@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZI1: (2018-01-14 )
MILTITMNPSIDSIYFTKHFELGTMTRFDSPVRYVGGKGINCGRASALLGSSVILTGFLGGYFGSMIQDMLKNENLFDLHFLPIAEESRGAVTIMHDDETQTELVEAGPEIADTTIKKLMNDIKLISKNNYLSVITINGSVNNPDPFLYAKLLQYIKEQIDPSTYILMDISGQHLREVLASKYKPMFIKPNIHEFSDIIHQKITQKSDIKHHLKTNPLFKDIDVIMISCGSYGAVVKVKEEFWNVEIPKIPIINTTGSGDATVGGFAHSLEQNYPLKECVRYAMACGMSNAQQSEVGKVIPADVKNLAKSIKITEMK
Atome Classification :
(20 SA)
.........10.......-.20-........30........40........50........60.-.......70........80....-.-...90........100-...---.-..----------..110.......120.-......130.......140---..-..-.-.----.150.......160.......170...---..-..180..-.....190.......200..-.--.--...210.......220-........230.......240.......250.......260.......270.......280.......290.......300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
L
T
I
TMNPSI
D
S
I
Y
F
T
K
-
H
FE-LGTMTRFDSP
V
R
YVGGKGINCG
R
A
S
A
LLG
S
S
V
I
L
T
G
F
L
G
G
Y
-
F
G
S
M
I
Q
D
M
LKNENL
F
D
L
H
F
L
PIA-E-ESR
G
A
V
T
I
M
HDDE
T
-
Q
-
T
E
L
---
V
-EA----------GPE
I
A
D
T
T
I
K
K
L
M
N
D
I
-
K
L
ISKNN
Y
L
S
V
I
T
INGSVN---NP-
D
P
-
F
-
L
----
Y
A
K
L
L
Q
Y
I
K
E
QIDPS
T
Y
I
L
M
DIS
G
Q
H
L
---
R
E
-
V
L
A
SKYK-
P
M
F
IKP
N
I
H
E
F
S
D
I
I
H
Q
KIT-
Q
--
K
--
S
D
I
K
H
H
LKTNPLFKD--I
D
V
I
M
I
SCGSY
G
A
V
V
K
V
K
E
E
FWNVEIPKI
P
I
I
NTTGSGDA
T
V
G
G
F
A
H
S
L
EQNY
P
L
K
E
C
V
R
Y
A
M
ACGMSNA
Q
Q
S
EVGKV
I
P
A
D
V
K
N
L
A
K
SIKITEMK
2
PsiBlast_PDB
77.72
35%
-43
- C1 -
-
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
-
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
-
F
T
S
I
K
-
E
-
E
T
R
D
S
I
A
I
L
H
E
G
-
N
-
Q
-
T
E
I
---
L
-
E
A
----------
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
-
D
Q
L
I
K
Q
--
A
E
I
V
T
I
S
G
S
L
A
---
K
G
-
L
P
-
S
D
F
----
Y
Q
E
L
V
Q
K
A
H
A
Q
---
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
Q
-
V
L
Q
G
P
W
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
-
E
--
N
P
L
A
A
V
Q
T
A
L
-
T
K
P
M
F
A
G
--
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
-
1
PsiBlast_PDB
77.71
35%
-41
- C1 -
-
2AWD
-
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
-
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
-
F
T
S
I
K
-
E
-
E
T
R
D
S
I
A
I
L
H
E
G
-
N
-
Q
-
T
E
I
---
L
-
E
A
----------
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
-
D
Q
L
I
K
Q
--
A
E
I
V
T
I
S
G
S
L
A
---
K
G
-
L
P
-
S
D
F
----
Y
Q
E
L
V
Q
K
A
H
A
Q
---
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
Q
-
V
L
Q
G
P
W
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
-
E
--
N
P
L
A
A
V
Q
T
A
L
-
T
K
P
M
F
A
G
--
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
-
79
HHSearch
76.56
37%
-5
- C1 -
-
2F02
1
LACC_ENTFA
B:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
-
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
-
I
P
Q
A
F
T
S
I
K
-
E
-
E
T
R
D
S
I
A
I
L
H
E
G
-
N
-
Q
-
T
E
I
---
L
-
E
A
----------
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
---
A
E
I
V
T
I
S
G
S
L
A
---
K
G
L
P
S
-
D
-
F
----
Y
Q
E
L
V
Q
K
A
H
---
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
Q
-
V
L
Q
G
P
W
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
-
E
NP
L
--
A
A
V
Q
T
A
L
T
K
P
M
F
-
A
G
--
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
-
78
HHSearch
75.83
37%
-1
- C1 -
-
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
-
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
-
I
P
Q
A
F
T
S
I
K
-
E
-
E
T
R
D
S
I
A
I
L
H
E
G
-
N
-
Q
-
T
E
I
---
L
-
E
A
----------
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
---
A
E
I
V
T
I
S
G
S
L
A
---
K
G
L
P
S
-
D
-
F
----
Y
Q
E
L
V
Q
K
A
H
---
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
Q
-
V
L
Q
G
P
W
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
-
E
NP
L
--
A
A
V
Q
T
A
L
T
K
P
M
F
-
A
G
--
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
-
83
HHSearch
74.79
32%
-47
- C1 -
-
2ABQ
-
?
A:
[1-304]
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
-
N
F
Q
-
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
-
I
G
L
S
F
I
E
V
E
-
G
-
D
T
R
I
N
V
K
I
K
G
K
--
Q
-
E
-
T
E
L
---
N
-
G
T
----------
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
-
T
E
L
E
K
---
G
D
V
L
V
L
A
G
S
V
P
---
Q
A
M
P
Q
-
T
-
I
----
Y
R
S
M
T
Q
I
A
K
---
E
R
G
A
F
V
A
V
D
T
S
G
E
A
L
---
H
E
-
V
L
A
--
A
K
-
P
S
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
-
S
--
I
--
E
D
A
I
P
H
V
Q
R
L
I
G
-
E
G
--
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
I
K
K
7
PsiBlast_PDB
74.23
29%
-57
- C1 -
-
2JG5
-
?
A:
[1-280]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
-
D
F
K
-
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
-
Q
S
N
F
I
E
V
D
-
E
-
D
T
R
I
N
V
K
L
K
T
G
Q
E
----
T
E
I
---
N
-
A
P
----------
G
P
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
-
K
N
T
T
S
E
D
---
I
V
I
V
A
G
S
V
P
---
S
S
-
I
P
-
S
D
A
----
Y
A
Q
I
A
Q
I
T
A
Q
T
---
G
A
K
L
V
V
D
A
E
K
E
L
A
---
E
S
-
V
L
--
P
Y
H
-
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
-
S
--
D
--
A
D
V
---
I
K
Y
G
R
L
L
V
D
K
G
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
--------------------------
3
PsiBlast_PDB
74.00
31%
-25
- C1 -
-
2JGV
-
LACC_STAA8
A:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
-
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
-
F
Y
N
I
K
-
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
-
T
E
I
---
L
-
E
Q
----------
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
---
V
E
A
V
A
I
S
G
S
L
P
K
GL
N
Q
-
D
----
Y
----
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
---
V
I
L
D
C
S
G
A
T
L
---
Q
T
-
V
L
E
N
P
Y
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
--
L
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
--
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
-
6
PsiBlast_PDB
73.68
32%
-59
* C1 *
-
2ABQ
-
?
A:
[2-280]
-
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
-
N
F
Q
-
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
-
G
L
S
F
I
E
V
E
-
G
-
D
T
R
I
N
V
K
I
K
G
K
Q
E
----
T
E
L
---
N
-
G
T
----------
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
-
T
E
L
E
K
G
D
---
V
L
V
L
A
G
S
V
P
---
Q
A
-
M
P
Q
T
-
I
----
Y
R
S
M
T
Q
I
A
K
E
R
---
G
A
F
V
A
V
D
T
S
G
E
A
L
---
H
E
-
V
L
A
A
--
K
-
P
S
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
-
S
--
I
--
E
D
A
I
P
H
V
Q
-
R
L
I
G
E
G
--
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
--------------------------
80
HHSearch
72.55
32%
-17
- C1 -
-
2JGV
-
LACC_STAA8
A:
[21-330]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
-
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
-
I
K
H
A
F
Y
N
I
K
-
G
-
E
T
R
N
C
I
A
I
L
H
E
G
-
Q
-
Q
-
T
E
I
---
L
-
E
Q
----------
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
---
V
E
A
V
A
I
S
G
S
L
P
---
K
G
L
N
Q
-
D
-
Y
----
Y
A
Q
I
I
E
R
C
Q
---
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
-
N
P
---
Y
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
--
L
--
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
G
--
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
-
5
PsiBlast_PDB
72.51
30%
-33
- C1 -
-
2JG1
1
LACC_STAA8
A:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
-
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
-
F
Y
N
I
K
-
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
-
T
E
I
---
L
-
E
Q
----------
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
-
E
Q
M
M
E
K
--
V
E
A
V
A
I
S
G
S
L
P
K
GL
N
Q
-
D
----
Y
----
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
---
V
I
L
D
C
S
G
A
T
L
---
Q
T
-
V
L
E
N
P
Y
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
--
L
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
--
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
-
81
HHSearch
70.63
28%
-21
- C1 -
-
2JG5
-
?
B:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
-
D
F
K
-
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
-
I
Q
S
N
F
I
E
V
D
-
E
-
D
T
R
I
N
V
K
L
K
T
---
G
-
Q
E
T
E
I
---
N
-
A
P
----------
G
P
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
-
K
N
T
T
S
---
E
D
I
V
I
V
A
G
S
V
P
---
S
S
I
P
S
-
D
-
A
----
Y
A
Q
I
A
Q
I
T
A
---
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
A
---
E
S
-
V
L
---
P
Y
H
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
-
S
--
D
--
A
D
V
I
K
Y
G
R
L
L
V
D
-
K
G
--
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
-
4
PsiBlast_PDB
69.99
31%
-24
- C- -
-
2Q5R
-
LACC_STAAC
A:
[2-310]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
-
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
-
F
Y
N
I
K
-
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
-
T
E
I
---
L
-
E
Q
----------
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
---
V
E
A
V
A
I
S
G
S
L
P
K
GL
N
Q
-
D
----
Y
----
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
---
V
I
L
D
C
S
G
A
T
L
---
Q
T
-
V
L
E
N
P
Y
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
--
L
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
--
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
-
77
HHSearch
69.68
31%
1
- C1 -
-
2JG1
2
LACC_STAA8
B:
[21-330]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
-
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
-
I
K
H
A
F
Y
N
I
K
-
G
-
E
T
R
N
C
I
A
I
L
H
-
E
-
G
-
Q
Q
T
E
I
---
L
-
E
Q
----------
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
---
V
E
A
V
A
I
S
G
S
L
P
---
K
G
L
N
Q
-
D
-
Y
----
Y
A
Q
I
I
E
R
C
Q
---
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
-
N
P
---
Y
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
--
L
--
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
G
--
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
-
85
HHSearch
63.02
23%
6
- C1 -
-
3UMO
4
PFKB_ECOLI
B:
[3-308]
R
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
-
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
-
V
P
V
A
T
V
E
A
K
-
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
-
G
-
E
Q
Y
R
F
---
V
-
M
P
----------
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
---
G
A
I
L
V
I
S
G
S
L
P
---
P
G
V
K
L
-
E
-
K
----
L
T
Q
L
I
S
A
A
Q
---
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
SA-
A
L
-
A
I
---
G
N
-
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
--
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
--
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
G
T
R
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
-----
84
HHSearch
62.49
27%
1
- C1 -
-
3Q1Y
1
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
-
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
D
-
K
L
Y
A
I
L
K
E
K
H
-
I
N
H
D
F
L
V
E
A
G
T
-
S
T
R
E
C
F
V
V
L
S
D
D
-
T
N
G
S
T
M
I
---
P
-
E
A
----------
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
---
E
D
M
V
V
I
A
G
S
P
P
---
P
H
Y
T
L
-
S
-
D
----
F
K
E
L
L
R
T
V
K
---
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
L
---
N
L
A
V
E
---
M
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
--------
S
L
E
E
N
I
R
T
L
A
E
--
K
--
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
A
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
-
14
PsiBlast_PDB
62.31
25%
4
- C1 -
-
3Q1Y
1
?
A:
[3-288]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
E
L
E
-
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
-
T
-
S
T
R
E
C
F
V
V
L
S
D
D
T
N
-
G
-
S
T
M
---
I
P
E
A
----------
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
---
M
V
V
I
A
G
S
------
P
-
P
P
-
H
-
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
---
G
A
F
L
G
C
D
N
S
G
E
Y
L
---
N
---
L
A
V
E
M
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
--------
N
S
L
E
E
N
I
R
T
--
L
A
E
K
--
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
A
V
M
Q
Q
D
----------------------
82
HHSearch
62.17
27%
3
- C1 -
-
3IE7
2
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
-
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
D
-
K
L
Y
A
I
L
K
E
K
H
-
I
N
H
D
F
L
V
E
A
G
T
-
S
T
R
E
C
F
V
V
L
S
D
D
-
T
N
G
S
T
M
I
---
P
-
E
A
----------
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
---
E
D
M
V
V
I
A
G
S
P
P
---
P
H
Y
T
L
-
S
-
D
----
F
K
E
L
L
R
T
V
K
---
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
L
---
N
L
A
V
E
---
M
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
--------
S
L
E
E
N
I
R
T
L
A
E
--
K
--
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
-
15
PsiBlast_PDB
62.17
25%
5
- C1 -
-
3IE7
2
?
A:
[3-288]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
E
L
E
-
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
-
T
-
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
-
T
M
I
---
P
-
E
A
----------
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
-
A
K
K
V
K
K
E
D
M
V
V
I
-----
A
G
---
S
P
-
P
P
-
H
-
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
---
G
A
F
L
G
C
D
N
S
G
E
Y
L
---
N
---
L
A
V
E
M
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
--------
N
S
L
E
E
N
I
R
T
--
L
A
E
K
--
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
----------------------
86
HHSearch
61.73
23%
6
- C1 -
-
3UQD
4
PFKB_ECOLI
D:
[3-308]
R
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
-
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
-
V
P
V
A
T
V
E
A
K
-
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
-
G
-
E
Q
Y
R
F
---
V
-
M
P
----------
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
---
G
A
I
L
V
I
S
G
S
L
P
---
P
G
V
K
L
-
E
-
K
----
L
T
Q
L
I
S
A
A
Q
---
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
SA-
A
L
-
A
I
---
G
N
-
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
--
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
--
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
G
T
R
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
-----
10
PsiBlast_PDB
60.67
27%
1
- C1 -
-
3N1C
2
PFKB_ECOLI
A:
[4-283]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
-
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
------
V
P
V
A
---------
T
V
E
A
K
D
W
T
-
R
-
Q
N
L
H
V
H
V
-
E
A
SG
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
---
A
I
L
V
I
S
G
S
L
-----
P
-
P
G
-
V
-
K
----
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
A
-
A
L
A
I
G
N
I
-
E
L
-
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
--
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
--
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
------------------------------