@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZW5: (2018-01-17 )
MRRLKKIRLIFLLGIAFLALAGCKGNGLANEDILERSKSTNEIIWGVKYDTRLFGMMDIESRTVQGFDVDIAKAITKKILGDNGKTEFVEVTSKTRIPLLKNGNIDAIIATMTITDERKKQVDFSDVYFDAGQALLVKKGSQIKSVDDLNASTTVLAVKGSTSAANIRQHAPDAKILELENYAEAFTALQSGQGDAMTTDNAILLGIADENPEYELVGGTFTNEPYGIAINKGQENFLKAVNQALEEMHADGTYDKIYQKWFPNETEGKVE
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........----80........90........100.......110.......120.......130.......140.-....------------------------....150.-.......160...---....170---...--.....180...---....190.-......200....------..--.210--.--.--------...-.-.-----.220--.-........230......-.240.......250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRR
L
K
K
I
R
L
I
F
L
L
G
I
A
F
L
A
LAGCKGNGLA
N
E
D
I
L
E
RSKSTN
E
I
I
W
G
V
KYD
T
R
L
F
G
M
MDIESRTVQGFD
V
D
I
A
K
A
I
T
K
K
I
----LGDNGK
T
E
F
V
E
VTSKTR
I
P
L
L
KNGNI
D
A
I
I
A
T
M
T
I
T
D
E
R
KKQVDF
S
D
V
Y
FDAG
Q
A
L
L
VKKG--S-QIKS------------------------VDDLN-AS-
T
T
V
L
A
VKGST
S
A
A
---
N
I
R
QHA----PD
A
--
K
I
L
E
L
E
N
Y
A
E
A
---
F
T
A
L
QSGQ-GDAMTTD
N
A
I
L
L
G
------IA--DEN---P--
E
--------
Y
E
L
-V-G-----GT----F-TNE
P
Y
G
I
A
INKG
Q
E
N
F
L
-
K
A
V
N
Q
A
L
E
E
M
HADG
T
Y
D
K
I
Y
Q
K
WFPNETEGKVE
1
PsiBlast_PDB
98.94
97%
-97
- C3 -
-
5EYF
1
?
A:
[5-245]
------------------------------
E
D
I
L
E
R
S
K
S
T
N
E
I
I
W
G
V
K
Y
D
T
R
L
F
G
M
M
D
I
E
S
R
T
V
Q
G
F
D
V
D
I
A
K
A
I
T
K
K
I
----
L
G
D
N
G
K
T
E
F
V
E
V
T
S
K
T
R
I
P
L
L
K
N
G
N
I
D
A
I
I
A
T
M
T
I
T
D
E
R
K
K
Q
V
D
F
S
D
V
Y
F
D
A
G
Q
A
L
L
V
K
K
G
--
S
-
Q
I
K
S
------------------------
V
D
D
L
N
-
A
S
-
T
T
V
L
A
V
K
G
S
T
S
A
A
---
N
I
R
Q
H
A
----
P
D
A
--
K
I
L
E
L
E
N
Y
A
E
A
---
F
T
A
L
Q
S
G
Q
-
G
D
A
M
T
T
D
N
A
I
L
L
G
------
I
A
--
D
E
N
---
P
--
E
--------
Y
E
L
-
V
-
G
-----
G
T
----
F
-
T
N
E
P
Y
G
I
A
I
N
K
G
Q
E
N
F
L
-
K
A
V
N
Q
A
L
E
E
M
H
A
D
G
T
Y
D
K
I
Y
Q
K
W
F
P
N
E
T
E
G
K
V
E
21
PsiBlast_CBE
97.24
97%
-94
- C3 -
-
5EYF
1
?
B:
[3-245]
----------------------------
A
N
E
D
I
L
E
R
S
K
S
T
N
E
I
I
W
G
V
K
Y
D
T
R
L
F
G
M
M
D
I
E
S
R
T
V
Q
G
F
D
V
D
I
A
K
A
I
T
K
K
I
----
L
G
D
N
G
K
T
E
F
V
E
V
T
S
K
T
R
I
P
L
L
K
N
G
N
I
D
A
I
I
A
T
M
T
I
T
D
E
R
K
K
Q
V
D
F
S
D
V
Y
F
D
A
G
Q
A
L
L
V
K
K
G
--
S
-
Q
I
K
S
------------------------
V
D
D
L
N
-
A
S
-
T
T
V
L
A
V
K
G
S
T
S
A
A
---
N
I
R
Q
H
A
----
P
D
A
--
K
I
L
E
L
E
N
Y
A
E
A
---
F
T
A
L
Q
S
G
Q
-
G
D
A
M
T
T
D
N
A
I
L
L
G
------
I
A
--
D
E
N
---
P
--
E
--------
Y
E
L
-
V
-
G
-----
G
T
----
F
-
T
N
E
P
Y
G
I
A
I
N
K
G
Q
E
N
F
L
-
K
A
V
N
Q
A
L
E
E
M
H
A
D
G
T
Y
D
K
I
Y
Q
K
W
F
P
N
E
T
E
G
K
V
E
53
HHSearch
90.26
99%
-33
- C3 -
-
5EYF
1
?
B:
[5-245]
------------------------------
E
D
I
L
E
R
S
K
S
T
N
E
I
I
W
G
V
K
Y
D
T
R
L
F
G
M
M
D
I
E
S
R
T
V
Q
G
F
D
V
D
I
A
K
A
I
T
K
K
I
----
L
G
D
N
G
K
T
E
F
V
E
V
T
S
K
T
R
I
P
L
L
K
N
G
N
I
D
A
I
I
A
T
M
T
I
T
D
E
R
K
K
Q
V
D
F
S
D
V
Y
F
D
A
G
Q
A
L
L
V
K
K
G
--
S
-
Q
I
K
S
------------------------
V
D
D
L
--
N
A
S
T
T
V
L
A
V
K
G
S
T
S
A
A
---
N
I
R
Q
H
A
----
P
D
A
--
K
I
L
E
L
E
N
Y
A
E
A
---
F
T
A
L
Q
S
G
Q
-
G
D
A
M
T
T
D
N
A
I
L
L
G
------
I
A
--
D
E
N
---
P
--
E
--------
Y
E
L
-
V
-
G
-----
G
T
----
F
-
T
N
E
P
Y
G
I
A
I
N
K
G
Q
E
N
F
L
-
K
A
V
N
Q
A
L
E
E
M
H
A
D
G
T
Y
D
K
I
Y
Q
K
W
F
P
N
E
T
E
G
K
V
E
44
HHSearch
66.25
29%
-64
- C3 -
-
1XT8
2
?
B:
[31-265]
---------------------------
S
K
T
L
N
S
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
E
K
-
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
----
F
G
D
E
N
K
V
Q
F
V
L
V
E
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
T
P
Q
R
A
E
Q
V
D
F
C
S
P
Y
M
K
V
A
L
G
V
A
V
P
K
D
--
S
-
N
I
T
S
------------------------
V
E
D
L
--
K
D
-
K
T
L
L
L
N
K
G
T
T
A
D
A
---
Y
F
T
Q
N
Y
----
P
N
I
--
K
T
L
K
Y
D
Q
N
T
E
T
---
F
A
A
L
M
D
K
R
-
G
D
A
L
S
H
D
N
T
L
L
F
A
------
W
V
--
K
D
H
---
P
--
D
--------
F
K
M
-
G
I
K
-----
E
L
----
G
-
N
K
D
V
I
A
P
A
V
K
K
G
D
K
E
L
K
-
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
L
K
--------
52
HHSearch
61.76
27%
-71
- C3 -
-
3KZG
-
?
B:
[18-245]
---------------------------------------
S
L
N
L
T
I
G
T
S
K
F
N
P
P
F
E
V
W
S
G
N
N
S
S
L
Y
G
F
D
I
D
L
M
Q
E
I
C
R
R
L
----
H
A
---
T
C
T
F
E
A
Y
I
F
D
D
L
F
P
A
L
K
N
R
E
V
D
L
V
I
A
S
M
I
I
T
D
E
R
K
K
H
F
I
F
S
L
P
Y
M
E
S
N
S
Q
Y
I
T
T
V
D
--
S
-
K
I
S
T
------------------------
F
D
D
L
--
H
G
-
K
K
I
G
V
R
K
G
T
P
Y
A
R
---
Q
V
L
S
E
N
----
R
N
N
--
Q
V
I
F
Y
E
L
I
Q
D
M
---
L
L
G
L
S
N
N
Q
-
V
D
A
S
L
M
D
Y
E
A
A
K
Y
------
W
M
--
A
S
E
---
P
--
Y
AYKLIGKK
Y
K
L
-
I
-
G
-----
K
K
----
I
S
I
G
E
G
Y
S
I
M
A
N
P
D
Q
F
V
L
I
-
K
K
I
N
K
I
L
L
E
M
E
A
D
G
T
Y
L
R
L
Y
S
E
Y
F
---------
27
PsiBlast_CBE
61.20
35%
-88
- C3 -
-
1XT8
2
?
B:
[37-217]
---------------------------------
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
-
E
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
----
F
G
D
E
N
K
V
Q
F
V
L
V
E
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
T
P
Q
R
A
E
Q
V
D
F
C
S
P
Y
M
K
V
A
L
G
V
A
V
P
K
D
--
S
-
N
I
T
S
------------------------
V
E
D
L
K
-
D
K
-
T
L
L
L
N
-
K
G
T
T
A
D
A
---
Y
F
T
Q
N
Y
----
P
N
I
--
K
T
L
K
Y
D
Q
N
T
E
T
---
F
A
A
L
M
D
K
R
-
G
D
A
L
S
H
D
N
T
L
L
F
A
------
W
V
--
K
D
H
---
P
--
D
--------
F
K
M
--------------------------------------------------------------------
56
HHSearch
60.90
23%
-24
- C3 -
-
4POW
6
NOCT_AGRFC
A:
[4-255]
---------------------------------------
Y
K
S
I
T
I
A
T
E
G
S
Y
A
P
Y
N
F
K
D
A
G
-
G
K
L
I
G
F
D
I
D
L
G
N
D
L
C
K
R
M
----
N
I
---
E
C
K
F
V
E
Q
A
W
D
G
I
I
P
S
L
T
A
G
R
Y
D
A
I
M
A
A
M
G
I
Q
P
A
R
E
K
V
I
A
F
S
R
P
Y
L
L
T
P
M
T
F
L
T
T
A
D
--
S
-
P
L
L
K
TQVAIENLPLDNIT
P
E
Q
K
A
E
L
D
K
F
T
K
I
F
--
E
G
-
V
K
F
G
V
Q
A
G
T
S
H
E
A
---
F
M
K
Q
M
M
----
P
S
V
--
Q
I
S
T
Y
D
T
I
D
N
V
---
V
M
D
L
K
A
G
R
-
I
D
A
S
L
A
S
V
S
F
L
K
P
------
L
T
--
D
K
P
---
D
NK
D
--------
L
K
M
-
F
-
G
-----
P
R
MTGG
L
-
F
G
K
G
V
G
V
G
I
R
K
E
D
A
D
L
K
-
A
L
F
D
K
A
I
D
A
A
I
A
D
G
T
V
Q
K
L
S
Q
Q
W
F
G
Y
D
A
-----
25
PsiBlast_CBE
60.29
35%
-61
- C3 -
-
2YJP
2
?
C:
[60-273]
---------------------------------------------
G
V
F
G
D
K
P
P
F
G
Y
V
D
A
N
G
K
N
-
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
----
L
G
S
P
D
K
V
E
F
V
L
T
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
A
L
G
V
V
S
P
K
N
--
K
-
P
I
T
D
------------------------
M
A
Q
L
K
--
D
-
Q
T
L
L
V
N
K
G
T
T
A
D
A
---
F
F
T
K
S
H
----
P
E
V
--
K
L
L
K
F
D
Q
N
T
E
T
---
F
D
A
L
K
D
G
R
-
G
V
A
L
A
H
D
N
A
L
L
W
A
------
W
A
--
K
E
N
---
P
--
N
--------
F
E
V
A
I
-
G
-----
N
L
----
G
-
P
A
E
F
I
A
P
A
V
Q
K
G
N
A
D
L
L
-
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
-----------
26
PsiBlast_CBE
60.13
35%
-61
- C3 -
-
2YJP
3
?
B:
[60-273]
---------------------------------------------
G
V
F
G
D
K
P
P
F
G
Y
V
D
A
N
G
K
N
-
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
----
L
G
S
P
D
K
V
E
F
V
L
T
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
A
L
G
V
V
S
P
K
N
--
K
-
P
I
T
D
------------------------
M
A
Q
L
K
--
D
-
Q
T
L
L
V
N
K
G
T
T
A
D
A
---
F
F
T
K
S
H
----
P
E
V
--
K
L
L
K
F
D
Q
N
T
E
T
---
F
D
A
L
K
D
G
R
-
G
V
A
L
A
H
D
N
A
L
L
W
A
------
W
A
--
K
E
N
---
P
--
N
--------
F
E
V
A
I
-
G
-----
N
L
----
G
-
P
A
E
F
I
A
P
A
V
Q
K
G
N
A
D
L
L
-
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
-----------
10
PsiBlast_PDB
59.84
35%
-82
- C3 -
-
1XT8
1
?
A:
[37-217]
---------------------------------
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
-
E
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
----
F
G
D
E
N
K
V
Q
F
V
L
V
E
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
T
P
Q
R
A
E
Q
V
D
F
C
S
P
Y
M
K
V
A
L
G
V
A
V
P
K
D
--
S
-
N
I
T
S
------------------------
V
E
D
L
K
-
D
K
-
T
L
L
L
N
-
K
G
T
T
A
D
A
---
Y
F
T
Q
N
Y
----
P
N
I
--
K
T
L
K
Y
D
Q
N
T
E
T
---
F
A
A
L
M
D
K
R
-
G
D
A
L
S
H
D
N
T
L
L
F
A
------
W
V
--
K
D
H
---
P
--
D
--------
F
K
M
--------------------------------------------------------------------
9
PsiBlast_PDB
59.77
35%
-59
- C3 -
-
2YJP
4
?
A:
[60-273]
---------------------------------------------
G
V
F
G
D
K
P
P
F
G
Y
V
D
A
N
G
K
N
-
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
----
L
G
S
P
D
K
V
E
F
V
L
T
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
A
L
G
V
V
S
P
K
N
--
K
-
P
I
T
D
------------------------
M
A
Q
L
K
--
D
-
Q
T
L
L
V
N
K
G
T
T
A
D
A
---
F
F
T
K
S
H
----
P
E
V
--
K
L
L
K
F
D
Q
N
T
E
T
---
F
D
A
L
K
D
G
R
-
G
V
A
L
A
H
D
N
A
L
L
W
A
------
W
A
--
K
E
N
---
P
--
N
--------
F
E
V
A
I
-
G
-----
N
L
----
G
-
P
A
E
F
I
A
P
A
V
Q
K
G
N
A
D
L
L
-
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
-----------
54
HHSearch
59.07
21%
-32
- C3 -
-
3KBR
8
PHEC_PSEAE
A:
[5-236]
------------------------------
E
S
R
L
D
R
I
L
E
S
G
V
L
R
V
A
T
T
G
D
Y
K
P
F
S
Y
R
T
E
E
-
G
G
Y
A
G
F
D
V
D
M
A
Q
R
L
A
E
S
L
----
G
A
---
K
L
V
V
V
P
T
S
W
P
N
L
M
R
D
F
A
D
D
R
F
D
I
A
M
S
G
I
S
I
N
L
E
R
Q
R
Q
A
Y
F
S
I
P
Y
L
R
D
G
K
T
P
I
T
L
C
S
EE
A
-
R
F
Q
T
------------------------
L
E
Q
I
D
Q
P
G
-
V
T
A
I
V
N
P
G
G
T
N
E
K
---
F
A
R
A
N
L
----
K
K
A
--
R
I
L
V
H
P
D
N
V
T
I
---
F
Q
Q
I
V
D
G
K
-
A
D
L
M
M
T
D
A
I
E
A
R
L
------
Q
S
--
R
L
H
---
P
--
E
--------
L
C
A
-
V
H
P
-----
Q
P
----
F
-
D
F
A
E
K
A
Y
L
L
P
R
-
D
E
A
F
K
-
R
Y
V
D
Q
W
L
H
I
A
E
Q
S
G
L
L
R
Q
R
M
E
H
W
L
---------
4
PsiBlast_PDB
58.32
36%
-22
- C3 -
-
2V25
1
PEB1A_CAMJE
A:
[29-257]
-------------------------------
G
K
L
E
S
I
K
S
K
G
Q
L
I
V
G
V
K
N
D
V
P
H
Y
A
L
L
D
Q
A
T
G
E
I
K
G
F
E
V
D
V
A
K
L
L
A
K
S
I
----
L
G
D
D
K
K
I
K
L
V
A
V
N
A
K
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
A
T
F
T
I
T
P
E
R
K
R
I
Y
N
F
S
E
P
Y
Y
Q
D
A
I
G
L
L
V
L
K
E
--
K
-
K
Y
K
S
------------------------
L
A
D
M
K
-
G
A
-
N
I
G
V
A
Q
A
A
T
T
K
K
A
I
G
E
A
A
K
K
I
G
----
I
D
V
--
K
F
S
E
F
P
D
Y
P
S
I
---
K
A
A
L
D
A
K
R
-
V
D
A
F
S
V
D
K
S
I
L
L
G
------
Y
V
--
D
D
-------
K
--------
S
E
I
-
L
-
P
-----
D
S
----
F
-
E
P
Q
S
Y
G
I
V
T
K
K
D
D
P
A
F
A
-
K
Y
V
D
D
F
V
K
E
H
K
N
E
--
I
D
A
L
A
K
K
W
----------
22
PsiBlast_CBE
58.23
36%
-20
- C3 -
-
2V25
1
PEB1A_CAMJE
B:
[29-257]
-------------------------------
G
K
L
E
S
I
K
S
K
G
Q
L
I
V
G
V
K
N
D
V
P
H
Y
A
L
L
D
Q
A
T
G
E
I
K
G
F
E
V
D
V
A
K
L
L
A
K
S
I
----
L
G
D
D
K
K
I
K
L
V
A
V
N
A
K
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
A
T
F
T
I
T
P
E
R
K
R
I
Y
N
F
S
E
P
Y
Y
Q
D
A
I
G
L
L
V
L
K
E
--
K
-
K
Y
K
S
------------------------
L
A
D
M
K
-
G
A
-
N
I
G
V
A
Q
A
A
T
T
K
K
A
IGE
A
A
K
K
I
G
----
I
D
V
--
K
F
S
E
F
P
D
Y
P
S
I
---
K
A
A
L
D
A
K
R
-
V
D
A
F
S
V
D
K
S
I
L
L
G
------
Y
V
--
D
D
-------
K
--------
S
E
I
-
L
-
P
-----
D
S
----
F
-
E
P
Q
S
Y
G
I
V
T
K
K
D
D
P
A
F
A
-
K
Y
V
D
D
F
V
K
E
H
K
N
E
--
I
D
A
L
A
K
K
W
----------
55
HHSearch
57.46
23%
-23
- C3 -
-
4P0I
1
NOCT_AGRFC
B:
[3-255]
--------------------------------------
D
Y
K
S
I
T
I
A
T
E
G
S
Y
A
P
Y
N
F
K
D
A
G
-
G
K
L
I
G
F
D
I
D
L
G
N
D
L
C
K
R
M
----
N
I
---
E
C
K
F
V
E
Q
A
W
D
G
I
I
P
S
L
T
A
G
R
Y
D
A
I
M
A
A
M
G
I
Q
P
A
R
E
K
V
I
A
F
S
R
P
Y
L
L
T
P
M
T
F
L
T
T
A
D
--
S
-
P
L
L
K
TQVAIENLPLDNIT
P
E
Q
K
A
E
L
D
K
F
T
K
I
F
--
E
G
-
V
K
F
G
V
Q
A
G
T
S
H
E
A
---
F
M
K
Q
M
M
----
P
S
V
--
Q
I
S
T
Y
D
T
I
D
N
V
---
V
M
D
L
K
A
G
R
-
I
D
A
S
L
A
S
V
S
F
L
K
P
------
L
T
--
D
K
P
---
D
NK
D
--------
L
K
M
-
F
-
G
-----
P
R
M
T
G
G
L
-
F
G
K
G
V
G
V
G
I
R
K
E
D
A
D
L
K
-
A
L
F
D
K
A
I
D
A
A
I
A
D
G
T
V
Q
K
L
S
Q
Q
W
F
G
Y
D
A
-----
59
HHSearch
56.40
25%
-53
* C3 *
-
2Y7I
2
?
A:
[4-228]
--------------------------------------
S
A
R
T
L
H
F
G
T
S
A
T
Y
A
P
Y
E
F
V
D
A
D
-
N
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
----
Q
A
---
E
C
S
F
T
N
Q
S
F
D
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
A
G
M
D
M
T
P
K
R
E
Q
Q
V
S
F
S
Q
P
Y
Y
E
G
L
S
A
V
V
V
T
R
K
--
G
-
A
Y
H
T
------------------------
F
A
D
L
--
K
G
-
K
K
V
G
L
E
N
G
T
T
H
Q
R
---
Y
L
Q
D
K
Q
----
Q
A
I
--
T
P
V
A
Y
D
S
Y
L
N
A
---
F
T
D
L
K
N
N
R
-
L
E
G
V
F
G
D
V
A
A
I
G
K
------
W
L
--
K
N
N
---
P
--
D
--------
Y
A
I
-
M
-
D
E
R
A
S
D
P
D
----
Y
-
Y
G
K
G
L
G
I
A
V
R
K
D
N
D
A
L
L
-
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
A
Q
M
Q
E
K
W
F
T
--------
58
HHSearch
56.35
29%
37
- C3 -
-
2IA4
2
?
B:
[6-251]
-----------------------------
A
G
S
T
L
D
K
I
A
K
N
G
V
I
V
V
G
H
R
E
S
S
V
P
F
S
Y
Y
D
N
Q
-
Q
K
V
V
G
Y
S
Q
D
Y
S
N
A
I
V
E
A
V
K
K
K
L
N
K
P
D
L
Q
V
K
L
I
P
I
T
S
Q
N
R
I
P
L
L
Q
N
G
T
F
D
F
E
C
G
S
T
T
N
N
V
E
R
Q
K
Q
A
A
F
S
D
T
I
F
V
V
G
T
R
L
L
T
K
K
G
--
G
-
D
I
K
D
------------------------
F
A
D
L
--
K
G
-
K
A
V
V
V
T
S
G
T
T
S
E
V
---
L
L
N
K
L
N
E
E
Q
K
M
N
M
--
R
I
I
S
A
K
D
H
G
D
S
---
F
R
T
L
E
S
G
R
-
A
V
A
F
M
M
D
D
A
L
L
A
G
------
E
R
--
A
K
A
KKP
D
--
N
--------
W
D
I
-
V
-
G
-----
K
P
----
Q
-
S
Q
E
A
Y
G
C
M
L
R
K
D
D
P
Q
F
K
-
K
L
M
D
D
T
I
A
Q
V
Q
T
S
G
E
A
E
K
W
F
D
K
W
F
K
N
P
I
-----
34
PsiBlast_CBE
56.04
32%
-61
- C3 -
-
2PYY
1
?
C:
[23-221]
---------------------------------------------------------------
L
S
G
F
S
I
D
L
W
R
S
I
A
T
Q
I
----
G
I
E
S
K
L
I
E
Y
S
S
V
P
E
--
L
I
S
A
I
K
D
N
K
V
N
L
G
I
A
A
I
S
I
T
A
E
R
E
Q
N
F
D
F
S
L
P
I
F
A
S
G
L
Q
I
M
V
R
N
---
G
-
D
I
R
S
------------------------
I
D
D
L
--
P
G
-
K
V
V
A
T
T
A
G
S
T
A
A
T
---
Y
L
R
E
H
------
H
I
--
S
V
L
E
V
P
K
I
E
E
A
---
Y
K
A
L
Q
T
K
K
-
A
D
A
V
V
F
D
A
P
V
L
L
F
------
Y
A
AN
E
G
K
---
G
--
K
--------
V
E
I
-
V
-
G
-----
S
I
----
L
-
R
E
E
S
Y
G
I
-
I
L
P
N
N
S
P
Y
R
-
K
P
I
N
Q
A
L
L
N
L
K
E
N
G
T
Y
Q
S
L
Y
D
K
W
F
---------
42
HHSearch
55.75
31%
12
- C3 -
-
2YJP
4
?
A:
[45-279]
------------------------------
A
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
A
N
-
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L---
G
S
-
P
D
K
V
E
F
V
L
T
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
A
L
G
V
V
S
P
K
N
--
K
-
P
I
T
D
------------------------
M
A
Q
L
--
K
D
-
Q
T
L
L
V
N
K
G
T
T
A
D
A
---
F
F
T
K
S
H
----
P
E
V
--
K
L
L
K
F
D
Q
N
T
E
T
---
F
D
A
L
K
D
G
R
-
G
V
A
L
A
H
D
N
A
L
L
W
A
------
W
A
--
K
E
N
---
P
--
N
--------
F
E
V
-
A
-
I
-----
G
N
----
L
G
P
A
E
F
I
A
P
A
V
Q
K
G
N
A
D
L
L
-
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
-----
2
PsiBlast_PDB
55.68
50%
10
- C3 -
-
4ZV1
1
?
A:
[23-231]
-----------------------------------------------------
F
G
F
K
D
E
N
G
K
L
V
-
G
F
D
I
D
L
A
K
A
I
A
K
K
L
-------
G
V
K
V
E
F
K
P
M
D
F
D
G
I
I
P
A
L
Q
S
G
K
I
D
V
V
I
A
G
M
T
I
T
E
E
R
K
K
Q
V
D
F
S
D
P
Y
F
E
A
G
Q
A
I
V
V
K
K
G
--
N
D
S
I
K
S
------------------------
L
E
D
L
K
-
G
K
-
K
V
G
V
Q
L
-
G
S
T
S
E
Q
---
H
V
K
K
V
A
----
K
D
A
G
V
K
V
K
K
F
D
N
F
S
E
A
---
F
Q
E
L
K
S
G
R
-
V
D
A
V
V
T
D
N
A
V
A
L
A
------
Y
V
--
K
Q
N
---
P
--
N
AG------
V
K
I
-
V
-
G
-----
E
T
----
F
-
S
G
E
P
Y
G
I
A
V
R
K
G
N
S
E
L
L
-
E
K
I
N
K
A
L
E
E
M
K
K
D
G
T
Y
D
K
I
Y
E
K
W
F
---------
3
PsiBlast_PDB
55.38
50%
13
- C3 -
-
4ZV2
1
?
A:
[23-231]
-----------------------------------------------------
F
G
F
K
D
E
N
G
K
L
V
-
G
F
D
I
D
L
A
K
A
I
A
K
K
L
-------
G
V
K
V
E
F
K
P
M
D
F
D
G
I
I
P
A
L
Q
S
G
K
I
D
V
V
I
A
G
M
T
I
T
E
E
R
K
K
Q
V
D
F
S
D
P
Y
F
E
A
G
Q
A
I
V
V
K
K
G
--
N
D
S
I
K
S
------------------------
L
E
D
L
K
-
G
K
-
K
V
G
V
Q
L
-
G
S
T
S
E
Q
---
H
V
K
K
V
A
------
A
G
V
K
V
K
K
F
D
N
F
S
E
A
---
F
Q
E
L
K
S
G
R
-
V
D
A
V
V
T
D
N
A
V
A
L
A
------
Y
V
--
K
Q
N
---
P
--
N
AG------
V
K
I
-
V
-
G
-----
E
T
----
F
-
S
G
E
P
Y
G
I
A
V
R
K
G
N
S
E
L
L
-
E
K
I
N
K
A
L
E
E
M
K
K
D
G
T
Y
D
K
I
Y
E
K
W
F
---------
38
PsiBlast_CBE
45.01
31%
-29
- C3 -
-
4KPT
9
?
B:
[52-247]
-----------------------------------------------------------------
G
I
D
V
D
I
M
Q
E
V
A
K
I
-------
N
D
W
K
L
E
M
S
Y
P
G
F
D
A
A
L
Q
N
L
K
A
G
Q
V
D
G
I
I
A
G
M
T
I
T
D
E
R
K
E
T
F
D
F
S
N
P
Y
Y
T
S
A
L
T
I
A
T
T
K
D
--
S
-
K
L
S
D
------------------------
Y
S
D
L
K
-
G
K
---
A
V
G
A
K
N
G
T
A
A
Q
---
T
W
L
Q
E
N
----
Q
K
K
--
Y
G
Y
T
I
K
T
Y
S
D
G
VHM
F
A
A
L
S
S
G
N
I
A
G
A
M
D
E
V
P
V
I
S
Y
A
MKQGQD
L
A
--
M
N
F
---
P
--
S
--------
I
S
L
-
P
-
G
-----
G
-----------
Y
G
F
A
V
M
K
G
K
N
S
T
L
V
D
G
F
N
K
A
L
A
E
M
K
S
N
G
D
Y
D
K
I
L
K
K
Y
----------