@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZE1: (2018-01-14 )
MSEEIRENIHDVNLTSEMKDSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKAHKKSARIVGDVMGKYHPHGDSAIYESMVRMAQPFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKIATEMLRDINKNTVDFQSNYDDTEKEPVVLPARFPNLLVNGTTGIAVGMATNIPPHNLSEVVAAIDLLMDNPDVTTNELMEVLPGPDFPTGGLVMGKSGIRRAYETGKGSITVRAKVEITEMPNGKERIIVTELPYMVNKAKLIERISELHRDKRIEGITDLRDESSREGMRIVIDIRRDASASVILNNLYKLTSLQNSFGFNMLAIEKGVPKVLSLKQILENYIEHQREVITRRTVFEKEKAEARAHILEGLRIALDHIDEIIAIIRGSKSDDEAKATMIERFDLSDRQSQAILDMRLRRLTGLEREKIENEYQELLKLIEDLTDILARPERVTEIIKNELADLNQRFGDKRRTELLVGEVLSLEDEDLIEEEEIVITLTNNGYIKRLANNEFRAQRRGGRGVQGMGIHNDDFVKNLVSCSTHDTLLFFTNNGKVYRAKGYEIPEYGRTAKGIPIINLLGIDSSESIQAIIAVTGEAEEGHYLFFTTRQGTVKRTSVTAFANIRSNGLIAIGLKEDDELVNVLLTDGQSNIIIGTHNGYSVTFKEEAVRDMGRTASGVRGIRLREEDYVVGAALMKENQEVLVITEKGYGKRTKVSEYPVKGRGGKGIKTANITEKNGPLAGLTTVSGDEDIMLITDKGVIIRFNVSTVSQTGRSTLGVRLMKMEADTKVVTMAAVEPEAAEQTVEEQGSEE
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..----....----.210.......220.......230.......240.......-250.......260.......270.......280.......290....-.-.-.300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.....-------------..410.------------------......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
E
E
I
R
E
N
IHDVN
L
T
S
E
M
K
D
S
F
I
D
Y
A
M
S
V
I
V
A
R
AL
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
ELGVTP
D
K
A
H
K
K
S
A
R
I
V
G
D
V
M
GKYHPHG
D
S
A
I
Y
E
S
M
V
R
MAQPF
S
Y
R
Y
M
L
V
DGHGNFGSVDGDG
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
A
T
E
M
L
R
DINKN
T
V
D
FQSNYDDTEKE
P
V
V
LPARFP
N
L
L
VNGTT
G
I
A
V
GMATNIPP
H
N
L
S
E
V
V
A
A
I
D
L
LMDNPDV----
T
T
N
E
----
L
M
E
VLPGPDFPTG
G
L
V
MG
K
S
G
I
R
R
A
Y
ETGK
G
S
I
T
V
R
A
K
V
E
I
-
T
EMPNGK
E
R
I
I
V
TEL
P
Y
M
V
N
K
A
K
L
I
E
R
I
S
E
L
H
R
D
K
RIEGITDLRDES-S-R-EG
M
R
I
V
I
D
IRRDA
S
A
S
V
I
L
N
N
L
Y
K
L
T
S
L
Q
N
SFGF
N
M
L
A
IEKG
V
P
K
V
L
S
L
K
Q
I
L
E
N
Y
I
E
H
Q
R
E
V
I
T
R
R
T
V
F
E
K
E
K
A
E
A
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
A
I
IRGSKSD
D
E
A
K
-------------
A
T
M
I
E
R------------------FDLS
D
R
Q
S
Q
A
I
L
D
M
R
L
R
R
LTGL
E
R
E
K
I
E
N
E
Y
Q
E
L
L
K
L
I
E
D
L
T
D
I
LAR
P
E
R
V
T
E
I
I
K
N
E
L
A
D
L
N
Q
RFG
D
K
R
R
T
E
L
L
V
G
E
V
LSLE
D
E
DLIEEE
E
I
V
I
T
LTNN
G
Y
I
K
R
LANN
E
F
R
A
QRRGGRGVQGMGIH
N
D
D
F
V
K
N
L
V
SCSTH
D
T
L
L
F
F
TNN
G
K
V
Y
R
AKGYEIPEYGRTAKG
I
P
I
I
N
L
LGIDSSES
I
Q
A
I
I
A
V
TGEAEEG
H
Y
L
F
F
TTRQG
T
V
K
R
T
S
V
T
A
F
A
NIRSN
G
L
I
A
I
GLKEDD
E
L
V
N
V
L
L
TDGQS
N
I
I
I
GTHN
G
Y
S
V
T
F
K
E
E
A
V
R
D
M
G
R
T
ASGVRG
I
R
LREED
Y
V
V
G
A
A
L
MKEN
Q
E
V
L
V
I
TEKGYGKRTKVSEYPVKGRGGKG
I
K
T
A
NITEKNGP
L
A
G
L
T
TVSGDE
D
I
M
L
I
TDK
G
V
I
I
R
F
N
V
S
T
V
SQTGRS
T
L
G
V
R
L
M
K
MEAD
T
K
V
V
T
M
A
AVE
P
E
A
A
E
Q
T
V
E
EQGSEE
103
HHSearch
83.19
75%
-85
- C5 -
-
4Z2C
1
?
A:
[3-486]
-----
D
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-
E
T
T
K
T
G
R
E
R
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
R
F
V
I
E
V
K
R
D
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.15
75%
-85
- C5 -
-
4Z2C
1
?
A:
[4-486]
------
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-
E
T
T
K
T
G
R
E
R
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
R
F
V
I
E
V
K
R
D
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.47
75%
-86
- C5 -
-
4Z2D
1
?
A:
[4-486]
------
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-
E
T
T
K
T
G
R
E
R
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
R
F
V
I
E
V
K
R
D
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.34
75%
-84
- C5 -
-
4Z2E
1
?
A:
[4-486]
------
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-
E
T
T
K
T
G
R
E
R
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
R
F
V
I
E
V
K
R
D
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.64
75%
-91
- C5 -
-
4Z2C
1
?
B:
[4-486]
------
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-
E
T
T
K
T
G
R
E
R
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
-
F
V
I
E
V
K
R
D
-
S
A
N
V
I
L
N
N
L
F
K
M
T
-
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.33
75%
-90
- C5 -
-
4Z2E
1
?
B:
[4-486]
------
K
N
L
V
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
D
G
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-----------
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
-
R
-
E
G
V
R
F
V
I
---
R
D
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
Q
N
G
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
S
E
T
D
A
E
A
Q
-------------
A
E
L
M
S
K
------------------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.77
68%
-90
- C5 -
-
4DDQ
1
GYRA_BACSU
F:
[34-489]
---------------------------------
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
A
M
N
D
L
G
M
T
S
D
K
P
Y
K
K
S
A
R
I
V
G
E
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
E
S
M
V
R
M
A
Q
D
F
N
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
V
D
G
D
S
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
S
M
E
I
L
R
D
I
T
K
D
T
I
D
Y
Q
D
N
Y
D
G
S
E
R
E
P
V
V
M
P
S
R
F
P
N
L
L
V
N
G
A
A
----
G
M
A
T
N
I
P
P
H
Q
L
G
E
I
I
D
G
V
L
A
V
S
E
N
P
D
I
----
T
I
P
E
----
L
M
E
V
I
P
G
P
D
F
P
T
A
G
Q
I
L
G
R
S
G
I
R
K
A
Y
E
S
G
R
G
S
I
T
I
R
A
K
A
E
I
-
E
Q
T
S
S
G
K
E
R
I
I
V
T
E
L
P
Y
Q
V
N
K
A
K
L
I
E
K
I
A
D
L
V
R
D
K
K
I
E
G
I
T
D
L
R
D
E
S
-
D
-
R
-
T
G
M
R
I
V
I
E
I
R
R
D
A
N
A
N
V
I
L
N
N
L
Y
K
Q
T
A
L
Q
T
S
F
G
I
N
L
L
A
L
V
D
G
Q
P
K
V
L
T
L
K
Q
C
L
E
H
Y
L
D
H
Q
K
V
V
I
R
R
R
T
A
Y
E
L
R
K
A
E
A
R
A
H
I
L
E
G
L
R
V
A
L
D
H
L
D
A
V
I
S
L
I
R
N
S
Q
T
A
E
I
A
R
-------------
T
G
L
I
E
Q
------------------
F
S
L
T
E
K
Q
A
Q
A
I
L
D
M
R
L
Q
R
L
T
G
L
E
R
E
K
I
E
E
E
Y
Q
S
L
V
K
L
I
A
E
L
K
D
I
L
A
N
E
Y
K
V
L
E
I
I
R
E
E
L
T
E
I
K
E
R
F
N
D
E
R
R
T
E
I
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.69
68%
-84
- C5 -
-
4DDQ
-
GYRA_BACSU
A:
[32-489]
-------------------------------
S
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
A
M
N
D
L
G
M
T
S
D
K
P
Y
K
K
S
A
R
I
V
G
E
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
E
S
M
V
R
M
A
Q
D
F
N
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
V
D
G
D
S
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
S
M
E
I
L
R
D
I
T
K
D
T
I
D
Y
Q
D
N
Y
D
G
S
E
R
E
P
V
V
M
P
S
R
F
P
N
L
L
V
N
G
A
A
G
I
A
V
G
M
A
T
N
I
P
P
H
Q
L
G
E
I
I
D
G
V
L
A
V
S
E
N
P
D
I
----
T
I
P
E
----
L
M
E
V
I
P
G
P
D
F
P
T
A
G
Q
I
L
G
R
S
G
I
R
K
A
Y
E
S
G
R
G
S
I
T
I
R
A
K
A
E
I
-
E
Q
T
S
S
G
K
E
R
I
I
V
T
E
L
P
Y
Q
V
N
K
A
K
L
I
E
K
I
A
D
L
V
R
D
K
K
I
E
G
I
T
D
L
R
D
E
S
-
D
-
R
-
T
G
M
R
I
V
I
E
I
R
R
D
A
N
A
N
V
I
L
N
N
L
Y
K
Q
T
A
L
Q
T
S
F
G
I
N
L
L
A
L
V
D
G
Q
P
K
V
L
T
L
K
Q
C
L
E
H
Y
L
D
H
Q
K
V
V
I
R
R
R
T
A
Y
E
L
R
K
A
E
A
R
A
H
I
L
E
G
L
R
V
A
L
D
H
L
D
A
V
I
S
L
I
R
N
S
Q
T
A
E
I
A
R
-------------
T
G
L
I
E
Q
------------------
F
S
L
T
E
K
Q
A
Q
A
I
L
D
M
R
L
Q
R
L
T
G
L
E
R
E
K
I
E
E
E
Y
Q
S
L
V
K
L
I
A
E
L
K
D
I
L
A
N
E
Y
K
V
L
E
I
I
R
E
E
L
T
E
I
K
E
R
F
N
D
E
R
R
T
E
I
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
76.38
67%
-26
- C5 -
-
5CDR
4
GYRA_STAAN
C:
[2-482]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.32
67%
-24
- C5 -
-
5IWI
10
GYRA_STAAN (first)
A:
[8-490]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.17
67%
-24
- C5 -
-
5CDP
4
GYRA_STAAN
A:
[1-483]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.08
67%
-24
- C5 -
-
5IWM
3
GYRA_STAAN (first)
A:
[8-490]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.03
67%
-26
- C5 -
-
5CDR
7
GYRA_STAAN
A:
[1-483]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
76.01
67%
-23
- C5 -
-
5IWI
7
GYRA_STAAN
C:
[9-489]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.95
67%
-25
- C5 -
-
5CDP
3
GYRA_STAAN
C:
[2-482]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
75.65
66%
-24
* C5 *
-
5IWI
10
GYRA_STAAN (first)
A:
[8-489]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
S
L
-
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.60
67%
-23
- C5 -
-
5IWM
4
GYRA_STAAN
C:
[9-489]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.56
67%
-27
- C5 -
-
5CDN
4
GYRA_STAAN (first)
A:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.40
67%
-28
- C5 -
-
5CDN
6
GYRA_STAAN (first)
C:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.26
67%
-29
- C5 -
-
5CDO
6
GYRA_STAAN
A:
[1-480]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.98
67%
-26
- C5 -
-
5CDQ
6
GYRA_STAAN
A:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
74.89
67%
-25
- C5 -
-
5CDM
7
GYRA_STAAN
A:
[1-481]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
S
L
-
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.69
67%
-25
- C5 -
-
5CDQ
6
GYRA_STAAN
C:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.61
67%
-25
- C5 -
-
5CDM
7
GYRA_STAAN
A:
[1-480]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.56
66%
-23
- C5 -
-
2XCR
3
GYRA_STAAN (first)
B:
[236-726]
F
A
E
L
P
Q
S
R
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.47
66%
-25
- C5 -
-
2XCR
3
GYRA_STAAN (first)
S:
[236-725]
F
A
E
L
P
Q
S
R
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.28
66%
-26
- C5 -
-
2XCR
3
GYRA_STAAN (first)
D:
[236-726]
F
A
E
L
P
Q
S
R
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.86
66%
-26
- C5 -
-
2XCR
3
GYRA_STAAN (first)
U:
[236-725]
F
A
E
L
P
Q
S
R
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
73.76
67%
-26
- C5 -
-
2XCR
3
GYRA_STAAN (first)
D:
[242-725]
------
S
R
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
S
L
-
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
73.36
48%
-81
- C5 -
-
3RAE
3
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.22
48%
-83
- C5 -
-
4I3H
2
?
B:
[651-1130]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.16
55%
-37
- C5 -
-
2Y3P
1
GYRA_ECOLI (first)
A:
[22-520]
-----------------------
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
----
S
I
E
G
----
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
D
A
K
T
G
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
S
-
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
LGNV
A
A
M
L
E
-DAARPEWLEPEFGVRDG
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
72.88
48%
-77
- C5 -
-
3K9F
4
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
72.81
48%
-77
- C5 -
-
3K9F
4
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
72.75
55%
-36
- C5 -
-
2Y3P
1
GYRA_ECOLI (first)
B:
[12-520]
-------------
I
E
E
E
L
K
S
S
Y
L
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
----
S
I
E
G
----
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
D
A
K
T
G
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
S
-
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
PWQLGNV
A
A
M
L
E
-DAARPEWLEPEFGVRDG
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
72.70
48%
-80
- C5 -
-
3RAE
3
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.61
48%
-82
- C5 -
-
3RAD
5
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.46
48%
-79
- C5 -
-
3RAF
2
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.40
48%
-78
- C5 -
-
4I3H
3
?
A:
[651-1130]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
72.02
48%
-76
- C5 -
-
3RAD
4
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.76
48%
-76
- C5 -
-
3RAF
2
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
71.74
48%
-78
- C5 -
-
3LTN
2
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
71.72
48%
-86
- C5 -
-
3KSA
2
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.71
48%
-78
- C5 -
-
3LTN
2
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
71.54
48%
-89
- C5 -
-
3KSB
2
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
---
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
71.49
48%
-88
- C5 -
-
3KSB
2
PARC_STRPN
A:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
---
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
71.46
48%
-86
- C5 -
-
3KSA
2
PARC_STRPN
B:
[3-482]
-------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
-
E
K
------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
S
-
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
68.04
54%
7
- C5 -
-
3IFZ
1
GYRA_MYCTU
B:
[29-501]
----------------------
I
D
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
----
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
-
E
E
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
-
S
D
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
-------------
A
G
L
I
E
L
------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
68.02
56%
7
- C5 -
-
3ILW
4
GYRA_MYCTU
A:
[7-469]
------------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
----
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
-
E
E
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
-
S
-
D
R
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
-------------
A
G
L
I
E
L
------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
68.00
55%
10
- C5 -
-
3ILW
4
GYRA_MYCTU
B:
[8-469]
-------------------------------
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
----
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
-
E
E
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
-
S
D
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
-------------
A
G
L
I
E
L
------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.98
54%
3
- C5 -
-
3IFZ
1
GYRA_MYCTU
A:
[13-499]
------
D
R
I
E
P
V
D
I
E
Q
E
M
Q
R
S
Y
I
D
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
----
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
-
E
E
D
S
R
----
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
-
S
D
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
-------------
A
G
L
I
E
L
------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.32
55%
8
- C5 -
-
3ILW
4
GYRA_MYCTU
A:
[7-469]
------------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
----
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
-
E
E
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
-
S
D
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
-------------
A
G
L
I
E
L
------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
63.48
48%
-82
- C5 -
-
3FOF
3
PARC_STRPN
A:
[5-479]
---------
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
--
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
----------
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
-
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
----
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
---------------------
I
E
L
-----
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.94
48%
-81
- C5 -
-
3FOE
3
PARC_STRPN
A:
[5-479]
---------
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
--
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
----------
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
-----
K
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
--
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
-
G
R
V
V
V
R
S
K
T
E
I
-
E
K
L
K
G
G
K
E
Q
I
V
I
T
E
I
----
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
---------------------
I
E
L
-----
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
-------------
E
N
L
K
V
S
------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
59.25
67%
14
- C5 -
-
5CDO
3
GYRA_STAAN
T:
[2-480]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
59.17
67%
12
- C5 -
-
5CDQ
2
GYRA_STAAN
R:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.39
67%
15
- C5 -
-
5CDQ
2
GYRA_STAAN
T:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
57.88
67%
15
- C5 -
-
5CDN
2
GYRA_STAAN
T:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
57.80
67%
20
- C5 -
-
5CDO
4
GYRA_STAAN
C:
[3-480]
----------
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
57.31
67%
19
- C5 -
-
5CDM
4
GYRA_STAAN
C:
[2-480]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.13
67%
14
- C5 -
-
5CDN
2
GYRA_STAAN
R:
[4-479]
------------
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
R
----
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
--
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
56.85
67%
20
- C5 -
-
5CDO
3
GYRA_STAAN
R:
[2-480]
---------
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
-
E
E
----
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
-------------
E
S
L
Q
Q
R
------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------