C
A
P
V
M
A
D
S
I
D
K
M
V
I
E
T
S
K
A
H
E
L
G
A
D
L
V
E
I
R
L
D
W
L
K
D
F
N
P
L
----
E
D
L
K
T
I
I
K
-
K
S
P
-
L
P
T
L
F
T
Y
R
P
K
W
E
G
G
Q
Y
E
G
D
E
N
E
R
R
D
V
L
R
L
A
-
M
E
-
L
G
-
A
D
Y
I
D
V
E
L
Q
V
A
S
E
F
I
K
S
I
D
-
G
K
K
P
G
----
K
F
K
V
I
V
S
S
H
N
Y
Q
N
T
P
S
V
E
D
L
D
G
L
V
A
R
I
Q
Q
T
G
A
D
I
V
K
I
A
T
T
A
V
D
I
A
D
V
A
R
M
F
H
I
T
-
S
K
-------
A
Q
V
P
T
I
G
L
V
M
G
E
R
G
L
M
S
R
I
L
C
S
K
F
G
G
Y
L
T
F
G
T
L
D
S
S
K
V
S
A
P
G
Q
P
T
I
K
D
L
L
D
L
Y
N
F
R
----
61
PsiBlast_CBE
69.33
33%
-90
- C5 -
-
2GPT
1
DHQSD_ARATH
A:
[7-246]
-----------------
I
C
A
P
V
M
A
D
S
I
D
K
M
V
I
E
T
S
K
A
H
E
L
G
A
D
L
V
E
I
R
L
D
W
L
K
D
---
F
N
P
L
E
D
L
K
T
I
I
K
K
---
S
P
L
P
T
L
F
T
Y
R
P
K
W
E
G
G
Q
Y
E
G
D
E
N
E
R
R
D
V
L
R
L
A
-
M
E
L
G
--
A
D
Y
I
D
V
E
L
-
Q
V
A
S
E
F
I
K
S
I
D
G
K
K
P
G
----
K
F
K
V
I
V
S
S
H
N
Y
Q
N
T
P
S
V
E
D
L
D
G
L
V
A
R
I
Q
Q
T
G
A
D
I
V
K
I
A
T
T
A
V
D
I
A
D
V
A
R
M
F
H
I
T
-
S
K
A
-
Q
------
V
P
T
I
G
L
V
M
G
E
R
G
L
M
S
R
I
L
C
S
K
F
G
G
Y
L
T
F
G
T
L
D
S
S
K
V
S
A
P
G
Q
P
T
I
K
D
L
-----------
63
PsiBlast_CBE
68.16
33%
-89
- C5 -
-
2O7Q
1
DHQSD_ARATH
A:
[7-243]
-----------------
I
C
A
P
V
M
A
D
S
I
D
K
M
V
I
E
T
S
K
A
H
E
L
G
A
D
L
V
E
I
R
L
D
W
L
K
D
---
F
N
P
L
E
D
L
K
T
I
I
K
K
---
S
P
L
P
T
L
F
T
Y
R
P
K
W
E
G
G
Q
Y
E
G
D
E
N
E
R
R
D
V
L
R
L
A
-
M
E
L
G
--
A
D
Y
I
D
V
E
L
-
Q
V
A
S
E
F
I
K
S
I
D
G
K
K
P
G
----
K
F
K
V
I
V
S
S
H
N
Y
Q
N
T
P
S
V
E
D
L
D
G
L
V
A
R
I
Q
Q
T
G
A
D
I
V
K
I
A
T
T
A
V
D
I
A
D
V
A
R
M
F
H
I
T
-
S
K
A
-
Q
------
V
P
T
I
G
L
V
M
G
E
R
G
L
M
S
R
I
L
C
S
K
F
G
G
Y
L
T
F
G
T
L
D
S
S
K
V
S
A
P
G
Q
P
T
I
K
D
L
-----------
62
PsiBlast_CBE
67.52
33%
-93
- C5 -
-
2O7S
1
DHQSD_ARATH
A:
[7-244]
-----------------
I
C
A
P
V
M
A
D
S
I
D
K
M
V
I
E
T
S
K
A
H
E
L
G
A
D
L
V
E
I
R
L
D
W
L
K
D
---
F
N
P
L
E
D
L
K
T
I
I
K
K
---
S
P
L
P
T
L
F
T
Y
R
P
K
W
E
G
G
Q
Y
E
G
D
E
N
E
R
R
D
V
L
R
L
A
-
M
E
L
G
--
A
D
Y
I
D
V
E
L
-
Q
V
A
S
E
F
I
K
S
I
D
G
K
K
P
G
----
K
F
K
V
I
V
S
S
H
N
Y
Q
N
T
P
S
V
E
D
L
D
G
L
V
A
R
I
Q
Q
T
G
A
D
I
V
K
I
A
T
T
A
V
D
I
A
D
V
A
R
M
F
H
I
T
-
S
K
A
-
Q
------
V
P
T
I
G
L
V
M
G
E
R
G
L
M
S
R
I
L
C
S
K
F
G
G
Y
L
T
F
G
T
L
D
S
S
K
V
S
A
P
G
Q
P
T
I
K
D
L
-----------
72
HHSearch
64.05
31%
-72
- C5 -
-
2OCZ
4
AROD_STRP1
A:
[3-226]
--------------
A
M
R
I
V
A
P
V
M
P
R
H
F
D
E
A
Q
A
-
I
D
I
S
K
Y
E
D
V
N
L
I
E
W
R
A
D
F
L
P
K
D
E
I
---
V
A
V
A
P
A
I
F
E
K
-
F
A
G
-
K
E
I
I
F
T
L
R
T
V
Q
E
G
G
N
I
T
L
S
S
Q
E
Y
V
D
I
I
K
E
I
N
A
I
-
Y
N
-
P
D
Y
I
D
F
E
Y
F
T
H
K
S
V
F
Q
E
M
-----
L
D
----
F
P
N
L
I
L
S
Y
H
N
F
E
E
T
P
E
--
N
L
M
E
A
F
S
E
M
T
K
L
A
P
R
V
V
K
I
A
V
M
P
Q
S
E
Q
D
V
L
D
L
M
N
Y
T
-
R
G
F
-
K
T
L
-
N
P
E
Q
E
F
A
T
I
S
M
G
K
L
G
R
L
S
R
F
A
G
D
V
I
G
S
S
W
T
Y
V
S
L
--------
G
Q
V
T
L
N
D
M
K
R
I
I
E
V
L
E
---