@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZD2: (2018-01-13 )
MITVNDVSLHFSDRKLFDDVNIKFTPGNCYGLIGANGAGKSTFLKVLSGDLQPSTGSVTMGPDERMAVLKQNHYDYEDYTVLETVIMGHKRLYEVLKEKDAIYMKEDFTDEDGIRAAELEGEFAELNGWEAEPEAAVLLQGLNIPEELHHQQMSELTGGQKVKVLLAQTLFGKPDVLLLDEPTNGLDIQSINWLEEFLINFENTVIVVSHDRHFLNKVCTHMADLDFGKIKLYVGNYDFWLESSQLAAKLQANANAKKEEQIKELQEFIARFSANASKSKQATSRKKMLEKITLDDIQPSSRRYPFVGFKPEREIGNDLLQVENVSVTIDGKKILDDISFNLSKEDKVAFVAENDITTTTLFKVIMGEITPDTGTVRWGVTTSNSYLPKDTTKEFDTDLTILDWLRQYASKEEDDNTFLRSFLGRMLFSGEEVLKPVNVLSGGEKVRCMLSKMMLSKANVLVLDDPTNHLDLESITALNDGLMAFTGSILFASHDHQFIQTLANRIIAVSDKGVIDRADTTYDEFLENADIQKQLNELWA
Atome Classification :
(20 SA)
---------------------------------------------------------------.........--10-.........20...-------------.....30........40........50........60.--.---------......70---.....--....80........----------90........-100........110...----....120....----.-..-130.....--..140.......150.......160.......170.......180......-.190-.......--..200---..---......210.......220.......230.......240.......250.......260.......270.......280..--.....290.......300.......-310.......320.......330-........340.......350.......360.......370.......380-----------.........390.------------.----------------.---------------------------..-------------..400----------...-----------------------------------------------------...--------------...410----.-------------------------......--420.......430.....----------...----------440.......450.......460.......470.......480...----.----..----.490.......500.......----510.....---..520.......530----------------------........540----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------
M
I
T
V
N
D
V
S
L
--
H
--FSDRKLFDD
V
N
I
K
F-------------TPG
N
C
Y
G
L
IGANGA
G
K
S
T
F
L
K
V
L
SGDLQPSTG
S
V
TMG
P
--
D
---------
E
R
M
A
V
L
K----QNHYD--Y
E
D
Y
T
V
L
E
T
V
I
MG
H
----------
K
R
L
Y
E
V
L
K
EK-D-
A
I
Y
MKEDFTDEDG
I
R
----
A
A
E
LEGEFAEL----N-GW-EAEP
E
A
A
V
--
L
LQGLNI
P
E
E
L
H
H
Q
Q
M
S
E
LTGG
Q
K
V
K
V
L
L
A
Q
T
LFGKP
D
V
L
L
L
DEPTNGLDI-
Q
S
---
I
N
W
L
E
E
F
--
L
INF----E
N
---
T
V
I
V
V
SH
D
R
H
F
L
N
K
V
C
T
H
M
ADLDF
G
K
I
K
L
Y
VG
N
Y
D
F
W
LE
S
S
Q
L
A
A
K
L
QANANA
K
K
E
E
Q
I
K
E
L
Q
E
F
I
A
R
FSANASK
S
K
Q
A
T
S
--
R
K
K
M
L
E
K
ITLDDIQPSSRRYPFVGF-K
P
E
R
E
IGND
L
L
Q
V
E
N
V
S
V
T
IDG--
K
K
I
L
D
D
ISFNLSKED
K
V
A
F
V
AENDI
T
T
T
T
L
F
K
V
I
M
G
EITPDT
G
T
V
R
W
G
V
-------------TTSNSYLPKDTTK------------E----------------F---------------------------DT-------------D
L
T
------------
I
L
D
-----------------------------------------------------
W
L
R
--------------
Q
YASKE----E-------------------------D
D
N
T
F
L
--
R
S
F
L
G
R
M
LFS
G
E
-
E
V
L
K
P
----------
V
N
V----------LSG
G
E
K
V
R
C
M
L
S
K
M
M
LSKA
N
V
L
V
LDDPTNHL
D
L
E
S
I
T
A
LN
D
G
L
M
A
F
----T----
G
S
----
I
L
FASH
D
H
Q
F
I
Q
T
L
A
N
R
I
I
AV----SDKGVIDR---ADT
T
Y
D
E
F
L
E
N
A
D
I
-----------------------
Q
K
Q
L
N
E
LWA------
2
PsiBlast_PDB
79.76
29%
16
- C1 -
-
4FIN
6
ETTA_ECOLI
A:
[19-532]
--------------------------------------------------------------------------------
R
H
I
L
K
N
I
S
L
S
F
-------------
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
--
D
---------
I
K
I
G
Y
L
P
----
Q
E
P
Q
L
--
N
P
E
H
T
V
R
E
S
I
E
E
A
V
----------
S
E
V
V
N
A
L
K
R
L
-
D
-
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
K
----
L
A
A
E
Q
G
R
L
E
E
I
IQ--------
L
N
V
Q
L
E
R
--
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
-
E
S
---
V
A
W
L
E
R
F
--
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
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G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
----
G
T
K
----
K
G
--
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
-------------
T
V
K
L
A
S
V
D
Q
-
F
R
D
------------
S
----------------
M
---------------------------
D
N
-------------
S
K
T
------------
V
W
E
-----------------------------------------------------
E
V
S
--------------
G
G
L
D
I
M
----
K
-------------------------
I
G
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
----------
V
G
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
----
Q
D
E
G
K
V
E
F
---
F
E
G
N
F
T
E
Y
E
E
------------------------------------------
1
PsiBlast_PDB
76.03
29%
26
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[19-532]
--------------------------------------------------------------------------------
R
H
I
L
K
N
I
S
L
S
F
-------------
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
--
D
---------
I
K
I
G
Y
L
P
----
Q
E
P
Q
L
--
N
P
E
H
T
V
R
E
S
I
E
E
A
V
----------
S
E
V
V
N
A
L
K
R
L
-
D
-
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
K
----
L
A
A
E
Q
G
R
L
E
E
I
IQAH
D
-
G
H
-
N
L
N
V
Q
L
E
R
--
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
-
E
S
---
V
A
W
L
E
R
F
--
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
----
G
T
K
G
R
Q
S
K
G
--
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
-------------
T
V
K
L
A
S
V
D
Q
-
F
R
D
------------
S
----------------
M
---------------------------
D
N
-------------
S
K
T
------------
V
W
E
-----------------------------------------------------
E
V
S
--------------
G
G
L
D
I
M
----
K
-------------------------
I
G
N
T
E
M
PS
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
----------
V
G
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
----
Q
D
E
G
K
V
E
F
---
F
E
G
N
F
T
E
Y
E
E
------------------------------------------
30
HHSearch
73.62
30%
46
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[10-526]
--------------------------------------------------------------------
R
V
G
K
--
V
V-
P
P
K
R
H
I
L
K
N
I
S
L
S
F
-------------
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
--
D
---------
I
K
I
G
Y
L
P
----
Q
E
P
Q
L
--
N
P
E
H
T
V
R
E
S
I
E
E
A
V
----------
S
E
V
V
N
A
L
K
R
L
-
D
-
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
K
LAAE
Q
G
R
L
E
E
I
I
Q
A
H
----
D
-
G
H
-
N
L
N
V
Q
L
E
R
--
A
A
D
A
L
R
L
P
--
D
W
D
A
K
I
A
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L
S
G
G
E
R
R
R
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A
L
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L
L
L
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L
L
L
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P
T
N
H
L
D
A
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E
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---
V
A
W
L
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R
F
--
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
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G
I
P
W
E
G
N
Y
S
S
W
L
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Q
K
D
Q
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L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
----
T
K
G
R
Q
S
K
G
KA
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
-
R
N
E
T
N
E
L
F
I
-
P
P
G
P
R
L
G
D
K
V
L
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V
S
N
L
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K
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Y
G
D
--
R
L
L
I
D
D
L
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F
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I
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K
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A
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G
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P
N
G
A
G
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S
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L
F
R
M
I
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G
Q
E
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P
D
S
G
T
I
T
L
G
E
-------------
T
V
K
L
A
S
V
D
Q
F
R
D
-------------
S
----------------
M
---------------------------
D
N
-------------
S
K
T
------------
V
W
E
-----------------------------------------------------
E
V
S
--------------
G
G
L
D
I
M
KI--
G
-------------------------
N
T
E
M
P
S
--
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
----------
V
G
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
----
Q
D
E
G
K
V
E
F
---
F
E
G
N
------------------------------------------------
39
HHSearch
69.74
25%
24
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[436-978]
------------------------------------------------------------------
L
C
N
C
E
F
--
S
L
A
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
R
Y
G
I
C
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P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
--
C
---------
R
T
V
Y
V
E
H
----
D
I
D
G
T
--
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----------
V
---------------------------------------------------
G
T
K
E
A
I
K
D
--
K
L
I
E
F
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F
T
D
E
M
I
A
M
P
I
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S
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G
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K
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K
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A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
---
V
A
W
L
V
N
Y
--
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
-------
K
--------
A
Y
E
E
L
-
S
N
T
D
--------
L
------------------
E
-
F
K
F
P
E
P
G
Y
L
-
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
-------------
N
C
R
I
A
Y
I
K
Q
H
A
F
A
------------
H
IESHLDKT
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
-----------------------------------------------------
N
I
G
MKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
R
G
----
E
LVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRP
L
T
R
K
E
I
--
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
----------
I
R
G
----------
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
----
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
----
K
D
-
G
R
M
T
P
-------------------------------------------------------
45
HHSearch
68.65
24%
23
- C1 -
-
2IX8
-
A:
[1430-1971]
------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
--
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
--
C
---------
R
T
V
Y
V
E
H
----
D
I
D
G
T
--
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----------
V
---------------------------------------------------
G
T
K
E
A
I
K
D
--
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
---
V
A
W
L
V
N
Y
--
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
------------
K
---
A
Y
E
E
L
-
S
N
T
D
--------
L
------------------
E
-
F
K
F
P
E
P
G
Y
L
-
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
-------------
N
C
R
I
A
Y
I
K
Q
H
A
F
A
H
IESHLDKT
P
S
E
Y
----------------
I
Q
W
R
------------------------
F
Q
-------------
T
G
-------------
D
R
E
TMDRANRQINENDAEAMN
K
I
F
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
G
MKSE
R
W
V
P
M
M
SVD
N
A
W
I
P
R
G
----
E
LVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFRP
L
T
R
K
E
I
--
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
----------
I
R
G
----------
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
----
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
----
K
D
-
G
R
M
T
--------------------------------------------------------
12
PsiBlast_PDB
63.94
22%
14
- C1 -
-
3BK7
2
?
A:
[117-543]
----------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
E
D
N
D
S
W
--
D
---------
N
V
I
R
A
F
R
----
G
N
--
E
--
L
Q
N
Y
-----------------------
F
E
R
L
K
N
G
-
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
L
----
P
K
A
V
K
G
K
V
R
E
L
----
L
-
K
K
-
V
D
E
V
G
K
F
E
--
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
K
V
A
R
V
I
R
R
--
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
-----------
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
--
R
V
D
-
V
E
R
E
T
L
V
E
-------
Y
P
-----
R
L
V
K
D
Y
G
S
F
K
L
E
V
E
-----------------
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
-------------
T
V
A
--
Y
K
P
Q
Y
I
K
A
------------
E
----------------
Y
---------------------------
E
G
---------------
T
------------
V
Y
E
-----------------------------------------------------
L
L
S
--------------
K
I
D
S
S
K
----
L
-------------------------
N
S
N
-------------
F
Y
K
T
-
E
L
L
K
P
----------
L
G
I
IDLYDRNVED
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
NE
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
---------------------------------------------------------------------
11
PsiBlast_PDB
63.09
22%
12
- C1 -
-
5LW7
-
?
B:
[103-530]
----------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
E
D
N
D
S
W
--
D
---------
N
V
I
R
A
F
R
----
G
N
--
E
--
L
Q
N
Y
-----------------------
F
E
R
L
K
N
G
-
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
L
----
P
K
A
V
K
G
K
V
R
E
L
----
L
-
K
K
-
V
D
E
V
G
K
F
E
--
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
RLK
V
A
R
V
I
R
R
--
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
-----------
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
--
R
V
D
-
V
E
R
E
T
L
V
E
-------
Y
P
-----
R
L
V
K
D
Y
G
S
F
K
L
E
V
E
-----------------
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
-------------
T
V
A
--
Y
K
P
Q
Y
I
K
A
------------
E
----------------
Y
---------------------------
E
G
---------------
T
------------
V
Y
E
-----------------------------------------------------
L
L
S
--------------
K
I
D
S
S
K
----
L
-------------------------
N
S
N
-------------
F
Y
K
T
-
E
L
L
K
P
----------
L
G
I
IDLYDRNVED
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
EKNE
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
--------------------------------------------------------------------
10
PsiBlast_PDB
62.46
22%
12
- C1 -
-
3J15
2
?
B:
[103-530]
----------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
E
D
N
D
S
W
--
D
---------
N
V
I
R
A
F
R
----
G
N
--
E
--
L
Q
N
Y
-----------------------
F
E
R
L
K
N
G
-
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
L
----
P
K
A
V
K
G
K
V
R
E
L
----
L
-
K
K
-
V
D
E
V
G
K
F
E
--
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
K
V
A
R
V
I
R
R
--
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
-----------
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
--
R
V
D
-
V
E
R
E
T
L
V
E
-------
Y
P
-----
R
L
V
K
D
Y
G
S
F
K
L
E
V
E
-----------------
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
-------------
T
V
A
--
Y
K
P
Q
Y
I
K
A
------------
E
----------------
Y
---------------------------
E
G
---------------
T
------------
V
Y
E
-----------------------------------------------------
L
L
S
--------------
K
I
D
S
S
K
----
L
-------------------------
N
S
N
-------------
F
Y
K
T
-
E
L
L
K
P
----------
L
G
I
IDLYDRNVED
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
--------------------------------------------------------------------
51
HHSearch
62.04
20%
2
- C1 -
-
1YQT
2
?
A:
[25-477]
-------------------------------------------------------------------
E
D
C
V
H
--
R
--
Y
G
V
N
A
F
V
L
Y
R
L
P
V
V
-------------
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
--
D
G
--------
V
I
R
A
F
R
G
----
N
E
--
L
--
Q
---
N
Y
F
E
K
L
K
N
G
E
----------
I
R
P
V
-
V
K
P
Q
Y
-
V
-
D
L
I
P
K
A
--
V
K
---
G
K
----
V
I
E
---
L
L
-------
K
-
K
A
-
D
E
T
G
K
L
E
E
--
V
V
K
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
---
R
L
N
A
A
R
A
--
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
-
H
V
V
Y
G
E
P
G
V
Y
-
G
I
F
S
Q
P
K
G
T
R
N
G
I
------------
N
E
--
F
L
R
G
Y
L
K
D
E
N
V
R
---
F
R
P
Y
----
E
----
I
K
F
T
--
K
T
G
E
-------
R
V
-----
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
---
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
---------------
L
T
V
A
Y
K
P
Q
Y
I
K
------------------------------
A
---------------------------
D
Y
-------------
E
G
T
------------
V
Y
E
-----------------------------------------------------
L
L
S
--------------
K
I
D
A
S
K
----
L
-------------------------
N
S
N
F
Y
K
--
T
E
L
L
K
P
L
G
I
I
D
--
L
Y
D
R
E
----------
V
N
E
----------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
----
E
G
-------------------------------------------------------------
16
PsiBlast_PDB
61.15
22%
23
- C1 -
-
1YQT
2
?
A:
[47-472]
----------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
--
D
---------
G
V
I
R
A
F
R
GNEL
Q
N
Y
F
E
--
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
YVDLIPKAVK
G
K
V
I
E
L
L
K
K
A
-
D
------
E
T
G
K
L
E
E
V
V
K
----
A
L
E
L
E
------------------------------
N
V
L
E
----
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
---
L
N
A
A
R
A
I
R
R
L
S
E
E
----
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
-
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
-----------
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
-
T
G
--
E
R
V
E
I
E
R
E
T
L
V
T
-------
Y
P
-----
R
L
V
K
D
Y
G
S
F
R
L
E
V
E
-----------------
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
L
-------------
T
V
A
--
Y
K
P
Q
Y
I
K
A
------------
D
----------------
Y
---------------------------
E
G
---------------
T
------------
V
Y
E
-----------------------------------------------------
L
L
S
--------------
K
I
D
A
S
K
----
L
-------------------------
N
S
N
-------------
F
Y
K
T
-
E
L
L
K
P
LGIIDLYDRE
V
N
E
----------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
----------------------------------------------------------------------
25
Fugue
60.42
19%
32
- C1 -
-
3J16
3
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
C
P
F
D
A
I
Q
I
--
I
--
N
L
P
T
N
L
E
A
H
V
T
H
R
Y
SAN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
--
E
---------
W
Q
E
I
I
K
Y
----
F
R
G
S
E
--
L
Q
N
Y
--
F
T
K
M
L
E
D
D
----------
I
K
A
I
I
K
P
Q
Y
V
-
D
-
N
I
P
R
A
I
K
G
P
V
Q
K
V
G
E
----
L
L
K
L
R
M
E
-------------
K
S
P
E
D
V
K
R
--
Y
I
K
I
L
Q
L
-
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
-
K
Q
---
R
L
N
A
A
Q
I
--
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
----
L
S
V
L
D
Y
L
S
D
----
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
-
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
--
L
Q
N
--------
D
S
A
S
R
A
F
S
Y
P
-----
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
-----------------
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
L
-------------
N
--
V
S
M
K
P
Q
K
I
A
P
------------
K
----------------
F
---------------------------
P
G
---------------
T
------------
V
R
Q
-----------------------------------------------------
L
F
F
--------------
K
K
I
R
G
Q
----
F
-------------------------
L
N
P
Q
F
Q
--
T
D
V
V
K
P
L
R
I
D
-
D
-
I
I
D
Q
E
----------
V
Q
H
----------
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
----
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
P
S
K
N
A
H
A
R
A
P
ES
L
L
T
G
C
N
R
F
L
K
N
L
N
V
TFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
LDNTGI
54
HHSearch
57.43
23%
-38
* C1 *
-
3RLF
2
MALK_ECOLI
A:
[3-221]
---------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
--
A
--
W
G
E
V
V
V
S
K
D
I
N
L
D
I
-------------
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
--
K
RMNDTPPAE
R
G
V
G
M
V
F
----
Q
S
Y
A
L
--
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
----------
K
L
A
G
--------------------------------------
A
----
K
-
K
E
-
V
I
N
Q
R
V
N
Q
--
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
-
A
L
---
R
V
Q
M
R
I
E
--
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
57.19
18%
-53
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
KRMNDTPPA----
E
R
G
V
G
M
V
F
Q
S
Y
A
------------------------------
L
---------------------------
Y
P
-------------
H
L
S
------------
V
A
E
-----------------------------------------------------
N
M
S
--------------
F
G
L
K
L
A
GAK
K
E
-------------------------
V
I
N
Q
R
V
--
N
Q
V
A
E
V
L
Q
L
A
H
--
L
L
D
R
K
----------
P
K
A
----------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
----
R
T
----
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
----
D
A
-
G
R
V
A
Q
----
V
G
K
P
L
E
L
--------------------------------------------
53
HHSearch
57.17
23%
-44
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-221]
---------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
--
A
--
W
G
E
V
V
V
S
K
D
I
N
L
D
I
-------------
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
--
K
RMNDTPPAE
R
G
V
G
M
V
F
----
Q
S
Y
A
L
--
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
----------
K
L
A
G
--------------------------------------
A
----
K
-
K
E
-
V
I
N
Q
R
V
N
Q
--
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
-
A
L
---
R
V
Q
M
R
I
E
--
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.00
24%
-33
- C1 -
-
2IWH
1
EF3A_YEAST
A:
[440-730]
--------------------------------------------------------------------
E
F
S
L
--
A
--
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
G
F
P
TQ
E
---------
E
C
R
T
V
Y
V
----
E
H
D
I
D
GT
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----------
V
G
T
K
E
A
I
K
D
K
-----
L
I
E
F
G
F
T
D
E
------------------------------------------------
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
---
V
A
W
L
V
N
Y
--
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
------
E
G
V
K
T
K
Q
-------
K
A
I
V
K
V
T
N
M
E
F
Q
-----
Y
P
G
T
S
--
K
P
Q
------------------------
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
55.87
24%
-31
- C1 -
-
2IX3
-
EF3A_YEAST
A:
[440-730]
--------------------------------------------------------------------
E
F
S
L
--
A
--
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
G
F
P
TQ
E
---------
E
C
R
T
V
Y
V
----
E
H
D
I
D
GT
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----------
V
G
T
K
E
A
I
K
D
K
-----
L
I
E
F
G
F
T
D
E
------------------------------------------------
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
---
V
A
W
L
V
N
Y
--
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
------
E
G
V
K
T
K
Q
-------
K
A
I
V
K
V
T
N
M
E
F
Q
-----
Y
P
G
T
S
--
K
P
Q
------------------------
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.78
29%
-38
- C1 -
-
5X40
2
CBIO_RHOCB
A:
[31-230]
---------------------------------------------------------------------------------
K
A
L
D
D
L
S
L
A
V
-------------
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
------------------
T
----
A
T
G
H
S
--
R
K
D
L
T
G
W
------
R
----------
R
R
V
G
L
V
L
Q
D
A
D
D
-
Q
L
F
A
T
T
V
F
E
D
V
--------------
S
F
G
P
L
----
N
L
G
L
S
E
A
E
A
R
A
R
V
E
E
A
L
A
A
L
S
I
-
S
D
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
-
A
G
---
T
E
Q
L
L
T
L
--
L
R
G
L
----
R
A
A
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.51
25%
-28
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[440-730]
--------------------------------------------------------------------
E
F
S
L
--
A
--
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
G
F
P
TQ
E
---------
E
C
R
T
V
Y
V
----
E
H
D
I
D
GT
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----------
V
G
T
K
E
A
I
K
D
K
-----
L
I
E
F
G
F
T
D
E
M
---------------------------
I
A
M
P
---------------------
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
---
V
A
W
L
V
N
Y
--
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
------
E
G
V
K
T
K
Q
-------
K
A
I
V
K
V
T
N
M
E
F
Q
-----
Y
P
G
T
S
--
K
P
Q
------------------------
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
54.69
21%
-35
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
KTIFSKNTNLPVR
E
R
R
L
G
Y
L
V
Q
E
G
V
------------------------------
L
---------------------------
F
P
-------------
H
L
T
------------
V
Y
R
-----------------------------------------------------
N
I
A
--------------
Y
G
L
G
N
G
KGRT
A
-------------------------
Q
E
R
Q
R
I
--
E
A
M
L
E
L
T
G
I
S
E
--
L
A
G
R
Y
----------
P
H
E
----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
LRAN
G
----
K
S
----
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
----
K
Q
-
G
R
I
L
Q
----
T
A
S
P
H
E
L
Y
R
------------------------------------------
48
HHSearch
54.31
20%
17
- C1 -
-
3OZX
2
?
B:
[133-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
-
R
E
---
R
M
N
M
A
K
A
--
I
R
E
L
LK--
N
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
Y
G
E
S
S
-
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
I
-----
N
N
F
L
K
--
G
---
Y
L
P
A
E
N
M
K
I
R
--------
P
-
D
--
E
I
K
--
F
M
L
------
K
-----------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
---
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
D
E
G
S
V
T
P
E
K
--------------
Q
I
L
S
Y
K
P
Q
R
I
F
------------------------------
P
---------------------------
N
Y
-------------
D
G
T
------------
V
Q
Q
-----------------------------------------------------
Y
L
E
--------------
N
A
S
K
D
A
L---
S
-------------------------
T
S
S
W
F
F
--
E
E
V
T
K
R
L
N
L
H
R
--
L
L
E
S
N
----------
V
N
D
----------
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
----
T
RERK
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
----
K
G
-
E
P
E
K
A
-------------------------------------------------------