@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZX7: (2018-01-17 )
MKTLKEPTAEEIKKKRIYAEWGLTDEEYRMIEEDILGRMPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTSGPHVLQGPGEGAGIVDIGDGLAVVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSMGARPIALLDSLRFGELDNPRTKYLLEEVVAGIGGYGNCIGIPTVGGEIAFDPCYEGNPLVNAMCVGLIEHKHIQKGQAAGVGNSIMYVGAKTGRDGIHGATFASEEFNQEEEQQRSAVQVGDPFMEKLLLEACLELILHHSDSLIGIQDMGAAGLVSSSAEMASKAGSGLILTLDEVPQRETGMTPYEMMLSESQERMLICVKSGEEEKIQELFQKYDLDAVTIGKVTDDGQYRLYHQGEEVANLPVDALAEDAPVYHKEMKEPARIVEFQQLAPYQPVIEEPGQVLLDLLQQPTIASKRSIYETYDSQVQTNTVVRPGSDAAVMRVRGTNKALAMTTDCNARYLYLDPKIGGQIAVAEAARNIIASGGKPLAITDCLNYGSPDKPEVFWELSTSADGIAAACETLGTPVISGNVSLYNETDGQAIYPTPMIGMVGLIEDHKHITTQEFKKSGDLIYILGKTFADFDGSELQKMQLGRIEGVIRNFDLSIEKRNQELVLTAIQNGLIESAHDCSEGGLAIALAESAFKHQLGISVQFELSSAQLFAETQSRFVLTVAPENKTRFEEMMGDAAVLAGKVTDEAIIEISATDGQIKIETAVARKCWEDAIVCLMK
Atome Classification :
(20 SA)
.........10........20........30..--..--....40........50........--------60..--------...----------------...70-----........--.80......---.------------------.90..---------------......100.......110.......120.--....--.--.130...-----....140....-----------------...150......-.160-........170.......180----------.--------------.......190.......200.......210.......220.......230.......240.......250......---.260..-----.....270-.......280.......290.......300.......----------------310....------------..-.320.......330.......340.......350.......360.--..--....370.......380.......390.......400.......410....----...420.......430.......440..---------.--------..-..450...-..-..460.......470.......480.......490...-.---...500.....----..510.......520....-...----530.......540..-----.....--------550......---.560.......570.......580-.....--...--590.......600-....-..--..610-.......620.......630-.......640.......650.......660..----.---------....670.......680.......690..-----.---...--.700.......710....-...720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKTLKEP
T
A
E
E
I
K
K
K
R
I
Y
AEWGL
T
D
E
E
Y
R
M
I
E
E
--
D
I
--
L
GRMPNY
T
E
T
G
L
F
S
V
M
W
S
EHCSYK--------NSK
P
--------
V
L
R
----------------KFPT------SGPHVLQG--PGEGA
G
I
V
D
---I------------------GD
G
L
A
---------------
V
V
F
K
AESHNHPSAVEPYEGAAT
G
V
G
G
I
I
R
D
--
I
F
SM--G--A
R
P
I
A
L
L
-----
D
SLRFGELDN
P
-----------------
R
T
K
Y
L
L
E
E
V
V
A
G-IGG--YGNCIGIPTVGG
E
I
A
FDPC-Y----------E--------------GN
P
L
V
N
A
M
C
V
G
L
I
E
H
K
HIQKGQAAGVGN
S
I
M
Y
V
GAKTGRDGIHGATF
A
S
E
EF
N
Q
E
E
E
Q
Q
R
S
AVQVG
D
P
F
M
E
K
L
L
L
E
---
A
C
L
E
L
I
-----
L
HHSD
S
L
I
-
G
I
Q
DMGAAGLVS
S
S
A
E
M
A
S
KAGS
G
L
I
L
TLDEVPQRET----------------GM
T
P
Y
E
M
------------
M
L-SESQ
E
R
M
L
I
C
VKSG
E
E
E
K
I
Q
E
L
F
Q
KYDL
D
A
V
T
I
G
K
VTDDG
Q
Y
R
L
Y
--HQ--G
E
E
V
ANL
P
V
D
A
LAEDAP
V
Y
H
K
E
MKE
P
A
R
I
V
E
F
Q
QLAPY
Q
P
V
IEE
P
G
Q
V
L
L
D
----
L
L
QQPTIA
S
K
R
S
I
Y
E
T
YDSQVQT
N
T
V
V
R---------P--------GS-
D
A
A
V
M
R
VR-GT-N
K
A
L
A
M
TTDC
N
A
R
Y
L
Y
LDPKIG
G
Q
I
A
V
A
E
A
A
R
N
I
I
ASG-G---K
P
L
A
I
T
D
C
LNY----GSPDK
P
E
V
F
W
E
LSTSA
D
G
I
-
A
A
A
----
C
E
T
LGT
P
V
ISG
N
V
S
L
-----
Y
NETD--------G
Q
A
IYPTP
M
---
I
G
M
V
G
LIEDHKHI
T
T
Q
E
F
KKSG
D
--
L
I
Y
I
L--GKT--FADF
D
G
S
E
L
Q
K
M
--
Q
L
G
R
-
I
E
--
G
V
I
R
N-FD
L
S
I
EKRN
Q
E
L
V
L
T
A
I
QN
G
-
L
I
E
SAHDCSEG
G
L
A
I
A
L
A
E
S
A
F
K
HQLG
I
S
V
Q
F
----
E
---------LSS
A
Q
L
F
A
ETQ
S
R
F
V
L
T
VAPEN
K
T
R
F
E
E
M
-----M---G
D
A
--
A
V
L
AGKVT
D
E
A
I
I
E
I
SAT-D
G
Q
I
K
I
E
T
A
V
A
R
K
C
W
E
D
A
I
V
C
LMK
1
PsiBlast_PDB
93.55
48%
-41
- C3 -
-
3VIU
2
PURL_THET8
A:
[7-672]
-------------------
E
I
G
I
P
E
G
E
Y
R
E
I
V
Q
--
R
---
L
G
R
E
P
N
R
V
E
L
L
L
F
K
V
M
W
S
E
H
C
A
Y
K
--------
N
S
R
P
--------
L
L
K
----------------
A
L
P
K
------
E
G
E
A
V
L
Q
G
--
P
G
E
N
A
G
V
V
R
---
V
------------------
G
E
G
W
A
---------------
V
A
F
K
I
E
S
H
N
H
P
S
A
V
E
P
F
Q
G
A
A
T
G
V
G
G
I
L
R
D
--
I
M
S
M
--
G
--
A
R
P
I
A
L
L
-----
D
S
L
R
F
G
P
P
E
E
A
-----------------
R
S
R
Y
L
L
K
G
V
V
S
G
-
I
A
F
--
Y
G
N
A
I
G
V
P
T
V
G
G
D
L
Y
F
H
E
G
-
Y
----------
R
--------------
E
N
P
L
V
N
A
M
C
L
G
L
L
R
E
E
H
L
K
R
S
R
A
S
-
L
G
R
P
I
Y
Y
A
G
A
K
T
G
R
D
G
I
----------------------
V
G
D
P
F
L
G
K
L
L
M
E
---
A
T
L
E
A
I
-------
E
L
D
L
V
E
-
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
H
K
S
G
L
G
V
E
L
H
L
D
L
V
P
T
R
E
E
----------------
G
M
T
P
E
E
L
------------
L
L
-
S
E
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
W
G
L
D
C
V
P
V
A
R
T
I
P
E
R
V
F
R
V
L
--
F
R
--
G
E
V
V
A
E
V
P
T
E
A
L
A
E
-
A
P
T
Y
V
R
V
G
R
E
D
P
E
V
R
R
L
R
E
-
T
P
I
P
P
L
E
A
D
P
Q
E
V
L
R
R
----
L
L
A
S
P
N
L
A
S
R
E
A
V
Y
E
R
Y
D
H
Q
V
G
T
R
T
A
L
L
---------
P
--------
G
K
G
D
A
A
V
L
W
I
K
-
G
T
-
R
L
G
V
A
A
K
V
D
Q
N
P
R
Y
S
R
L
H
P
R
L
G
A
M
H
A
L
A
E
A
C
R
N
V
S
V
V
G
-
A
---
K
P
L
A
Y
T
D
G
L
N
L
----
G
S
P
E
T
P
E
G
Y
H
E
L
A
E
T
I
A
G
L
-
K
E
A
----
S
E
A
L
G
V
P
V
V
S
G
N
V
S
L
-----
Y
N
E
S
G
--------
G
K
R
I
P
P
T
A
M
---
V
G
V
V
G
V
L
E
V
D
K
R
-
A
E
M
G
F
R
R
P
G
E
--
V
L
L
L
I
--
G
E
E
--
R
G
E
L
G
A
S
E
V
L
Y
L
--
L
T
G
K
-
E
F
--
G
H
P
P
R
-
L
D
L
G
R
E
K
A
V
Q
E
A
I
R
D
L
I
Q
R
G
-
L
T
R
T
A
H
D
V
A
E
G
G
L
L
L
A
L
A
E
M
T
F
P
Y
G
V
G
A
T
V
E
V
R---
E
---------
E
G
L
E
A
L
F
G
E
A
P
S
R
V
L
F
T
V
---
E
K
T
R
L
Q
E
----------------------------------------------------------
25
HHSearch
81.56
39%
-71
- C3 -
-
2HS3
1
PURL_THEMA
A:
[11-601]
-----------------------------------
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------------
T
G
--
F
E
G
N
A
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
-------------------------
I
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
-
K
A
T
K
L
S
I
Q
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
-----
E
E
--
G
L
V
E
-
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
-
I
-----------
P
-
E
F
K
----------
R
V
E
F
E
E
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
-
R
--
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
--
P
V
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
-
Q
K
V
A
K
----
P
K
P
S
--
K
V
F
A
V
--
G
W
N
--
D
----------------------------
F
E
L
E
R
E
K
E
L
W
R
A
I
R
K
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
----
L
T
R
T
H
V
E
T
F
R
--
E
Y
G
L
K
I
E
V
----
K
L
P
EVRPA--
H
Q
M
V
L
V
F
S
E
R
-
T
P
-
V
V
D
V
P
V
K
E
I
G
T
L
------------------------------------------------------------
4
PsiBlast_PDB
73.84
40%
-37
- C3 -
-
2HS4
2
PURL_THEMA
A:
[5-506]
---------------------------
Y
L
N
I
L
K
--
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------
T
G
---
F
E
G
-----
N
A
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
-------------------------
I
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
K
A
T
K
L
S
-
I
Q
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
--------
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
-----
F
E
E
------------------
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
--
R
-
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.19
40%
-47
- C3 -
-
2HRY
1
PURL_THEMA
A:
[5-506]
---------------------------
Y
L
N
I
L
K
--
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------
T
--------------
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
A
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
I
-------------------------
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
----------------------
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
--------
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
-----
F
E
E
------------------
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
--
R
-
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.94
40%
-34
- C3 -
-
2HS3
1
PURL_THEMA
A:
[5-506]
---------------------------
Y
L
N
I
L
K
--
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------
T
G
---
F
E
G
-----
N
A
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
-------------------------
I
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
K
A
T
K
L
S
-
I
Q
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
--------
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
-----
F
E
E
------------------
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
--
R
-
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.50
40%
-46
- C3 -
-
2HS0
2
PURL_THEMA
A:
[5-506]
---------------------------
Y
L
N
I
L
K
--
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------
T
G
---
F
E
G
-----
N
A
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
-------------------------
I
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
--------------------
I
Q
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
--------
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
-----
F
E
E
------------------
V
N
A
R
E
V
F
E
Q
Y
D
---
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
--
R
-
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.87
40%
-43
- C3 -
-
2HRU
1
PURL_THEMA
A:
[5-506]
---------------------------
Y
L
N
I
L
K
--
E
K
--
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
----------------
R
L
P
K
------
T
G
---
F
E
G
-----
N
A
G
V
V
N
---
L
------------------
D
D
Y
Y
S
---------------
V
A
F
K
I
E
S
A
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
--
G
--
A
R
P
T
A
I
F
-----
D
S
L
H
M
S
R
I
-------------------------
I
D
G
I
I
E
G
-
I
A
D
--
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
-
Y
----------
A
--------------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
----------------------
V
G
D
P
F
A
E
K
M
L
I
E
---
A
F
L
E
M
V
--------
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
----------------
D
M
E
P
W
E
I
------------
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
--
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
-----
F
E
E
------------------
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
---------
P
--------
G
F
-
G
A
A
V
M
R
I
K
--
R
-
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
-
A
---
E
P
L
A
I
T
N
C
V
N
Y
----
G
D
P
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
-
K
N
A
----
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
---
V
G
M
L
G
K
V
N
P
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
70.67
24%
11
- C3 -
-
4LGY
1
PUR4_SALTY
A:
[176-1001]
------
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
--
L
G
R
N
P
N
D
I
E
L
Y
M
W
A
Q
A
N
S
E
H
C
R
H
K
--------
I
F
N
A
--------
D
W
I
I
DGKPQPKS
L
F
K
M
I
K
N
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
---
G
S
A
V
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
P
A
H
---------------
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
--
E
G
A
T
--
G
R
G
A
K
P
K
A
G
L
-----
V
G
F
S
V
S
N
L
R
I
P
GFEQPWEEDFGKPERIV
T
A
L
D
I
M
T
E
G
P
L
G
-
G
A
A
--
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
K
V
NSHN
G
E
E
L
R
G
Y
--------------
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
-
G
E
I
V
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
R
C
Q
E
V
I
D
R
C
W
Q
L
G
-----
D
A
--
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
--
D
N
HF
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
--
R
A
---
D
I
T
I
A
D
A
V
K
R
----
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
T
G
M
V
A
R
D
---------
Q
MVGPWQVP
V
A
-
D
C
A
V
T
T
A
S
-
L
D
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
-
I
GDI
K
R
I
K
L
S
A
N
W
M
A
----
A
A
-
G
H
P
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
E
E
L
----
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
-----
S
M
K
T
R
W
Q
EGN
E
Q
R
E
M
T
S
P
L
S
L
V
---
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
--
A
L
L
L
I
DL
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
--
Y
-
R
Q
-
L
G
--
D
K
P
A
D
V
R
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
----
A
ALGD-----
D
H
L
A
A
L
F
N
E
E
L
-
G
G
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
-----
L
A
Q
Y
G
L
A
DC
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
W
A
E
T
T
W
Q
M
Q
-
23
HHSearch
69.08
24%
11
- C3 -
-
3UJN
1
PUR4_SALTY
A:
[174-999]
------
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
--
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
--------
I
F
N
A
--------
D
W
I
I
DGKPQPKS
L
F
K
M
I
K
N
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
---
G
S
A
V
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
P
A
H
---------------
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
--
E
G
A
T
GR
G
--
A
K
P
K
A
G
L
-----
V
G
F
S
V
S
N
L
R
I
P
GFEQPWEEDFGKPERIV
T
A
L
D
I
M
T
E
G
P
L
G
-
G
A
A
--
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
K
V
NSHN
G
E
E
L
R
G
Y
--------------
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
-
G
E
I
V
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
R
C
Q
E
V
I
D
R
C
W
Q
L
G
-----
D
A
--
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
--
D
N
HF
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
--
R
A
---
D
I
T
I
A
D
A
V
K
R
----
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
T
G
M
V
A
R
D
---------
Q
MVGPWQVP
V
A
-
D
C
A
V
T
T
A
S
-
L
D
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
-
I
GDI
K
R
I
K
L
S
A
N
W
M
A
----
A
A
-
G
H
P
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
E
E
L
----
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
-----
S
M
K
T
R
W
Q
E
GN
E
Q
R
E
M
T
S
P
L
S
L
V
---
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
--
A
L
L
L
I
DL
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
--
Y
-
R
Q
-
L
G
--
D
K
P
A
D
V
R
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
----
A
ALGD-----
D
H
L
A
A
L
F
N
E
E
L
-
G
G
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
-----
L
A
Q
Y
G
L
A
DC
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
W
A
E
T
T
W
Q
M
Q
-
7
PsiBlast_PDB
67.67
25%
26
- C3 -
-
3UGJ
1
PUR4_SALTY
A:
[190-992]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
GEE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
----------
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
9
PsiBlast_PDB
67.29
25%
30
- C3 -
-
1T3T
1
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
GSA
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
------------------
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
G
EE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
8
PsiBlast_PDB
67.06
25%
28
- C3 -
-
4R7G
1
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
I
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
------------------
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
G
EE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
12
PsiBlast_PDB
66.92
25%
31
- C3 -
-
4MGH
3
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
------------------
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
AAA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
GEE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
14
PsiBlast_PDB
66.88
24%
28
- C3 -
-
4LGY
1
PUR4_SALTY
A:
[192-992]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
W
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
G
EE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
13
PsiBlast_PDB
66.78
25%
30
- C3 -
-
4L78
4
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
-----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
GEE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
11
PsiBlast_PDB
66.45
25%
29
- C3 -
-
3UMM
2
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
GSA
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
P
A
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
-----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
GEE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
AL
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
10
PsiBlast_PDB
66.07
25%
28
- C3 -
-
3UJN
1
PUR4_SALTY
A:
[190-990]
----------------------
L
A
E
D
E
I
D
Y
L
Q
E
--
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
----------------
T
F
E
T
------
T
P
D
Y
V
L
S
A
--
Y
K
D
N
A
A
V
M
E
G
S
A
V
------------------
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
P
A
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
--
G
--
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
WEEDFGKPE--------
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
---
Y
F
R
T
-
Y
----------
E
E
KVNSHN
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
----------------
D
F
A
S
V
Q
R
D
N
P
E
M
E
R
-------
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
----------------
G
M
S
P
L
E
I
------------
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
---------
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
-
T
G
M
V
A
R
DQMVGPWQV
P
--------
V
A
-
D
C
A
V
T
T
A
S
L
D
S
-
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
---
D
I
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
G
E
D
A
G
L
Y
------
D
A
V
-
K
A
V
GEE
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
D
L
--
G
K
G
--
H
N
A
L
G
A
T
A
L
A
Q
V
Y
R
Q
L
G
D
-
K
P
--
A
D
V
R
---
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
---
A
D
C
--
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
-
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
---------
47
HHSearch
47.60
21%
-36
- C3 -
-
2HS3
1
PURL_THEMA
A:
[49-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------
F
--------
E
G
-
N
A
G
V
V
N
L
D
-
D
--
Y
Y
S
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
V
L
A
M
G
-
A
---
R
P
T
A
I
F
D
S
L
H
M
------
S
R
------
I
I
D
G
I
I
E
G
I
-
A
D
Y
----
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
-----
S
S
L
Y
A
-----------
H
N
P
L
V
N
---
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
--
V
I
V
I
F
--
G
G
A
TG
R
D
G
I
H
G
A
S
F
A
S
E
--
D
L
T
G
D
K
A
TK
L
S
I
Q
V
-
G
D
P
F
A
E
K
M
L
I
E
A
F
L
E
M
V
E
E
G
-
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
----
D
RVPLREPDM
E
P
W
E
I
L
I
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-----
A
R
K
H
L
L
F
--
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
-----
30
HHSearch
40.46
20%
-0
- C3 -
-
3U0O
-
SELD_ECOLI
B:
[13-338]
-------------------------------------------------------
H
G
A
G
C
G
C
K
--------
I
S
P
K
--------
V
L
E
----------------
T
I
L
H
S
E
QAKF
V
D
P
N
L
L
V
G
NE
T
R
D
D
A
A
V
Y
D
---
L
------------------
G
N
G
T
S
---------------
V
I
S
T
T
D
F
F
-
M
P
I
V
D
N
P
F
D
F
G
R
I
A
A
T
N
A
I
S
D
--
I
F
A
M
--
G
--
G
K
P
I
M
A
I
-----
A
I
L
G
W
P
I
N
K
-------------------
L
S
P
E
I
A
R
E
V
T
E
G
-
G
R
Y
--
A
C
R
Q
A
G
I
A
L
A
G
G
H
S
I
D
A
P
-----------------------------
E
P
I
F
G
L
A
V
T
G
I
V
P
T
E
R
V
K
K
N
S
T
A
Q
A
G
C
K
L
F
L
----
T
K
P
L
G
I
G
V
L
T
T
A
E
K
K
-
S
L
---
L
K
P
E
H
Q
G
L
A
T
E
V
M
C
R
M
-
N
I
---
A
G
A
S
F
A
-----
N
I
--
E
G
V
K
-
A
M
T
D
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
V
Q
A
R
V
D
Y
E
A
I
P
K
L
P
G
V
E
E
Y
I
K
L
GAVPG
G
T
E
R
N
F
A
S
Y
G
H
LMGEMP
R
E
V
R
D
L
L
C
D
P
Q
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
F
G
I
E
L
T
A
I
G
E
L
V
P
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
39.84
20%
3
- C3 -
-
3U0O
-
SELD_ECOLI
A:
[29-338]
-------------------------------------------------------------------------------------------------------
I
L
H
SEQA
K
F
V
D
P
N
L
L
V
G
NE
T
R
D
D
A
A
V
Y
D
---
L
------------------
G
N
G
T
S
---------------
V
I
S
T
T
D
F
F
-
M
P
I
V
D
N
P
F
D
F
G
R
I
A
A
T
N
A
I
S
D
--
I
F
A
M
--
G
--
G
K
P
I
M
A
I
-----
A
I
L
G
W
P
I
N
K
-------------------
L
S
P
E
I
A
R
E
V
T
E
G
-
G
R
Y
--
A
C
R
Q
A
G
I
A
L
A
G
G
H
S
I
D
A
P
-----------------------------
E
P
I
F
G
L
A
V
T
G
I
V
P
T
E
R
V
K
K
N
S
T
A
Q
A
G
C
K
L
F
L
----
T
K
P
L
G
I
G
V
L
T
T
A
E
K
K
-
S
L
---
L
K
P
E
H
Q
G
L
A
T
E
V
M
C
R
M
-
N
I
---
A
G
A
S
F
A
-----
N
I
--
E
G
V
K
-
A
M
T
D
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
V
Q
A
R
V
D
Y
E
A
I
P
K
L
P
G
V
E
E
Y
I
KLGAVP
G
G
T
E
R
N
F
A
S
Y
G
H
LMGEMP
R
E
V
R
D
L
L
C
D
P
Q
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
F
G
I
E
L
T
A
I
G
E
L
V
P
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------