@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZZ0: (2018-01-18 )
MKVFDYEDIQLIPNKCIVNSRSECDTTVTLGKHTFKMPVVPANMQTIIDETIAEFLAENGYFYIMHRFDEAARIPFIKKMKKRGLITSISVGVKKEEYSFIEKLAEESLNPDYITIDIAHGHANSVIDMIQHIKKYLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSVRFGATMVMIGSLFAGHEESPGETKVENGIVYKEYFGSASEFQKGEKRNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAGGRDLEAIRKVDYVIVKNSIFNGDTI
Atome Classification :
(24 SA)
-----------------.........10........-20........30-.-.--......40........50........60......-.----.70.---..-------......--------------80---------.----------.......90........100.......110.......120.......130.......140.......150.......160.......170.......180.........190......---.---200--........210.......220.......230.......240.......250......---------.260......-.270.......280.......290.......300.......-310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------MKVFDYEDIQLIP
N
K
CIVN-SRSECD
T
T
V
T
LG-K-
H
--
T
F
KMPVVP
A
N
M
Q
T
I
I
D
E
T
I
A
E
F
L
AEN
G
Y
F
Y
I
M
HR-F----DE-A---AR-------
I
P
F
I
K
K
--------------
M
K
---------K----------RG
L
I
T
S
I
SVGVK
K
E
E
Y
S
F
I
E
K
L
A
E
ESLNP
D
Y
I
T
I
D
IAHGH
A
N
S
V
I
D
M
I
Q
H
I
K
K
YLPE
T
F
V
I
AGNVG
T
P
E
A
V
R
E
L
E
NAGADATKVGIGPG
K
V
C
I
T
K
IKT--GFGTGG
W
Q
L
A
A
L
R
W
C
A
K
A
---A---RK---
P
I
IADGGIRT
H
G
D
I
A
K
S
V
RFG
A
T
M
V
M
I
G
S
L
FAGHEESPGETKVEN
G
I
V
Y
K
E
YFG
S
A
S
---------
E
FQKGEKRNV-EG
K
K
I
W
I
Q
HKG
S
L
K
D
T
L
V
E
M
Q
Q
D
L
Q
S
S
ISYAGGR
D
L
E
A
I
R
K-V
D
Y
V
I
V
KNSIFNGDTI
1
PsiBlast_PDB
98.22
82%
-108
- C1 -
-
2A1Y
1
GUAC_BACAN
A:
[13-330]
-------------------
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
-
S
R
S
E
C
D
T
T
V
T
L
G
-
K
-
H
--
K
F
K
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
-
F
----
Q
P
-
E
---
K
R
-------
I
S
F
I
R
D
--------------
M
Q
---------
S
----------
R
G
L
I
A
S
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
H
L
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
--
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
---
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
F
G
S
---------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
R
T
-
V
D
Y
V
V
V
K
N
S
I
F
-----
125
HHSearch
92.56
81%
-71
* C1 *
-
2A1Y
1
GUAC_BACAN
A:
[13-330]
-------------------
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
-
S
R
S
E
C
D
T
T
V
T
L
G
-
K
-
H
--
K
F
K
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
-
F
----
Q
P
-
E
---
K
R
-------
I
S
F
I
R
D
--------------
M
Q
---------
S
----------
R
G
L
I
A
S
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
H
L
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
GF
G
T
G
G
W
--
Q
L
A
A
L
R
W
C
A
K
A
---
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
F
G
S
---------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
R
T
-
V
D
Y
V
V
V
K
N
S
I
F
-----
54
PsiBlast_CBE
68.40
36%
-24
- C1 -
-
4QM1
3
?
B:
[35-358]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
44
PsiBlast_CBE
67.13
36%
-27
- C1 -
-
5URS
3
?
B:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
8
PsiBlast_PDB
66.75
36%
-25
- C1 -
-
5URR
3
?
A:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K---------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
32
PsiBlast_CBE
66.45
36%
-25
- C1 -
-
5UUW
3
?
D:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
4
PsiBlast_PDB
66.25
36%
-24
- C1 -
-
4MYA
4
?
A:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K---------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
24
PsiBlast_CBE
66.19
36%
-25
- C1 -
-
5UUZ
3
?
E:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEK----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
10
PsiBlast_PDB
66.15
36%
-25
- C1 -
-
5URS
4
?
A:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
6
PsiBlast_PDB
65.64
36%
-29
- C1 -
-
4MYX
5
?
A:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
100
PsiBlast_CBE
65.62
35%
-24
- C1 -
-
4Q33
5
?
F:
[12-339]
--------------------
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
-
P
N
E
V
S
L
K
T
Q
L
T
K
-
K
-
I
--
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
-
N
MTIE
D
Q
-
A
---
R
E
-------
V
D
R
V
K
R
-------------------------
S
----------
G
G
L
L
C
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
---
G
---
K
K
LGI
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
LGAMAK----------
K
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
-
N
A
N
F
V
V
Q
T
S
-------
66
PsiBlast_CBE
65.60
36%
-25
- C1 -
-
4MY9
2
?
E:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
51
PsiBlast_CBE
65.57
36%
-25
- C1 -
-
5URR
3
?
B:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
---------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
70
PsiBlast_CBE
65.54
36%
-24
- C1 -
-
4MY8
7
?
D:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MSIE
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEKGSK--------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
52
PsiBlast_CBE
65.48
36%
-25
- C1 -
-
4QM1
3
?
D:
[35-357]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MSIE
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAME------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
48
PsiBlast_CBE
65.45
36%
-25
- C1 -
-
5URR
3
?
E:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
47
PsiBlast_CBE
65.43
36%
-23
- C1 -
-
5URR
2
?
F:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
KGSK-------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
67
PsiBlast_CBE
65.31
36%
-22
- C1 -
-
4MY9
3
?
D:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAME------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
69
PsiBlast_CBE
65.21
36%
-25
- C1 -
-
4MY9
3
?
B:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MS
I
E
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G
SK--------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
22
PsiBlast_CBE
65.13
36%
-22
- C1 -
-
5UUZ
1
?
G:
[35-353]
--------------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
E
-
S
-
L
--
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
MSIE
Q
Q
-
A
---
E
Q
-------
V
D
K
V
K
R
-------------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEK----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----------------
130
HHSearch
59.41
33%
-17
- C1 -
-
4FEZ
5
?
B:
[12-366]
------------------
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
--
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
--
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
-
N
----
M
S
I
E
---
Q
Q
A
A
Q
----
V
H
Q
V
K
I
FESKPN
A
C
K
-----
D
E
---------
Q
----------
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
--
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
--
G
V
G
V
P
--
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
---
G
I
---
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
-----------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
-------
137
HHSearch
57.18
33%
3
- C1 -
-
5AHM
1
?
A:
[28-385]
-------------------
A
L
T
F
D
D
V
L
L
I
P
G
-
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
--
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
-
N
----
M
G
I
E
---
Q
Q
A
A
E
----
V
R
K
V
K
K
H
E
T
A
KAKTYPLASK
D
E
---------
Q
----------
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
--
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
--
G
V
G
V
P
--
Q
I
S
A
I
A
N
V
A
A
A
---
L
EGT
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L----------------
V
P
-
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
145
HHSearch
53.51
34%
-20
- C1 -
-
5AHN
1
?
A:
[7-467]
------------------
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-
R
G
I
--
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
-
N
----
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H--------------------------------TYPL
A
S
K
D
EQ
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
--
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
--
G
V
G
V
P
--
Q
I
S
A
I
A
N
V
A
A
A
---
L
EGT
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
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A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
-------
113
Fugue
46.93
30%
29
- C1 -
-
1B3O
2
IMDH2_HUMAN
A:
[10-498]
TSYVPDDGLT
A
Q
Q
L
F
N
C
G
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
--F
T
A
D
Q
V
D
L
T
S
A
L
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-
K
--KI
T
L
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T
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L
V
S
S
P
M
D
T
V
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M
A
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A
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T
G
G
I
G
F
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H
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----
T
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-
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---
F
Q
-------
A
N
E
V
R
K
--------------
V
K
DYPL
A
S
K
D
A
K
----------
K
Q
L
L
C
G
A
A
I
G
T
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D
D
K
Y
R
L
D
L
L
A
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A
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--
D
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V
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M
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A
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A
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D
A
L
R
V
G
M
G
-----------------
S
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
---
A
---
R
R
F
G
V
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V
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A
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N
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A
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L
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A
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M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
---------------------------------------------
D
K
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Y
L
I
A
G
I
Q
H
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C
Q
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