@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZW8: (2018-01-17 )
MKKRMIRLTDNRPIGFIDSGVGGLTVVKEALKQLPNENILFVGDTARCPYGPRPAEQVIQYTWEMTDYLVEQGIKMLVIACNTATAVALEEIKAALSIPVIGVILPGTRAAVKKTQNKQVGIIGTIGTVKSQAYEKALKEKVPELTVTSLACPKFVSVVESNEYHSSVAKKIVAETLAPLTTKKIDTLILGCTHYPLLRPIIQNVMGENVQLIDSGAETVGEVSMLLDYFNLSNSPQNGRTLCQFYTTGSAKLFEEIAEDWLGIGHLNVEHIELGGK
Atome Classification :
(62 SA)
.........10.......-.20........30........40........50..-......60........-70........80........90...-.-..-..100.......110.--.--...-..120--.......130.......140.......150.......160..-..-...-170.......180--.......190.......200..-....------.210---.------........220.....---..230.....---..240--.---......250.......260.......270.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
K
R
M
I
R
LTDNRP
I
G
F
ID-SGVG
G
L
T
V
V
K
E
A
L
K
QLPNE
N
I
L
F
VGDTARCPYGPR-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
EQG
I
K
M
L
V
I
ACN
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-LS-I
P
V
I
G
V
ILPG
T
R
A
A
V
K
--K--TQN-KQ
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
KVPE
L
T
V
TSLA
C
P
K
F
V
S
V
VESN
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
LAP
L
T
T--KK
I
D
T
L
I
LGCTH
Y
P
L
L
R
P
I
I
Q
N
-
V
MGE------
N
V
-----
Q
------
L
IDSG
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
FNLSNSPQ---NG
R
T
L
--
C
---
Q
F
YTTG
S
A
K
L
F
E
E
I
A
E
D
W
L
GIGH
L
N
V
E
H
I
ELGGK
54
HHSearch
97.27
100%
-147
- C2 -
-
2JFU
-
?
A:
[19-289]
----
M
I
R
L
T
D
N
R
P
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
K
E
A
L
K
Q
L
P
N
E
N
I
L
F
V
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
E
Q
G
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
S
-
I
P
V
I
G
V
I
L
P
G
T
R
A
A
V
K
--
K
--
T
Q
N
-
K
Q
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
K
V
P
E
L
T
V
T
S
L
A
C
P
K
F
V
S
V
V
E
S
N
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
L
A
P
L
T
T
--
K
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
E
------
N
V
-----
Q
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
N
L
S
N
S
P
Q
---
N
G
R
T
L
--
C
---
Q
F
Y
T
T
G
S
A
K
L
F
E
E
I
A
E
D
W
L
G
I
G
H
L
N
V
E
H
I
E
L
G
--
1
PsiBlast_PDB
96.83
98%
-147
- C2 -
-
2JFU
-
?
A:
[19-289]
----
M
I
R
L
T
D
N
R
P
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
K
E
A
L
K
Q
L
P
N
E
N
I
L
F
V
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
E
Q
G
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
S
-
I
P
V
I
G
V
I
L
P
G
T
R
A
A
V
K
--
K
--
T
Q
N
-
K
Q
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
K
V
P
E
L
T
V
T
S
L
A
C
P
K
F
V
S
V
V
E
S
N
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
L
A
P
L
T
T
--
K
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
E
------
N
V
-----
Q
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
N
L
S
N
S
P
Q
---
N
G
R
T
L
--
C
---
Q
F
Y
T
T
G
S
A
K
L
F
E
E
I
A
E
D
W
L
G
I
G
H
L
N
V
E
H
I
E
L
G
--
3
PsiBlast_PDB
96.62
98%
-145
- C2 -
-
2JFW
1
?
A:
[19-288]
----
M
I
R
L
T
D
N
R
P
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
K
E
A
L
K
Q
L
P
N
E
N
I
L
F
V
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
E
Q
G
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
S
-
I
P
V
I
G
V
I
L
P
G
T
R
A
A
V
K
--
K
--
T
Q
N
-
K
Q
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
K
V
P
E
L
T
V
T
S
L
A
C
P
K
F
V
S
V
V
E
S
N
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
L
A
P
L
T
T
--
K
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
E
------
N
V
-----
Q
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
N
L
S
N
S
P
Q
---
N
G
R
T
L
--
C
---
Q
F
Y
T
T
G
S
A
K
L
F
E
E
I
A
E
D
W
L
G
I
G
H
L
N
V
E
H
I
E
L
---
73
Fugue
96.57
100%
-147
- C2 -
-
2JFV
-
?
A:
[19-288]
----
M
I
R
L
T
D
N
R
P
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
K
E
A
L
K
Q
L
P
N
E
N
I
L
F
V
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
E
Q
G
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
S
-
I
P
V
I
G
V
I
L
P
G
T
R
A
A
V
K
--
K
--
T
Q
N
-
K
Q
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
K
V
P
E
L
T
V
T
S
L
A
C
P
K
F
V
S
V
V
E
S
N
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
L
A
P
L
T
T
--
K
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
E
------
N
V
-----
Q
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
N
L
S
N
S
P
Q
---
N
G
R
T
L
--
C
---
Q
F
Y
T
T
G
S
A
K
L
F
E
E
I
A
E
D
W
L
G
I
G
H
L
N
V
E
H
I
E
L
---
2
PsiBlast_PDB
96.12
98%
-147
- C2 -
-
2JFV
-
?
A:
[19-288]
----
M
I
R
L
T
D
N
R
P
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
K
E
A
L
K
Q
L
P
N
E
N
I
L
F
V
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
I
Q
Y
T
W
E
M
T
D
Y
L
-
V
E
Q
G
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
S
-
I
P
V
I
G
V
I
L
P
G
T
R
A
A
V
K
--
K
--
T
Q
N
-
K
Q
V
G
I
--
I
G
T
I
G
T
V
K
S
Q
A
Y
E
K
A
L
K
E
K
V
P
E
L
T
V
T
S
L
A
C
P
K
F
V
S
V
V
E
S
N
E
Y
-
H
S
-
S
V
A
-
K
K
I
V
A
E
T
L
A
P
L
T
T
--
K
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
E
------
N
V
-----
Q
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
N
L
S
N
S
P
Q
---
N
G
R
T
L
--
C
---
Q
F
Y
T
T
G
S
A
K
L
F
E
E
I
A
E
D
W
L
G
I
G
H
L
N
V
E
H
I
E
L
---
5
PsiBlast_PDB
89.31
70%
-152
- C2 -
-
2JFO
1
MURI_ENTFA
A:
[22-288]
--------
S
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
6
PsiBlast_PDB
88.79
70%
-151
- C2 -
-
2JFP
1
MURI_ENTFA
A:
[22-288]
--------
S
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
22
PsiBlast_CBE
88.60
70%
-148
- C2 -
-
2JFP
1
MURI_ENTFA
B:
[22-288]
--------
S
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
59
HHSearch
87.83
70%
-148
- C2 -
-
2VVT
2
MURI_ENTFA
B:
[23-288]
---------
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
21
PsiBlast_CBE
87.83
70%
-148
- C2 -
-
2VVT
2
MURI_ENTFA
B:
[23-288]
---------
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
23
PsiBlast_CBE
86.74
70%
-148
- C2 -
-
2JFO
1
MURI_ENTFA
B:
[22-288]
--------
S
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
E
---
A
P
T
Q
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
4
PsiBlast_PDB
85.52
70%
-151
- C2 -
-
2VVT
2
MURI_ENTFA
A:
[17-288]
---
R
G
S
H
M
S
N
Q
E
A
I
G
L
I
D
-
S
G
V
G
G
L
T
V
L
K
E
A
L
K
Q
L
P
N
E
R
L
I
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
P
A
E
Q
V
V
Q
F
T
W
E
M
A
D
F
L
-
L
K
K
R
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
E
I
K
A
-
A
-
L
P
-
I
P
V
V
G
V
I
L
P
G
A
R
A
A
V
K
--
V
--
T
K
N
-
N
K
I
G
V
--
I
G
T
L
G
T
I
K
S
A
S
Y
E
I
A
I
K
S
K
A
P
A
I
E
V
T
S
L
A
C
P
K
F
V
P
I
V
E
S
N
Q
Y
-
R
S
-
S
V
A
-
K
K
I
V
A
E
T
L
Q
A
L
Q
L
--
K
G
L
D
T
L
I
L
G
C
T
H
Y
P
L
L
R
P
V
I
Q
N
-
V
M
G
S
------
H
V
-----
T
------
L
I
D
S
G
A
E
T
V
G
E
V
S
M
L
L
---
D
Y
F
D
I
A
H
T
P
--------
P
--
H
---
E
F
Y
T
T
G
S
A
K
M
F
E
E
I
A
S
S
W
L
G
I
E
N
L
K
A
Q
Q
I
H
L
G
--
10
PsiBlast_PDB
85.09
58%
-163
- C2 -
-
2OHO
-
MURI_STRP1
A:
[5-273]
---
R
G
S
H
M
M
D
T
R
P
I
G
F
L
D
-
S
G
V
G
G
L
T
V
V
C
E
L
I
R
Q
L
P
H
E
K
I
V
Y
I
G
D
S
A
R
A
P
Y
G
P
R
-
P
K
K
Q
I
K
E
Y
T
W
E
L
V
N
F
L
-
L
T
Q
N
V
K
M
I
V
F
A
C
N
T
A
T
A
V
A
W
E
E
V
K
A
-
A
-
L
D
-
I
P
V
L
G
V
V
L
P
G
A
S
A
A
I
K
--
S
--
T
T
K
-
G
Q
V
G
V
--
I
G
T
P
M
T
V
A
S
D
I
Y
R
K
K
I
Q
L
L
A
P
S
I
Q
V
R
S
L
A
C
P
K
F
V
P
I
V
E
S
-------
S
I
A
-
K
K
I
V
Y
D
S
L
A
P
L
-
V
--
G
K
I
D
T
L
V
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
P
------
S
V
-----
K
------
L
I
D
S
G
A
E
C
V
R
D
I
S
V
L
L
---
N
Y
F
D
I
N
G
N
Y
H
---
Q
K
A
V
E
--
H
---
R
F
F
T
T
A
N
P
E
I
F
Q
E
I
A
S
I
W
L
K
-
Q
K
I
N
V
E
H
V
T
L
---
60
HHSearch
82.11
61%
-145
- C2 -
-
3IST
1
MURI_LISMO
A:
[2-268]
-------
N
A
M
K
Q
A
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
R
E
V
L
K
Q
L
P
H
E
Q
V
Y
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
D
K
E
E
V
A
K
F
T
W
E
M
T
N
F
L
-
V
D
R
G
I
K
M
L
V
I
A
C
N
T
A
T
A
A
A
L
Y
D
I
R
E
-
K
-
L
D
-
I
P
V
I
G
V
I
Q
P
G
S
R
A
A
L
K
--
A
--
T
R
N
-
N
K
I
G
V
--
L
G
T
L
G
T
V
E
S
M
A
Y
P
T
A
L
K
G
L
N
R
R
V
E
V
D
S
L
A
C
P
K
F
V
S
V
V
E
S
G
E
Y
-
K
S
-
A
I
A
-
K
K
V
V
A
E
S
L
L
P
L
K
S
--
T
K
I
D
T
V
I
L
G
C
T
H
Y
P
L
L
K
P
I
I
E
N
-
F
M
G
D
------
G
V
-----
A
------
V
I
N
S
G
E
E
T
A
S
E
V
S
A
L
L
---
D
Y
H
N
L
L
D
A
T
D
----
E
E
I
E
--
H
---
R
F
F
T
T
G
S
T
Q
I
F
K
D
I
A
K
D
W
L
N
M
P
D
M
T
V
E
H
I
K
L
G
--
11
PsiBlast_PDB
81.83
59%
-156
- C2 -
-
2OHG
-
MURI_STRP1
A:
[2-264]
---------
D
T
R
P
I
G
F
L
D
-
S
G
V
G
G
L
T
V
V
C
E
L
I
R
Q
L
P
H
E
K
I
V
Y
I
G
D
S
A
R
A
P
Y
G
P
R
-
P
K
K
Q
I
K
E
Y
T
W
E
L
V
N
F
L
-
L
T
Q
N
V
K
M
I
V
F
A
C
N
T
A
T
A
V
A
W
E
E
V
K
A
-
A
-
L
D
-
I
P
V
L
G
V
V
L
P
G
A
S
A
A
I
K
--
S
--
T
T
K
-
G
Q
V
G
V
--
I
G
T
P
M
T
V
A
S
D
I
Y
R
K
K
I
Q
L
L
A
P
S
I
Q
V
R
S
L
A
C
P
K
F
V
P
I
V
E
S
N
E
M
-
C
S
-
S
I
A
-
K
K
I
V
Y
D
S
L
A
P
L
-
V
--
G
K
I
D
T
L
V
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
P
------
S
V
-----
K
------
L
I
D
S
G
A
E
C
V
R
D
I
S
V
L
L
---
N
Y
F
D
I
N
G
N
Y
H
---
Q
-
A
V
E
--
H
---
R
F
F
T
T
A
N
P
E
I
F
Q
E
I
A
S
I
W
L
K
-
Q
K
I
N
V
E
H
V
T
L
---
12
PsiBlast_PDB
81.50
59%
-158
- C2 -
-
2OHV
1
MURI_STRP1
A:
[2-264]
---------
D
T
R
P
I
G
F
L
D
-
S
G
V
G
G
L
T
V
V
C
E
L
I
R
Q
L
P
H
E
K
I
V
Y
I
G
D
S
A
R
A
P
------
K
K
Q
I
K
E
Y
T
W
E
L
V
N
F
L
-
L
T
Q
N
V
K
M
I
V
F
A
C
N
T
A
T
A
V
A
W
E
E
V
K
A
-
A
-
L
D
-
I
P
V
L
G
V
V
L
P
G
A
S
A
A
I
K
--
S
--
T
T
K
-
G
Q
V
G
V
--
I
G
T
P
M
T
V
A
S
D
I
Y
R
K
K
I
Q
L
L
A
P
S
I
Q
V
R
S
L
A
C
P
K
F
V
P
I
V
E
S
N
E
M
-
C
S
-
S
I
A
-
K
K
I
V
Y
D
S
L
A
P
L
-
V
--
G
K
I
D
T
L
V
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
P
------
S
V
-----
K
------
L
I
D
S
G
A
E
C
V
R
D
I
S
V
L
L
---
N
Y
F
D
I
N
G
N
Y
H
---
Q
-
A
V
E
--
H
---
R
F
F
T
T
A
N
P
E
I
F
Q
E
I
A
S
I
W
L
K
-
Q
K
I
N
V
E
H
V
T
L
---
61
HHSearch
81.22
60%
-156
- C2 -
-
2OHG
-
MURI_STRP1
A:
[2-264]
---------
D
T
R
P
I
G
F
L
D
-
S
G
V
G
G
L
T
V
V
C
E
L
I
R
Q
L
P
H
E
K
I
V
Y
I
G
D
S
A
R
A
P
Y
G
P
R
-
P
K
K
Q
I
K
E
Y
T
W
E
L
V
N
F
L
-
L
T
Q
N
V
K
M
I
V
F
A
C
N
T
A
T
A
V
A
W
E
E
V
K
A
-
A
-
L
D
-
I
P
V
L
G
V
V
L
P
G
A
S
A
A
I
K
--
S
--
T
T
K
-
G
Q
V
G
V
--
I
G
T
P
M
T
V
A
S
D
I
Y
R
K
K
I
Q
L
L
A
P
S
I
Q
V
R
S
L
A
C
P
K
F
V
P
I
V
E
S
N
E
M
-
C
S
-
S
I
A
-
K
K
I
V
Y
D
S
L
A
P
L
V
---
G
K
I
D
T
L
V
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
P
------
S
V
-----
K
------
L
I
D
S
G
A
E
C
V
R
D
I
S
V
L
L
---
N
Y
F
D
I
N
G
N
Y
H
---
Q
-
A
V
E
--
H
---
R
F
F
T
T
A
N
P
E
I
F
Q
E
I
A
S
I
W
L
K
Q
K
-
I
N
V
E
H
V
T
L
---
8
PsiBlast_PDB
81.11
60%
-151
- C2 -
-
3IST
1
MURI_LISMO
A:
[6-268]
-----------
Q
A
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
R
E
V
L
K
Q
L
P
H
E
Q
V
Y
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
D
K
E
E
V
A
K
F
T
W
E
M
T
N
F
L
-
V
D
R
G
I
K
M
L
V
I
A
C
N
T
A
T
A
A
A
L
Y
D
I
R
E
-
K
-
L
D
-
I
P
V
I
G
V
I
Q
P
G
S
R
A
A
L
K
--
A
--
T
R
N
-
N
K
I
G
V
--
L
G
T
L
G
T
V
E
S
M
A
Y
P
T
A
L
K
G
L
N
R
R
V
E
V
D
S
L
A
C
P
K
F
V
S
V
V
E
S
G
E
Y
-
K
S
-
A
I
A
-
K
K
V
V
A
E
S
L
L
P
L
K
S
--
T
K
I
D
T
V
I
L
G
C
T
H
Y
P
L
L
K
P
I
I
E
N
-
F
M
G
D
------
G
V
-----
A
------
V
I
N
S
G
E
E
T
A
S
E
V
S
A
L
L
---
D
Y
H
N
L
L
D
A
-
T
---
D
E
E
I
E
--
H
---
R
F
F
T
T
G
S
T
Q
I
F
K
D
I
A
K
D
W
L
N
M
P
D
M
T
V
E
H
I
K
L
G
--
62
HHSearch
80.78
59%
-162
- C2 -
-
2OHO
-
MURI_STRP1
B:
[10-273]
--------
M
D
T
R
P
I
G
F
L
D
-
S
G
V
G
G
L
T
V
V
C
E
L
I
R
Q
L
P
H
E
K
I
V
Y
I
G
---------
R
-
P
K
K
Q
I
K
E
Y
T
W
E
L
V
N
F
L
-
L
T
Q
N
V
K
M
I
V
F
A
C
N
T
A
T
A
V
A
W
E
E
V
K
A
-
A
-
L
D
-
I
P
V
L
G
V
V
L
P
G
A
S
A
A
I
K
--
S
--
T
T
K
-
G
Q
V
G
V
--
I
G
T
P
M
T
V
A
S
D
I
Y
R
K
K
I
Q
L
L
A
P
S
I
Q
V
R
S
L
A
C
P
K
F
V
P
I
V
E
S
N
E
M
-
C
S
-
S
I
A
-
K
K
I
V
Y
D
S
L
A
P
L
V
---
G
-
I
D
T
L
V
L
G
C
T
H
Y
P
L
L
R
P
I
I
Q
N
-
V
M
G
P
------
S
V
-----
K
------
L
I
D
S
G
A
E
C
V
R
D
I
S
V
L
L
---
N
Y
F
D
I
N
G
N
Y
H
---
Q
K
A
V
E
--
H
---
R
F
F
T
T
A
N
P
E
I
F
Q
E
I
A
S
I
W
L
K
Q
K
-
I
N
V
E
H
V
T
L
---
7
PsiBlast_PDB
80.77
60%
-152
- C2 -
-
3HFR
3
MURI_LISMO
A:
[6-268]
-----------
Q
A
I
G
F
I
D
-
S
G
V
G
G
L
T
V
V
R
E
V
L
K
Q
L
P
H
E
Q
V
Y
Y
L
G
D
T
A
R
C
P
Y
G
P
R
-
D
K
E
E
V
A
K
F
T
W
E
M
T
N
F
L
-
V
D
R
G
I
K
M
L
V
I
A
C
N
T
A
T
A
A
A
L
Y
D
I
R
E
-
K
-
L
D
-
I
P
V
I
G
V
I
Q
P
G
S
R
A
A
L
K
--
A
--
T
R
N
-
N
K
I
G
V
--
L
G
T
L
G
T
V
E
S
M
A
Y
P
T
A
L
K
G
L
N
R
R
V
E
V
D
S
L
A
C
P
K
F
V
S
V
V
E
S
G
E
Y
-
K
S
-
A
I
A
-
K
K
V
V
A
E
S
L
L
P
L
K
S
--
T
K
I
D
T
V
I
L
G
C
T
H
Y
P
L
L
K
P
I
I
E
N
-
F
M
G
D
------
G
V
-----
A
------
V
I
N
S
G
E
E
T
A
S
E
V
S
A
L
L
---
D
Y
H
N
L
L
D
A
-
T
---
D
E
E
I
E
--
H
---
R
F
F
T
T
G
S
T
Q
I
F
K
D
I
A
K
D
W
L
N
M
P
D
M
T
V
E
H
I
K
L
G
--
57
HHSearch
78.78
47%
-144
- C2 -
-
2DWU
2
?
A:
[5-269]
--------
H
K
H
S
V
I
G
V
L
D
-
S
G
V
G
G
L
T
V
A
S
E
I
I
R
Q
L
P
K
E
S
I
C
Y
I
G
D
N
E
R
C
P
Y
G
P
R
-
S
V
E
E
V
Q
S
F
V
F
E
M
V
E
F
L
-
K
Q
F
P
L
K
A
L
V
V
A
C
N
T
A
A
A
A
T
L
A
A
L
Q
E
-
A
-
L
S
-
I
P
V
I
G
V
I
H
P
G
A
R
A
A
I
K
--
V
--
T
K
K
-
G
K
I
G
V
--
I
G
T
V
G
T
I
Q
S
N
M
Y
E
K
A
L
H
E
L
D
T
Y
L
K
V
H
S
H
A
C
P
T
L
A
T
V
V
E
N
R
L
E
-
D
T
-
A
Y
V
-
T
Q
Q
V
K
Q
A
L
L
P
L
T
K
--
E
D
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
E
S
Y
I
K
K
-
E
L
G
E
------
D
V
-----
T
------
I
I
S
S
A
E
E
T
A
I
E
L
S
T
I
L
---
Q
H
K
G
I
L
A
D
N
-----
L
N
P
K
--
H
---
R
F
F
T
T
G
S
V
S
S
F
E
H
I
A
E
R
W
L
G
Y
Q
-
I
S
V
D
C
V
D
L
P
V
-
56
HHSearch
78.21
47%
-143
* C2 *
-
2DWU
3
?
B:
[5-269]
--------
H
K
H
S
V
I
G
V
L
D
-
S
G
V
G
G
L
T
V
A
S
E
I
I
R
Q
L
P
K
E
S
I
C
Y
I
G
D
N
E
R
C
P
Y
G
P
R
-
S
V
E
E
V
Q
S
F
V
F
E
M
V
E
F
L
-
K
Q
F
P
L
K
A
L
V
V
A
C
N
T
A
A
A
A
T
L
A
A
L
Q
E
-
A
-
L
S
-
I
P
V
I
G
V
I
H
P
G
A
R
A
A
I
K
--
V
--
T
K
K
-
G
K
I
G
V
--
I
G
T
V
G
T
I
Q
S
N
M
Y
E
K
A
L
H
E
L
D
T
Y
L
K
V
H
S
H
A
C
P
T
L
A
T
V
V
E
N
R
L
E
-
D
T
-
A
Y
V
-
T
Q
Q
V
K
Q
A
L
L
P
L
T
K
--
E
D
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
E
S
Y
I
K
K
-
E
L
G
E
------
D
V
-----
T
------
I
I
S
S
A
E
E
T
A
I
E
L
S
T
I
L
---
Q
H
K
G
I
L
A
D
N
-----
L
N
P
K
--
H
---
R
F
F
T
T
G
S
V
S
S
F
E
H
I
A
E
R
W
L
G
Y
Q
-
I
S
V
D
C
V
D
L
P
V
-
15
PsiBlast_PDB
75.40
49%
-149
- C2 -
-
2DWU
2
?
A:
[10-257]
-------------
I
G
V
L
D
-
S
G
V
G
G
L
T
V
A
S
E
I
I
R
Q
L
P
K
E
S
I
C
Y
I
G
D
N
E
R
C
P
Y
G
P
R
-
S
V
E
E
V
Q
S
F
V
F
E
M
V
E
F
L
-
K
Q
F
P
L
K
A
L
V
V
A
C
N
T
A
A
A
A
T
L
A
A
L
Q
E
-
A
-
L
S
-
I
P
V
I
G
V
I
H
P
G
A
R
A
A
I
K
--
V
--
T
K
K
-
G
K
I
G
V
--
I
G
T
V
G
T
I
Q
S
N
M
Y
E
K
A
L
H
E
L
D
T
Y
L
K
V
H
S
H
A
C
P
T
L
A
T
V
V
E
N
R
L
E
-
D
T
-
A
Y
V
-
T
Q
Q
V
K
Q
A
L
L
P
L
T
K
--
E
D
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
E
S
Y
I
K
K
-
E
L
G
E
------
D
V
-----
T
------
I
I
S
S
A
E
E
T
A
I
E
L
S
T
I
L
---
Q
H
K
G
I
L
A
D
N
L
---
N
P
K
H
-------
R
F
F
T
T
G
S
V
S
S
F
E
H
I
A
E
R
W
L
G
--------------
30
PsiBlast_CBE
74.88
49%
-148
- C2 -
-
2DWU
3
?
B:
[10-257]
-------------
I
G
V
L
D
-
S
G
V
G
G
L
T
V
A
S
E
I
I
R
Q
L
P
K
E
S
I
C
Y
I
G
D
N
E
R
C
P
Y
G
P
R
-
S
V
E
E
V
Q
S
F
V
F
E
M
V
E
F
L
-
K
Q
F
P
L
K
A
L
V
V
A
C
N
T
A
A
A
A
T
L
A
A
L
Q
E
-
A
-
L
S
-
I
P
V
I
G
V
I
H
P
G
A
R
A
A
I
K
--
V
--
T
K
K
-
G
K
I
G
V
--
I
G
T
V
G
T
I
Q
S
N
M
Y
E
K
A
L
H
E
L
D
T
Y
L
K
V
H
S
H
A
C
P
T
L
A
T
V
V
E
N
R
L
E
-
D
T
-
A
Y
V
-
T
Q
Q
V
K
Q
A
L
L
P
L
T
K
--
E
D
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
E
S
Y
I
K
K
-
E
L
G
E
------
D
V
-----
T
------
I
I
S
S
A
E
E
T
A
I
E
L
S
T
I
L
---
Q
H
K
G
I
L
A
D
N
L
---
N
P
K
H
-------
R
F
F
T
T
G
S
V
S
S
F
E
H
I
A
E
R
W
L
G
--------------
29
PsiBlast_CBE
74.69
49%
-149
- C2 -
-
2DWU
2
?
C:
[10-257]
-------------
I
G
V
L
D
-
S
G
V
G
G
L
T
V
A
S
E
I
I
R
Q
L
P
K
E
S
I
C
Y
I
G
D
N
E
R
C
P
Y
G
P
R
-
S
V
E
E
V
Q
S
F
V
F
E
M
V
E
F
L
-
K
Q
F
P
L
K
A
L
V
V
A
C
N
T
A
A
A
A
T
L
A
A
L
Q
E
-
A
-
L
S
-
I
P
V
I
G
V
I
H
P
G
A
R
A
A
I
K
--
V
--
T
K
K
-
G
K
I
G
V
--
I
G
T
V
G
T
I
Q
S
N
M
Y
E
K
A
L
H
E
L
D
T
Y
L
K
V
H
S
H
A
C
P
T
L
A
T
V
V
E
N
R
L
E
-
D
T
-
A
Y
V
-
T
Q
Q
V
K
Q
A
L
L
P
L
T
K
--
E
D
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
E
S
Y
I
K
K
-
E
L
G
E
------
D
V
-----
T
------
I
I
S
S
A
E
E
T
A
I
E
L
S
T
I
L
---
Q
H
K
G
I
L
A
D
N
L
---
N
P
K
H
-------
R
F
F
T
T
G
S
V
S
S
F
E
H
I
A
E
R
W
L
G
--------------
28
PsiBlast_CBE
74.45
48%
-92
- C2 -
-
2JFQ
1
MURI_STAAR
B:
[22-284]
----------
N
K
P
I
G
V
I
D
-
S
G
V
G
G
L
T
V
A
K
E
I
M
R
Q
L
P
N
E
T
I
Y
Y
L
G
D
I
G
R
C
P
Y
G
P
R
-
P
G
E
Q
V
K
Q
Y
T
V
E
I
A
R
K
L
-
M
E
F
D
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
Y
L
Q
K
-
T
-
L
S
-
I
S
V
I
G
V
I
E
P
G
A
R
T
A
I
M
--
T
--
T
R
N
-
Q
N
V
L
V
--
L
G
T
E
G
T
I
K
S
E
A
Y
R
T
H
I
K
R
I
N
P
H
V
E
V
H
G
V
A
C
P
G
F
V
P
L
V
E
Q
M
R
Y
-
S
D
P
T
I
T
-
S
I
V
I
H
Q
T
L
K
R
W
R
N
--
S
E
S
D
T
V
I
L
G
C
T
H
Y
P
L
L
Y
K
P
I
Y
D
-
Y
F
G
G
------
K
K
-----
T
------
V
I
S
S
G
L
E
T
A
R
E
V
S
A
L
L
---
T
F
S
N
-
E
H
A
S
Y
---
T
E
H
P
D
--
H
---
R
F
F
A
T
G
D
T
T
H
I
T
N
I
I
K
E
W
L
N
L
S
-
V
N
V
E
R
I
S
V
---
14
PsiBlast_PDB
73.60
48%
-90
- C2 -
-
2JFQ
1
MURI_STAAR
A:
[22-284]
----------
N
K
P
I
G
V
I
D
-
S
G
V
G
G
L
T
V
A
K
E
I
M
R
Q
L
P
N
E
T
I
Y
Y
L
G
D
I
G
R
C
P
Y
G
P
R
-
P
G
E
Q
V
K
Q
Y
T
V
E
I
A
R
K
L
-
M
E
F
D
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
Y
L
Q
K
-
T
-
L
S
-
I
S
V
I
G
V
I
E
P
G
A
R
T
A
I
M
--
T
--
T
R
N
-
Q
N
V
L
V
--
L
G
T
E
G
T
I
K
S
E
A
Y
R
T
H
I
K
R
I
N
P
H
V
E
V
H
G
V
A
C
P
G
F
V
P
L
V
E
Q
M
R
Y
-
S
D
P
T
I
T
-
S
I
V
I
H
Q
T
L
K
R
W
R
N
--
S
E
S
D
T
V
I
L
G
C
T
H
Y
P
L
L
Y
K
P
I
Y
D
-
Y
F
G
G
------
K
K
-----
T
------
V
I
S
S
G
L
E
T
A
R
E
V
S
A
L
L
---
T
F
S
N
-
E
H
A
S
Y
---
T
E
H
P
D
--
H
---
R
F
F
A
T
G
D
T
T
H
I
T
N
I
I
K
E
W
L
N
L
S
-
V
N
V
E
R
I
S
V
---
63
HHSearch
72.50
49%
-90
- C2 -
-
2JFQ
1
MURI_STAAR
B:
[21-285]
---------
M
N
K
P
I
G
V
I
D
-
S
G
V
G
G
L
T
V
A
K
E
I
M
R
Q
L
P
N
E
T
I
Y
Y
L
G
D
I
G
R
C
P
Y
G
P
R
-
P
G
E
Q
V
K
Q
Y
T
V
E
I
A
R
K
L
-
M
E
F
D
I
K
M
L
V
I
A
C
N
T
A
T
A
V
A
L
E
Y
L
Q
K
-
T
-
L
S
-
I
S
V
I
G
V
I
E
P
G
A
R
T
A
I
M
--
T
--
T
R
N
-
Q
N
V
L
V
--
L
G
T
E
G
T
I
K
S
E
A
Y
R
T
H
I
K
R
I
N
P
H
V
E
V
H
G
V
A
C
P
G
F
V
P
L
V
E
Q
M
R
Y
-
S
D
-
P
T
I
T
S
I
V
I
H
Q
T
L
K
R
W
R
N
--
S
E
S
D
T
V
I
L
G
C
T
H
Y
P
L
L
Y
K
P
I
Y
D
-
Y
F
G
G
------
K
K
-----
T
------
V
I
S
S
G
L
E
T
A
R
E
V
S
A
L
L
---
T
F
S
N
E
H
A
S
Y
T
----
E
H
P
D
--
H
---
R
F
F
A
T
G
D
T
T
H
I
T
N
I
I
K
E
W
L
N
L
S
-
V
N
V
E
R
I
S
V
N
--
31
PsiBlast_CBE
70.66
40%
-138
- C2 -
-
5HJ7
1
MURI_MYCTU
B:
[9-258]
------------
P
V
G
V
F
D
-
S
G
V
G
G
L
T
V
A
R
A
I
I
D
Q
L
P
D
E
D
I
V
Y
V
G
D
T
G
N
G
P
Y
G
P
L
-
T
I
P
E
I
R
A
H
A
L
A
I
G
D
D
L
-
V
G
R
G
V
K
A
L
V
I
A
C
N
S
A
S
S
A
C
L
R
D
A
R
E
-
R
-
Y
Q
-
V
P
V
V
E
V
I
L
P
A
V
R
R
A
V
A
--
A
--
T
R
N
-
G
R
I
G
V
--
I
G
T
R
A
T
I
T
S
H
A
Y
Q
D
A
F
A
-
A
A
R
D
T
E
I
T
A
V
A
C
P
R
F
V
D
F
V
E
R
G
V
T
-
S
G
-
R
Q
V
-
L
G
L
A
Q
G
Y
L
E
P
L
Q
R
--
A
E
V
D
T
L
V
L
G
C
T
H
Y
P
L
L
S
G
L
I
Q
L
-
A
M
G
E
------
N
V
-----
T
------
L
V
S
S
A
E
E
T
A
K
E
V
V
R
V
L
T
E
I
D
L
L
R
P
H
D
A
P
P
---
A
T
R
I
--------
F
E
A
T
G
D
P
E
A
F
T
K
L
A
A
R
F
L
G
--------------
16
PsiBlast_PDB
70.10
40%
-142
- C2 -
-
5HJ7
1
MURI_MYCTU
A:
[9-257]
------------
P
V
G
V
F
D
-
S
G
V
G
G
L
T
V
A
R
A
I
I
D
Q
L
P
D
E
D
I
V
Y
V
G
D
T
G
N
G
P
Y
G
P
L
-
T
I
P
E
I
R
A
H
A
L
A
I
G
D
D
L
-
V
G
R
G
V
K
A
L
V
I
A
C
N
S
A
S
S
A
C
L
R
D
A
R
E
-
R
-
Y
Q
-
V
P
V
V
E
V
I
L
P
A
V
R
R
A
V
A
--
A
--
T
R
N
-
G
R
I
G
V
--
I
G
T
R
A
T
I
T
S
H
A
Y
Q
D
A
F
A
-
A
A
R
D
T
E
I
T
A
V
A
C
P
R
F
V
D
F
V
E
R
G
V
T
-
S
G
-
R
Q
V
-
L
G
L
A
Q
G
Y
L
E
P
L
Q
R
--
A
E
V
D
T
L
V
L
G
C
T
H
Y
P
L
L
S
G
L
I
Q
L
-
A
M
G
E
------
N
V
-----
T
------
L
V
S
S
A
E
E
T
A
K
E
V
V
R
V
L
T
E
I
D
L
L
R
P
H
D
A
P
P
---
A
T
R
I
--------
F
E
A
T
G
D
P
E
A
F
T
K
L
A
A
R
F
L
---------------
55
HHSearch
66.06
55%
-44
- C2 -
-
1ZUW
1
MURI1_BACSU
C:
[2-268]
---------
L
E
Q
P
I
G
V
I
D
-
S
G
V
G
G
L
T
V
A
K
E
I
M
R
Q
L
P
K
E
N
I
I
Y
V
G
D
T
K
R
C
P
Y
G
P
R
-
P
E
E
E
V
L
Q
Y
T
W
E
L
T
N
Y
L
L
E
N
H
H
I
K
M
L
V
I
A
C
N
T
A
T
A
I
A
L
D
D
I
Q
R
-
S
-
V
G
-
I
P
V
V
G
V
I
Q
P
G
A
R
A
A
I
K
--
V
--
T
D
N
-
Q
H
I
G
V
--
I
G
T
E
N
T
I
K
S
N
A
Y
E
E
A
L
L
A
L
N
P
D
L
K
V
E
N
L
A
C
P
L
L
V
P
F
V
E
S
G
K
F
-
L
D
-
Q
T
A
-
D
E
I
V
K
T
S
L
Y
P
L
K
D
--
T
S
I
D
S
L
I
L
G
C
T
H
Y
P
I
L
K
E
A
I
Q
R
-
Y
M
G
E
------
H
V
-----
N
------
I
I
S
S
G
D
E
T
A
R
E
V
S
T
I
L
---
S
Y
K
G
L
L
N
Q
S
P
----
I
A
P
D
--
H
---
Q
F
L
T
T
G
A
R
D
Q
F
A
K
I
A
D
D
W
F
-----
H
V
E
C
I
S
L
Q
E
-
52
HHSearch
65.45
38%
-68
- C2 -
-
5IJW
1
MURI_MYCS2
A:
[3-272]
------
M
S
D
R
L
A
P
I
G
I
F
D
-
S
G
V
G
G
L
T
V
A
R
A
I
I
D
Q
L
P
D
E
D
I
V
Y
V
G
D
T
G
N
G
P
Y
G
P
L
-
T
I
P
Q
I
R
A
H
S
L
A
I
G
D
D
L
-
V
S
R
G
V
K
A
L
V
I
A
C
N
T
A
S
S
A
C
L
R
D
A
R
E
-
R
Y
S
P
-
V
P
V
V
E
V
I
L
P
A
V
R
R
A
V
A
--
A
--
T
R
N
-
G
R
I
G
V
--
I
G
T
Q
A
T
I
A
S
G
A
Y
Q
D
A
F
A
A
A
R
-
D
T
E
V
F
T
V
A
C
P
R
F
V
D
F
V
E
R
G
V
T
-
S
G
-
R
Q
V
-
L
G
L
A
E
G
Y
L
E
P
L
Q
L
--
A
E
V
D
T
L
V
L
G
C
T
H
Y
P
M
L
S
G
L
I
Q
L
-
A
M
G
D
------
N
V
-----
T
------
L
V
S
S
A
E
E
T
A
K
D
L
L
R
V
L
---
T
E
L
D
L
L
R
P
H
P
DDP
S
V
T
A
V
--
R
---
R
F
E
A
T
G
D
P
E
A
F
T
A
L
A
A
R
F
L
G
P
T
L
D
G
V
R
P
V
R
----
17
PsiBlast_PDB
64.56
40%
-76
- C2 -
-
5IJW
1
MURI_MYCS2
A:
[9-262]
------------
P
I
G
I
F
D
-
S
G
V
G
G
L
T
V
A
R
A
I
I
D
Q
L
P
D
E
D
I
V
Y
V
G
D
T
G
N
G
P
Y
G
P
L
-
T
I
P
Q
I
R
A
H
S
L
A
I
G
D
D
L
-
V
S
R
G
V
K
A
L
V
I
A
C
N
T
A
S
S
A
C
L
R
D
A
R
E
-
R
-
Y
S
P
V
P
V
V
E
V
I
L
P
A
V
R
R
A
V
A
--
A
--
T
R
N
-
G
R
I
G
V
--
I
G
T
Q
A
T
I
A
S
G
A
Y
Q
D
A
F
A
-
A
A
R
D
T
E
V
F
T
V
A
C
P
R
F
V
D
F
V
E
R
G
V
T
-
S
G
-
R
Q
V
-
L
G
L
A
E
G
Y
L
E
P
L
Q
L
--
A
E
V
D
T
L
V
L
G
C
T
H
Y
P
M
L
S
G
L
I
Q
L
-
A
M
G
D
------
N
V
-----
T
------
L
V
S
S
A
E
E
T
A
K
D
L
L
R
V
L
---
T
E
L
D
L
L
R
P
H
P
---
D
D
P
S
V
--
T
A
V
R
R
F
E
A
T
G
D
P
E
A
F
T
A
L
A
A
R
F
L
G
--------------
32
PsiBlast_CBE
63.97
40%
-78
- C2 -
-
5IJW
1
MURI_MYCS2
B:
[9-265]
------------
P
I
G
I
F
D
-
S
G
V
G
G
L
T
V
A
R
A
I
I
D
Q
L
P
D
E
D
I
V
Y
V
G
D
T
G
N
G
P
Y
G
P
L
-
T
I
P
Q
I
R
A
H
S
L
A
I
G
D
D
L
-
V
S
R
G
V
K
A
L
V
I
A
C
N
T
A
S
S
A
C
L
R
D
A
R
E
-
R
-
Y
S
P
V
P
V
V
E
V
I
L
P
A
V
R
R
A
V
A
--
A
--
T
R
N
-
G
R
I
G
V
--
I
G
T
Q
A
T
I
A
S
G
A
Y
Q
D
A
F
A
-
A
A
R
D
T
E
V
F
T
V
A
C
P
R
F
V
D
F
V
E
R
G
V
T
-
S
G
-
R
Q
V
-
L
G
L
A
E
G
Y
L
E
P
L
Q
L
--
A
E
V
D
T
L
V
L
G
C
T
H
Y
P
M
L
S
G
L
I
Q
L
-
A
M
G
D
------
N
V
-----
T
------
L
V
S
S
A
E
E
T
A
K
D
L
L
R
V
L
---
T
E
L
D
L
L
R
P
H
P
---
D
D
P
S
V
--
T
AVR
R
F
E
A
T
G
D
P
E
A
F
T
A
L
A
A
R
F
L
G
--------------
74
Fugue
63.28
38%
-148
- C2 -
-
1B74
1
MURI_AQUPY
A:
[1-252]
-----------
M
K
I
G
I
F
D
-
S
G
V
G
G
L
T
V
L
K
A
I
R
N
R
Y
R
K
V
D
I
V
Y
L
G
D
T
A
R
V
P
Y
G
I
R
-
S
K
D
T
I
I
R
Y
S
L
E
C
A
G
F
L
-
K
D
K
G
V
D
I
I
V
V
A
C
N
T
A
S
A
Y
A
L
E
R
L
K
K
-
E
-
I
N
-
V
P
V
F
G
V
I
E
P
G
V
K
E
A
L
K
--
K
--
S
R
N
-
K
K
I
G
V
--
I
G
T
P
A
T
V
K
S
G
A
Y
Q
R
K
L
E
E
--
G
G
A
D
V
F
A
K
A
C
P
L
F
A
P
L
A
E
E
G
L
L
-
E
G
-
E
I
T
-
R
K
V
V
E
H
Y
L
K
E
F
K
---
G
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
K
K
E
I
K
K
-
F
L
G
-------
D
A
-----
E
------
V
V
D
S
S
E
A
L
S
L
S
L
H
N
F
I
-----------
K
D
---
D
G
S
S
S
--
L
---
E
L
F
F
T
D
L
S
P
N
L
Q
F
L
I
K
L
I
L
G
-
R
D
Y
P
V
K
L
A
E
G
V
F
-
68
HHSearch
62.68
38%
-148
- C2 -
-
1B74
1
MURI_AQUPY
A:
[1-247]
-----------
M
K
I
G
I
F
D
-
S
G
V
G
G
L
T
V
L
K
A
I
R
N
R
Y
R
K
V
D
I
V
Y
L
G
D
T
A
R
V
P
Y
G
I
R
-
S
K
D
T
I
I
R
Y
S
L
E
C
A
G
F
L
-
K
D
K
G
V
D
I
I
V
V
A
C
N
T
A
S
A
Y
A
L
E
R
L
K
K
-
E
-
I
N
-
V
P
V
F
G
V
I
E
P
G
V
K
E
A
L
K
--
K
--
S
R
N
-
K
K
I
G
V
--
I
G
T
P
A
T
V
K
S
G
A
Y
Q
R
K
L
E
E
G
G
A
--
D
V
F
A
K
A
C
P
L
F
A
P
L
A
E
E
G
L
L
-
E
G
-
E
I
T
-
R
K
V
V
E
H
Y
L
K
E
F
-
K
--
G
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
K
K
E
I
K
K
-
F
L
G
-------
D
A
-----
E
------
V
V
D
S
S
E
A
L
S
L
S
L
H
N
F
I
---
K
D
D
G
-----------
S
S
S
--
L
---
E
L
F
F
T
D
L
S
P
N
L
Q
F
L
I
K
L
I
L
G
R
D
-
Y
P
V
K
L
------
64
HHSearch
59.77
35%
-73
- C2 -
-
3OUT
1
?
C:
[5-265]
--------
L
D
N
R
P
I
G
V
F
D
-
S
G
I
G
G
L
T
I
V
K
N
L
M
S
I
L
P
N
E
D
I
I
Y
F
G
D
I
A
R
I
P
Y
G
T
K
-
S
R
A
T
I
Q
K
F
A
A
Q
T
A
K
F
L
-
I
D
Q
E
V
K
A
I
I
I
A
C
N
T
I
S
A
I
A
K
D
I
V
Q
E
-
I
A
K
A
-
I
P
V
I
D
V
I
T
A
G
V
S
L
-
V
D
------
N
L
-
N
T
V
G
V
--
I
A
T
P
A
T
I
N
S
N
A
Y
A
L
Q
I
H
K
K
N
P
N
I
E
V
Y
S
N
P
C
G
L
F
V
S
M
I
E
E
G
F
V
-
S
G
-
H
I
V
-
E
L
V
A
K
E
Y
L
S
Y
F
H
D
--
K
N
I
Q
A
L
I
L
G
C
T
H
Y
P
I
I
K
E
S
I
A
K
-
I
L
--------
D
V
-----
K
------
L
I
D
P
S
L
Q
A
S
K
M
L
Y
S
L
L
---
F
E
N
K
L
L
N
T
T
K
----
S
N
P
E
--
Y
---
R
F
Y
V
T
D
I
P
L
K
F
R
S
V
G
E
M
F
L
Q
T
E
M
Q
H
L
E
I
V
S
L
---
34
PsiBlast_CBE
58.85
33%
-62
- C2 -
-
3UHO
3
MURI_CAMJE
A:
[27-271]
-------------
I
G
V
F
D
-
S
G
V
G
G
L
S
V
L
K
S
L
Y
E
A
R
L
F
D
E
I
I
Y
Y
G
D
T
A
R
V
P
Y
G
V
K
-
D
K
D
T
I
I
K
F
C
L
E
A
L
D
F
F
-
E
Q
F
Q
I
D
M
L
I
I
A
C
N
T
A
S
A
Y
A
L
D
A
L
R
A
-
K
-
A
H
-
F
P
V
Y
G
V
I
D
A
G
V
E
A
T
I
K
A
L
H
--
D
K
N
-
K
E
I
L
V
--
I
A
T
K
A
T
I
K
S
E
E
Y
Q
K
R
L
L
S
Q
-
G
Y
T
N
I
N
A
L
A
T
G
L
F
V
P
M
V
E
E
G
I
F
-
E
G
-
D
F
L
-
Q
S
A
M
E
Y
Y
F
K
N
I
T
T
--
P
--
D
A
L
I
L
A
C
T
H
F
P
L
L
G
R
S
L
S
K
-
Y
F
G
D
------
K
T
-----
K
------
L
I
H
S
G
D
A
I
---
V
E
F
L
K
---
E
R
E
N
I
--
D
L
K
---
N
H
K
A
K
--
L
---
H
F
Y
A
S
S
D
V
E
S
L
K
N
T
A
K
I
W
L
N
L
-------------
19
PsiBlast_PDB
58.85
44%
-161
- C2 -
-
1B74
1
MURI_AQUPY
A:
[3-200]
-------------
I
G
I
F
D
-
S
G
V
G
G
L
T
V
L
K
A
I
R
N
R
Y
R
K
V
D
I
V
Y
L
G
D
T
A
R
V
P
Y
G
I
R
-
S
K
D
T
I
I
R
Y
S
L
E
C
A
G
F
L
-
K
D
K
G
V
D
I
I
V
V
A
C
N
T
A
S
A
Y
A
L
E
R
L
K
K
-
E
-
I
N
-
V
P
V
F
G
V
I
E
P
G
V
K
E
A
L
K
--
K
--
S
R
N
-
K
K
I
G
V
--
I
G
T
P
A
T
V
K
S
G
A
Y
Q
R
K
L
E
E
G
G
A
D
--
V
F
A
K
A
C
P
L
F
A
P
L
A
E
E
G
L
L
-
E
G
-
E
I
T
-
R
K
V
V
E
H
Y
L
K
E
F
K
G
---
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
K
K
E
I
K
K
-
F
L
G
-------
D
A
-----
E
------
V
V
D
S
-------------------------------------------------------------------------
33
PsiBlast_CBE
58.69
33%
-60
- C2 -
-
3UHO
4
MURI_CAMJE
B:
[27-271]
-------------
I
G
V
F
D
-
S
G
V
G
G
L
S
V
L
K
S
L
Y
E
A
R
L
F
D
E
I
I
Y
Y
G
D
T
A
R
V
P
Y
G
V
K
-
D
K
D
T
I
I
K
F
C
L
E
A
L
D
F
F
-
E
Q
F
Q
I
D
M
L
I
I
A
C
N
T
A
S
A
Y
A
L
D
A
L
R
A
-
K
-
A
H
-
F
P
V
Y
G
V
I
D
A
G
V
E
A
T
I
K
AL
H
--
D
K
N
-
K
E
I
L
V
--
I
A
T
K
A
T
I
K
S
E
E
Y
Q
K
R
L
L
S
Q
-
G
Y
T
N
I
N
A
L
A
T
G
L
F
V
P
M
V
E
E
G
I
F
-
E
G
-
D
F
L
-
Q
S
A
M
E
Y
Y
F
K
N
I
T
T
--
P
--
D
A
L
I
L
A
C
T
H
F
P
L
L
G
R
S
L
S
K
-
Y
F
G
D
------
K
T
-----
K
------
L
I
H
S
G
D
A
I
---
V
E
F
L
K
---
E
R
E
N
I
--
D
L
K
---
N
H
K
A
K
--
L
---
H
F
Y
A
S
S
D
V
E
S
L
K
N
T
A
K
I
W
L
N
L
-------------
36
PsiBlast_CBE
58.52
33%
-59
- C2 -
-
3UHF
3
MURI_CAMJE
A:
[27-271]
-------------
I
G
V
F
D
-
S
G
V
G
G
L
S
V
L
K
S
L
Y
E
A
R
L
F
D
E
I
I
Y
Y
G
D
T
A
R
V
P
Y
G
V
K
-
D
K
D
T
I
I
K
F
C
L
E
A
L
D
F
F
-
E
Q
F
Q
I
D
M
L
I
I
A
C
N
T
A
S
A
Y
A
L
D
A
L
R
A
-
K
-
A
H
-
F
P
V
Y
G
V
I
D
A
G
V
E
A
T
I
K
A
L
H
--
D
K
N
-
K
E
I
L
V
--
I
A
T
K
A
T
I
K
S
E
E
Y
Q
K
R
L
L
S
Q
-
G
Y
T
N
I
N
A
L
A
T
G
L
F
V
P
M
V
E
E
G
I
F
-
E
G
-
D
F
L
-
Q
S
A
M
E
Y
Y
F
K
N
I
T
T
--
P
--
D
A
L
I
L
A
C
T
H
F
P
L
L
G
R
S
L
S
K
-
Y
F
G
D
------
K
T
-----
K
------
L
I
H
S
G
D
A
I
---
V
E
F
L
K
---
E
R
E
N
I
--
D
L
K
---
N
H
K
A
K
--
L
---
H
F
Y
A
S
S
D
V
E
S
L
K
N
T
A
K
I
W
L
N
L
-------------
20
PsiBlast_PDB
57.24
35%
-63
- C2 -
-
3OUT
1
?
A:
[6-262]
---------
D
N
R
P
I
G
V
F
D
-
S
G
I
G
G
L
T
I
V
K
N
L
M
S
I
L
P
N
E
D
I
I
Y
F
G
D
I
A
R
I
P
Y
G
T
K
-
S
R
A
T
I
Q
K
F
A
A
Q
T
A
K
F
L
-
I
D
Q
E
V
K
A
I
I
I
A
C
N
T
I
S
A
I
A
K
D
I
V
Q
E
I
A
-
K
A
-
I
P
V
I
D
V
I
T
A
G
----
V
S
--
L
--
V
D
N
L
N
T
V
G
V
--
I
A
T
P
A
T
I
N
S
N
A
Y
A
L
Q
I
H
K
K
N
P
N
I
E
V
Y
S
N
P
C
G
L
F
V
S
M
I
E
E
G
F
V
-
S
G
-
H
I
V
-
E
L
V
A
K
E
Y
L
S
Y
F
H
D
--
K
N
I
Q
A
L
I
L
G
C
T
H
Y
P
I
I
K
E
S
I
A
K
-
I
L
--------
D
V
-----
K
------
L
I
D
P
S
L
Q
A
S
K
M
L
Y
S
L
L
---
F
E
N
K
L
L
N
T
T
K
----
N
P
E
Y
------
R
F
Y
V
T
D
I
P
L
K
F
R
S
V
G
E
M
F
L
---
Q
T
E
M
Q
H
L
E
I
---
35
PsiBlast_CBE
56.65
33%
-59
- C2 -
-
3UHF
2
MURI_CAMJE
B:
[27-271]
-------------
I
G
V
F
D
-
S
G
V
G
G
L
S
V
L
K
S
L
Y
E
A
R
L
F
D
E
I
I
Y
Y
G
D
T
A
R
V
P
Y
G
V
K
-
D
K
D
T
I
I
K
F
C
L
E
A
L
D
F
F
-
E
Q
F
Q
I
D
M
L
I
I
A
C
N
T
A
S
A
Y
A
L
D
A
L
R
A
-
K
-
A
H
-
F
P
V
Y
G
V
I
D
A
G
V
E
A
T
I
K
A
L
H
--
D
K
N
-
K
E
I
L
V
--
I
A
T
K
A
T
I
K
S
E
E
Y
Q
K
R
L
L
S
Q
-
G
Y
T
N
I
N
A
L
A
T
G
L
F
V
P
M
V
E
E
G
I
F
-
E
G
-
D
F
L
-
Q
S
A
M
E
Y
Y
F
K
N
I
T
T
--
P
--
D
A
L
I
L
A
C
T
H
F
P
L
L
G
R
S
L
S
K
-
Y
F
G
D
------
K
T
-----
K
------
L
I
H
S
G
D
A
I
---
V
E
F
L
K
---
E
R
E
N
I
--
D
L
K
---
N
H
K
A
K
--
L
---
H
F
Y
A
S
S
D
V
E
S
L
K
N
T
A
K
I
W
L
N
L
-------------
67
HHSearch
55.28
33%
-67
- C2 -
-
3UHF
3
MURI_CAMJE
A:
[18-271]
----
L
Y
F
Q
S
N
A
M
K
I
G
V
F
D
-
S
G
V
G
G
L
S
V
L
K
S
L
Y
E
A
R
L
F
D
E
I
I
Y
Y
G
D
T
A
R
V
P
Y
G
V
K
-
D
K
D
T
I
I
K
F
C
L
E
A
L
D
F
F
-
E
Q
F
Q
I
D
M
L
I
I
A
C
N
T
A
S
A
Y
A
L
D
A
L
R
A
-
K
-
A
H
-
F
P
V
Y
G
V
I
D
A
G
V
E
A
T
I
K
--
A
L
H
D
K
N
-
K
E
I
L
V
--
I
A
T
K
A
T
I
K
S
E
E
Y
Q
K
R
L
L
S
Q
G
Y
T
-
N
I
N
A
L
A
T
G
L
F
V
P
M
V
E
E
G
I
F
-
E
G
------
D
F
L
Q
S
A
M
E
Y
Y
F
K
NI
T
T
P
D
A
L
I
L
A
C
T
H
F
P
L
L
G
R
S
L
S
K
-
Y
F
G
D
------
K
T
-----
K
------
L
I
H
S
G
D
A
I
V
E
F
L
K
E
R
E
---
N
I
D
L
K
-
N
-------
H
K
A
K
--
L
---
H
F
Y
A
S
S
D
V
E
S
L
K
N
T
A
K
I
W
L
N
L
-------------
65
HHSearch
55.26
32%
-75
- C2 -
-
2JFZ
1
MURI_HELPJ
B:
[1-255]
-----------
M
K
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
VE
D
K
N
-
A
P
I
L
V
--
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
G
Y
L
-
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
-
E
--
I
L
P
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
-
Y
F
M
G
HFALPT
P
P
-----
L
------
L
I
H
S
G
D
A
I
V
E
Y
L
Q
Q
K
Y
---
A
L
--------------
P
K
--
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
38
PsiBlast_CBE
55.16
33%
-66
- C2 -
-
5W1Q
4
?
A:
[23-274]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
Q
I
F
D
K
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
K
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
H
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
Q
Q
V
K
--
D
K
N
-
A
P
I
L
V
--
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
V
S
H
L
A
T
S
L
F
V
P
L
I
E
E
N
I
L
-
E
G
-
E
L
L
-
E
T
C
M
R
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
V
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
-
Y
F
M
E
------
H
F
-----
A
LSTP
P
L
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
T
L
K
---
K
---
N
A
C
T
F
P
K
V
---
E
F
H
A
S
G
D
V
V
W
L
E
K
Q
A
K
E
W
L
K
--------------
37
PsiBlast_CBE
55.03
33%
-67
- C2 -
-
5W1Q
5
?
B:
[23-274]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
Q
I
F
D
K
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
K
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
H
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
Q
QV
K
--
D
K
N
-
A
P
I
L
V
--
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
V
S
H
L
A
T
S
L
F
V
P
L
I
E
E
N
I
L
-
E
G
-
E
L
L
-
E
T
C
M
R
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
V
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
-
Y
F
M
E
------
H
F
-----
A
LSTPPL
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
T
L
K
---
K
---
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
V
W
L
E
K
Q
A
K
E
W
L
K
--------------
66
HHSearch
54.85
32%
-72
- C2 -
-
4B1F
1
MURI_HELPJ
A:
[1-255]
-----------
M
K
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
V
E
D
K
N
-
A
P
I
L
V
--
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
G
Y
L
-
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
-
E
--
I
L
P
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
-
Y
F
M
G
HFALPT
P
P
-----
L
------
L
I
H
S
G
D
A
I
V
E
Y
L
Q
Q
K
Y
---
A
L
K
N
N
A
---
C
----
T
F
P
K
--
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
47
PsiBlast_CBE
54.18
33%
-71
- C2 -
-
2JFY
1
MURI_HELPJ
B:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
40
PsiBlast_CBE
54.01
33%
-73
- C2 -
-
4B1F
1
MURI_HELPJ
A:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
L
V
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTP
P
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
P
K
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
42
PsiBlast_CBE
53.86
33%
-71
- C2 -
-
2W4I
2
MURI_HELPJ
E:
[3-254]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
--------------
43
PsiBlast_CBE
53.82
33%
-69
- C2 -
-
2W4I
2
MURI_HELPJ
B:
[3-254]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
--------------
41
PsiBlast_CBE
53.75
33%
-68
- C2 -
-
2W4I
2
MURI_HELPJ
F:
[3-254]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
--------------
48
PsiBlast_CBE
53.67
33%
-70
- C2 -
-
2JFY
1
MURI_HELPJ
A:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
L
V
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTP
P
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
P
K
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
45
PsiBlast_CBE
53.60
33%
-73
- C2 -
-
2JFZ
1
MURI_HELPJ
B:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
-------------PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
39
PsiBlast_CBE
53.52
33%
-72
- C2 -
-
4B1F
1
MURI_HELPJ
B:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
50
PsiBlast_CBE
53.39
33%
-81
- C2 -
-
2JFX
1
MURI_HELPJ
A:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
L
V
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTP
P
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
------------
F
P
K
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
49
PsiBlast_CBE
53.29
33%
-76
- C2 -
-
2JFX
1
MURI_HELPJ
B:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
LV
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTPP
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
--------------PK
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
44
PsiBlast_CBE
52.86
33%
-67
- C2 -
-
2W4I
2
MURI_HELPJ
A:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
L
V
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTP
P
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
P
K
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
46
PsiBlast_CBE
51.55
33%
-69
- C2 -
-
2JFZ
1
MURI_HELPJ
A:
[3-255]
-------------
I
G
V
F
D
-
S
G
V
G
G
F
S
V
L
K
S
L
L
K
A
R
L
F
D
E
I
I
Y
Y
G
D
S
A
R
V
P
Y
G
T
K
-
D
P
T
T
I
K
Q
F
G
L
E
A
L
D
F
F
-
K
P
H
E
I
E
L
L
I
V
A
C
N
T
A
S
A
L
A
L
E
E
M
Q
K
-
Y
-
S
K
-
I
P
I
V
G
V
I
E
P
S
I
L
A
I
K
R
--
Q
--
V
E
D
-
K
N
A
P
I
L
V
L
G
T
K
A
T
I
Q
S
N
A
Y
D
N
A
L
K
Q
Q
-
G
Y
L
N
I
S
H
L
A
T
S
L
F
V
P
L
I
E
E
S
I
L
-
E
G
-
E
L
L
-
E
T
C
M
H
Y
Y
F
T
P
L
E
I
--
L
P
-
E
V
I
I
L
G
C
T
H
F
P
L
I
A
Q
K
I
E
G
Y
F
M
G
H
------
F
A
LPTP
P
L
------
L
I
H
S
G
D
A
I
---
V
E
Y
L
Q
---
Q
K
Y
A
L
K
N
------
N
A
C
T
F
P
K
V
---
E
F
H
A
S
G
D
V
I
W
L
E
R
Q
A
K
E
W
L
K
L
-------------
75
Fugue
46.25
36%
-1
- C2 -
-
1B74
1
MURI_AQUPY
A:
[1-252]
-----------
M
K
I
G
I
F
D
S
G
-
V
G
G
L
T
V
L
K
A
I
R
N
R
Y
R
K
V
D
I
V
Y
L
G
D
T
A
R
V
P
Y
G
I
R
S-
K
D
T
I
I
R
Y
S
L
E
C
A
G
F
L
-
K
D
K
G
V
D
I
I
V
V
A
C
N
T
A
S
A
Y
A
L
E
R
L
K
K
-
E
-
I
N
-
V
P
V
F
G
V
I
E
P
G
V
K
E
A
L
K
--
K
--
S
R
N
-
K
K
I
G
V
--
I
G
T
P
A
T
V
K
S
G
A
Y
Q
R
K
L
E
E
G
G
A
D
V
F
A
K
A
--
C
P
L
F
A
P
L
A
E
E
G
L
L
-
E
G
-
E
I
T
-
R
K
V
V
E
H
Y
L
K
E
F
K
G
---
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
L
K
K
E
I
K
K
-
F
L
G
-------
D
A
-----
E
------
V
V
D
S
S
E
A
L
S
L
S
L
H
N
F
I
---
K
--------
D
---
D
G
S
S
S
--
L
---
E
L
F
F
T
D
L
S
P
N
L
Q
F
L
I
K
L
I
L
G
-
R
D
Y
P
V
K
L
A
E
G
V
F
-
78
Fugue
24.68
36%
-58
- C2 -
-
1B74
1
MURI_AQUPY
A:
[106-213]
------------------------------------------------------------------------------------------------------------------------------
N
-
K
K
I
G
V
--
I
G
T
P
A
T
V
K
S
G
A
Y
Q
R
K
L
E
E
G
--
G
A
D
V
F
A
K
A
C
P
L
F
A
P
L
A
E
E
G
L
L
E-
G
-
E
I
T
-
R
K
V
V
E
H
Y
L
K
E
F
K
---
G
K
I
D
T
L
I
L
G
C
T
H
Y
P
L
-
L
K
K
E
I
K
-
K
F
L
G
------
D
A
-----
E
------
V
V
D
S
S
E
A
L
S
L
S
L
H
N
F
I
---
K
---------------------------------------------------------