@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZK8: (2018-01-15 )
MQEMETRYTHSPEDIRHYSTEQLRKEFLVEKVFEPGKISLTYTHNDRMIFGGVTPTEKELEITLDKELGVDYFLERRELGVINIGGPGFIEIDGQKEEMKKQDGYYIGKETRHVVFSSQDAENPAKFYISSVPAHHKYPNVKISIDQVKPMETGEGLTLNERKIYQYIHPNVCESCQLQMGYTILEPGSAWNTMPCHTHERRMEAYVYFDYANEDTRVFHMMGKPDETKHLVVDNEQAIISPSWSIHSGVGTSNYSFIWAMCGENITYTDMDMVQMDQLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.--.--..--....70........80........-90........100.....-..110.......120.......130..-.-.--------.--------.-.140------------------------------------..-.---------------------------------.....150.....---.----..-----.160..-.....170-.-..-.....180...-....190....-...200.......210.......220-....-------.---..230.........240.......250-.--.--.....260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQE
M
E
T
RYTH
S
P
E
D
I
R
HY
S
T
E
Q
L
R
K
E
F
L
V
E
KVFEP
G
K
I
S
L
T
Y
THND
R
M
I
FGGVTPTE
K
E
L
E
I
--
T
--
L
D--KEL
G
V
D
Y
F
L
E
RREL
G
V
I
N
IGGP
G
F
-
I
E
IDG
Q
K
E
E
M
K
K
QD
G
Y
Y
I-G
K
E
T
R
H
V
V
FSSQDAENPA
K
F
Y
I
SSVPA-H-H--------K--------Y-P
N
-
V
------------------------------------
K
I
-
S
---------------------------------
I
D
Q
V
KP--METGE---G----LT-----
L
N
E
R
K
I
-
Y
Q
Y
IHP-
N
-
V
-
C
E
-
S
C
Q
LQMG
Y
T
I
L-EPGSAWNTMPC-
H
T
H
E
R
R
M
E
A
Y
V
Y
F
D
YANED
T
R
V
F
H
MM-GKPD-------E---T
K
H
--
L
V
VDNE
Q
A
I
ISPS
W
S
I
HSGVGT-S--N--
Y
S
F
I
W
AMCGENITYTD
M
D
M
V
Q
MDQLK
7
HHSearch
96.00
89%
-88
- C5 -
-
1YWK
-
KDUI1_ENTFA
C:
[999-1259]
-
Q
N
M
E
T
R
Y
T
H
S
P
A
D
I
R
H
Y
S
T
E
Q
L
R
D
E
F
L
V
E
K
V
F
I
P
G
A
I
S
L
T
Y
T
H
N
D
R
M
I
F
G
G
V
T
P
T
T
E
E
L
E
I
--
I
--
L
D
--
K
E
L
G
V
D
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
P
G
F
-
I
E
I
D
G
A
K
E
T
M
K
K
Q
D
G
Y
Y
I
-
G
K
E
T
K
H
V
R
F
S
S
E
N
P
D
N
P
A
K
F
Y
I
S
C
V
P
A
-
H
-
H
--------
K
--------
Y
-
P
N
-
V
------------------------------------
K
I
-
S
---------------------------------
I
D
E
I
T
P
--
M
E
T
G
D
---
P
----
L
T
-----
L
N
Q
R
K
I
-
Y
Q
Y
I
H
P
-
N
-
V
-
C
E
-
S
C
Q
L
Q
M
G
Y
T
I
L
-
E
P
G
S
A
W
N
T
---------
R
M
E
A
Y
V
Y
F
D
M
E
-
E
D
T
R
I
F
H
M
M
-
G
K
P
D
-------
E
---
T
K
H
--
L
V
M
S
N
E
Q
A
A
I
S
P
S
W
S
I
H
S
G
V
G
T
-
S
--
N
--
Y
S
F
I
W
A
M
C
G
-----------------
1
PsiBlast_PDB
95.31
88%
-87
- C5 -
-
1YWK
-
KDUI1_ENTFA
A:
[998-1260]
L
Q
N
M
E
T
R
Y
T
H
S
P
A
D
I
R
H
Y
S
T
E
Q
L
R
D
E
F
L
V
E
K
V
F
I
P
G
A
I
S
L
T
Y
T
H
N
D
R
M
I
F
G
G
V
T
P
T
T
E
E
L
E
I
--
I
--
L
D
--
K
E
L
G
V
D
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
P
G
F
-
I
E
I
D
G
A
K
E
T
M
K
K
Q
D
G
Y
Y
I
-
G
K
E
T
K
H
V
R
F
S
S
E
N
P
D
N
P
A
K
F
Y
I
S
C
V
P
A
-
H
-
H
--------
K
--------
Y
-
P
N
-
V
------------------------------------
K
I
-
S
---------------------------------
I
D
E
I
T
P
--
M
E
T
G
D
---
P
----
L
T
-----
L
N
Q
R
K
I
-
Y
Q
Y
I
H
P
-
N
-
V
-
C
E
-
S
C
Q
L
Q
M
G
Y
T
I
L
-
E
P
G
S
A
W
N
T
---------
R
M
E
A
Y
V
Y
F
D
-
M
E
E
D
T
R
I
F
H
M
M
-
G
K
P
D
-------
E
---
T
K
H
--
L
V
M
S
N
E
Q
A
A
I
S
P
S
W
S
I
H
S
G
V
G
T
-
S
--
N
--
Y
S
F
I
W
A
M
C
G
E
----------------
8
HHSearch
95.16
89%
-88
- C5 -
-
1YWK
-
KDUI1_ENTFA
A:
[998-1260]
L
Q
N
M
E
T
R
Y
T
H
S
P
A
D
I
R
H
Y
S
T
E
Q
L
R
D
E
F
L
V
E
K
V
F
I
P
G
A
I
S
L
T
Y
T
H
N
D
R
M
I
F
G
G
V
T
P
T
T
E
E
L
E
I
--
I
--
L
D
--
K
E
L
G
V
D
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
P
G
F
-
I
E
I
D
G
A
K
E
T
M
K
K
Q
D
G
Y
Y
I
-
G
K
E
T
K
H
V
R
F
S
S
E
N
P
D
N
P
A
K
F
Y
I
S
C
V
P
A
-
H
-
H
--------
K
--------
Y
-
P
N
-
V
------------------------------------
K
I
-
S
---------------------------------
I
D
E
I
T
P
--
M
E
T
G
D
---
P
----
L
T
-----
L
N
Q
R
K
I
-
Y
Q
Y
I
H
P
-
N
-
V
-
C
E
-
S
C
Q
L
Q
M
G
Y
T
I
L
-
E
P
G
S
A
W
N
T
---------
R
M
E
A
Y
V
Y
F
D
M
E
-
E
D
T
R
I
F
H
M
M
-
G
K
P
D
-------
E
---
T
K
H
--
L
V
M
S
N
E
Q
A
A
I
S
P
S
W
S
I
H
S
G
V
G
T
-
S
--
N
--
Y
S
F
I
W
A
M
C
G
E
----------------
9
HHSearch
85.41
53%
-34
- C5 -
-
1XRU
1
KDUI_ECOLI
A:
[2-281]
-
S
A
M
D
V
R
Q
S
I
H
S
A
H
A
K
T
L
D
T
Q
G
L
R
N
E
F
L
V
E
K
V
F
V
A
D
E
Y
T
M
V
Y
S
H
I
D
R
I
I
V
G
G
I
M
P
I
T
K
T
V
S
V
--
G
--
G
E
V
G
K
Q
L
G
V
S
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
A
G
T
-
I
T
V
D
G
Q
C
Y
E
I
G
H
R
D
A
L
Y
V
-
G
K
G
A
K
E
V
V
F
A
S
I
D
T
G
T
P
A
K
F
Y
Y
N
C
A
P
A
-
H
-
T
--------
T
--------
Y
-
P
T
-
K
------------------------------------
K
V
-
T
---------------------------------
P
D
E
V
S
P
--
V
T
L
G
D
---
N
----
L
T
-----
S
N
R
R
T
I
-
N
K
Y
F
V
P
-
D
-
V
-
L
E
-
T
C
Q
L
S
M
G
L
T
E
L
-
A
P
G
N
L
W
N
T
M
P
C
-
H
T
H
E
R
R
M
E
V
Y
F
Y
F
N
M
D
-
D
D
A
C
V
F
H
M
M
-
G
Q
P
Q
-------
E
---
T
R
H
--
I
V
M
H
N
E
Q
A
V
I
S
P
S
W
S
I
H
S
G
V
G
T
-
K
--
A
--
Y
T
F
I
W
G
M
V
G
E
N
Q
V
F
D
D
M
D
H
V
A
V
K
E
I
C
3
PsiBlast_PDB
85.38
50%
-35
- C5 -
-
1XRU
1
KDUI_ECOLI
A:
[4-280]
---
M
D
V
R
Q
S
I
H
S
A
H
A
K
T
L
D
T
Q
G
L
R
N
E
F
L
V
E
K
V
F
V
A
D
E
Y
T
M
V
Y
S
H
I
D
R
I
I
V
G
G
I
M
P
I
T
K
T
V
S
V
--
G
G
E
V
G
--
K
Q
L
G
V
S
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
A
G
T
-
I
T
V
D
G
Q
C
Y
E
I
G
H
R
D
A
L
Y
V
-
G
K
G
A
K
E
V
V
F
A
S
I
D
T
G
T
P
A
K
F
Y
Y
N
C
A
P
A
-
H
-
T
--------
T
--------
Y
-
P
T
-
K
------------------------------------
K
V
-
T
---------------------------------
P
D
E
V
S
P
--
V
T
L
G
D
---
N
----
L
T
-----
S
N
R
R
T
I
-
N
K
Y
F
V
P
-
D
-
V
-
L
E
-
T
C
Q
L
S
M
G
L
T
E
L
-
A
P
G
N
L
W
N
T
M
P
C
-
H
T
H
E
R
R
M
E
V
Y
F
Y
F
N
-
M
D
D
D
A
C
V
F
H
M
M
-
G
Q
P
Q
-------
E
---
T
R
H
--
I
V
M
H
N
E
Q
A
V
I
S
P
S
W
S
I
H
S
G
V
G
T
-
K
--
A
--
Y
T
F
I
W
G
M
V
G
E
N
Q
V
F
D
D
M
D
H
V
A
V
K
E
I
-
29
Fugue
83.95
52%
-43
- C5 -
-
1X8M
-
KDUI_ECOLI
A:
[1002-1268]
--
S
L
D
V
R
Q
S
I
H
S
A
H
A
K
T
L
D
T
Q
G
L
R
N
E
F
L
V
E
K
V
F
V
A
D
E
Y
T
M
V
Y
S
H
I
D
R
I
I
V
G
G
I
M
P
I
T
K
T
V
S
V
G
G
E
--
V
G
--
K
Q
L
G
V
S
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
A
G
T
-
I
T
V
D
G
Q
C
Y
E
I
G
H
R
D
A
L
Y
V
-
G
K
G
A
K
E
V
V
F
A
S
I
D
T
G
T
P
A
K
F
Y
Y
N
C
A
P
A
-
H
-
T
--------
T
--------
Y
-
P
T
-
K
------------------------------------
K
V
-
T
---------------------------------
P
D
E
V
S
P
--
V
T
L
G
D
---
N
----
L
T
-----
S
N
R
R
T
I
-
N
K
Y
F
V
P
-
D
-
V
-
L
E
-
T
C
Q
L
S
M
G
L
T
E
L
-
A
P
G
N
L
W
N
T
---------
R
M
E
V
Y
F
Y
F
N
-
M
D
D
D
A
C
V
F
H
M
M
-
G
Q
P
Q
-------
E
---
T
R
H
--
I
V
M
H
N
E
Q
A
V
I
S
P
S
W
S
I
H
S
G
V
G
T
-
K
--
A
--
Y
T
F
I
W
G
M
V
G
E
N
Q
V
F
------------
2
PsiBlast_PDB
82.82
55%
-48
- C5 -
-
1X8M
-
KDUI_ECOLI
A:
[1019-1268]
-------------------
T
Q
G
L
R
N
E
F
L
V
E
K
V
F
V
A
D
E
Y
T
M
V
Y
S
H
I
D
R
I
I
V
G
G
I
M
P
I
T
K
T
V
S
V
--
G
G
E
V
G
--
K
Q
L
G
V
S
Y
F
L
E
R
R
E
L
G
V
I
N
I
G
G
A
G
T
-
I
T
V
D
G
Q
C
Y
E
I
G
H
R
D
A
L
Y
V
-
G
K
G
A
K
E
V
V
F
A
S
I
D
T
G
T
P
A
K
F
Y
Y
N
C
A
P
A
-
H
-
T
--------
T
--------
Y
-
P
T
-
K
------------------------------------
K
V
-
T
---------------------------------
P
D
E
V
S
P
--
V
T
L
G
D
---
N
----
L
T
-----
S
N
R
R
T
I
-
N
K
Y
F
V
P
-
D
-
V
-
L
E
-
T
C
Q
L
S
M
G
L
T
E
L
-
A
P
G
N
L
W
N
T
---------
R
M
E
V
Y
F
Y
F
N
-
M
D
D
D
A
C
V
F
H
M
M
-
G
Q
P
Q
-------
E
---
T
R
H
--
I
V
M
H
N
E
Q
A
V
I
S
P
S
W
S
I
H
S
G
V
G
T
-
K
--
A
--
Y
T
F
I
W
G
M
V
G
E
N
Q
V
F
------------
24
HHSearch
40.83
13%
-80
- C5 -
-
2PHL
-
PHSB_PHAVU
B:
[239-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
S
S
I
E
M
-
E
E
G
A
---
L
F
V
P
-
H
Y
Y
S
K
A
I
V
I
L
V
--
V
N
E
--
G
E
A
H
V
E
L
V
-
G
P
K
G
ETL
E
Y
E
S
Y
---
R
----
A
E
L
S
K
D
D
V
F
V
I
P
A
A
Y
P
V
A
I
K
A
T
-
S
--
N
--
V
N
F
T
G
F
G
I
N
-----------------
11
HHSearch
40.75
13%
-13
- C5 -
-
1SEF
-
?
A:
[84-257]
---------------------------------------------------------------------------------
I
Q
T
L
-
V
Y
V
I
D
G
R
L
R
-
V
S
D
G
Q
E
T
H
E
L
E
A
G
G
Y
A
Y
F
-
T
P
E
M
K
M
Y
L
A
N
-
A
Q
-
E
A
D
T
E
V
F
L
Y
K
K
R
Y
-
Q
-
P
--------
L
A
G
H
-----
Q
P
Y
K
-
V
------------------------------------
V
G
-
S
---------------------------------
I
H
D
Q
Q
P
--
E
E
Y
E
G
---------------
M
T
D
V
L
L
-
W
S
L
L
P
K
-
E
---
F
--
D
F
D
M
N
M
H
I
L
S
F
-
E
P
G
A
-
S
-
H
A
Y
I
-
E
T
H
V
-
Q
E
H
G
A
Y
--
L
I
S
---
G
Q
G
M
Y
N
L
-
D
--
N
-------
E
---
W
----
Y
P
V
E
K
G
D
Y
I
F
M
S
A
Y
V
P
Q
A
A
Y
A
V
-
G
--
R
E-
E
P
L
M
Y
V
Y
S
K
D
----------------
5
PsiBlast_PDB
40.63
31%
-86
- C5 -
-
3CEW
-
?
A:
[55-103]
-----------------------------------------------------------------------------------------
L
S
G
K
G
F
-
I
T
I
D
G
E
K
I
E
L
Q
A
G
D
W
L
R
I
-
A
P
D
G
K
R
Q
I
S
A
A
S
D
--
S
P
I
G
F
L
C
I
Q
V
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
39.94
11%
-19
- C5 -
-
3RNS
-
?
A:
[58-223]
-----------------------------------------------------------------------------------
N
R
Y
Y
Y
C
F
N
G
N
G
E
-
I
F
I
E
N
N
K
K
T
I
S
N
G
D
F
L
E
I
-
T
A
N
H
N
Y
S
I
-
E
A
R
---
D
N
L
K
L
I
E
I
G
E
K
I
------------------------------------------------------------------------------------------------------
S
A
F
N
LA
E
V
V
E
Y
---
Q
----
E
G
K
----
I
V
S
K
N
----
L
V
--------
A
-
K
P
N
L
V
M
T
I
M
S
F
-
W
K
G
E
---
S
L
D
P
-
H
K
A
P
-
G
D
A
L
V
--
T
V
L
D
---
G
E
G
K
Y
Y
V
-
D
--
G
-------
K
---
P
----
F
I
V
K
K
G
E
S
A
V
L
P
A
N
I
P
H
A
V
E
A
E
-
T
E
-
N
--
F
K
M
L
L
I
--------------------
16
HHSearch
39.79
11%
-27
- C5 -
-
3H7J
1
BACB_BACSU
B:
[55-225]
-----------------------------------------------------------------------------------
V
Q
I
G
M
V
V
S
G
E
L
M
-
M
T
V
G
D
V
T
R
K
M
T
A
L
E
S
A
Y
I
A
P
P
H
V
P
H
G
A
R
N
D
-
T
-
D
Q
E
V
I
A
I
D
I
K
R
L
K
-
A
-
D
--------
E
T-------
Y
-
T
S
-
P
E-----------------------------------
D
Y
-
F
---------------------------------
L
D
I
F
K
T
--
R
D
L
L
P
---------
G
-----
M
E
V
-----
T
F
F
V
---------
E
D
W
V
E
I
M
L
A
K
I
P
G
N
G
G
---
E
M
P
F
-
H
K
H
R
-
N
E
Q
I
G
I
C
I
G
G
----
G
Y
D
M
T
-
V
-
E
--
G
-------
C
---
T
----
V
E
M
K
F
G
T
A
Y
F
C
E
P
R
E
D
H
G
A
I
N
R
-
S
EK
E
--
S
K
S
I
N
I
F
F
P
P
R
Y
N
R
------------
28
HHSearch
39.78
7%
-28
- C5 -
-
1SFN
-
?
B:
[2069-2237]
-----------------------------------------------------------------------------------
Q
R
F
A
F
V
L
S
G
E
V
D
-
V
A
V
G
G
E
T
R
T
L
R
E
Y
D
Y
V
Y
L
-
P
A
G
E
K
H
M
L
T
-
A
K
---
T
D
A
R
V
S
V
F
E
K
P
Y
-
Q
-
T
V-------
E
GVQ-----
A
P
G
V
-
Y
------------------------------------
W
G
-
N
---------------------------------
E
R
E
N
P
G
--
Y
P
F
E
----------
G
-----
D
D
H
L
I
A
-
R
K
L
L
P
--
D
---
E
P
-
A
F
D
F
M
V
S
T
M
S
F
-
A
P
G
A
-
S
-
L
P
Y
A
-
E
V
H
Y
-
M
E
H
G
L
-
L
-
M
L
E
---
G
E
G
L
Y
K
L
-
E
--
E
-------
N
---
Y
----
Y
P
V
T
A
G
D
I
I
W
M
G
A
H
C
P
Q
W
Y
G
A
L
-
G
RN
W
--
S
K
Y
L
L
Y
--------------------
20
HHSearch
39.36
12%
-92
- C5 -
-
1IPK
-
GLCB_SOYBN
C:
[247-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
F
L
S
S
V
D
I
-
N
E
G
A
---
L
L
L
P
-
H
F
N
S
K
A
I
V
I
L
V
I
--
N
E
---
G
D
A
N
I
E
L
V
G
I
K
---------PLE
V
Q
R
Y
R
A
E
L
S
E
D
D
V
F
V
I
P
A
A
Y
P
F
V
V
N
A
T
-
S
--
N
--
L
N
F
L
A
F
--------------------
18
HHSearch
39.06
9%
-26
- C5 -
-
4E2S
1
UGHY_ARATH
D:
[89-258]
--------------------------------------------------------------------------------
D
I
E
R
L
-
I
F
V
V
E
G
A
V
T
-
L
T
N
-
S
S
S
K
K
L
T
V
D
S
Y
A
Y
L
-
P
P
N
F
H
H
S
L
-
D
C
V
---
E
S
A
T
L
V
V
F
E
R
R
Y
-
E
-
Y
--------
L
GSH-----
T
-
T
E
L
I
------------------------------------
V
G
-
S
---------------------------------
T
D
K
Q
P
L
--
L
-
E
T
P
---------
G
------
E
V
F
E
L
-
R
K
L
L
P
--
M
---
S
V
-
A
Y
D
F
N
I
H
T
M
D
F
-
Q
P
G
E
-
F
L
N
V
-
K
-
E
V
H
Y
-
N
Q
H
G
L
--
L
L
L
E
---
G
Q
G
I
Y
R
L
-
G
--
D
-------
N
---
W
----
Y
P
V
Q
A
G
D
V
I
W
M
A
P
F
V
P
Q
W
Y
A
A
L
-
G
--
K
TR
S
R
Y
L
L
Y
--------------------
13
HHSearch
38.17
11%
-17
- C5 -
-
1SQ4
-
?
A:
[89-254]
--------------------------------------------------------------------------------
N
A
E
A
-
V
L
F
V
V
E
G
E
L
S
-
L
T
L
Q
G
Q
V
H
A
M
Q
P
G
G
Y
A
F
I
-
P
P
G
A
D
Y
K
V
-
R
N
T
T
-
G
Q
H
T
R
F
H
W
I
R
K
H
Y
-
Q
-
K
V
D
GV----
P
--------
L
-
P
E
-
A
------------------------------------
F
V
T
N
---------------------------------
E
Q
D
I
Q
P
--
L
-
V
M
P
---------
D
-----
T
E
G
R
W
S
T
T
R
F
V
D
M
-
S
---
D
M
-
R
H
D
M
H
V
N
I
V
N
F
-
E
P
G
G
---
V
I
P
F
A
E
T
H
V
-
M
E
H
G
L
Y
V
L
E
----
G
K
A
V
Y
R
L
--
N
--
Q
-------
D
---
W
----
V
E
V
E
A
G
D
F
M
W
L
R
A
F
C
P
Q
A
C
Y
S
G
-
G
-------------------------------
17
HHSearch
37.89
11%
-29
- C5 -
-
3H9A
1
BACB_BACSU
B:
[55-225]
-----------------------------------------------------------------------------------
V
Q
I
G
M
V
V
S
G
E
L
M
-
M
T
V
G
D
V
T
R
K
M
T
A
L
E
S
A
Y
I
A
P
P
H
V
P
H
G
A
R
N
D
-
T
-
D
Q
E
V
I
A
I
D
I
K
R
L
K
-
A
-
D
--------
E
T-------
Y
-
T
S
-
P
E-----------------------------------
D
Y
-
F
---------------------------------
L
D
I
F
K
T
--
R
D
L
L
P
---------
G
-----
M
E
V
-----
T
F
F
V
---------
E
D
W
V
E
I
M
L
A
K
I
P
G
N
G
G
---
E
M
P
F
-
H
K
H
R
-
N
E
Q
I
G
I
C
I
G
G
----
G
Y
D
M
T
-
V
-
E
--
G
-------
C
---
T
----
V
E
M
K
F
G
T
A
Y
F
C
E
P
R
E
D
H
G
A
I
N
R
-
S
EK
E
--
S
K
S
I
N
I
F
F
P
P
R
Y
N
R
------------
25
HHSearch
37.09
14%
11
- C5 -
-
2D40
-
?
A:
[120-337]
---------------------------------------------------------------------------------
Q
S
A
L
-
R
F
I
V
E
G
K
G
A
F
T
A
V
D
G
E
R
T
P
M
N
E
G
D
F
I
L
T
-
P
Q
W
R
W
H
D
H
G
-
N
P
G
-
D
E
P
V
I
W
L
D
G
L
D
L
P
-
L
V
N
--------
I
L
GC
G
F
A
E
D
Y
-
P
---------------------------------------
Q
Q
-
P
VTRKEG
D
Y
L
P
R
YAANMLPL
R
H
Q
T
G
NSSPIFNYR
Y
D
R
S
R
E
--
V
L
H
D
L
T
R
L
G
D---
A
D
-----
E
W
D
G
Y
K
-
M
R
Y
V
N
P
V
T
-
G
-
G
Y
P
M
P
S
M
G
A
F
L
Q
L
L
-
P
K
G
F
-
A
--
S
R
V
-
A
R
T
T
-
D
S
T
I
Y
H
--
V
V
E
---
G
S
G
Q
V
I
I
-
G
--
N
-------
E
---
T
----
F
S
F
S
A
K
D
I
F
V
V
P
T
W
H
G
V
-
S
F
Q
T
T
Q
--
D
--
S
V
L
F
S
F
--------------------
21
HHSearch
37.09
12%
21
* C5 *
-
3NW4
5
?
A:
[122-349]
--------------------------------------------------------------------------------
S
Q
N
A
F
-
R
F
V
V
E
G
E
G
V
W
T
V
V
N
G
D
P
V
R
M
S
R
G
D
L
L
L
T
-
P
G
W
C
F
H
G
H
M
-
N
D
T
-
D
Q
P
M
A
W
I
D
G
L
D
I
P
F
S
-
Q
Q
M
DV
G
F
F
E
F
--------
G
-
S
D
-
R
VTDYATPNFS
R
G
E
R
L
WCHPGLRPLSGLQNTVASPIG
A
Y
-
R
---------------------------------
W
E
F
T
D
R
--
A
L
T
E
Q
---
L
L
L
E
D
E
G
QPATV
A
P
G
H
A
A
-
I
R
Y
V
N
P
-
T
T
G
G
D
V
-
M
P
T
L
R
C
E
F
H
R
L
-
R
A
G
T
---
E
T
A
T
-
R
N
E
V
-
G
S
T
V
F
Q
--
V
F
E
---
G
A
G
A
V
V
M
-
N
--
G
-------
E
---
T
----
T
K
L
E
K
G
D
M
F
V
V
P
S
W
V
P
W
S
L
Q
A
E
-
T
--
Q
--
F
D
L
F
R
F
S
-------------------
19
HHSearch
36.33
9%
-26
- C5 -
-
4E2Q
-
UGHY_ARATH
M:
[89-258]
--------------------------------------------------------------------------------
D
I
E
R
L
-
I
F
V
V
E
G
A
V
T
-
L
T
N
-
S
S
S
K
K
L
T
V
D
S
Y
A
Y
L
-
P
P
N
F
H
H
S
L
-
D
C
V
---
E
S
A
T
L
V
V
F
E
R
R
Y
-
E
-
Y
--------
L
GSH-----
T
-
T
E
L
I
------------------------------------
V
G
-
S
---------------------------------
T
D
K
Q
P
L
--
L
-
E
T
P
---------
G
------
E
V
F
E
L
-
R
K
L
L
P
--
M
---
S
V
-
A
Y
D
F
N
I
H
T
M
D
F
-
Q
P
G
E
-
F
L
N
V
-
K
-
E
V
H
Y
-
N
Q
H
G
L
--
L
L
L
E
---
G
Q
G
I
Y
R
L
-
G
--
D
-------
N
---
W
----
Y
P
V
Q
A
G
D
V
I
W
M
A
P
F
V
P
Q
W
Y
A
A
L
-
G
--
K
TR
S
R
Y
L
L
Y
--------------------