@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZK4: (2018-01-15 )
MSNRMILNETSYFGKGAIESIVPEFQQRGFGKAAVITDKGLIEHGIATKVTELLDKAAIAYALYDGIVPNPTIQNVKDGVAFVKEAEADCLIAIGGGSPIDTAKAIGIILTNPEFSDVISLEGVADTKNPCLPILAIPTTSGTAAEVTINYVITDEVNHRKFVCVDPHDIPIVAFIDSDMMMGMPKKLAASTGMDAMTHAIEGFITKGAWEMTDMLHLKAIEIIGHSLEVSVDGDQNGREKMALGQYIAGMGFSNVGLGLVHGMAHPLSAWYNIPHGVACAALLPTVMKYNKEYTGEKYREIALVLGIKGAAEMSLEDVREAACGEIDRLSKAVGIPETISELGVKEADIPAIAEDALRDVCTPGNPRETTVEEIIALYQSLM
Atome Classification :
(20 SA)
.....---....10........20........30........40--.--.......50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......--230-.--.--...--..240.......250.......260.......270.......280.......290.......300......-------.310.......320.......330.......340.......350.......360..-.....370.......380.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSN
R
M
---
I
LNETSYFGK
G
A
I
E
S
I
V
P
E
F
Q
Q
RGFG
K
A
A
V
I
TD
K
G
L
--
I
--EHG
I
A
T
K
V
T
E
L
L
D
K
A
A
I
A
Y
A
L
Y
DGIVPNP
T
I
Q
N
V
K
D
G
V
A
F
V
K
EAEA
D
C
L
I
A
IGGGSPIDT
A
K
A
I
G
I
I
L
TNPEFS
D
V
I
S
LEGVADTKNP
C
L
P
I
L
A
I
PTTSG
T
A
A
E
V
T
I
N
Y
V
ITDEVNH
R
K
F
V
C
VDPHD
I
P
I
V
A
F
ID
S
D
M
M
MG
M
P
K
K
L
A
AST
G
M
D
A
M
T
H
A
I
E
G
F
I
TKGA
W
E
M
T
D
M
L
H
L
K
A
I
E
IIG
H
S
L
E
--
V
S
V-D--G--DQN--G
R
E
K
M
A
L
G
Q
Y
I
A
GMGF
S
N
V
G
L
G
L
V
H
GMA
H
P
L
S
A
W
YNIP
H
G
V
A
C
A
A
L
L
P
T
V
M
K
YNKEYT
G
E
K
Y
R
E
I
A
L
V
L
GI-------KG
A
A
EM
S
L
E
D
V
R
E
A
AC
G
E
I
D
R
L
S
K
AVGI
P
E
T
I
S
ELGVKEADI
P
A
I
A
E
D
A
L
R
D
VCTP-GNPRE
T
T
V
E
E
I
I
A
L
Y
Q
SLM
1
PsiBlast_PDB
99.05
62%
-115
- C4 -
-
2BI4
1
FUCO_ECOLI
A:
[11-390]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
22
PsiBlast_CBE
98.53
62%
-112
- C4 -
-
2BI4
1
FUCO_ECOLI
B:
[11-390]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
21
PsiBlast_CBE
97.52
62%
-113
- C4 -
-
2BL4
1
FUCO_ECOLI
B:
[11-390]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
40
HHSearch
97.21
63%
-113
- C4 -
-
5BR4
3
FUCO_ECOLI
B:
[2-383]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
V
E
G
-
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
39
HHSearch
97.20
63%
-109
- C4 -
-
1RRM
2
FUCO_ECOLI
A:
[2-383]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
V
E
G
-
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
2
PsiBlast_PDB
97.02
62%
-110
- C4 -
-
2BL4
1
FUCO_ECOLI
A:
[11-390]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
23
PsiBlast_CBE
96.77
62%
-111
- C4 -
-
5BR4
3
FUCO_ECOLI
B:
[2-381]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
3
PsiBlast_PDB
96.73
62%
-110
- C4 -
-
5BR4
3
FUCO_ECOLI
A:
[2-381]
M
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
4
PsiBlast_PDB
95.75
60%
-107
- C4 -
-
1RRM
2
FUCO_ECOLI
A:
[3-381]
-
A
N
R
M
---
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
--
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
--
G
S
V
-
A
--
G
--
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
-------
K
-
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
--
37
HHSearch
76.35
39%
-67
- C4 -
-
3OX4
1
ADH2_ZYMMO
B:
[3-383]
-
S
S
T
F
---
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
D
N
--
G
K-
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
-------
D
I
A
N
-
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
5
PsiBlast_PDB
75.95
39%
-80
- C4 -
-
3OWO
-
ADH2_ZYMMO
A:
[14-381]
---------------
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
-
D
--
N
GK
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
DIANLG
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
--------
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
--
38
HHSearch
75.28
41%
-63
- C4 -
-
3BFJ
-
DHAT_KLEPN
J:
[4-387]
R
M
F
D
Y
---
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
K
G
L
--
R
--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
--
E
G
D
L
Y
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
--
Q
A
V
A
L
--
G
S-
N
L
Q
--
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
-------
N
I
T
G
-
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
-
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
26
PsiBlast_CBE
74.75
39%
-77
- C4 -
-
3OX4
1
ADH2_ZYMMO
B:
[14-381]
---------------
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
-
D
--
N
GK
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
DIANLGD
K
E
G
A
E
A
T
I
Q
A
V
R
D
--------
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
--
25
PsiBlast_CBE
74.11
39%
-76
- C4 -
-
3OX4
1
ADH2_ZYMMO
C:
[14-381]
---------------
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
-
D
--
N
GK
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
DIANLGD
K
E
G
A
E
A
T
I
Q
A
V
R
D
--------
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
--
6
PsiBlast_PDB
74.11
39%
-77
- C4 -
-
3OX4
1
ADH2_ZYMMO
A:
[14-381]
---------------
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
-
D
--
N
GK
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
DIANLG
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
--------
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
--
24
PsiBlast_CBE
73.65
39%
-72
- C4 -
-
3OX4
1
ADH2_ZYMMO
D:
[14-381]
---------------
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
M
--
N
--
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
--
T
A
C
-
D
--
N
GK
D
M
P
--
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
DIANLGD
K
E
G
A
E
A
T
I
Q
A
V
R
D
--------
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
--
41
HHSearch
67.22
38%
-11
- C4 -
-
4FR2
-
?
A:
[16-398]
-
A
Y
D
F
---
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
K
F
L
--
E
N
L
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
S
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
--
G
D
D
I
T
K
L
A
G
I
E
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
--
E
A
V
A
N
--
G
H-
N
L
Q
--
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
M
G
E
-------
N
T
D
G
-
L
S
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
D
L
M
A
E
N
A
L
K
D
G
N
A
F
-
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
7
PsiBlast_PDB
65.65
40%
-3
- C4 -
-
3BFJ
-
DHAT_KLEPN
A:
[4-385]
---
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
K
G
L
R----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
--
G
D
L
Y
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
-
G
--
S
--
N
L
Q
--
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
--------
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
-
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
8
PsiBlast_PDB
65.01
37%
-8
- C4 -
-
4FR2
-
?
A:
[19-395]
----
F
---
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
K
F
L
E
N
L
--
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
S
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
D
--
D
I
T
K
L
A
G
I
E
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
--
E
A
V
-
A
--
N
--
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
M
G
--------
E
N
T
D
G
L
S
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
D
L
M
A
E
N
A
L
K
D
G
N
A
F
-
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
---
11
PsiBlast_PDB
61.18
26%
-71
- C4 -
-
3JZD
4
?
A:
[19-350]
---------------
F
G
A
G
S
S
S
Q
V
A
A
E
V
E
R
L
G
A
K
R
A
L
V
L
C
T
P
N
------
Q
Q
A
E
A
E
R
I
A
D
L
L
G
P
--
L
S
A
G
V
Y
A
G
A
V
M
H
V
P
I
E
S
A
R
D
A
T
A
R
A
R
E
A
G
A
D
C
A
V
A
V
G
G
G
S
T
T
G
L
G
K
A
I
A
L
--------------------
E
T
G
M
P
I
V
A
I
P
T
T
Y
-
A
G
S
E
V
T
P
V
Y
G
L
T
E
A
G
T
K
R
--
T
G
R
D
P
R
V
L
P
R
T
V
I
Y
D
P
A
L
T
V
G
L
P
R
G
L
S
V
T
S
A
L
N
A
I
A
H
A
A
E
G
L
Y
A
R
D
A
N
P
V
M
S
L
M
A
E
E
G
I
R
A
L
A
A
G
I
P
--
A
V
F
-
N
DP
A
--
D
L
D
--
A
R
S
Q
C
L
Y
G
A
W
L
C
G
T
V
L
G
G
V
G
M
A
L
H
H
K
L
C
H
T
L
G
G
S
F
N
L
P
H
A
E
T
H
T
I
V
L
P
H
A
L
A
Y
N
A
A
A
V
P
E
A
---
M
A
R
I
R
R
A
-------
T
G
A
G
E
Q
S
-------
A
A
A
T
L
F
D
L
A
Q
R
H
G
A
P
V
A
L
R
D
I
G
M
R
E
E
D
L
D
R
A
A
D
I
A
L
---
A
S
P
Y
W
N
P
R
P
I
E
R
E
P
I
R
A
L
L
Q
A
--