@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZY8: (2018-01-18 )
MADCILKMADITKKFSGIRALDCVNLMIERGEIHALCGENGAGKSTLMNVLSGLYPYGSYDGEIFYDGKLCQFKDLKDSEEKGIVIIHQELALSPYLSIKENIFLGNEQAERGVIDWELTEKKTYELLNKVGLSIDPNLLVSQIGVGQQQLVEIAKALSKSVRLLILDEPTAALNEEESANLLRLIRELKEQGVTSIIISHKLNEIVDIADRITILRDGQTIETLENEMISEEHIIRGMVGRDLVDRYPERKPDIGEVYFKVEDWTVYHPLDHERIINDHINLHLKKGEIVGIAGLMGAGRTEFAMSLFGHSYGSKISGRILKEGAEISVKTVPSAIANGLAYVSEDRKSLGLNLLMDIRENVTLSSLDKISQKGVLDKEKEVTEAENFRKKMRIKTNSIHQIVSSLSGGNQQKVVLSKWLMTQPDILFLDEPTRGIDVGAKYEIYTIIEEMAANGKAVCLISSELPEILGMCDRIYTMNEGRITGEVSREDADQEVLMKLMTKEEVG
Atome Classification :
(22 SA)
-------------------------------------------------.........10...--.--.-.---..20.....-----------------------...30........40........50......--..60.......-----------.70..--.--.-....80--..----------......90........100..--....--.--110.-.-------.------...--..---120---...----------------.....130-.--..-.....140-......----...150.......160.......170....----...180.....-..190--..-.......200.......210.......220.-.-.....230..-----------------------.----..--------------------------.-.-------------------------------.--------------------------------------240------..------.-------------------------------------------------------.---------------------------------------------.--.--.---------..------------------250----------------------------------------------------------------------------------------------------------------.------------------------.--------------------------------------------------------.----------------------------.-----------------------------------------------------------------------------------------------------.....260.......270--.--......280....-------...290.......300.......310.......320.......330.--.......340....--------------------------...--------------------------350..-----------------------.-.-----.----.---------------.360........370-.---.-.......380------------------------.........390..--.-.-.-..400.......410.......420.......430.......440.......450..-.-....460.......470.......-480.........490.......500......-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------
M
A
D
C
I
L
K
M
A
D
I
T
K
K
--F--S-G---I
R
A
L
D
C
V
N
L
-----------------------
M
I
ERG
E
I
H
A
L
CGENGA
G
K
S
T
L
M
N
V
L
S
G
LYPY--GSYD
G
E
I
F
YDG-----------KL
C
Q
F--K--D-LKDSEE--K
G
----------
I
V
I
I
H
Q
ELALSP
Y
L
SIK
E
N
I
F
--LG
N
E
--
Q
--
A
E-R-G-------
V
------
I
D
W
--EL---T
E
----
K
K
T
----------------
Y
E
L
L
N
K
V--G--LS-ID
P
N
L
L
---
V
S
QIGV----
G
Q
Q
Q
L
V
E
I
A
K
A
L
S
KS
V
R
L
L
I
LDEPTAALN
E
----
E
E
S
A
N
L
L
R
L
I
R
-
E
L
K
----EQ-GV
T
S
I
I
I
S
H
K
L
N
E
I
V
D
I
A
D
R
I
T
I
LRDG
Q
T
I
E
-
T
-
L
E
N
E
MI
S
-
E
E
-----------------------
H
----
I
I
--------------------------
R
-
G
-------------------------------
M
--------------------------------------
V
--------
G
R
------
D
-------------------------------------------------------
L
---------------------------------------------
V
--
D
--R---------YP------------------E------------------------------------------------------------------------------------------------------------------R------------------------K--------------------------------------------------------P----------------------------D-----------------------------------------------------------------------------------------------------I
G
E
V
Y
F
K
VE
D
W
T
V
YHPL
D
--
H
--
E
R
I
I
N
DH
I
N
L
H
L
K-------KG
E
I
V
G
IAGLMGA
G
R
T
E
F
A
M
S
L
F
GHSYG
S
K
I
S
G
R
I
L
KEG
A
E
I
S
V
-
K
T--
V
P
S
A
I
A
N
G
L
A
Y
V
S
E
--------------------------
D
R
K
--------------------------
S
L
G
L
N
-----------------------
L
-
L
-----
M
----
D
---------------
I
R
-ENV
T
L
S
S
L
D
K
---
I
---
S
-QKGVLD
K
E
--------------------------
K
E
V
T
E
A
E
N
F
R
K
K
MR--I-K-
T
-
N
S
I
H
Q
I
V
S
S
LSGGNQ
Q
K
V
V
L
S
K
WLMTQP
D
I
L
F
LDEPTRGIDVGA
K
Y
E
I
Y
T
I
I
E
E
M
AA-N-G
K
A
V
C
L
I
S
S
E
L
P
E
I
L
G
M
C
D
R
I
Y
TM-N--EG
R
I
T
G
EVSREDA
D
Q
E
V
L
M
K
L
M
T
KEEVG-------------------------------------
68
HHSearch
74.71
23%
30
- C4 -
-
4F4C
2
PGP1_CAEEL
A:
[414-1306]
----------------------------------------------------
G
D
I
T
V
E
N
V
H
F
T
--
Y
--
P
-
S
RPD
V
P
I
L
R
G
M
N
L
-----------------------
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
--
L
--
K
G
K
I
T
I
D
G
-----------
V
D
V
R
D
--
I
--
N
-
L
-
E
F
L
R
--
K
N
----------
V
A
V
V
S
Q
E
P
A
L
F
N
-
C
T
I
E
E
N
I
S
--
L
G
K
E
--
G
--
I
T
-
R
-
E
-------
E
------
M
V
A
--
A
C
---
K
M
----
A
N
A
----------------
E
K
F
I
K
T
L
PN
G
--
Y
N
-
T
L
V
G
D
R
---
G
T
Q
L
S
G
----
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
----
E
S
E
G
I
V
Q
Q
A
L
D
-
K
A
A
-----
K
-
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
-
V
-
G
D
H
R
A
L
M
-
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G-------ER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
-
I
-------------------------------
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
A
--------
G
N
------
P
ADFL
S
Q
G
H
F
----------------------------------------------
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QH
I
--
G
--
F
---------
F
D
SPQNA-------------
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
-------------------------------------
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
--------------------------------------------------------
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
---------------
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKK
K
L
Y
G
K
V
I
F
K
N
V
R
F
--
A
Y
P
--
E
RP
E
I
E
I
L
K
G
L
S
F
S
V
E
-------
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
--
D
T
L
G
G
E
I
F
I
D
G
S
E
I
K
T
-
L
N
---
P
E
H
T
R
S
Q
I
A
I
V
S
Q
--------------------------
E
P
------------------------------
T
L
-----------------------
F
-
D
-----
C
----
S
---------------
I
A
-
E
N
I
I
Y
G
L
D
P
S
---
S
---
V
-
T
M
A
Q
V
E
E
A
--------------------------
A
R
L
A
N
I
H
N
F
I
A
E
L
P
EG
F
-
E
---
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
--
E
-
G
R
T
C
I
V
I
A
H
R
L
N
T
V
M
-
N
A
D
C
I
A
V
V
-
S
--
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
K
------------------------------------------------
69
HHSearch
69.60
23%
42
- C4 -
-
5KO2
-
MDR1A_MOUSE
B:
[386-1224]
----------------------------------------------------
G
N
L
E
F
K
N
I
H
F
S
--
Y
--
P
-
S
RKE
V
Q
I
L
K
G
L
N
L
-----------------------
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
--
L
--
D
G
M
V
S
I
D
G
-----------
Q
D
I
R
T
--
I
--
N
-
V
R
-
Y
L
R
--
E
I
----------
I
G
V
V
S
Q
E
P
V
L
F
A
T
-
T
I
A
E
N
I
R
--
Y
G
R
E
--
D
--
V
T
-
M
-
D
-------
E
------
I
E
K
--
A
V
---
K
E
----
A
N
A
----------------
Y
D
F
I
M
K
L
--
P
HQ
F
D
-
T
L
V
G
E
R
---
G
A
Q
L
S
G
----
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
T
----
E
S
E
A
V
V
Q
A
A
L
D
-
K
A
R
-----
E
-
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
-
Q
-
G
N
H
D
E
L
M
-
R
E
KGIYFKLVMTQTDVPPASFW---
R
----
I
L
--------------------------
K
-
L
NSTEWPYFVVGIFCAIINGGLQPAFSVIFSK
V
--------------------------------------
V
GVFTN---
G
G
------
P
PETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQ
D
---------------------------------------------
V
--
S
--
W
---------
F
D
DP----------------
K
NTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQ
S
LQIPYR------------------
N
AMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAM
A
VGQVSSFAPDYAKATVSASHIIRIIEKT
P
EIDSYSTQGLKPN----------------------------------------------------------------------------------------
M
L
E
G
N
V
Q
F
S
G
V
V
F
--
N
Y
P
TR
P
--
S
I
P
V
L
Q
G
L
S
L
E
V
K
-------
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
--
D
P
M
A
G
S
V
F
L
D
G
K
E
I
K
Q
-
L
N
---
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
--------------------------
E
P
------------------------------
I
L
-----------------------
F
-
D
-----
C
----
S
---------------
I
A
-
E
N
I
A
Y
G
D
N
S
R
---
V
---
V
-
S
Y
E
E
I
V
R
A
--------------------------
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
--
D
-
K
Y
N
-
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
E
---
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
-
N
A
D
L
I
V
V
I
-
Q
--
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
--------------------------------------------------
85
HHSearch
68.68
21%
7
- C3 -
-
1YQT
2
?
A:
[25-486]
---------------------------------------------------------
E
D
C
V
H
R
--
Y
--
G
-
V
---
N
A
F
V
L
Y
R
L
P
-----------------------
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
--
N
L
C
G
D
N
D
S
W
D
G
-----------
V
-
I
R
A
--
F
--
R
-
G
N
E
-
L
Q
--
N
Y
F
E
K
L
K
N
GE
I
R
P
V
V
K
P
Q
Y
V
D
L
I
P
K
-
A
V
K
G
K
V
I
----------------
E
-------
L
------
L
K
K
--
A
D
---
E
T
----
G
K
L
----------------
E
E
V
V
K
A
L
--
E
--
L
E
-
N
V
L
E
R
E
---
I
Q
H
L
S
G
----
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
N
A
A
R
A
I
R
-
R
L
S
----
E
E
-
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
-
H
V
V
Y
G
E
P
G
V
-
Y
-
G
I
F
S
Q
P
K
-
G
T
R
N
---------------------
G
----
I
N
--------------------------
E
-
F
-------------------------------
L
--------------------------------------
R
GYLKDE--
N
V
R-----
F
-------------------------------------------------------
R
---------------------------------------------
P
--
Y
E
I
K
---------
F
T
------------------
K
------------------------------------------------------------------------------------------------------------------
T
------------------------
G
--------------------------------------------------------
E
RVE-------------------------
I
-----------------------------------------------------------------------------------------------------
E
R
E
T
L
V
T
Y
P
R
L
V
K
--
D
Y
G
------
S
F
R
L
E
V
E
P
G
E
I
K
-------
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
--
E
P
T
E
G
K
I
E
W
D
L
-----------------
T
V
A
Y
K
P
Q
--------------------------
Y
I
-----------------------------
K
A
D
-----------------------
Y
-
E
-----
G
----
T
---------------
V
Y
-
E
L
L
S
K
I
D
A
S
K
-------------
L
-----------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
--
I
-
I
---
D
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
-
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
-
E
--
G
E
P
G
K
Y
G
R
A
L
-------------------------------------------------------
67
HHSearch
68.00
22%
42
- C4 -
-
5KO2
-
MDR1A_MOUSE
A:
[386-1223]
----------------------------------------------------
G
N
L
E
F
K
N
I
H
F
S
--
Y
--
P
-
S
RKE
V
Q
I
L
K
G
L
N
L
-----------------------
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
--
L
--
D
G
M
V
S
I
D
G
-----------
Q
D
I
R
T
--
I
--
N
-
V
R
-
Y
L
R
--
E
I
----------
I
G
V
V
S
Q
E
P
V
L
F
A
T
-
T
I
A
E
N
I
R
--
Y
G
R
E
--
D
--
V
T
-
M
-
D
-------
E
------
I
E
K
--
A
V
---
K
E
----
A
N
A
----------------
Y
D
F
I
M
K
L
--
P
HQ
F
D
-
T
L
V
G
E
R
---
G
A
Q
L
S
G
----
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
T
----
E
S
E
A
V
V
Q
A
A
L
D
-
K
A
R
-----
E
-
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
-
Q
-
G
N
H
D
E
L
M
-
R
E
KG
I
Y
F
K
L
V
M
T
Q
TD
V
P
P
A
S
F
W
---
R
----
I
L
--------------------------
K
-
L
N
STE
W
P
Y
F
V
V
G
I
F
C
A
I
I
N
G
G
L
Q
P
A
F
S
V
I
F
S
K
V
V
G
V
F
----------------------------------
T
N-------
G
G
PPET
Q
R
Q
N
S
N
L
F
S
L
L
F
L
I
L
G
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q------
D
---------------------------------------------
V
--
S
--
W
---------
F
D
DP----------------
K
NT
T
G
A
L
T
T
R
L
A
NDAAQ
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
TR
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
------------------
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
QLMT
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
APD
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
KT
P
EIDSYSTQGLKPN----------------------------------------------------------------------------------------
M
L
E
G
N
V
Q
F
S
G
V
V
F
--
N
Y
P
TR
P
--
S
I
P
V
L
Q
G
L
S
L
E
V
K
-------
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
--
D
P
M
A
G
S
V
F
L
D
G
K
E
I
K
Q
-
L
N
---
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
--------------------------
E
P
------------------------------
I
L
-----------------------
F
-
D
-----
C
----
S
---------------
I
A
-
E
N
I
A
Y
G
D
N
S
R
---
V
---
V
-
S
Y
E
E
I
V
R
A
--------------------------
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
--
D
K
Y
-
N
-
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
E
---
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
-
N
A
D
L
I
V
V
I
-
Q
--
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
---------------------------------------------------
1
PsiBlast_PDB
61.92
30%
-44
- C4 -
-
4U00
1
?
A:
[3-218]
----------------------------------------------------
P
I
I
R
I
R
N
L
H
K
W
--
F
--
G
-
P
---
L
H
V
L
K
G
I
H
L
-----------------------
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
----
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
--
K
--
D
-
D
R
A
L
R
E
I
R
R
E
----------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
--
L
A
P
M
--
R
--
V
R
-
R
------------------
W
P
R
E
K
---
A
E
----
K
K
A
----------------
L
E
L
L
E
R
V
--
G
--
I
L
-
D
Q
A
R
K
Y
---
P
A
Q
L
S
G
----
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
-
D
L
A
----
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.89
30%
-46
- C4 -
-
4U02
-
?
A:
[2-218]
---------------------------------------------------
E
P
I
I
R
I
R
N
L
H
K
W
--
F
--
G
-
P
---
L
H
V
L
K
G
I
H
L
-----------------------
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
----
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
--
K
--
D
-
D
R
A
L
R
E
I
R
R
E
----------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
--
L
A
P
M
--
R
--
V
R
-
R
------------------
W
P
R
E
K
---
A
E
----
K
K
A
----------------
L
E
L
L
E
R
V
--
G
--
I
L
-
D
Q
A
R
K
Y
---
P
A
Q
L
S
G
----
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
-
D
L
A
----
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.51
35%
-32
- C4 -
-
2IT1
-
?
A:
[4-215]
------------------------------------------------------
I
K
L
E
N
I
V
K
K
--
F
--
G
-
N
---
F
T
A
L
N
N
I
N
L
-----------------------
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
--
T
S
--
G
K
I
Y
F
D
E
-----------
K
D
V
T
E
--
L
--
P
-
P
K
D
-----
R
N
----------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
--
F
P
L
E
L
R
K
--
A
P
-
R
-
E
-------
E
------
I
D
--------------
K
K
V
----------------
R
E
V
A
K
M
L
--
H
--
I
D
-
K
L
L
N
R
Y
---
P
W
Q
L
S
G
----
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
-
E
L
--------
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
-
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
59.39
19%
13
- C2 -
-
2IW3
1
EF3A_YEAST
A:
[435-978]
-------------------------------------------------------
D
L
C
N
C
E
F
S
--
L
A
Y
G
-
A
---
K
I
L
L
N
K
T
Q
L
-----------------------
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
----
F
P
T
Q
E
E
----------------------------
C
--
R
T
----------
V
Y
V
E
H
D
I
D
G
T
H
S
D
T
S
V
L
D
F
V
F
--
E
S
G
V
--
G
--
T
------------------------------
K
----
E
A
I
----------------
K
D
K
L
I
E
F
--
G
--
F
T
D
E
M
I
A
M
P
---
I
S
A
L
S
G
----
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
-
T
-------
C
-
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
-
G
N
F
T
E
F
V
-
K
K
-----------------------
C
PAAK
A
Y
--------------------------
E
-
E
-------------------------------
L
--------------------------------------
S
--------
N
T
------
D
-------------------------------------------------------
L
---------------------------------------------
E
--
F
--
K
---------
F
P
------------------
E
------------------------------------------------------------------------------------------------------------------
P
GYLEG-------------------
V
--------------------------------------------------------
K
----------------------------
T
-----------------------------------------------------------------------------------------------------
K
Q
K
A
I
V
K
V
T
N
M
E
F
--
Q
Y
P
G-
T
--
S
K
P
Q
I
T
D
I
N
F
Q
C
S
-------
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
--
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
L
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEN
D
A
E
A
-------------------------
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
-
E
C
S
---
F
----
L
---------------
L
G
-
E
N
I
G
M
K
S
E
R
W
V
P
M
M
---
S
V
D
N
A
W
I
P
R
G
ELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRP
L
T
R
K
E
I
E
E
H
C
S
M
L
G
--
L
-
D
-
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
-----
E
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
-
K
--
D
G
R
M
T
P
-----------------------------------------------------------
57
Fugue
58.91
26%
37
- C4 -
-
1OXS
-
?
C:
[1-352]
-------------------------------------------------
M
V
R
--
I
I
V
K
N
V
S
K
V
--
F
--
K
-
K
GK-
V
V
A
L
D
N
V
N
I
-----------------------
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
--
S
T
--
G
E
L
Y
F
D
D
-----------
R
L
V
A
S
NG
K
--
L
-
I
V
P
P
E
D
--
R
K
----------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
--
F
P
L
T
--
N
--
M
K
-
M
-----------------
S
K
--
E
E
---
I
R
----
K
R
V
----------------
E
E
V
A
K
I
L
--
D
--
I
H
-
H
V
L
N
H
F
---
P
R
E
L
S
G
----
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
----
R
M
R
D
S
A
R
A
L
V
K
-
E
V
Q
----
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
-
G
K
P
E
D
L
Y
-
D
N
-----------------------
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Q
V
A
S
L
I
G
E
I
--
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
-
L
R
--
F
P
V
S
V
S
S
D
-----------------------------------------------------------------
R
-----------------------
A
-
I
-----
I
----
G
---------------
I
R
P
E
D
V
K
L
S
K
D
V
I
---
K
---
D
-
D
S
W
I
L
V
G
K
--------------------------
G
K
V
K
V
I
G
Y
Q
-------------------------
G
G
L
F
R
I
T
I
T
P
---
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
-
F
-
E
K
-------------------------------------------------------------------------------------------
76
HHSearch
58.15
22%
36
- C3 -
-
3J5S
-
ETTA_ECOLI
D:
[3-523]
---------------------------------------------------
Q
F
V
Y
T
M
H
R
V
G
K
V
--
V
--
P
P
K
---
R
H
I
L
K
N
I
S
L
-----------------------
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
--
I
--
E
G
E
A
R
P
Q
----------------------------
P
D
--
I
K
----------
I
G
Y
L
P
Q
E
P
Q
L
N
P
E
H
T
V
R
E
S
I
E
--
E
A
V
S
--
E
--
V
V
N
A
-
L
KRLDEVY
A
LYADPD
A
D
F
--
D
K
LAA
E
Q
----
G
R
L
EEIIQAHDGHNLNVQL
E
R
A
A
D
A
L
--
R
--
L
--
P
D
W
D
A
K
---
I
A
N
L
S
G
----
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
-
D
F
--------
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
-
W
E
G
N
Y
S
S
W
L
-
E
Q
KDQRLAQ----------------
E
----
A
S
--------------------------
Q
E
A
-------------------------------
A
RRKSIEKE------------------------------
L
EWVRQGTK
G
R
------
Q
-------------------------------------------------------
S
KGKAR----------------------------------------
L
--
A
--
R
---------
F
E
ELNSTEYQKRNETNELFI
P
------------------------------------------------------------------------------------------------------------------
P
------------------------
G
--------------------------------------------------------
P
----------------------------
R
-----------------------------------------------------------------------------------------------------
L
G
D
K
V
L
E
V
S
N
L
R
K
--
S
Y
G
--
D
---
R
L
L
I
D
D
L
S
F
S
I
P
-------
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
--
Q
P
D
S
G
T
I
T
L
G
E
T
V
K
L
---------------
A
S
V
D
Q
--------------------------
F
----------------------------
R
D
S
M
D
-----------------------
N
-
S
-----
K
----
T
---------------
V
W
-
E
E
V
S
G
G
L
D
I
M
---
K
------
I
G
---
N
----------------------------
T
E
M
P
S
R
A
Y
V
G
R
F
N
--
F
-
K
-
G
-
V
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
-----
P
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
-
Q
--
D
E
G
K
V
E
F
F
---------------------------------------------------------
80
HHSearch
57.58
18%
14
- C3 -
-
4CRM
2
RLI1_YEAST
P:
[99-558]
----------------------------------------------------------------------------------------------------------
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
--
N
--
L
G
R
F
D
D
P
P
EWQEIIKYFRG
S
E
L
Q
N
--
Y
--
F
-
T
-
K
M
L
E
--
D
D
----------
I
K
A
I
I
K
P
-------
Q
Y
V
D
N
I
P
--
R
A
I
K
--
G
PV
Q
K
V
G
E
L
L------
K
------
L
R
M
--
E
K
---
S
P
----
E
D
V
----------------
K
R
Y
I
K
I
L
--
Q
--
L
E
-
N
V
L
K
R
D
---
I
E
K
L
S
G
----
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
Q
R
L
N
A
A
Q
I
I
R
-
S
L
L
----
A
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
-
V
V
T
L
P
A
S
V
R
E
-----------------------
G
----
I
N
--------------------------
I
-
F
-------------------------------
L
--------------------------------------
D
--------
G
H
------
I
-------------------------------------------------------
P
---------------------------------------------
A
EN
L
--
R
FRTEALQFR
I
A
------------------
D
------------------------------------------------------------------------------------------------------------------
A
TEDL--------------------
Q
--------------------------------------------------------
N
----------------------------
D
-----------------------------------------------------------------------------------------------------
S
A
S
R
A
F
S
Y
P
S
L
K
K
----
T
--
Q
--
G
D
F
V
L
N
V
E
E
G
E
F
S
-------
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
--
K
P
D
E
G
Q
D
I
P
K
L
-----------------
N
V
S
M
K
P
Q
--------------------------
K
I
-----------------------------
A
P
K
-----------------------
F
-
P
-----
G
----
T
---------------
V
R
-
Q
L
F
F
K
K
I
R
G
Q
-------------
F
-----------------------------
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
--
I
-
D
---
D
I
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
-
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
-
E
GI
P
S
K
N
A
H
A
R
A
P
E
S
L
L
---------------------------------------------------
83
HHSearch
57.45
19%
17
- C3 -
-
2IX8
-
A:
[1429-1975]
-------------------------------------------------------
D
L
C
N
C
E
F
S
L
A
Y
--
G
-
A
---
K
I
L
L
N
K
T
Q
L
-----------------------
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
------
G
F
P
T
Q
E
E
----------------------------
C
--
R
T
----------
V
Y
V
E
H
D
I
D
G
T
H
S
D
T
S
V
L
D
F
V
F
--
E
S
G
V
--
G
--
T
------------------------------
K
----
E
A
I
----------------
K
D
K
L
I
E
F
--
G
--
F
T
D
E
M
I
A
M
P
---
I
S
A
L
S
G
----
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
-
T
-------
C
-
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
-
G
N
F
T
E
F
V
-
K
K
C
PAA-------------------
K
----
A
Y
--------------------------
E
-
E
-------------------------------
L
--------------------------------------
S
--------
N
T
------
D
-------------------------------------------------------
L
---------------------------------------------
E
--
F
--
K
---------
F
P
------------------
E
------------------------------------------------------------------------------------------------------------------
P
G
Y
L
E
G-------------------
V
--------------------------------------------------------
K
----------------------------
T
-----------------------------------------------------------------------------------------------------
K
Q
K
A
I
V
K
V
T
N
M
E
F
--
Q
Y
P
G-
T
--
S
K
P
Q
I
T
D
I
N
F
Q
C
S
-------
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
--
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
L
D
K
T
P
S
--------------------------
E
Y
I
Q
W
R
F
Q
TGDRETMDRANRQINENDAEA
M
N
K
I
F
-----------------------
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
-
E
N
I
G
M
K
S
E
R
W
---
V
P
M
M
S
V
D
N
A
W
I
P
R
G
ELVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFRP
L
T
R
K
E
I
E
E
H
C
S
M
L
G
--
L
-
D
-
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
-----
E
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
-
K
--
D
G
R
M
T
P
S
G
H
--------------------------------------------------------
14
PsiBlast_PDB
57.06
28%
-48
- C4 -
-
4YMW
-
?
J:
[6-216]
----------------------------------------------------------
D
V
Y
K
N
--
F
--
G
-
S
---
L
E
V
L
K
G
V
T
L
-----------------------
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
----
P
T
K
G
E
V
F
I
D
G
V----------
K
I
N
N
G
--
K
--
V
-
N
I
N
K
V
R
--
Q
K
----------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
--
L
A
P
V
--
K
--
V
K
-
K
----------------
M
N
K
--
K
E
---
A
E
----
E
L
A
----------------
V
D
L
L
A
K
V
--
G
--
L
L
-
D
K
K
D
Q
Y
---
P
I
K
L
S
G
----
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
----
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.96
28%
-47
- C4 -
-
4YMU
1
?
J:
[6-216]
----------------------------------------------------------
D
V
Y
K
N
--
F
--
G
-
S
---
L
E
V
L
K
G
V
T
L
-----------------------
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
----
P
T
K
G
E
V
F
I
D
G
V----------
K
I
N
N
G
--
K
--
V
-
N
I
N
K
V
R
--
Q
K
----------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
--
L
A
P
V
--
K
--
V
K
-
K
----------------
M
N
K
--
K
E
---
A
E
----
E
L
A
----------------
V
D
L
L
A
K
V
--
G
--
L
L
-
D
K
K
D
Q
Y
---
P
I
K
L
S
G
----
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
----
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
56.87
18%
-98
- C4 -
-
2AWN
1
MALK_ECOLI
B:
[3-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
--
A
W
G
--
E
---
V
V
V
S
K
D
I
N
L
D
I
H
-------
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
--
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
-
T
-----
P
P
A
E
R
G
V
G
M
V
F
Q
--------------------------
S
Y
-----------------------------
A
L
Y
-----------------------
P
-
H
-----
L
----
S
---------------
V
A
-
E
N
M
S
F
G
L
K
L
A
---
G
---
A
------
K
K
E
--------------------------
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
--
L
-
A
---
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
-
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
-
D
--
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
---------------------------------------------------
19
PsiBlast_PDB
56.81
31%
-29
- C4 -
-
1OXS
-
?
C:
[1-222]
-------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
--
G
-
K
---
V
V
A
L
D
N
V
N
I
-----------------------
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
--
S
T
--
G
E
L
Y
F
D
D
-----------
R
L
V
A
S
NG
K
--
L
-
I
V
P
P
E
D
--
R
K
----------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
FP
L
T
N
M
--
K
--
M
S
-
K
---------------------
E
E
---
I
R
----
K
R
V
----------------
E
E
V
A
K
I
L
--
D
--
I
H
-
H
V
L
N
H
F
---
P
R
E
L
S
G
----
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
----
R
M
R
D
S
A
R
A
L
V
K
-
E
V
Q
----
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.48
33%
-69
- C4 -
-
2YYZ
1
?
A:
[4-214]
------------------------------------------------------
I
R
V
V
N
L
K
K
Y
--
F
--
G
-
K
---
V
K
A
V
D
G
V
S
F
-----------------------
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
--
T
S
--
G
E
I
Y
F
D
D
-----------
V
L
V
N
D
--
I
--
P
-
P
K
Y
R
E
---------------
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
--
F
P
-
L
--
R
--
A
R
-
R
----------------
I
S
K
--
D
E
---
V
E
----
K
R
V
----------------
V
E
I
A
R
K
------
L
L
-
I
D
-
N
L
L
DRK
P
T
Q
L
S
G
----
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
--------
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
-
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
56.38
18%
-106
* C4 *
-
3RLF
2
MALK_ECOLI
A:
[3-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
--
A
W
G
--
E
---
V
V
V
S
K
D
I
N
L
D
I
H
-------
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
--
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
-
T
-----
P
P
A
E
R
G
V
G
M
V
F
Q
--------------------------
S
Y
-----------------------------
A
L
Y
-----------------------
P
-
H
-----
L
----
S
---------------
V
A
-
E
N
M
S
F
G
L
K
L
A
---
G
---
A
------
K
K
E
--------------------------
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
--
L
-
A
---
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
-
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
-
D
--
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
---------------------------------------------------
62
Fugue
56.04
17%
35
* C3 *
-
3J16
3
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
E
I
L
C
I
G
C
G
I
C
V
K
--
K
--
C
-
P
---
F
D
A
I
Q
I
I
N
L
PT
N
L
E
A
H
VTHRYSAN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
NL
G
R
F
D
D
P
P
E
W
Q
E
-----------
I
I
K
Y
F
--
R
GS
E
-
L
Q
N
Y
F
T
--
K
M
----------
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
--
K
G
P
V
--
Q
--
K
V
-
G
-
E
-------
L
------
L
K
L
R
M
E
K
---
S
P
----
E
D
V
----------------
K
R
Y
I
K
I
L
--
Q
--
L
E
-
N
V
L
K
R
D
---
I
E
K
L
S
G
----
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
Q
R
L
N
A
A
Q
I
I
R
-
S
L
L
----
A
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
-
V
V
T
L
P
A
S
-
V
R
-----------------------
E
----
G
I
--------------------------
N
-
I
-------------------------------
F
--------------------------------------
L
D
GHIP---
A
E
------
N
-------------------------------------------------------
L
---------------------------------------------
R
--
F
--
R
---------
T
E
------------------
A
------------------------------------------------------------------------------------------------------------------
L
------------------------
Q
--------------------------------------------------------
F
----------------------------
R
-----------------------------------------------------------------------------------------------------
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
--
Y
--
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
--
G
Q
D
I
P
K
L
N
V
S
M
K
-
P
Q
--
K
I
A
P
K
F
P
G
T
V
R
Q
L
F
--------------------------
F
K
K
--------------------------
I
R
G
Q
F
-----------------------
L
-
N
-----
P
----
Q
---------------
F
Q
-
T
D
V
----
V
K
P
---
L
---
R
-
I
D
D
I
I
D
Q
E
------------------------------------------------------
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
-
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
--
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
FRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
11
PsiBlast_PDB
56.01
28%
-47
- C4 -
-
4YMT
-
?
J:
[6-216]
----------------------------------------------------------
D
V
Y
K
N
--
F
--
G
-
S
---
L
E
V
L
K
G
V
T
L
-----------------------
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
----
P
T
K
G
E
V
F
I
D
G
V----------
K
I
N
N
G
--
K
--
V
-
N
I
N
K
V
R
--
Q
K
----------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
--
L
A
P
V
--
K
--
V
K
-
K
----------------
M
N
K
--
K
E
---
A
E
----
E
L
A
----------------
V
D
L
L
A
K
V
--
G
--
L
L
-
D
K
K
D
Q
Y
---
P
I
K
L
S
G
----
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
----
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
48.03
31%
-15
- C4 -
-
2HYD
2
Y1866_STAAM
A:
[357-566]
-----------------------------------------------------------------------------
L
K
D
I
N
L
-----------------------
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
--
T
S
--
G
Q
I
L
I
D
G
-----------
H
--
N
I
--
K
--
D
F
L
T
G
S
L
R
--
N
Q
----------
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
--
L
G
R
P
--
T
--
A
T
-------------------
D
E
--
E
V
---
V
E
A
A
K
M
A
N
A
----------------
H
D
F
I
M
N
L
--
P
--
Q
G
-
Y
D
T
E
-----
V
G
E
R
G
V
KLS
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
-
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
----
S
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
-
T
G
T
H
R
E
L
I
A
-
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
47.32
31%
-14
- C4 -
-
2HYD
2
Y1866_STAAM
B:
[357-566]
-----------------------------------------------------------------------------
L
K
D
I
N
L
-----------------------
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
--
T
S
--
G
Q
I
L
I
D
G
-----------
H
--
N
I
--
K
--
D
F
L
T
G
S
L
R
--
N
Q
----------
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
--
L
G
R
P
--
T
--
A
T
-------------------
D
E
--
E
V
---
V
E
AAKM
A
N
A
----------------
H
D
F
I
M
N
L
--
P
--
Q
G
-
Y
D
T
E
-----
V
G
E
R
G
V
KLSG
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
-
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
----
S
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
-
T
G
T
H
R
E
L
I
A
-
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------