@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZE2: (2018-01-14 )
MTEERSLVERAKEYDASQIQVLEGLEAVRKRPGMYIGSTSSEGLHHLVWEIVDNSIDEVLAGFATKIHVIIEKDNSITVIDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVKVYKEGNVYYQEYRRGAVVDDLKIIEQTDRHGTTVHFTPDPEIFTETTEFDFSKLATRIRELAFLNRGMRISIEDKREEEPVINEYHYDGGIKSYVEYLNANKTVIFPEPVYLEGEQQDIAVEVSMQYTDGYHSNIMSFANNIHTYEGGTHESGFKTALTRVINDYARKQKLMKENDDNLTGEDVREGLTAVISIKHPDPQFEGQTKTKLGNSEVRTVTDRLFSEHFMKFLLENPSVGRQIVEKGLLASRARLAAKRAREVTRRKGALEISNLPGKLADCSSNDPEKCELFIVEGDSAGGSAKQGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGEDFDVSKARYHKLVIMTDADVDGAHIRTLLLTLFYRYMRPIVEAGYVYIAQPPLYGVKQGKNITYVQPGKNAEEELKQVVASLPASPKPSVQRYKGLGEMDDHQLWETTMDPSNRMMARVSVDDAIAADQIFEMLMGDRVEPRRAFIEENAHYVKNLDI
Atome Classification :
(46 SA)
.........10........-20........30........40.-........50........60...--.....70...-.....80........90........100.......110.......120------........130.......140.--......150......-.160...--.--.--.--.170........-------.180.......190.......200.......210.....-----..220----...-..---------------....230.......240.......250....-...260.......270-..-.....280.......290.......300.......310.......320.......330.......340.........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
E
E
R
S
L
V
E
R
A
K
EY
D
A
S
Q
I
-
Q
V
L
E
G
L
E
A
V
R
KRP
G
M
Y
IGSTS-S-E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
V
L
A
G
F
A
--
T
K
I
H
V
I
I
EKD-N
S
I
T
V
I
DDGRG
I
P
V
D
I
QAKTGR
P
A
V
E
T
V
F
T
V
L
HAGGKFGGG
G
Y
K
VSG-------GLH
G
V
G
S
S
V
V
N
A
L
STQL
D
V
K
V
Y
--KEGN
V
Y
Y
Q
E
YRRGAV-
V
D
D
L
K
I
I
--
E
--Q--T--DR--HG
T
T
V
H
FT-------PDPE
I
F
T
ETTEF
D
F
S
K
L
A
T
R
I
R
E
L
A
F
LNRG
M
R
I
S
IEDKR-----EEE------PV
I
-
N
E---------------YHYDG
G
I
K
S
Y
V
E
Y
LNAN
K
T
V
IFPE
P
V
Y
LEGE-QQ
D
I
A
V
E
V
S
M
Q
YTDG
Y
-
H
S
-
N
I
M
S
F
ANNIHTYEGGTHES
G
F
K
T
A
L
T
R
V
I
N
D
Y
A
R
K
Q
K
L
M
KENDDNL
T
G
E
D
V
R
E
G
L
T
A
V
I
S
IKHPDP--QFEGQTKTKLGN
S
E
V
R
T
V
T
D
R
L
F
S
E
H
F
M
K
F
L
LENPSV
G
R
Q
I
V
E
K
G
L
L
A
S
R
A
R
L
A
A
K
R
A
R
E
V
T
R
RKG
A
L
E
ISNLPGKLADCSSN
D
P
E
K
C
E
L
F
I
V
EGDSAGGSAKQGRNR
E
F
Q
A
I
LPIR
G
K
I
L
NV
E
K
A
S
M
D
K
I
L
A
N
E
E
I
R
S
L
F
T
A
M
GTGFGEDFDVSK
A
R
Y
H
K
L
V
I
M
TDADVD
G
A
H
I
R
T
L
L
L
T
L
F
Y
R
Y
M
R
P
I
V
EA
G
Y
V
Y
IAQPPLYGVKQGK
N
I
T
Y
VQPGK
N
A
E
E
E
L
K
Q
V
V
A
SLPASPKP
S
V
Q
R
Y
KGLGEMD
D
H
Q
L
W
E
TTMDPSN
R
M
M
A
R
V
SVDD
A
I
A
A
D
Q
I
F
E
M
L
MGDRV
E
P
R
R
A
F
I
E
ENAH
Y
V
KNLDI
2
PsiBlast_PDB
100.00
51%
0
- C- -
-
4I3H
2
?
A:
[24-647]
---------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
--
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
GT
A
--
P
--
K
--
S
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
------
A
I
---
E
---------------
F
H
Y
E
N
G
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
T
P
-
V
L
Y
F
E
G
E
-
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
-
N
I
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
---------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
G
---
A
Y
A
W
-
D
G
E
L
E
E
L
R
--------------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
------
1
PsiBlast_PDB
76.98
51%
32
- C2 -
-
4JUO
1
PARE_STRPN
C:
[47-663]
---------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
--
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
--
G
--
T
--
A
PK
S
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
------
A
I
---
E
---------------
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
T
P
-
V
L
Y
F
E
G
E
-
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
-
N
I
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
HL
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-----------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-----
124
HHSearch
67.53
48%
-66
- C3 -
-
3ZKB
-
GYRB_MYCTU
H:
[17-427]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
G
L
-
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
-----
V
--------
V
K
S
-
R
T
---------------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.72
46%
-18
- C3 -
-
3ZKD
2
GYRB_MYCTU
F:
[16-426]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VT------------------K
V
K
S
R
T
---------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.62
46%
-8
- C3 -
-
3ZKD
2
GYRB_MYCTU
C:
[17-426]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQDE---------------
R
A
A
E
S
T
APHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
--
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.52
46%
-10
- C3 -
-
3ZKD
2
GYRB_MYCTU
H:
[17-426]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQ-----------------K
V
K
S
R
T
---------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
63.28
48%
1
- C3 -
-
3ZKB
2
GYRB_MYCTU
D:
[12-427]
--------
K
A
Q
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
G
L
-
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
-----
V
T
Q
STAPHK
V
K
S
-
R
T
---------------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.67
46%
-14
- C3 -
-
3ZKB
2
GYRB_MYCTU
A:
[16-428]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.51
46%
-20
- C3 -
-
3ZKD
2
GYRB_MYCTU
G:
[16-425]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.42
46%
-19
- C3 -
-
3ZKD
2
GYRB_MYCTU
B:
[17-425]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------------H
K
V
K
S
R
T
--------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
----
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
62.37
46%
-1
- C3 -
-
3ZKB
2
GYRB_MYCTU
D:
[16-427]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQ-----------------STAPHK
V
K
S
R
T
----
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.09
46%
-11
- C3 -
-
3ZKB
2
GYRB_MYCTU
B:
[16-429]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------------VK
S
R
T
----------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.62
46%
-10
- C3 -
-
3ZKD
2
GYRB_MYCTU
E:
[17-427]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQ-----------------PHKV
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
--
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
61.27
47%
-1
- C3 -
-
1KIJ
3
GYRB_THET8
B:
[7-388]
-----------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
--
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
-
T
E
P
L
R
V
V
--
G
EA
P
--
R
--
G
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
-----
H
G
--------
K
E
-
E
V
---------------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
-
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
-
E
I
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.99
46%
-11
- C3 -
-
3ZKD
2
GYRB_MYCTU
A:
[17-429]
-------------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------------HKVK
S
R
T
--------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
-----
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
60.68
46%
3
- C3 -
-
3ZKB
2
GYRB_MYCTU
C:
[16-430]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------------A
P
H
K
V
K
S
R
T
------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
60.63
46%
-7
- C3 -
-
3ZKD
2
GYRB_MYCTU
D:
[16-428]
------------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
-
S
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
--
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
E
P
-
L
-
G
L
K
Q
G
--
A
--
P
--
T
--
K
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------------K
V
K
S
R
T
---------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
-
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
-
S
V
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
---
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Fugue
60.35
50%
20
- C3 -
-
1EI1
4
GYRB_ECOLI
A:
[1-391]
----------
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
--------
E
-
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
60.35
51%
19
- C3 -
-
1EI1
4
GYRB_ECOLI
B:
[2-389]
-----------
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
--------
K
E
-
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Fugue
60.17
50%
19
- C3 -
-
1EI1
4
GYRB_ECOLI
A:
[1-391]
----------
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
--------
G
K
E
-
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.83
46%
-12
- C3 -
-
1KIJ
3
GYRB_THET8
B:
[7-372]
-----------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
--
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
-
T
E
P
L
R
V
V
--
G
--
E
--
A
--
P
R
GK
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
-
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
HG---
K
E
E
------
V
F
L
-
D
K
-------------------
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
-
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
-
E
I
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.96
50%
17
- C3 -
-
4WUC
1
GYRB_ECOLI
A:
[3-373]
------------
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.94
50%
16
- C3 -
-
4WUB
1
GYRB_ECOLI
A:
[3-373]
------------
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.60
46%
-14
- C3 -
-
1KIJ
3
GYRB_THET8
A:
[7-372]
-----------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
--
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
-
T
E
P
L
R
V
V
--
G
--
E
--
A
--
P
R
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
-
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
HG---
K
E
E
------
V
F
L
-
D
K
-------------------
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
-
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
-
E
I
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.55
50%
14
- C3 -
-
4XTJ
1
GYRB_ECOLI
A:
[3-373]
------------
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
58.28
50%
18
- C3 -
-
1EI1
4
GYRB_ECOLI
B:
[9-373]
------------------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.18
50%
15
- C3 -
-
4WUD
1
GYRB_ECOLI
A:
[3-373]
------------
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.04
50%
12
- C3 -
-
4PRX
2
GYRB_ECOLI
A:
[16-380]
------------------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----------
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.02
50%
18
- C3 -
-
1EI1
4
GYRB_ECOLI
A:
[9-373]
------------------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
56.79
50%
10
- C3 -
-
4PU9
1
GYRB_ECOLI
A:
[16-380]
------------------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
-----------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
56.69
35%
-9
- C3 -
-
1S16
2
PARE_ECOLI
B:
[4-383]
------------
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
-----
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
--
R
D
G
Q
V
Y
N
I
A
F
E
N
G
E
K
-
V
Q
D
L
Q
V
V
--
G
--
T
CG
K
--
R
N
--
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
-----
N
N
--------
T
E
-
Q
R
---------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
P
F
I
G
N
F
A
-
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
-
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
-
R
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.53
50%
12
- C3 -
-
4PRV
1
GYRB_ECOLI
A:
[16-380]
------------------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
--
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
--
E
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
------
E
---
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-------------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
55.30
37%
-17
- C3 -
-
4HXZ
1
PARE_FRATH
A:
[8-381]
-----------------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
T
N
I
-----
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-----------------
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
--
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
E
I
I
--
D
NV
G
--
K
--
K
N
--
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
-----
K
K
--------
E
K
-
L
T
---------------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
-
T
L
P
A
E
P
F
I
I
D
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
E
D
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
N
S
L
S
V
-
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
I
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.65
85%
-82
- C3 -
-
4KSG
2
GYRB_ENTFA
A:
[1-207]
------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
--
K
D
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
-
V
D
D
L
K
V
I
--
E
--
E
--
T
--
D
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
-----
E
G
Q
------
E
D
K
-
K
E
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.63
85%
-86
- C3 -
-
4K4O
2
GYRB_ENTFA
A:
[1-207]
------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
--
K
D
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
-
V
D
D
L
K
V
I
--
E
--
E
--
T
--
D
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
-----
E
G
Q
------
E
D
K
-
K
E
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.72
85%
-85
- C3 -
-
4HXW
2
GYRB_ENTFA
A:
[1-207]
------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
--------------------------
V
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
--
K
D
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
-
V
D
D
L
K
V
I
--
E
--
E
--
T
--
D
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
-----
E
G
Q
------
E
D
K
-
K
E
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.52
64%
-76
- C3 -
-
4URM
1
?
A:
[25-231]
-------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
--------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
52.39
64%
-76
- C3 -
-
4URM
1
?
B:
[25-231]
-------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
F
G
-------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
50.67
64%
-83
- C3 -
-
4URO
2
GYRB_STAAU
D:
[25-230]
-------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
------
P
A
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.50
64%
-81
- C3 -
-
4URM
2
?
C:
[25-231]
-------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
50.32
64%
-75
- C3 -
-
4URO
1
GYRB_STAAU
B:
[26-231]
--------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
49.79
64%
-80
- C3 -
-
4URO
1
GYRB_STAAU
A:
[26-231]
--------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
--------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
49.73
64%
-75
- C3 -
-
4URO
1
GYRB_STAAU
C:
[25-230]
-------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
----------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
48.80
64%
-71
- C3 -
-
4URM
1
?
D:
[26-231]
--------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
--
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
-
Q
F
D
L
K
E
V
--
G
--
T
--
T
--
D
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
------
N
V
R
E
D
S
---------------
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Fugue
43.51
48%
-69
- C3 -
-
1EI1
1
GYRB_ECOLI
A:
[220-391]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
-
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
-
N
I
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Fugue
38.33
49%
17
* C3 *
-
1EI1
4
GYRB_ECOLI
A:
[1-219]
----------
S
N
S
S
D
S
S
S
I
K
-
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
--HC
K
E
I
I
V
T
I
H
A
-D
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-------NSYKVSG
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
RE
G
K
I
H
R
Q
I
Y
E
--
H
G
V
P
-
Q
A
P
L
A
V
T
--
G
--
E
--
T
----E
K
T
G
T
M
V
R
F
W
P
SLETFT-------
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-
K
-----
R
D
--------
G
K
-
E
D
---------------
H
F
H
Y
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------