@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y058: (2018-01-18 )
MYLKRIEIAGFKSFADKTVIDFENSVTAVVGPNGSGKSNITEAIRWVLGEQSAKSLRGGKMPDIIFAGSDTRKQLNIAEVTVILDNSDHYLPLEYNEISVTRRYRRTGESEFFINKQSCRLKDIQELFLDSGLGKESFSIISQGKVEAIFSSKPEDRRGIFEEAAGVLKYKQRKKKAEQKLFETEDNLSRVQDIIHELEEQLTPLAAQSEAAKEFLRLKETLTQTDVSLMVAEIKTAKKDWDNKQAQLAKFNLELGKLSESIQEQESILAKQRKENAQADRLIEKNQQVLLDLSEKLKQTEGQKDVLQERTKHTQKSSQEYQTSLAEAQKKVKHFEKLQESLMKAAAEKETEIQKAEANLIKTQQELEKYQKSTKELLAELRDQYVDLMQEQAAVGNELKYLERQYIQETAKSKQTLAKQSEVEASVDRLILQKEELTQKQAQLKSSLTETKEKLEMIQQNGKKFQEALAKEQPKMYQLMNQVQQLRARKKSLQEIQENYFGFYQGVRLVLQHKQQLSGIVGAVAELIDVPADFTLAIEAALGGAAQHVIVENEKDARQAITYLKQQRGGRATFLPLTTIKPRQLPAHILTQAAAVEGFIGIASEQVSYPDQIQTVVQNLLGTILLAKDLTSANAIAQTIRYQYRVVSLEGDVMNAGGSMTGGANKRGNQGSLFVQNQELKRLTSEFEEADKQLQAQEKKVQELQQETARLAEEQEVLRTRGEQLRFEEQEATNQLQNIINELERFEKEKQISTFETRELQQFIEDYEKQTNELKDKQTDLESQRQKIDEEIKSLSQESDQMEARRAQVQSQKAQEQADLAVLKEQFNHLQIQLRGARVQKAEATERQEAIEKQLATLTADFSDHEVTEESLEKQINELSAQRETLKAELAKAKEQRDRRQKEIDKLEAVLAERNREQKARLSEQSKLEVQKDRAEMILDNHLTYLQSEYQLTFEKASQDYQETTDIEDSRTKVSSLKEQIEKLGPVNLNSIEQYEQVSERHTFLATQRDDLLAAKNQLFETMDEMDDEVRTRFKEVFEAIRQEFKIVFPNMFGGGKAELVLTEPTDLLKTGIEIEVQPPGKKLQSLSLLSGGERALTAIALLFSIIRVCPVPFCILDEVEAALDEANVKRFGRYLSDFQDDTQFIVVTHRKGTMVAADVLYGVTMQESGVSKIVSVRMEDINEEAKINETKV
Atome Classification :
(23 SA)
.........10......-..20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....----------..500.......510....---...520.......530..-......540.......550.......560.......570.......580.......590.....---..--600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920......---.930.......---940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.........1190
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Y
L
K
R
I
E
IAGFKSFAD
K
-
T
V
I
DFEN
S
V
T
A
V
VGPNGSG
K
S
N
I
T
E
A
I
R
W
V
LGEQ
S
A
K
SLRGGKM
P
D
I
I
FAGSDT
R
K
Q
L
N
I
A
E
V
T
V
I
L
DNSD
H
Y
L
P
L
E
YNE
I
S
V
T
R
R
Y
RRTGES
E
F
F
I
NKQSC
R
L
K
D
I
Q
E
L
F
L
DSGLGK
E
S
F
S
I
ISQG
K
V
E
A
IFSSKPE
D
R
R
G
I
F
E
E
A
A
G
V
L
K
Y
K
Q
R
K
K
K
A
E
Q
K
L
FETED
N
L
S
R
V
Q
D
I
I
H
E
L
E
E
QLTPLAA
Q
S
E
A
A
K
E
F
L
R
L
K
E
T
L
T
Q
T
D
V
S
L
M
V
A
E
I
K
T
A
KKDWDN
K
Q
A
Q
L
A
K
F
N
L
E
L
G
K
L
S
E
S
I
Q
E
Q
E
S
I
L
A
K
Q
R
KEN
A
Q
A
D
R
L
I
E
K
N
Q
Q
V
L
L
D
L
S
E
K
L
K
QTE
G
Q
K
D
V
L
Q
E
R
T
K
HTQKS
S
Q
E
Y
Q
T
S
L
A
E
A
Q
K
K
V
K
H
F
E
K
L
Q
E
S
L
M
K
A
A
A
E
K
E
T
E
I
Q
K
A
E
A
N
L
I
K
T
Q
Q
E
L
E
K
Y
Q
K
S
T
K
E
L
L
A
E
L
R
D
Q
Y
V
D
L
M
Q
E
Q
A
AVG
N
E
L
K
Y
L
E
R
Q
Y
I
Q
E
T
A
K
S
K
Q
T
L
A
K
Q
S
E
V
E
A
S
V
D
R
L
I
L
Q
K
E
E
L
T
Q
K
Q
A
Q
L
K
S
S
L
T
E
T
K
E
K
L
E
M
I
Q
QN
G
K
K
F
Q
E
A
L
A
KEQ
P
K
M
Y
Q
L
M
N
Q
V
Q
Q
L
R
A
R
K
K
S
L
Q
E
I
Q
----------
E
N
Y
F
G
F
Y
Q
G
V
R
L
V
L
Q
H
K
Q
Q
---
L
S
G
I
V
G
A
V
A
E
L
IDVP-AD-
F
T
L
A
I
E
A
ALGGA
A
Q
H
V
I
VENE
K
D
A
R
Q
A
I
T
Y
L
K
Q
QRGG
R
A
T
F
L
P
L
TTIKPRQL
P
A
H
I
L
T
Q
A
A
A
V
E
---
G
F
--
I
GIASEQVSY
P
D
Q
I
Q
T
V
V
Q
N
L
L
G
T
I
L
L
A
K
DLT
S
A
N
A
I
A
Q
T
I
R
Y
Q
Y
R
V
V
S
LEG
D
V
MNAGGSMTGGANKRGNQG
S
L
F
V
Q
N
Q
E
L
K
R
L
T
S
E
F
E
E
A
D
K
Q
L
Q
A
Q
E
K
K
V
Q
E
L
Q
Q
E
T
A
R
L
A
E
E
Q
E
V
L
R
TR
G
E
QLR
F
E
E
Q
E
A
T
N
Q
L
Q
N
I
I
N
E
L
E
R
F
E
K
E
KQIST
F
E
T
R
E
L
Q
Q
F
I
E
D
Y
E
K
Q
T
N
E
LK
D
K
QT
D
L
E
S
Q
R
Q
K
I
D
E
E
I
K
S
L
S
Q
E
S
D
Q
M
E
A
R
R
A
Q
V
Q
S
Q
K
A
Q
E
Q
A
D
L
A
V
L
K
E
QFN
H
L
Q
I
Q
L
RG
A
R
V
Q
K
A
E
A
T
E
R
Q
E
A
I
E
K
Q
L
A
T
L
TADFSDHE
V
T
E
E
S
L
E
K
Q
I
N
E
L
S
A
Q
R
E
T
L
K
A
E
L
A
K
A
K
E
Q
R
D
R
R
Q
K
E
I
D
K
L
E
A
V
L
A
ER
N
R
E
Q
K
A
RLS
E
Q
S
K
L
---
E
V
Q
K
D
R
A
E
M
I
L
---
D
N
H
L
T
Y
L
Q
S
E
Y
Q
L
T
F
E
K
AS
Q
D
Y
Q
ETTDIED
S
R
T
K
V
S
S
L
K
E
Q
I
E
KLGPVN
L
N
S
I
E
Q
Y
E
Q
V
S
E
R
H
T
F
L
ATQ
R
D
D
L
L
A
A
K
N
Q
L
F
E
T
M
D
E
M
D
D
E
V
R
T
R
F
K
E
V
F
E
A
I
R
Q
E
F
K
I
VFPNMFGG
G
K
A
E
L
V
L
TE
P
T
D
L
L
KTG
I
E
I
E
VQPPG
K
K
L
Q
S
L
SLLSG
G
E
R
A
L
T
A
I
A
L
L
F
S
I
I
R
VCPV
P
F
C
I
L
D
E
V
E
A
A
L
D
E
A
N
V
K
R
F
G
R
Y
L
S
D
FQDDT
Q
F
I
V
V
THRKG
T
M
V
A
A
D
V
LY
G
V
TMQES
G
V
S
K
I
V
S
V
R
M
E
---DINEEAKINETKV
85
HHSearch
82.67
76%
-93
- C2 -
-
5H67
1
SMC_BACSU
A:
[1-192]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
A
R
S
L
R
G
G
K
M
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.19
75%
-93
- C2 -
-
5H67
1
SMC_BACSU
A:
[1-199]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
A
R
S
L
R
G
G
K
M
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
D
I
L
H
E
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.67
75%
-110
- C2 -
-
5H66
-
?
A:
[1-199]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
------------
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
D
I
L
H
E
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
80.49
76%
-110
- C2 -
-
5H66
-
?
A:
[1-192]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
------------
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.53
44%
-75
- C4 -
-
5H69
-
?
A:
[26-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
T
K
A
R
Q
Q
W
L
E
E
M
Q
----------
H
D
Y
S
G
F
V
Q
G
V
K
E
V
L
K
A
R
D
L
---
L
P
G
I
H
G
A
I
V
E
L
I
R
V
P
-
D
R
-
Y
E
T
A
I
E
T
A
L
G
G
A
M
Q
H
I
V
V
D
S
E
Q
A
A
R
Q
A
I
H
Y
L
K
T
N
G
Y
G
R
A
T
F
L
P
L
D
V
I
K
A
R
A
L
S
E
---
R
E
R
A
A
I
D
RHP
A
F
--
V
G
I
A
S
E
L
V
E
Y
D
R
A
Y
R
A
A
I
A
H
L
L
G
H
V
I
V
T
A
D
L
K
G
A
N
E
L
A
K
L
L
H
Y
R
Y
R
L
V
T
L
D
G
D
V
V
S
P
G
G
A
M
T
G
G
G
A
A
K
-
K
T
A
S
L
L
S
R
N
R
E
L
E
M
L
S
A
K
L
Q
E
M
D
E
T
I
A
R
L
E
R
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
70.53
43%
-168
- C4 -
-
5H69
-
?
A:
[60-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
I
H
G
A
I
V
E
L
I
R
V
P
-
D
R
-
Y
E
T
A
I
E
T
A
L
G
G
A
M
Q
H
I
V
V
D
S
E
Q
A
A
R
Q
A
I
H
Y
L
K
T
N
G
Y
G
R
A
T
F
L
P
L
D
V
I
K
A
R
A
L
S
E
R
E
R
A
A
I
D
R
H
P
---
A
F
--
V
G
I
A
S
E
L
V
E
Y
D
R
A
Y
R
A
A
I
A
H
L
L
G
H
V
I
V
T
A
D
L
K
G
A
N
E
L
A
K
L
L
H
Y
R
Y
R
L
V
T
L
D
G
D
V
V
S
P
G
G
A
M
T
G
G
G
A
A
K
K
T
A
S
L
L
-
S
R
N
R
E
L
E
M
L
S
A
K
L
Q
E
M
D
E
T
I
A
R
L
E
R
A
V
A
A
K
R
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
70.23
65%
-122
- C2 -
-
5H67
1
?
B:
[2-181]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
K
F
L
S
E
Q
K
E
D
L
T
E
A
K
N
T
L
F
Q
V
I
E
E
M
D
E
E
M
T
K
R
F
N
D
T
F
V
Q
I
R
S
H
F
D
Q
V
F
R
S
L
F
G
G
G
R
A
E
L
R
L
T
D
P
N
D
L
L
H
S
G
V
E
I
I
A
Q
P
P
G
K
K
L
Q
N
L
N
L
L
S
G
G
E
R
A
L
T
A
I
A
L
L
F
S
I
L
K
V
R
P
V
P
F
C
V
L
D
Q
V
E
A
A
L
D
E
A
N
V
F
R
F
A
Q
Y
L
K
K
Y
S
S
D
T
Q
F
I
V
I
T
H
R
K
G
T
M
E
E
A
D
V
L
Y
G
V
T
M
Q
E
S
G
V
S
K
V
I
S
V
K
L
E
----------------
4
PsiBlast_PDB
68.94
39%
-119
- C2 -
-
5XEI
-
?
A:
[295-520]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
E
V
L
R
K
E
I
E
D
M
E
A
E
I
K
A
L
E
P
V
N
M
K
A
I
E
D
F
E
V
V
E
R
R
Y
L
E
L
K
S
K
R
E
K
L
E
A
E
K
E
S
I
I
E
F
I
N
E
I
E
K
E
K
K
N
V
F
M
R
T
L
E
A
I
A
K
N
F
S
E
L
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
P
E
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
I
F
A
I
Q
R
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
R
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
R
V
V
S
L
S
L
E
K
A
M
K
I
L
E
E
A
K
------
16
PsiBlast_PDB
67.97
25%
9
- C4 -
-
4U4P
-
SMC2_HUMAN
A:
[475-706]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
S
L
L
E
K
R
R
Q
L
S
R
D
I
G
R
L
K
E
T
Y
----------
E
A
L
L
A
R
F
P
N
L
R
F
A
Y
K
D
P
E
K
NWN
R
N
C
V
K
G
L
V
A
S
L
I
S
V
K
D
T
S
-
A
T
T
A
L
E
L
V
A
G
E
R
L
Y
N
V
V
V
D
T
E
V
T
G
K
K
L
L
E
R
G
E
L
K
R
--
R
Y
T
I
I
P
L
N
K
I
S
A
R
C
I
A
P
E
T
L
R
V
A
Q
N
L
V
---
G
P
DN
V
H
V
A
L
S
L
V
E
Y
K
P
E
L
Q
K
A
M
E
F
V
F
G
T
T
F
V
C
D
N
M
D
N
A
K
K
V
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
D
V
F
D
P
H
G
T
L
S
G
G
A
--
R
S
Q
A
A
S
I
L
T
K
F
Q
E
L
K
D
V
Q
D
E
L
R
I
K
E
N
E
L
R
A
L
E
E
E
L
A
G
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
65.45
35%
-4
- C2 -
-
5XEI
-
?
A:
[2-196]
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
R
K
V
V
I
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
T
R
I
S
D
L
I
F
A
G
S
K
G
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
K
R
R
V
Y
P
D
G
R
S
A
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
L
L
S
A
A
M
I
S
P
E
G
Y
N
L
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
Q
L
I
D
E
I
S
G
I
A
E
Y
D
A
K
K
E
K
A
L
E
E
L
K
Q
A
E
E
N
L
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
64.06
31%
-180
- C4 -
-
1GXJ
-
?
A:
[498-658]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
---
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
K
-
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
---
I
S
G
L
E
N
E
R
---
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.98
30%
-0
- C4 -
-
1GXL
-
?
A:
[475-679]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
R
L
R
E
I
Q
F
E
K
E
M
I
E
R
D
M
R
E
Y
R
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
---
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
K
-
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
------
F
N
R
I
S
G
L
E
NER
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
R
S
S
--
N
V
F
E
R
R
I
K
L
K
H
L
E
Q
E
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Fugue
61.87
17%
-0
- C2 -
-
4UX3
1
SMC3_YEAST
A:
[3-527]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
R
V
I
I
K
G
F
K
T
Y
R
N
E
T
I
I
D
N
F
S
P
H
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
L
S
D
D
Y
S
N
L
K
R
E
E
R
Q
G
L
I
H
Q
G
S
G
G
S
V
M
S
A
S
V
E
I
V
I
R
R
T
V
G
L
K
K
D
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
V
R
M
L
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
Q
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
G
A
K
S
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
---
E
L
E
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
L
N
E
V
I
N
Q
M
E
T
S
D
Q
L
L
Q
R
L
N
D
M
N
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
P
R
G
T
A
K
L
I
I
H
--------
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
Q
L
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
E
N
K
-
I
S
T
V
I
E
V
N
R
E
---
E
A
I
G
F
I
R
------
10
PsiBlast_PDB
61.03
30%
-89
- C4 -
-
1GXJ
-
?
A:
[498-658]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
---
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
K
-
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
------
F
N
R
I
S
G
L
E
NER
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.96
30%
-83
- C4 -
-
1GXK
-
?
A:
[501-658]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
V
R
A
V
F
E
E
K
E
R
---
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
K
-
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
------
F
N
R
I
S
G
L
E
NER
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
60.35
30%
-180
* C4 *
-
1GXJ
-
?
A:
[514-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
K
-
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
I
---
S
G
L
E
N
E
R
---
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
HHSearch
60.10
34%
-8
- C2 -
-
3KTA
1
?
C:
[2-169]
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
-----
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Fugue
60.05
30%
11
- C2 -
-
1E69
-
?
A:
[1-1164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
----
V
F
G
E
K
F
D
M
I
F
AGS
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
----------------------
L
K
D
I
R
D
R
F
A
G
T
G
L
G
V
D
F
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
G
E
G
R
L
-------------
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
-
G
V
S
A
I
V
P
V
E
V
-----------------
14
PsiBlast_PDB
59.10
34%
-38
- C- -
-
3NWC
-
SMC_PYRFU
A:
[516-652]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
G
---
I
G
G
I
Y
G
T
L
A
E
L
I
K
V
K
-
D
E
A
Y
A
L
A
I
E
V
A
L
G
N
R
A
D
N
V
V
V
E
D
E
L
V
A
E
K
A
I
K
Y
L
K
E
H
K
L
G
R
L
T
F
L
P
L
N
K
I
K
P
K
H
V
D
S
S
V
G
L
P
A
V
D
V
---------------
I
E
Y
D
Q
K
I
E
N
A
V
K
F
A
L
G
D
T
V
I
V
N
S
M
E
E
A
R
P
H
I
G
K
V
----
R
M
V
T
I
E
G
E
L
Y
E
R
S
G
A
I
T
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.66
34%
-8
- C2 -
-
1XEX
1
?
A:
[3-167]
-
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
K
N
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
45.16
75%
-166
- C2 -
-
5H68
1
?
B:
[4-59]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
D
R
-
V
S
I
E
F
V
P
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
42.63
43%
-167
* C2 *
-
3AUY
1
?
B:
[3-67]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
--
S
R
I
K
F
E
K
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
41.16
43%
-170
- C2 -
-
3AUY
1
?
A:
[3-58]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
--
S
R
I
K
F
E
K
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------