@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZF2: (2018-01-14 )
MNIEKMTTTLQEAIAEAQQIAVTRKHQDIDIAHVWKIFLQSNHFGRNFYTDAGLDVESFEHEIDRLLDEYPVVSGGNVQYGQNLSQNFFRLLNEADQIRESFGDEFLSTEVVILALMKLKNYPLTVYLNKNGLSEKELRKNIEEMRGGERVTSQNQEEQYKALEKYGVDLVQQVKSGKMDPIIGRDEEIRDVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIFSLDMGALIAGAKFRGEFEERLKAVLKEVKKSDGRILLFIDEIHNIVGAGKTEGSMDAGNLLKPMLARGELHLIGATTLDEYRQYMEKDKALERRFQKVLVKEPTVEDTISILRGLKERFEIHHGVNIHDNALVAAATLSDRYITDRFLPDKAIDLIDEASATIRVEMNSMPTELDQVTRRLMQLEIEEAALKKESDDASKKRLKNLQEELAELREEANAMKMQWETEKEEVNSVSAKRAEIDKAKHELEDAENNYDLERAAVLRHGTIPQLEKELKELEAKAKDSEIKMVQESVTENEIAQVVGRLTGIPVTKLVEGEREKLIKLNETLHKRVIGQDEAVDAVSDAVIRSRAGLQDPNRPLGSFLFLGPTGVGKTELAKALAENLFDSEDHMVRIDMSEYMEKHAVSRLVGAPPGYVGYEEGGQLTEAVRRNPYTIVLLDEIEKAHPDVFNILLQVLDDGRLTDSKGRVVDFKNTVLIMTSNIGSQLLLEGVTADGTIPEAVAEQVNTLLRGNFKPEFLNRIDDTILFTPLSLDNVKGIVDKMVAQLAQRLEHQEILLTISDEAKTWIAENAYEPAYGARPLKRFITKEVETPLAKEIVAGHVMPKSKVTITLLDGQLHFKTEELEEIV
Atome Classification :
(24 SA)
.........10........20........30....-....40...-..-----....50........60........70........80........90........100.......110.......120.--......130.......140.....----.-.---150.......--160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.--......440.......450.......460.......470.......480.......490.......500.......510.....-..520......-.530.--......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730......------.740-----........750.......760.......770.......780.......790...--....800.......810.......820.......830.......840.......850.......860.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
I
E
K
M
T
T
T
L
Q
E
A
I
A
E
A
Q
Q
I
A
VTRKHQDI
D
I
A
H
V
W
-
K
I
F
L
Q-SNH-FG-----RNFYTDAGL
D
V
E
S
F
E
H
E
I
D
R
L
L
D
EYPVVSGGNVQYG
Q
N
L
S
Q
N
F
F
R
L
L
N
E
A
D
Q
I
R
E
S
F
G
D
E
F
L
S
T
E
V
V
I
L
A
L
M
K
LKNY
P
--
L
T
V
Y
LNKNGL
S
E
K
E
L
R
K
N
I
E
E
MRG----G-E---RVTSQ
N
Q
E
E
Q
--
Y
K
A
L
E
K
Y
G
V
D
L
V
Q
Q
V
KSGKMDPIIGR
D
E
E
I
R
D
V
I
R
I
L
S
R
KTKNN
P
V
L
I
GEPGV
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
R
K
DVPENLKD
K
T
I
F
S
L
D
M
G
A
L
I
AGAKF
R
G
E
F
E
E
R
L
K
A
V
L
K
E
V
K
KSD
G
R
I
L
L
F
I
D
E
I
H
N
I
V
GAGKTEGSM
D
A
G
N
L
L
K
P
M
LARG
E
L
H
L
I
GAT
T
L
D
E
Y
R
Q
Y
M
E
K
D
K
A
L
E
R
R
F
Q
K
V
L
VKEP
T
V
E
D
T
I
S
I
L
R
G
L
K
E
R
F
E
IHHGVNIHDN
A
L
V
A
A
A
TLSDRYITDRFL
P
D
K
A
I
D
L
I
DEAS
A
T
I
R
V
EMNSMP
T
E
L
D
Q
V
T
R
R
L
M
Q
L
E
I
E
E
A
A
LKK--ESD
D
A
S
K
K
R
L
K
N
L
Q
E
E
L
A
E
L
R
E
E
A
N
A
M
K
M
Q
WE
T
E
K
E
E
V
N
S
V
S
A
K
R
A
E
I
D
K
A
K
H
E
L
E
DAENNY
D
L
E
R
A
A
V
LRHGT
I
P
Q
L
E
K
E
L
K
E
-
L
E
AKAKD
S
E
I
K
-
M
V
Q
E
S--V
T
E
N
E
I
A
Q
V
V
G
R
LTGI
P
V
T
K
LVEG
E
R
E
K
L
I
K
L
N
E
T
L
H
K
R
VIG
Q
D
E
A
V
D
A
V
S
D
A
V
I
R
S
RAGLQDPNRPLG
S
F
L
F
LGPTGV
G
K
T
E
L
A
K
A
L
A
E
NLFDSED
H
M
V
R
I
D
M
S
E
Y
M
E
K
H
A
V
S
R
L
VGAPPGYVGYEEGG
Q
L
T
E
A
V
RRNP
Y
T
I
V
L
L
D
E
I
E
K
AH
P
D
V
F
N
I
L
L
Q
VLDDGRLTDSKG
R
V
V
D
FK
N
T
V
L
I
M
TSNI
G
S
Q
L
L
L
EGVTADGT
I
------
P
E
A
------
V
A
E
Q
V
N
T
L
L
RGNF
K
P
E
F
L
N
RIDD
T
I
L
FTPL
S
L
D
N
V
K
G
I
V
D
K
M
V
A
Q
L
A
Q
R
LEH
Q
E
--
I
L
L
T
ISDE
A
K
T
W
I
AENAYEPAYG
A
R
P
L
K
R
F
I
T
K
EVET
P
L
A
K
E
I
V
AGHVMPK
S
K
V
T
I
T
L
LD
G
Q
L
H
F
K
T
E
E
L
E
E
IV
98
Fugue
97.85
54%
0
- C- -
-
1QVR
-
CLPB_THET8
A:
[4-850]
---
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
-
A
V
L
L
K
-
D
E
R
S
L
A
-----
W
R
L
L
E
K
A
G
A
D
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
--
K
V
E
G
A
E
V
G
Q
Y
L
T
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
K
D
R
Y
V
A
V
D
T
L
V
L
A
L
A
E
A
-----------
T
P
G
L
P
G
L
E
A
L
K
G
A
L
K
E
L
R
G
----
G
-
R
---
T
V
Q
T
E
H
A
E
S
T
--
Y
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
Q
M
-----------
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
S
Q
G
E
V
I
L
F
I
D
E
-------------------
L
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
L
E
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
--
E
K
D
P
D
S
Q
E
R
L
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
Y
D
L
N
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
-
L
S
E
K
L
R
G
A
--
R
-
F
V
R
L
E
--
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
-----
109
HHSearch
73.50
46%
35
- C2 -
-
3J3U
-
CLPC_BACSU
B:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
-
L
G
L
V
R
E
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
-----
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
--
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
----
S
N
E
TGS
S
A
A
G
T
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
---------
V
Q
--------------
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
------
E
Q
V
E
D
---------------------------
T
K
K
S
W
K
---------
E
K
Q
G
-
Q
E
N
S
E
--
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
Q
D
E
T
Q
N
H
K
D
------
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
4
PsiBlast_PDB
73.02
44%
42
- C2 -
-
3J3U
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
-
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
-
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
----
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
--
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
SNET
G
-
S
---
S
A
A
G
T
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
-------------------------------
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
-------------------------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
-----
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
-
Q
G
Q
E
N
SE
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
------
Q
D
E
TQNHKD
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
3
PsiBlast_PDB
71.96
44%
41
- C2 -
-
3J3R
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
-
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
-
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
----
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
--
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
SNET
G
-
S
---
S
A
A
G
T
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
-------------------------------
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
-------------------------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
-----
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
-
Q
G
Q
E
N
SE
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
------
Q
D
E
TQNHKD
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
2
PsiBlast_PDB
71.58
44%
41
- C2 -
-
3J3T
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
-
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
-
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
----
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
--
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
SNET
G
-
S
---
S
A
A
G
T
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
-------------------------------
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
-------------------------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
-----
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
-
Q
G
Q
E
N
SE
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
------
Q
D
E
TQNHKD
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
1
PsiBlast_PDB
70.11
44%
47
- C2 -
-
3J3S
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
-
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
-
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
----
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
--
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
SNET
G
-
S
---
S
A
A
G
T
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
E
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
-------------------------------
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
-------------------------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
-----
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
-
Q
G
Q
E
N
SE
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
------
Q
D
E
TQNHKD
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
110
HHSearch
69.41
46%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
-
L
G
L
V
R
E
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
-----
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
AA
R
V
L
N
--
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
----
S
N
E
TGS-----
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
--------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
-----------------------------
V
Q
S
Q
E
F
E
K
A
A
S
----
L
R
D
T
E
Q
R
L
R
E
------------------------------
Q
V
E
D
-
T
K
K
S
W
K
-
E
K
Q
G
-
Q
---
E
--
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
---------------------------
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
T
A
-----
6
PsiBlast_PDB
68.65
41%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
-
G
E
G
-
I
A
-----
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
-
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
----
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
--
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
SNET
G
-
S
--------
N
S
N
A
N
--
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
------------
A
--------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
-------------------------------
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
-------------------------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
-----
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
-
Q
G
Q
E
---
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
---------------------
S
------
E
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
--
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
-------
25
PsiBlast_CBE
65.94
61%
-151
- C2 -
-
4LJ7
1
CLPB_THET8
B:
[34-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
10
PsiBlast_PDB
65.55
61%
-148
- C2 -
-
4LJ7
1
CLPB_THET8
A:
[30-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
22
PsiBlast_CBE
65.34
40%
41
- C2 -
-
5KNE
2
HS104_YEAST
D:
[13-852]
----------------
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
-
A
A
F
I
E
-
T
P
E
-
D
G
SVPYL
Q
N
L
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
--
F
N
D
S
S
--
I
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
I
K
Q
Q
A
L
E
L
R
G
----
N
-
T
---
R
I
D
S
R
G
A
D
T
N
TP
L
E
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
-------
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
--------
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
DE
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
----------------------------------------------------------------S
M
I
Q
N
V
--
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
----
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
--
N
S
Q
Q
G
S
K
I
------
Q
E
S
------
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
Q
N
D
KH
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
------------------
115
HHSearch
64.57
61%
-143
- C2 -
-
4FCV
1
CLPB_THET8
A:
[7-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
-------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
24
PsiBlast_CBE
64.52
61%
-156
- C2 -
-
4LJ7
1
C:
[34-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
9
PsiBlast_PDB
64.06
61%
-141
- C2 -
-
4LJ5
1
A:
[6-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
16
PsiBlast_PDB
63.88
59%
-154
- C2 -
-
4FCW
1
CLPB_THET8
A:
[16-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
21
PsiBlast_CBE
63.40
40%
-11
* C2 *
-
5KNE
3
HS104_YEAST
E:
[160-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
-------
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
--------
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
DE
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
----------------------------------------------------------------S
M
I
Q
N
V
--
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
-----
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
--
N
S
Q
Q
G
S
K
I
------
Q
E
S
------
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
Q
N
D
KH
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
------------------
8
PsiBlast_PDB
63.38
61%
-139
- C2 -
-
4LJ4
-
A:
[6-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
-
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
15
PsiBlast_PDB
62.91
59%
-144
- C2 -
-
4FCV
1
CLPB_THET8
A:
[16-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
14
PsiBlast_PDB
62.80
60%
-151
- C2 -
-
4FD2
1
CLPB_THET8
A:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
27
PsiBlast_CBE
62.79
60%
-153
- C2 -
-
4FD2
1
CLPB_THET8
B:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
113
HHSearch
62.77
61%
-128
- C2 -
-
4LJ9
1
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
11
PsiBlast_PDB
62.60
61%
-128
- C2 -
-
4LJ9
1
A:
[6-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
26
PsiBlast_CBE
62.59
60%
-152
- C2 -
-
4FD2
1
D:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------
12
PsiBlast_PDB
61.99
61%
-137
- C2 -
-
4LJA
2
A:
[6-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
------
Y
E
R
------
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
--
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
---------