@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZA2: (2018-01-13 )
MAKRKVVVALGGNAILSTDASAKAQQEALMETAKYLVKFIEQGDELIISHGNGPQVGNLLIQQQAADSEKTPAMPLDTCVAMTEGSIGYWLQNAMGEVLKEKGIDKDVVSLVTQVIVDENDPSFKNPSKPVGPFYTEEEAKEQMNADSTVTFKEDAGRGWRKVVASPKPISIKEARVIETLVDQGVITVSVGGGGIPVVETATGLEGREAVIDKDFASEKLAEIIDADLLIVLTGVDNVYVNYQKPDQKKLETVTVSEMKQYIDEKQFAPGSMLPKVEAAIAFVEAKPNAKAIITSLENIENLLASEEGTIIVAD
Atome Classification :
(30 SA)
.........10........--20.....--...30........40........50........60...-..-...70........80........90........100.......110.......120.......130.......140-.......150.......160.......170.......180.......190..-....-.200.......210.......220.......230.......240...-....250.......260.......270.......280.......290.......300....-.-..310...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAK
R
K
V
V
V
A
LGG
N
A
I
LSTD--AS
A
K
A
Q
Q
--
E
A
L
M
E
T
A
K
Y
L
V
K
F
I
EQG
D
E
L
I
I
SHGNGP
Q
V
G
N
L
L
I
Q
QQ-AA-DSEKTPAMP
L
D
T
C
VAMTEG
S
I
G
Y
W
L
Q
N
A
M
G
E
V
L
K
EKGI
D
K
D
V
V
S
L
V
T
Q
V
I
VDENDPSFKNPSKPVGPFY
T
E
E
E
A
K
E
-QMNADS
T
V
T
F
KEDAGR
G
W
R
K
VVASPKPIS
I
K
E
A
R
V
I
E
T
L
VDQ
G
V
I
T
V
S
VGGG-G
I
P
V
-
V
E
TATGLEG
R
E
A
V
ID
K
D
F
A
S
E
K
L
A
E
I
IDA
D
L
L
I
V
L
TGVD
N
V
Y
V
NYQK-PDQKKL
E
T
V
T
V
S
E
M
K
Q
Y
I
D
E
KQFAPGSMLP
K
V
E
A
A
I
A
F
V
EAKPN
A
K
A
I
I
T
S
L
E
N
I
E
N
L
LAS-E-EG
T
I
I
VAD
22
PsiBlast_CBE
93.47
65%
-90
- C1 -
-
2WE5
1
ARCC1_ENTFA
B:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
--
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
--
G
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
21
PsiBlast_CBE
93.03
65%
-87
- C1 -
-
2WE5
1
ARCC1_ENTFA
C:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
--
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
--
G
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
2
PsiBlast_PDB
92.96
65%
-89
- C1 -
-
2WE4
-
ARCC1_ENTFA
A:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
--
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
--
G
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
3
PsiBlast_PDB
92.83
65%
-86
- C1 -
-
2WE5
1
ARCC1_ENTFA
A:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
--
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
--
G
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
72
Fugue
91.94
65%
-87
- C1 -
-
1B7B
-
ARCC1_ENTFC
A:
[2-308]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
-
G
A
-
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
--
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
--
M
S
-
G
-
D
E
I
V
G
T
V
V
1
PsiBlast_PDB
90.02
65%
-83
- C1 -
-
1B7B
-
ARCC1_ENTFC
A:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
--
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
--
G
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
73
Fugue
89.88
65%
-82
- C1 -
-
1B7B
-
ARCC1_ENTFC
A:
[2-308]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
A
-
D
S
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
-
A
M
Q
A
G
A
I
--
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
--
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
-
I
V
G
T
V
V
--
53
HHSearch
82.89
62%
-13
- C1 -
-
2WE5
1
ARCC1_ENTFA
A:
[2-310]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
D
-
S
-
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
-
A
E
A
K
-
E
A
-
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
V
G
Q
E
L
---
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
52
HHSearch
80.32
62%
-9
- C1 -
-
2WE4
-
ARCC1_ENTFA
D:
[2-310]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
L
S
N
D
--
A
S
A
H
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
D
-
S
-
E
K
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
-
A
E
A
K
-
E
A
-
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
V
G
Q
E
L
---
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
35
PsiBlast_CBE
74.63
43%
16
- C1 -
-
4JZ9
1
?
B:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
37
PsiBlast_CBE
73.86
43%
12
- C1 -
-
4JZ8
1
?
C:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
8
PsiBlast_PDB
73.69
43%
12
- C1 -
-
4OLC
2
?
A:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
31
PsiBlast_CBE
73.67
43%
9
- C1 -
-
4OLC
2
?
C:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
32
PsiBlast_CBE
73.61
43%
14
- C1 -
-
4OLC
2
?
B:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
39
PsiBlast_CBE
73.34
43%
11
- C1 -
-
4JZ7
1
?
D:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
38
PsiBlast_CBE
73.25
43%
16
- C1 -
-
4JZ8
1
?
B:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
6
PsiBlast_PDB
73.12
43%
12
- C1 -
-
4JZ8
1
?
A:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
30
PsiBlast_CBE
72.89
43%
13
- C1 -
-
4OLC
1
?
D:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
34
PsiBlast_CBE
72.88
43%
13
- C1 -
-
4JZ9
1
?
C:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
7
PsiBlast_PDB
72.77
43%
10
- C1 -
-
4JZ9
1
?
A:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
40
PsiBlast_CBE
72.39
43%
12
- C1 -
-
4JZ7
1
?
C:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
33
PsiBlast_CBE
72.11
43%
15
- C1 -
-
4JZ9
1
?
D:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
36
PsiBlast_CBE
71.98
43%
12
- C1 -
-
4JZ8
1
?
D:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
44
PsiBlast_CBE
70.33
43%
10
- C1 -
-
3KZF
1
?
B:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
--------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
--
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
43
PsiBlast_CBE
68.80
43%
7
- C1 -
-
3KZF
1
?
C:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
-------------------------
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
-----
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
55
HHSearch
68.38
42%
18
- C1 -
-
4JZ9
1
?
A:
[3-317]
S
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
A
G
V
--
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
-
E
Q
E
A
K
D
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
-
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
-
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
5
PsiBlast_PDB
67.88
43%
1
- C1 -
-
4JZ7
1
?
A:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
--------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
54
HHSearch
67.80
42%
22
- C1 -
-
4JZ8
1
?
D:
[3-317]
S
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
D
T
QR
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
A
G
V
--
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
-
E
Q
E
A
K
D
L
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
-
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
-
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
41
PsiBlast_CBE
66.50
43%
10
- C1 -
-
4JZ7
1
?
B:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
--------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D
42
PsiBlast_CBE
66.44
43%
14
- C1 -
-
3KZF
1
?
D:
[4-317]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
EK
G
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
-
A
A
--
A
G
V
S
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
--------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
C
--------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
-
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
D