@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0C8: (2018-01-19 )
MISKEKRTSILYSFIALLFSIALYFNANGQSVPNTLSGNEAYNQTVTGVPIKISYDSKRYYIHGYENAVTVKLSSANRVQLNAEANEDTRMFRVTADITKLGEGTHEVPLKIQNLSSAVTAKIEPSTITVTVEKKVIKDFDVETLIPSTFTPSGYELDDTSVSPKKVSITTGDKTLAEIKRVVADVDASMVTDDGINSEVPIQALNAAGEVLSIVSDPVQVTVRADSIKPSKSVRLYGIQQGTPAAGVESYDFSFSKLEAEVSGSSDLLASIGDSIAVPINVSGINHRTTRKIEIPVEEGLSIKPESVSVEITPVLQTSSSSSASTSSRTQENTSTSRSISSADSGTEPSTTTISSSSESGTSSSTTSTEETSETSESTQMSRTNSSEN
Atome Classification :
(20 SA)
-----------------------------------------...------......10........20......---..30.....-...40........50........60-----------.........70.......--.80......-.--.90........100.....--------...110.......120........130..-----.....--140......-.150.......160---.........170..--.....----180.......190.......--200....-...210......-----.220-----------.........230.-....--..240-.......250.....--------.-.--.260.......270..--.....----------280.-....-..290.--------------------......--300--.---........310.......320.......330.......340-.......350----.......360.......-----------370.......380.......--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------MIS------
K
E
K
R
T
S
I
L
Y
S
F
I
A
L
L
F
S
I
A
L
Y
F
NA---NGQSVPNTL-SGNEAYNQTVT
G
V
P
I
K
I
SYDS
K
R
Y
------------
Y
I
H
GYE
N
A
V
T
V
K
LSSA
N
R
--
V
Q
L
NAEANE-D--
T
R
M
F
R
V
TA
D
I
T
K
L-GEGTH--------EV
P
L
K
I
QNLSS
A
V
T
A
-KIEP
S
T
I
T
V
T
V
E
K
-----
K
V
I
K
D--FDVETLIPS-TFTPSGYELDDT-----SVSP
K
K
V
S
I
TTGD
K
--
T
L
A
E
I
----
K
R
V
V
A
DV
D
A
S
MVTDDGINSE--V
P
I
Q
A
L
N
-AA
G
E
V
L
S
I
VSD
P
-----
V
Q
-------------
V
T
V
R
ADSIKPSK
S
-
V
R
L
Y
--
G
IQQG-TPAAGVESY-DFS
F
S
--------
K
-
L
--
E
A
EVSGS
S
D
L
L
A
SIGD--
S
I
A
V
P
----------
I
N
VS-GINH-R
T
T
R
K
I
--------------------
E
I
PVEE--G----L---SIKP
E
S
V
S
V
E
I
T
P
V
L
QTSSSSSASTSSRTQENTSTSRSISS-ADSGTEPS
T
T
----
T
ISSSSESGTSSSTTST-----------EETSETSESTQMSRTNSSEN--------------------------
1
PsiBlast_PDB
79.39
41%
-45
- C6 -
-
4QDY
2
?
A:
[7-186]
------------------------------------------------------------------------------------------
E
T
Y
T
N
T
V
T
N
V
P
I
D
I
R
Y
N
S
D
K
Y
------------
F
I
S
G
F
A
S
E
V
S
V
V
L
T
G
A
N
R
--
L
S
L
A
S
E
M
Q
E
-
S
--
T
R
K
F
K
V
T
A
D
L
T
D
A
-
G
V
G
T
I
--------
E
V
P
L
S
I
E
D
L
P
N
G
L
T
A
-
V
A
T
P
Q
K
I
T
V
K
I
G
K
-----
K
A
Q
K
D
K
V
K
I
V
P
E
I
D
P
S
-
Q
I
D
-
S
R
V
Q
I
E
N
V
-----
M
V
S
D
K
E
V
S
I
T
S
D
Q
E
--
T
L
D
R
I
----
D
K
I
I
A
V
L
P
T
S
E
R
I
T
G
N
Y
S
G
S
--
V
P
L
Q
A
I
D
-
R
N
G
V
V
L
P
A
V
I
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
77.65
38%
18
- C6 -
-
4QDY
2
?
A:
[10-196]
---------------------------------------------------------------------------------------------
T
N
T
V
T
N
V
P
I
D
I
R
Y
N
S
D
K
Y
------------
F
I
S
G
F
A
S
E
V
S
V
V
L
T
G
A
N
R
L
S
L
A
S
E
M
-----
Q
ES
T
R
K
F
K
V
T
A
D
L
T
D
A
-
G
V
G
T
I
--------
E
V
P
L
S
I
E
D
L
P
N
G
L
T
A
-
V
A
T
P
Q
K
I
T
V
K
I
G
K
-----
K
A
Q
K
D
K
-
V
K
I
V
P
E
I
D
P
S
Q
-
I
D
S
R
V
Q
I
E
N
V
-----
M
V
S
D
K
E
V
S
I
T
S
D
Q
E
--
T
L
D
R
I
----
D
K
I
I
A
V
L
P
T
S
E
R
I
T
G
N
Y
S
G
S
--
V
P
L
Q
A
I
D
-
R
N
G
V
V
L
P
A
V
I
T
P
-----
F
D
-------------
T
I
M
K
V
T
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.36
36%
-147
- C6 -
-
5HQH
-
?
A:
[11-103]
----------------------------------------------------------------------------------------------
E
V
I
E
N
V
P
V
K
V
Y
Y
D
K
T
N
L
------------
Y
I
S
G
I
P
E
T
V
T
V
T
L
S
G
P
R
S
--
I
V
Q
S
A
K
A
Q
Q
-
D
-----
F
T
V
Y
A
D
L
K
N
A
-
S
I
G
T
Q
--------
E
V
K
L
Q
V
K
D
V
S
D
R
L
K
V
-
K
V
N
P
A
T
V
N
V
N
V
Q
E
-----
K
V
T
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
60.98
35%
-151
- C6 -
-
5HQH
-
?
A:
[11-103]
----------------------------------------------------------------------------------------------
E
V
I
E
N
V
P
V
K
V
Y
Y
D
K
T
N
L
------------
Y
I
S
G
I
P
E
T
V
T
V
T
L
S
G
P
R
S
--
I
V
Q
S
A
---
K
-
A
--
Q
Q
D
F
T
V
Y
A
D
L
K
N
A
-
S
I
G
T
Q
--------
E
V
K
L
Q
V
K
D
V
S
D
R
L
K
V
-
K
V
N
P
A
T
V
N
V
N
V
Q
E
-----
K
V
T
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.73
23%
-124
- C6 -
-
2KQ1
-
?
A:
[8-98]
---------------------------------------------------------------------------------------------
N
L
S
L
G
E
L
E
L
T
V
L
Y
D
E
E
R
Y
------------
D
I
V
E
Q
T
E
T
V
Q
V
D
L
E
G
P
R
G
--
V
L
T
V
F
R
F
A
R
-
P
--
S
--
Y
E
V
F
V
D
L
T
E
A
-
G
E
G
S
H
--------
T
V
D
V
E
H
R
G
F
P
G
D
L
A
V
-
T
V
E
P
R
M
A
R
V
Q
L
E
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
57.67
27%
-125
- C6 -
-
2KXY
-
?
A:
[1-100]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
L
R
K
L
S
K
S
-
V
P
V
K
--
L
E
L
T
G
-
D
K
A
S
N
V
S
S
I
-
S
Y
S
F
D
--------
R
-
G
--
H
V
T
I
V
G
S
Q
E
A
M
D
K
I
-
D
--
S
I
T
V
P
----------
V
D
I
S
-
Q
V
T
E
-
D
T
S
K
T
L
--------------------
E
L
K
-
A
E
--
G
----
V
---
T
V
Q
P
S
T
V
K
V
N
L
K
V
T
Q
K
L
E
H
H
H
H
H
H
----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.20
32%
-169
- C6 -
-
2KXY
-
?
A:
[6-87]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
K
S
-
V
P
V
K
--
L
E
L
T
G
-
D
K
A
S
N
V
S
S
I
-
S
Y
S
F
D
--------
R
-
G
--
H
V
T
I
V
G
S
Q
E
A
M
D
K
I
-
D
--
S
I
T
V
P
----------
V
D
I
S
-
Q
V
T
E
-
D
T
S
K
T
L
--------------------
E
L
K
A
-
E
--
G
----
V
---
T
V
Q
P
S
T
V
K
V
N
L
-----------------------------------------------------------------------------------------------------------------------
51
Fugue
54.21
17%
-12
- C3 -
-
4QNU
1
CMOB_ECOLI
A:
[1-323]
-----------------------------------------
M
I
D
------
F
----
G
N
F
Y
S
L
I
A
-----------------------------------------------------------------
K
N
H
L
S
H
W
L
E
T
L
P
A
--
Q
I
A
N
W
Q
R
E
Q
-
Q
--
H
G
L
F
K
Q
W
S
N
A
V
E
F
----
L
P
--------
E
I
K
P
Y
R
L
D
L
L
H
S
V
T
A
-
E
S
E
E
P
-----
L
S
A
-----
G
Q
I
K
R
--
I
E
T
L
M
R
N
L
M
-
P
W
R
K
G
P
F
S
L
Y
G
V
-----
N
I
D
----
T
E
W
R
S
D
W
--
K
W
D
R
V
----
L
P
H
L
S
D
L
T
G
R
T
I
L
D
V
G
C
G
S
G
--
Y
H
M
W
R
M
I
-
G
A
G
A
H
L
A
V
G
I
D
P
T
Q
L
F
L
C
Q
-------------
F
E
A
V
R
K
L
L
G
N
D
Q
R
-
A
H
L
L
PL
G
I
E
Q
----
L
P
A
L
K
A
F
-
D
T
V
F
S
M
GVLYHRR
S
-
P
--
L
E
H
L
W
Q
L
K
D
Q
L
V
N
E
G
E
--
L
V
L
E
T
----------
L
V
I
D
-
G
----------------------------------
D
E
--
N
----
T
---
V
L
V
P
G
D
R
Y
A
Q
M
R
N
V
Y
F
I
P
S
A
L
A
L
K
N
W
L
K
K
C
G
F
V
D
I
R
I
A
D
V
S
-
V
T
T
T
E
E
Q
R
R
T
EWMV
T
E
S
L
A
D
F
L
D
P
H
D
P
G
K
T
V
-----------
E
G
Y
P
A
P
K
R
A
V
L
I
A
R
K
P
------------------------------
44
Fugue
53.21
18%
-103
- C6 -
-
2KQ1
-
?
A:
[1-119]
-------------------------------------------------------------------------------------
M
-
P
T
F
D
H
G
N
L
S
L
G
E
L
E
L
T
V
L
Y
D
E
E
R
Y
------------
D
I
V
E
Q
T
E
T
V
Q
V
D
L
E
--
G
P
--
R
G
V
L
T
V
F
R
F
-
A
--
R
P
S
Y
E
V
F
V
D
L
T
E
A
-
G
E
G
S
H
--------
T
V
D
V
E
H
R
G
F
P
G
D
L
A
V
-
T
V
E
P
R
M
A
R
V
Q
L
E
E
-----
R
Q
T
V
S
--
V
P
V
T
V
E
M
I
N
-
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
49.07
19%
25
- C6 -
-
4QDY
2
?
A:
[6-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
T
-----
Y
T
N
T
V
--
T
N
V
P
I
D
I
R
Y
---
N
S
D
K
Y
F
I
S
G
------
F
A
S
E
V
S
V
V
L
T
G
A
N
R
L
S
L
A
S
E
M
QEST
R
K
F
K
V
T
A
D
L
T
-
D
A
G
V
G
-
T
I
E
--
V
P
L
S
I
E
D
L
P
N
G
--
L
T
A
V
A
T
P
-----
Q
K
-------------
I
T
V
K
I
G
K
K
-
A
Q
K
D
K
V
K
I
V
--
P
E
I
D
P
S
Q
I
D
-
S
R
V
Q
I
E
N
V
M
V
S
--------
D
-
K
--
E
V
S
I
T
S
D
Q
E
T
L
D
R
I
-
D
--
K
I
I
A
V
----------
L
P
T
S
E
R
I
T
G
-
N
Y
S
G
S
V
--------------------
P
L
Q
A
I
D
RN
G
VVLP
A
---
V
I
T
P
F
D
T
I
M
K
V
T
T
K
--------------------------------------------------------------------------------------------------------------------
31
HHSearch
48.86
21%
7
- C6 -
-
2KQ1
-
?
A:
[9-112]
----------------------------------------------------------------------------------------------
L
S
L
G
E
L
E
L
T
V
L
Y
D
E
E
R
Y
------------
D
I
V
E
Q
T
E
T
V
Q
V
D
L
E
G
P
R
G
--
V
L
T
V
F
---
R
F
A
--
R
P
S
Y
E
V
F
V
D
L
T
E
A
-
G
E
G
S
H
--------
T
V
D
V
E
H
R
G
F
P
G
D
L
A
V
-
T
V
E
P
R
M
A
R
V
Q
L
E
E
-----
R
Q
T
V
S
--
V
P
V
T
V
E
M
I
N
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
47.25
13%
-4
- C4 -
-
4CZB
-
NAH1_METJA
A:
[1-415]
------------------------M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
------
A
K
I
A
E
K
L
K
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
---
F
L
Q
I
I
P
------------
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
------------
I
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
--
V
-
I
K
T
V
V
R
L
-
D
--
T
I
T
F
L
I
T
L
L
I
S
G
F
-
I
F
N
M
V
L
NL-----
P
Y
T
S
P
V
G
Y
L
F
G
A
I
T
A
-
A
T
D
P
A
T
L
I
P
V
F
S
R
V
RTN
P
E
V
A
I
T
--
L
E
A
E
S
I
F
N
D
-
P
L
G
I
V
S
T
S
V
I
L
G
L
F
GLF
S
S
S
N
P
L
I
D
L
I
T
L
A
G
--
G
A
I
V
V
----
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y
--
V
A
P
L
V
L
G
-
G
A
M
L
L
L
Y
V
G
-
D
D
-----
L
L
-------------
P
S
I
C
G
Y
G
F
S
G
Y
M
A
-
V
A
I
M
--
G
L
Y
L
G
-
D
A
L
F
R
A
D
D
I
-
D
Y
K
Y
I
--------
V
-
S
--
F
C
D
-
D
L
S
L
L
A
R
V
F
I
F
V
--
F
L
G
A
C
----------
I
K
L
S
-
M
L
E
N
-
Y
F
I
P
G
L
--------------------
L
V
A
L
G
S
--
I
----
F
---
L
A
R
P
L
G
V
F
L
G
L
I
G
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
G
P
R
G
V
V
P
A
A
L
A
V
T
V
-
G
I
E
I
L
K
N
A
D
K
----
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
---------------------------
52
Fugue
42.50
16%
29
- C2 -
-
4LLG
-
RPOD_ECOLI
F:
[6-612]
QS
Q
L
K
L
L
V
T
R
G
K
EQGYLT
Y
A
E
V
N
D
H
LPEDIVDSD
Q
I
E
D
I
I
Q
M
I
N
D
MGIQV
M
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
---
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
EEARLSD
L
I
T
G
F
V
D
D
P
E
L
A
R
E
K
F
A
E
--
L
R
A
Q
Y
V
V
T
R
-
D
--
T
I
K
A
T
A
Q
E
E
I
L
K
L
-
S
E
V
F
K
--------
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
-
M
R
V
M
M
D
R
V
R
T
Q
E
R
-----
L
I
M
K
L
--
C
V
E
Q
C
K
M
P
K
-
K
N
F
I
T
L
F
T
G
N
E
T
-----
S
D
T
W
F
N
A
A
I
A
M
N
K
P
--
W
S
E
K
L
----
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
-
D
I
N
R
R
M
S
I
G
E
A
K
-----
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
-
Q
F
L
D
--
L
I
Q
E
G
-
N
I
G
L
M
K
A
V
D
-
K
F
E
Y
R
--------
R
G
Y
--
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
--
S
I
A
D
Q
ART
I
R
I
P
V
H
M
I
E
T
I
-
N
K
L
N
-
R
I
S
R
Q
M
LQEMGREPTPEELAERMLMP
E
D
K
I
R
K
--
V
----
L
---
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
-
L
R
A
A
T
H
D
V
L
A
----
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
-----------
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
RHP
S
R
S
E
V
L
RSFLD
30
HHSearch
42.26
31%
100
- C6 -
-
2KXY
-
?
A:
[6-91]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
K
S
-
V
P
V
K
--
L
E
L
T
G
-
D
K
A
-
S
N
V
S
S
I
S
Y
S
F
D
--------
R
-
G
--
H
V
T
I
V
G
S
Q
E
A
M
D
K
I
-
D
--
S
I
T
V
P
----------
V
D
I
S
-
Q
V
T
E
-
D
T
S
K
T
L
--------------------
E
L
K
-
A
E
--
G
----
V
---
T
V
Q
P
S
T
V
K
V
N
L
K
V
T
Q
-------------------------------------------------------------------------------------------------------------------
46
Fugue
41.78
15%
-105
* C6 *
-
2KPU
-
?
A:
[1-96]
---------------------------------------------------------------------------------------
S
S
Q
T
L
D
R
D
P
T
L
T
L
S
L
I
A
K
N
T
P
A
N
S
------------
M
I
M
T
K
L
P
S
V
R
V
K
T
E
G
Y
N
P
--
S
I
N
V
N
E
----------
L
F
A
Y
V
D
L
S
G
S
-
E
P
G
E
H
--------
D
Y
E
V
K
V
E
P
I
P
N
I
K
I
V
-
E
I
S
P
R
V
V
T
L
Q
L
E
H
-----
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
41.74
16%
-70
- C6 -
-
3LYW
-
?
A:
[3-85]
-----------------------------------------------------------------------------------------------
P
T
L
T
L
S
L
I
A
K
N
T
P
A
N
S
------------
M
I
M
T
K
L
P
S
V
R
V
K
T
E
G
Y
N
P
--
S
---
I
-----
N
--
V
N
E
L
F
A
Y
V
D
L
S
G
S
-
E
P
G
E
H
--------
D
Y
E
V
K
V
E
-
P
I
P
N
I
K
I
V
E
I
S
P
R
V
V
T
L
Q
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
39.34
16%
-35
- C6 -
-
2L5N
-
?
A:
[8-91]
----------------------------------------------------------------------------------------------
D
P
T
L
T
L
S
L
I
A
K
N
T
P
A
N
S
------------
M
I
M
T
K
L
P
S
V
R
V
K
T
E
G
Y
N
P
--
S
---
I
-----
N
--
V
N
E
L
F
A
Y
V
D
L
S
G
S
-
E
P
G
E
H
--------
D
Y
E
V
K
V
E
-
P
I
P
N
I
K
I
V
E
I
S
P
R
V
V
T
L
Q
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
37.62
16%
74
* C4 *
-
4XFK
-
?
A:
[9-399]
-------------------------------A
E
P
L
K
I
A
L
V
E
T
L
S
------
G
P
Q
A
S
T
G
L
L
Y
R
A
A
V
L
Y
Q
L
G
K
I
N
E
A
GGF
N
G
E
K
I
Q
I
L
E
-
Y
D
N
Q
G
G
P
V
G
A
A
D
R
V
K
A
A
I
A
D
G
A
Q
I
------------
I
V
Q
G
S
S
S
A
V
A
G
Q
I
T
E
D
V
R
--
K
Y
N
L
R
N
K
G
K
-
E
--
V
L
Y
L
N
L
G
A
E
A
L
E
L
T
G
S
K
C
H
FYHFRFSP
N
A
A
I
R
F
K
T
V
A
Q
G
M
K
D
-
K
G
I
L
G
E
R
A
Y
S
I
N
Q
-----
N
Y
S
W
G
--
V
D
V
E
N
T
V
V
A
-
N
A
K
E
I
G
Y
E
V
V
D
K
-----
T
L
H
E
V
N
-
K
I
Q
D
F
S
P
--
Y
V
A
K
I
----
Q
A
--
A
N
V
D
T
V
F
T
G
N
W
S
N
D
L
L
--
L
L
M
K
A
A
S
-
G
A
G
L
K
A
K
F
A
T
S
F
-----
L
D
-------------
Q
P
G
N
I
G
N
A
G
A
I
A
E
-
G
H
I
V
--
S
T
P
F
N
-
P
E
A
N
G
E
A
S
---
M
A
F
A
--------
E
-
D
--
Y
K
K
V
T
G
H
Y
P
S
Y
V
E
P
A
A
--
V
F
G
L
Q
----------
L
F
G
E
-
A
L
K
N
-
V
K
P
G
E
G
--------------------
K
I
N
T
T
D
I
-
A
----
L
---
A
I
E
N
A
S
V
K
T
P
M
G
D
Y
S
M
R
S
D
D
H
Q
A
K
F
P
M
V
V
Q
E
V
S
K
K
A
R
I
K
A
D
G
T
E
Y
G
F
L
P
F
K
T
----
F
-------------
T
G
D
-----------
E
S
I
D
P
V
Q
E
S
C
S
M
K
R
P
G
------------------------------
32
HHSearch
37.58
19%
-123
- C6 -
-
2KXY
-
?
A:
[6-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
K
S
--
V
P
V
K
L
E
L
T
G
-
D
-
K
A
S
N
V
S
S
I
S
Y
-----
S
F
D
R
G
H
V
T
I
V
G
S
Q
E
--
A
M
D
K
I
----
D
S
I
T
V
P
V
D
I
S
-
Q
V
T
E
D
T
S
K
T
--
L
E
L
K
----
A
E
G
----
V
T
V
Q
P
-----
S
T
-------------
V
K
V
N
L
K
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
36.18
15%
11
- C6 -
-
3LYW
-
?
A:
[3-84]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
-
L
T
L
S
--
L
I
A
K
N
-
T
P
--
A
N
S
M
I
---
M
T
K
--------
L
-
P
S
V
R
V
K
T
E
G
Y
N
P
S
---
I
-
N
VN
E
L
F
A
Y
----------
V
D
L
S
-
G
S
E
P
G
E
H
D
Y
E
V
--------------------
K
V
E
P
I
P
--
N
----
I
KIV
E
I
S
P
R
V
V
T
L
Q
L
E
----------------------------------------------------------------------------------------------------------------------