@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0E0: (2018-01-20 )
MVKVEVKHLTKIFGKKTQAALDMMNDHQPKTEILKKTGATVGVYDVNFDVKEGEIFVIMGLSGSGKSTLIRLLNRLIEPTSGSIYIDGEDVSKLSKEELREVRRHKINMVFQNFGLFPHRTILENTEYGLEVRGVPKEERQEKAEKALENSSLLSFKDQYPSQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRREMQDELLDLQANVQKTIIFITHDLNEALRIGDRIALMKDGEIMQIGTGEEILTNPANDYVREFVEEVDRSKVLTAQNIMVPALTTNIESDGPNVALTRMRNEEVSMLMAVDRKRHLKGIITADQALEARKQKRPLIDFLDENVTVIGKDMVVSDIFNIIYDSPTPLAVVEDGKLKGVVIRGSVIEALAETSEVSEHE
Atome Classification :
(42 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120...-....130....-.....140.......150...-....160-----.........170.......180.......190...----....200.....-..210-.....---....220.......230.......240.......250.......260......-.270..-.....280......---.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
K
V
E
V
K
H
L
T
K
I
FGK
K
T
Q
A
A
L
D
M
MNDHQ
P
K
T
E
I
L
K
KTG
A
T
V
G
V
Y
D
V
N
F
D
VKEG
E
I
F
V
I
MGLSGS
G
K
S
T
L
I
R
L
L
N
R
LIEPTS
G
S
I
Y
ID
G
E
D
V
S
K
L
S
K
E
E
L
R
E
V
R
R
H
K
I
N
M
V
F
Q
NFGLFP
H
R
T
I
LEN-TEY
G
L
--
E
VRG-V
P
K
E
E
R
Q
E
K
A
E
K
A
LENSSL
L
S
-
F
K
D
Q
Y
-------
P
S
Q
L
S
G
G
M
Q
Q
R
V
G
L
A
R
A
LANDP
E
I
L
L
M
D
E
A
F
S
A
L
D
----
P
L
I
R
R
E
M
Q
D
E
L
L
-
D
L
Q
---ANV
Q
K
---
T
I
I
F
I
THD
L
N
E
A
L
RIG
D
R
I
A
L
MKDG
E
I
M
Q
IGTG
E
E
ILTNP
A
N
D
Y
V
R
E
F
V
E
E
VD-RS
K
V
L
T-AQ
N
I
M
V
P
A
L
TTNIE---SDGP
N
V
A
L
T
RMRN
E
E
V
S
M
L
M
A
V
D
R
K
R
H
L
K
G
I
I
T
A
D
Q
A
L
E
A
R
K
QKR
P
L
I
D
F
LDEN
V
T
V
IG
K
D
M
V
V
S
D
I
F
N
I
IYDSPT
P
L
A
V
VEDG
K
L
K
G
V
V
I
R
G
S
V
I
E
A
L
A
E
TSEVSEHE-
146
Fugue
85.68
29%
-123
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
--------------------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
-
H
L
D
I
P
E
-
D
---
Y
Q
E
R
L
Q
A
E
P
F
---
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
----------------
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
-----------------
167
HHSearch
83.25
41%
-116
- C1 -
-
2IT1
-
?
A:
[1-236]
M
V
E
I
K
L
E
N
I
V
K
K
F
G
N
------------------------
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
K
------
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
-
I
A
F
P
L
--
E
L
R
K
-
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
-------
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
R
A
E
L
K
-
R
L
Q
---
K
E
L
G
I
---
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
-----------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.01
36%
-123
- C1 -
-
1V43
-
?
A:
[10-249]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
------------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
L
----
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
-------
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
A
M
R
A
E
I
K
-
K
L
Q
---
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
-------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.32
40%
-115
- C1 -
-
2IT1
-
?
A:
[9-234]
--------------------------------
I
V
K
K
F
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
K
D
------
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
-
I
A
F
P
L
--
E
L
R
K
-
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
-------
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
R
A
E
L
K
-
R
L
Q
---
K
E
L
G
I
---
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-------------------------------------------------------------------------------------------------------------------------------------------
165
HHSearch
77.28
39%
-108
- C1 -
-
2D62
1
?
A:
[4-243]
M
A
E
V
K
L
I
N
I
W
K
R
F
G
D
------------------------
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
A
D
P
E
K
G
V
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
-
I
A
F
P
L
--
K
L
R
K
-
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
-
L
L
N
R
K
-------
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
K
M
R
A
E
L
K
-
K
L
Q
---
R
Q
L
G
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
-------------------------------------------------------------------------------------------------------------------------------------------
157
HHSearch
76.41
39%
-120
- C1 -
-
2YYZ
1
?
A:
[2-236]
-
P
S
I
R
V
V
N
L
K
K
Y
F
G
K
------------------------
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
N
D
I
P
P
K
------
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
-
I
A
F
P
L
--
R
A
R
R
-
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
-
L
L
D
R
K
-------
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
----
A
N
L
R
M
I
M
R
A
E
I
K
-
H
L
Q
---
Q
E
L
G
I
---
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
-----------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.26
36%
-121
- C1 -
-
1VCI
1
?
A:
[10-249]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
------------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
L
----
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
-------
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
A
M
R
A
E
I
K
-
K
L
Q
---
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
-------------------------------------------------------------------------------------------------------------------------------------------
164
HHSearch
76.09
39%
-115
- C1 -
-
1Z47
-
?
A:
[14-249]
--
T
I
E
F
V
G
V
E
K
I
Y
P
G
-----------------------
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
-
V
S
F
G
L
--
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
-------
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
-
Q
V
H
---
D
E
M
G
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
----------------------------------------------------------------------------------------------------------------------------------------
166
HHSearch
75.93
38%
-126
- C1 -
-
3TUI
1
METN_ECOLI
C:
[23-263]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
--------------------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
--------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.43
39%
-133
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[46-265]
--------------------------------------------
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------------
153
HHSearch
75.13
35%
-129
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[2-237]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
------------------------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
L
--
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
-------
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
----
A
A
L
R
V
Q
M
R
I
E
I
S
-
R
L
H
---
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
----------------------------------------------------------------------------------------------------------------------------------------
160
HHSearch
74.91
35%
-118
- C1 -
-
1OXU
-
?
C:
[1-243]
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
----------------------
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
P
-
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
-
I
A
F
P
L
--
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
-------
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
R
A
L
V
K
-
E
V
Q
---
S
R
L
G
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
-----------------------------------------------------------------------------------------------------------------------------------------
162
HHSearch
74.68
38%
-115
- C1 -
-
1Z47
-
?
B:
[14-249]
--
T
I
E
F
V
G
V
E
K
I
Y
P
G
-----------------------
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
-
V
S
F
G
L
--
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
-------
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
-
Q
V
H
---
D
E
M
G
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
----------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.43
39%
-127
- C1 -
-
3TUI
1
METN_ECOLI
D:
[46-265]
--------------------------------------------
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
74.24
35%
-125
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[2-237]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
------------------------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
L
--
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
-------
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
----
A
A
L
R
V
Q
M
R
I
E
I
S
-
R
L
H
---
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
----------------------------------------------------------------------------------------------------------------------------------------
147
Fugue
74.11
28%
-73
- C1 -
-
1OXS
-
?
C:
[1-352]
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
----------------------
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
-
I
A
F
P
L
--
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
-------
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
R
A
L
V
K
-
E
V
Q
---
S
R
L
G
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
-
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
---
V
S
S
D
R
A
I
I
G
-
I
R
P
E
D
V
K
L
S
-------------------
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
----
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
28
PsiBlast_CBE
74.01
39%
-139
- C1 -
-
3TUI
1
METN_ECOLI
H:
[46-265]
--------------------------------------------
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------------
156
HHSearch
73.69
34%
-116
- C1 -
-
1OXX
-
?
K:
[1-243]
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
----------------------
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
P
-
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
-
I
A
F
P
L
--
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
-------
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
R
A
L
V
K
-
E
V
Q
---
S
R
L
G
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
-----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.14
34%
-92
- C1 -
-
1Z47
-
?
A:
[26-307]
-------------------------------------
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
-
V
S
F
G
L
--
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
-------
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
-
Q
V
H
---
D
E
M
G
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
-
N
G
R
I
E
V
A
G
A
A
L
P
V
D
PAV
S
E
G
S
E
V
A
V
V
-
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
----------------------------------------------------------------------------
11
PsiBlast_PDB
73.01
39%
-126
- C1 -
-
3TUI
1
METN_ECOLI
C:
[46-265]
--------------------------------------------
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
---
R
R
L
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
72.24
43%
-30
- C1 -
-
4YMU
1
?
A:
[6-239]
-------------------------------
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
----
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.90
43%
-29
- C1 -
-
4YMV
1
?
A:
[6-239]
-------------------------------
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
----
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.78
43%
-26
- C1 -
-
4YMU
1
?
J:
[6-239]
-------------------------------
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
----
E
M
V
K
E
V
L
-
N
V
M
KQL
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.75
43%
-28
- C1 -
-
4YMV
1
?
J:
[6-239]
-------------------------------
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
----
E
M
V
K
E
V
L
-
N
V
M
KQL
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.10
41%
-28
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[22-241]
--------------------------------------------
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
--
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
-
I
A
Y
G
L
G-
N
G
K
G
-
R
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
-------
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
---
A
N
-
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
-----------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
58.70
41%
-30
- C1 -
-
3FVQ
2
FBPC_NEIG1
A:
[22-246]
--------------------------------------------
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
--
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
-
I
A
Y
G
L
G-
N
G
K
G
-
R
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
-------
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
---
A
N
-
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.16
44%
-15
- C1 -
-
4U00
1
?
A:
[23-241]
---------------------------------------------
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
--
D
D
R
A
L
R
E
I
R
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
----
E
M
V
G
E
V
L
-
D
V
M
---
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
----------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.50
45%
-26
- C1 -
-
3TIF
4
Y796_METJA
A:
[23-223]
--------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
-
V
E
L
P
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
-
K
L
N
---
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
55.37
45%
-25
- C1 -
-
3TIF
3
Y796_METJA
B:
[23-223]
--------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
-
V
E
L
P
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
-
K
L
N
---
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
55.19
45%
-23
- C1 -
-
1L2T
3
Y796_METJA
A:
[23-223]
--------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
-
V
E
L
P
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
-
K
L
N
---
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.90
45%
-27
- C1 -
-
1L2T
3
Y796_METJA
B:
[23-223]
--------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
-
V
E
L
P
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
-
K
L
N
---
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
145
PsiBlast_CBE
37.43
33%
-30
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
133
PsiBlast_CBE
36.79
33%
-46
- C1 -
-
2PMK
1
A:
[23-234]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
134
PsiBlast_CBE
36.63
33%
-43
- C1 -
-
2FF7
1
A:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
142
PsiBlast_CBE
36.57
33%
-31
- C1 -
-
2FGJ
2
D:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
139
PsiBlast_CBE
36.00
33%
-36
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
138
PsiBlast_CBE
35.50
33%
-35
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
137
PsiBlast_CBE
34.45
33%
-35
- C1 -
-
2FGK
2
D:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
143
PsiBlast_CBE
34.18
33%
-26
- C1 -
-
2FGJ
2
HLYBP_ECOLX
C:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
144
PsiBlast_CBE
33.91
33%
-32
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
YESE
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
140
PsiBlast_CBE
32.97
33%
-36
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[27-238]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
N
T
I
V
G
EQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------
136
PsiBlast_CBE
32.81
33%
-36
- C1 -
-
3B5J
1
A:
[23-234]
--------------------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
-
I
S
--
L
--
A
N
P
G
-
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
NTIVGEQ
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
-------
K
---
I
C
K
G
R
---
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------