@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZW1: (2018-01-17 )
MSLQAQLQSLKEATLVKITAAQDLNELNQIRVETLGKKGPITEVLRGMKDLSPEERPKVGSFANEIRDLLTEEIERKKQVLEEEALNAALAKETIDVTLPGRKVKHGTRHIVTQIMEEIEDIFVGMGYQIVEGYEVESDHYNFERMNLPKDHPARDMQDTFYISDEILIRTHTSPVQARTMEKHDFSKGALRMISPGKVFRRDTDDATHSHQFHQIEGLVVDKNITMGDLKGTLEVVMKKMFGKDREIRLRPSYFPFTEPSVEVDVSCFKCGGAGCNVCKYTGWIEILGAGMVHPNVLKMSGIDPEEYSGFAFGLGPDRVAMLRYGVNDIRNFYQNDLRFLSQFKGE
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100--........110.......120.......130.---------......140.......150.......160..---------------.---------------.---------------...170.......180.......190.......200.......210.......220-----------------------------------.......230.......240.......250.......260.......270.......280.......290.......300------....--.---------.--..310.......320.......330.......340.....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
Q
A
Q
L
Q
S
LKE
A
T
L
V
K
I
T
A
A
Q
D
L
N
E
L
N
Q
I
R
V
E
TLGKKG
P
I
T
E
V
L
R
G
M
KDL
S
P
E
ERPKV
G
S
F
A
N
E
I
R
D
L
L
T
E
E
I
E
R
K
K
Q
V
L
E
E
E
A
L
N
A
A
L
AK
E
T
I
D
V
TLPG---RKVKHG
T
R
H
I
V
T
Q
I
M
E
E
I
E
D
I
F
V
GMG
Y
Q
I
V
E
G
---------
Y
E
VESDHYNFERMNLPKDHPARD
M
Q
D
T
F
Y
IS---------------
D
---------------
E
---------------
I
L
I
R
THTSPV
Q
A
R
TMEKHDFSKG
A
L
R
MISPGK
V
F
RRDTDDATHSH
Q
F
H
Q
I
E
G
L
V
VD-----------------------------------KNI
T
M
G
D
L
K
G
T
L
E
V
V
M
K
K
M
FGKD
R
E
I
R
LRPSYFPFTEP
S
V
E
V
D
V
S
C
F
KCGGAGCNVCKYT
G
W
I
E
I
LGAGMVHP
N
V
L
KMS-------GI
D
P
--
E
---------
E
--YS
G
F
AFGLG
P
D
R
V
A
M
L
R
Y
G
V
N
D
I
R
N
F
Y
Q
N
D
L
R
F
L
S
Q
FKGE-
1
PsiBlast_PDB
91.58
74%
-95
- C3 -
-
2RHQ
1
SYFA_STAHJ
A:
[27-288]
-----------------------------------------------------------------------------------
E
K
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
---
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
E
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
---------------
D
---------------
E
---------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
-----------------------------------
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
C
F
K
C
K
G
K
G
C
N
V
C
K
H
T
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
---------
E
--
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
--
21
PsiBlast_CBE
91.50
74%
-95
- C3 -
-
2RHS
1
SYFA_STAHJ
C:
[27-288]
-----------------------------------------------------------------------------------
E
K
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
---
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
E
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
---------------
D
---------------
E
---------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
-----------------------------------
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
C
F
K
C
K
G
K
G
C
N
V
C
K
H
T
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
---------
E
--
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
--
33
HHSearch
90.56
76%
-95
- C3 -
-
2RHS
1
SYFA_STAHJ
C:
[33-288]
-----------------------------------------------------------------------------------------
L
A
E
E
T
I
D
V
T
L
P
S
---
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
E
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
---------------
D
---------------
E
---------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
-----------------------------------
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
C
F
K
C
K
G
K
G
C
N
V
C
K
H
T
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
---------
E
--
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
--
34
HHSearch
88.21
76%
-94
- C3 -
-
2RHS
1
SYFA_STAHJ
A:
[33-288]
-----------------------------------------------------------------------------------------
L
A
E
E
T
I
D
V
T
L
P
S
---
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
E
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
---------------
D
---------------
E
---------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
-----------------------------------
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
----------------
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
---------
E
--
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
--
2
PsiBlast_PDB
88.11
74%
-94
- C3 -
-
2RHS
1
SYFA_STAHJ
A:
[30-288]
--------------------------------------------------------------------------------------
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
---
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
E
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
---------------
D
---------------
E
---------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
-----------------------------------
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
----------------
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
---------
E
--
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
--
31
HHSearch
83.75
50%
-86
- C3 -
-
3PCO
2
SYFA_ECOLI
C:
[5-327]
-------
A
E
L
V
A
S
A
K
A
A
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
L
A
A
E
T
I
D
V
S
L
P
G
---
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
E
I
E
D
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
D
---------------
T
---------------
T
---------------
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
A
Q
---
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
D
Q
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
D
-----------------------------------
T
N
I
S
F
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
M
G
-----------
K
N
G
K
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
P
--
E
---------
V
--
Y
S
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
---
26
PsiBlast_CBE
83.08
48%
-85
- C3 -
-
3PCO
2
SYFA_ECOLI
C:
[5-327]
-------
A
E
L
V
A
S
A
K
A
A
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
L
A
A
E
T
I
D
V
S
L
P
G
---
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
E
I
E
D
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
D
---------------
T
---------------
T
---------------
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
A
Q
---
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
Y
D
Q
-
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
D
-----------------------------------
T
N
I
S
F
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
-----------
M
G
K
N
G
K
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
P
--
E
---------
V
--
Y
S
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
---
27
HHSearch
82.14
54%
-113
- C3 -
-
4P72
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
S
G
N
--------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
25
PsiBlast_CBE
81.85
53%
-113
- C3 -
-
4P72
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
S
G
N
--------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
7
PsiBlast_PDB
81.74
53%
-111
- C3 -
-
4P75
1
SYFA_PSEAE
C:
[90-338]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
--------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
24
PsiBlast_CBE
81.67
53%
-114
- C3 -
-
4P73
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
---------
Q
T
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
5
PsiBlast_PDB
81.51
53%
-115
- C3 -
-
4P73
1
SYFA_PSEAE
C:
[88-338]
------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
------------
Q
T
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
22
PsiBlast_CBE
81.35
53%
-112
- C3 -
-
4P75
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
S
G
---------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
28
HHSearch
81.19
54%
-113
- C3 -
-
4P74
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
S
G
N
--------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
4
PsiBlast_PDB
81.10
53%
-114
- C3 -
-
4P72
1
SYFA_PSEAE
C:
[90-338]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
--------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
23
PsiBlast_CBE
80.87
53%
-113
- C3 -
-
4P74
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
V
I
C
S
G
N
--------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
6
PsiBlast_PDB
80.36
53%
-111
- C3 -
-
4P74
1
SYFA_PSEAE
C:
[90-338]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
---
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
E
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
N
---------------
A
---------------
N
---------------
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
---
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
D
-
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
-----------------------------------
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C
--------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
---------
K
--
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
---
47
Fugue
78.94
46%
-10
- C3 -
-
1EIY
-
SYFA_THET8
A:
[6-350]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
---
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
K
----------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
-------
D
A
Y
R
--
E
R
L
GLPPAYR
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
11
PsiBlast_PDB
77.58
42%
-12
- C3 -
-
1EIY
-
SYFA_THET8
A:
[6-348]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
30
HHSearch
77.56
50%
-105
- C3 -
-
3PCO
2
SYFA_ECOLI
A:
[86-327]
----------------------------------------------------------------------------------------
R
L
A
A
E
T
I
D
V
S
L
P
G
---
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
E
I
E
D
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
D
---------------
T
---------------
T
---------------
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
A
Q
---
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
D
Q
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
D
-----------------------------------
T
N
I
S
F
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
M
G
-----------
K
N
G
K
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
P
--
E
---------
V
--
Y
S
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
---
35
HHSearch
73.29
49%
-24
- C3 -
-
2AKW
1
SYFA_THETH
A:
[2-264]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
---------------
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
---
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
----------
E
G
G
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
18
PsiBlast_PDB
71.70
43%
-27
- C3 -
-
2AKW
1
SYFA_THETH
A:
[2-264]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
---
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
---------
Y
RG
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
15
PsiBlast_PDB
71.59
42%
-27
- C3 -
-
3HFZ
1
SYFA_THET8
A:
[85-348]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
20
PsiBlast_PDB
71.40
43%
-26
- C3 -
-
2AMC
1
SYFA_THETH
A:
[2-264]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
---
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
---------
Y
RG
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
17
PsiBlast_PDB
71.31
42%
-25
- C3 -
-
4TVA
1
SYFA_THETH
A:
[85-348]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
19
PsiBlast_PDB
70.71
43%
-21
- C3 -
-
2ALY
1
SYFA_THETH
A:
[2-264]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
---
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
---------
Y
RG
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
29
HHSearch
70.06
47%
-20
- C3 -
-
1B7Y
1
SYFA_THETH
A:
[86-348]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
---------------
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
----------
E
G
G
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
YR-------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
13
PsiBlast_PDB
69.92
42%
-23
- C3 -
-
1JJC
1
SYFA_THET8
A:
[85-348]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLGE
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
12
PsiBlast_PDB
69.57
42%
-17
- C3 -
-
1B70
1
SYFA_THETH
A:
[86-348]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
16
PsiBlast_PDB
68.39
42%
-21
- C3 -
-
3TEH
1
SYFA_THETH
A:
[85-348]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
GFRLEGPLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
10
PsiBlast_PDB
68.38
42%
-19
- C3 -
-
1B7Y
1
SYFA_THETH
A:
[86-348]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
---
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
E
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
---------------
G
---------------
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
T
---
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
-----------------------------------
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
W
P
E
G
G
----------
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
---------
G
--
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
--
37
HHSearch
57.33
33%
9
- C3 -
-
5MGW
1
SYFM_HUMAN
A:
[20-299]
---------------------------------------------------------------------------------------------
N
L
T
R
K
V
L
T
R
VG
R
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
P
L
F
S
V
Y
DNL
S
P
V
V
T
T
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
N
---------------
R
---------------
T
---------------
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
A
-----
G
L
D
A
F
L
V
V
G
D
V
Y
R
R
D
Q
I
D
S
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
K
H
E
L
F
AGIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
N
F
------------
H
G
E
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
D
---------------
R
I
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
---