@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0K9: (2018-01-21 )
MIDAKKLRNDFPILFQDVNDEPLVYLDNAATTQKPKQVLQALAYYYEHDNANVHRGVHTLAERATHDYEQAREKVRAFIHAKETAEVLFTRGTTTSLNWVARTFGDRYIKAGDEIVLSYMEHHSNVIPWQQLAKRTGAVLKYIELTEEGFLDMEDAAKKITDKTKIVSIAHVSNVLGVFNPVQELAELVHENGGVIVVDGAQSAPHMAIDVQALDCDFFAFSGHKMCGPTGIGVLYGKRKWLEEMEPVEFGGEMIDFVELYDSTWKELPWKFEAGTPNIAGAIALGHAIDYLQKLGMDNIHRYEEELAAYVLPKLQAIDGLTVYGPQDPNFRTGVVAFNLDGLHPHDVATALDMEGVAVRAGHHCAQPLLKYLEVSATARASFYFYNTTQDADRLVEAIMATKEFFQHGTI
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-..-..230.......240.......250.......260-.......270.......280.......290.......300.......310.......320.--......330-........340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
D
A
K
K
L
RNDF
P
I
L
F
Q
DVNDE
P
L
V
Y
LDNAATTQ
K
P
K
Q
V
L
Q
A
L
A
Y
Y
Y
EHDNA
N
V
H
R
G
V
H
T
L
A
E
R
ATH
D
Y
E
Q
A
R
E
K
V
R
A
F
I
H
A
K
E
T
A
E
V
L
F
TRGTTT
S
L
N
W
V
A
R
T
FG
D
R
YIKA
G
D
E
I
V
L
S
Y
M
E
H
HSNVI
P
W
Q
Q
L
A
K
RT
G
A
V
L
K
Y
I
EL
T
E
EGFL
D
M
E
D
A
A
K
KITDK
T
K
I
V
S
I
A
H
V
S
N
V
L
G
V
F
N
P
V
Q
E
L
A
E
L
V
HENG
G
V
I
V
VDGAQSAP
H
M
A
I
D
V
Q
A
L
D
C
D
F
F
AFSGHK-MC-GPTG
I
G
V
L
YG
K
R
K
W
L
E
EM
E
P
V
EFGG
E
M
I
D
F
V
E
L
Y
D
-
S
T
W
K
EL
P
W
K
FEAGTPN
I
A
G
A
I
A
L
G
H
A
I
D
Y
L
Q
K
LG
M
D
N
I
H
R
Y
E
E
E
L
A
A
Y
V
L
P
K
L
QAID
G
L
T
V
--YGPQDPNF--R
T
G
V
V
A
F
NLDGL
H
P
H
D
V
A
T
A
LDME
G
V
A
VRAG
H
H
C
A
Q
P
L
L
K
Y
L
E
VS
A
T
A
R
A
S
F
Y
F
Y
NTTQ
D
A
D
R
L
V
E
A
I
M
A
T
K
E
F
F
QHGTI
57
HHSearch
95.75
65%
-107
- C1 -
-
5J8Q
2
SUFS_BACSU
A:
[3-404]
---
I
T
D
I
R
E
Q
F
P
I
L
H
Q
Q
V
N
G
H
D
L
V
Y
L
D
S
A
A
T
S
Q
K
P
R
A
V
I
E
T
L
D
K
Y
Y
N
Q
Y
N
S
N
V
H
R
G
V
H
T
L
G
T
R
A
T
D
G
Y
E
G
A
R
E
K
V
R
K
F
I
N
A
K
S
M
A
E
I
I
F
T
K
G
T
T
T
S
L
N
M
V
A
L
S
Y
A
R
A
N
L
K
P
G
D
E
V
V
I
T
Y
M
E
H
H
A
N
I
I
P
W
Q
Q
A
V
K
A
T
G
A
T
L
K
Y
I
P
L
Q
E
D
G
T
I
S
L
E
D
V
R
E
T
V
T
S
N
T
K
I
V
A
V
S
H
V
S
N
V
L
G
T
V
N
P
I
K
E
M
A
K
I
A
H
D
N
G
A
V
I
V
V
D
G
A
Q
S
T
P
H
M
K
I
D
V
Q
D
L
D
C
D
F
F
A
L
S
S
H
K
-
M
C
-
G
P
T
G
V
G
V
L
Y
G
K
K
A
L
L
E
N
M
E
P
A
E
F
G
G
E
M
I
D
F
V
G
L
Y
E
-
S
T
W
K
E
L
P
W
K
F
E
A
G
T
P
I
I
A
G
A
I
G
L
G
A
A
I
D
F
L
E
E
I
G
L
D
E
I
S
R
H
E
H
K
L
A
A
Y
A
L
E
R
F
R
Q
L
D
G
V
T
V
--
Y
G
P
E
---
E
--
R
A
G
L
V
T
F
N
L
D
D
V
H
P
H
D
V
A
T
V
L
D
A
E
G
I
A
V
R
A
G
H
H
-
A
Q
P
L
M
K
W
L
D
V
T
A
T
A
R
A
S
F
Y
L
Y
N
T
E
E
E
I
D
K
L
V
E
A
L
Q
K
T
K
E
Y
F
T
N
---
1
PsiBlast_PDB
94.61
64%
-106
- C1 -
-
5J8Q
2
SUFS_BACSU
A:
[6-402]
------
I
R
E
Q
F
P
I
L
H
Q
Q
V
N
G
H
D
L
V
Y
L
D
S
A
A
T
S
Q
K
P
R
A
V
I
E
T
L
D
K
Y
Y
N
Q
Y
N
S
N
V
H
R
G
V
H
T
L
G
T
R
A
T
D
G
Y
E
G
A
R
E
K
V
R
K
F
I
N
A
K
S
M
A
E
I
I
F
T
K
G
T
T
T
S
L
N
M
V
A
L
S
Y
A
R
A
N
L
K
P
G
D
E
V
V
I
T
Y
M
E
H
H
A
N
I
I
P
W
Q
Q
A
V
K
A
T
G
A
T
L
K
Y
I
P
L
Q
E
D
G
T
I
S
L
E
D
V
R
E
T
V
T
S
N
T
K
I
V
A
V
S
H
V
S
N
V
L
G
T
V
N
P
I
K
E
M
A
K
I
A
H
D
N
G
A
V
I
V
V
D
G
A
Q
S
T
P
H
M
K
I
D
V
Q
D
L
D
C
D
F
F
A
L
S
S
H
K
-
M
C
-
G
P
T
G
V
G
V
L
Y
G
K
K
A
L
L
E
N
M
E
P
A
E
F
G
G
E
M
I
D
F
V
G
L
Y
E
-
S
T
W
K
E
L
P
W
K
F
E
A
G
T
P
I
I
A
G
A
I
G
L
G
A
A
I
D
F
L
E
E
I
G
L
D
E
I
S
R
H
E
H
K
L
A
A
Y
A
L
E
R
F
R
Q
L
D
G
V
T
V
--
Y
G
P
E
E
-----
R
A
G
L
V
T
F
N
L
D
D
V
H
P
H
D
V
A
T
V
L
D
A
E
G
I
A
V
R
A
G
H
H
-
A
Q
P
L
M
K
W
L
D
V
T
A
T
A
R
A
S
F
Y
L
Y
N
T
E
E
E
I
D
K
L
V
E
A
L
Q
K
T
K
E
Y
F
-----
5
PsiBlast_PDB
89.27
49%
-91
- C1 -
-
5DB5
5
SUFS_ECOLI
A:
[4-399]
-
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
--
Y
G
P
Q
N
-----
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
-
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
------------
9
PsiBlast_PDB
89.06
44%
-112
- C1 -
-
4W91
-
?
A:
[20-421]
--
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
--
F
G
-
N
A
P
D
---
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
A
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
-----
52
HHSearch
88.41
45%
-114
- C1 -
-
4W91
-
?
B:
[19-421]
-
Y
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
--
F
G
N
A
P
--
D
--
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
A
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
-----
22
PsiBlast_CBE
87.99
49%
-92
- C1 -
-
5DB5
5
SUFS_ECOLI
B:
[3-399]
I
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
--
Y
G
P
Q
N
-----
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
-
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
------------
21
PsiBlast_CBE
87.21
52%
-82
- C1 -
-
1T3I
4
CSD_SYNY3
B:
[10-413]
---
A
A
T
V
R
Q
D
F
P
I
L
N
Q
E
I
N
G
H
P
L
V
Y
L
D
N
A
A
T
S
Q
K
P
R
A
V
L
E
K
L
M
H
Y
Y
E
N
D
N
A
N
V
---
A
H
Q
L
S
V
R
A
T
D
A
Y
E
A
V
R
N
K
V
A
K
F
I
N
A
R
S
P
R
E
I
V
Y
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
M
N
N
L
K
A
G
D
E
I
I
T
T
V
M
E
H
H
S
N
L
V
P
W
Q
M
V
A
A
K
T
G
A
V
L
K
F
V
Q
L
D
E
Q
E
S
F
D
L
E
H
F
K
T
L
L
S
E
K
T
K
L
V
T
V
V
H
I
S
N
T
L
G
C
V
N
P
A
E
E
I
A
Q
L
A
H
Q
A
G
A
K
V
L
V
D
A
C
Q
S
A
P
H
Y
P
L
D
V
Q
L
I
D
C
D
W
L
V
A
S
G
H
K
-
M
C
-
A
P
T
G
I
G
F
L
Y
G
K
E
E
I
L
E
A
M
P
P
F
F
G
G
G
E
M
I
A
E
V
F
F
D
H
-
F
T
T
G
E
L
P
H
K
F
E
A
G
T
P
A
I
A
E
A
I
A
L
G
A
A
V
D
Y
L
T
D
L
G
M
E
N
I
H
N
Y
E
V
E
L
T
H
Y
L
W
Q
G
L
G
Q
I
P
Q
L
R
L
--
Y
G
P
-
N
P
K
H
GD
R
A
A
L
A
S
F
N
V
A
G
L
H
A
S
D
V
A
T
M
V
D
Q
D
G
I
A
I
R
S
G
H
H
C
T
Q
P
L
H
R
L
F
D
A
S
G
S
A
R
A
S
L
Y
F
Y
N
T
K
E
E
I
D
L
F
L
Q
S
L
Q
A
T
I
R
F
F
-----
3
PsiBlast_PDB
85.87
49%
-91
- C1 -
-
1JF9
1
SUFS_ECOLI
A:
[4-400]
I
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
--
Y
G
P
Q
N
-----
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
------------
4
PsiBlast_PDB
85.71
49%
-94
- C1 -
-
1I29
2
SUFS_ECOLI
A:
[2-398]
I
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
--
Y
G
P
Q
N
-----
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
------------
59
HHSearch
84.77
41%
-110
- C1 -
-
4LW2
3
CSDA_ECOLI
B:
[8-403]
--
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
-----
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
----
Q
--
D
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
----
55
HHSearch
84.07
40%
-115
- C1 -
-
5FT6
9
CSDA_ECOLI
A:
[4-400]
-
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
-----
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
----
Q
--
D
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
----
41
PsiBlast_CBE
82.21
41%
-109
- C1 -
-
4LW2
3
CSDA_ECOLI
B:
[6-395]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
14
PsiBlast_PDB
81.65
41%
-114
- C1 -
-
5FT4
6
CSDA_ECOLI
A:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
6
PsiBlast_PDB
81.46
49%
-95
- C1 -
-
1C0N
2
SUFS_ECOLI
A:
[8-398]
------
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
A
G
A
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
A
A
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
--
Y
G
P
Q
A
-----
R
L
G
V
I
A
F
N
L
G
A
H
H
A
Y
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
------------
16
PsiBlast_PDB
81.45
41%
-111
- C1 -
-
4LW2
2
CSDA_ECOLI
A:
[6-395]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
17
PsiBlast_PDB
81.10
41%
-115
- C1 -
-
4LW4
2
CSDA_ECOLI
A:
[6-395]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
------
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
42
PsiBlast_CBE
80.91
40%
-111
- C1 -
-
5FT6
6
CSDA_ECOLI
B:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
19
PsiBlast_PDB
80.74
40%
-113
- C1 -
-
5FT6
9
CSDA_ECOLI
A:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
15
PsiBlast_PDB
79.97
41%
-111
- C1 -
-
5FT8
10
CSDA_ECOLI
A:
[5-394]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
40
PsiBlast_CBE
79.45
41%
-114
- C1 -
-
4LW2
3
CSDA_ECOLI
C:
[6-395]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
43
PsiBlast_CBE
79.37
40%
-112
- C1 -
-
5FT5
8
CSDA_ECOLI
B:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
31
PsiBlast_CBE
79.36
41%
-112
- C1 -
-
5FT4
11
CSDA_ECOLI
B:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
-
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
39
PsiBlast_CBE
79.12
41%
-111
- C1 -
-
4LW4
2
CSDA_ECOLI
B:
[6-395]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
18
PsiBlast_PDB
78.56
40%
-112
- C1 -
-
5FT5
12
CSDA_ECOLI
A:
[3-392]
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-
Q
D
A
G
----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
-
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
--
F
R
C
Q
D
------
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
-
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
------------
62
HHSearch
74.69
44%
-50
- C1 -
-
5B7U
2
?
A:
[21-417]
M
R
I
P
E
D
V
R
K
D
I
P
L
T
N
------
E
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
-
F
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
-
K
G
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
-
G
P
M
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
V
K
R
T
T
E
G
L
D
E
L
-
E
V
P
W
--
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
G
V
M
E
E
L
V
K
G
L
-----
61
HHSearch
73.83
45%
-50
- C1 -
-
5B89
3
?
B:
[23-417]
--
I
P
E
D
V
R
K
D
I
P
L
T
N
------
E
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
-
F
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
-
G
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
-
G
P
M
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
V
K
R
T
T
E
G
L
D
E
L
-
E
V
P
W
--
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
G
V
M
E
E
L
V
K
G
L
-----
30
PsiBlast_CBE
68.51
45%
-54
- C1 -
-
5B87
4
?
B:
[27-407]
------
V
R
K
D
I
P
L
T
N
E
------
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
F
-
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
G
-
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
G
P
M
-
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
---
V
K
R
T
T
E
G
L
D
E
L
E
V
P
W
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
---------------
12
PsiBlast_PDB
67.93
45%
-52
- C1 -
-
5B89
5
?
A:
[27-407]
------
V
R
K
D
I
P
L
T
N
E
------
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
F
-
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
G
-
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
G
P
M
-
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
---
V
K
R
T
T
E
G
L
D
E
L
E
V
P
W
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
---------------
13
PsiBlast_PDB
67.72
45%
-54
- C1 -
-
5B7U
2
?
A:
[27-407]
------
V
R
K
D
I
P
L
T
N
E
------
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
F
-
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
G
-
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
G
P
M
-
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
---
V
K
R
T
T
E
G
L
D
E
L
E
V
P
W
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
---------------
29
PsiBlast_CBE
67.09
45%
-53
- C1 -
-
5B89
3
?
B:
[27-407]
------
V
R
K
D
I
P
L
T
N
E
------
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
F
-
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
G
-
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
G
P
M
-
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
---
V
K
R
T
T
E
G
L
D
E
L
E
V
P
W
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
---------------
11
PsiBlast_PDB
65.88
45%
-51
- C1 -
-
5B87
4
?
A:
[27-407]
------
V
R
K
D
I
P
L
T
N
E
------
V
I
Y
F
D
N
T
A
T
S
L
T
P
K
P
V
V
E
A
M
D
E
Y
Y
L
K
Y
R
A
N
V
H
R
G
V
H
R
L
S
Q
M
A
T
H
K
Y
E
E
S
R
K
I
V
A
D
F
I
G
A
K
-
F
E
E
I
V
F
T
K
N
T
S
E
S
L
N
L
V
A
L
G
L
G
H
I
F
-
K
R
G
D
K
I
V
T
T
P
Y
E
H
H
S
D
L
L
P
W
Q
R
L
A
T
K
L
G
L
K
L
E
F
I
E
G
D
D
E
G
N
L
D
L
S
D
A
E
K
K
I
K
G
-
A
K
L
V
A
V
Q
H
V
S
N
A
L
G
V
I
H
E
V
E
E
L
G
K
I
A
K
D
E
G
A
I
F
V
V
D
A
A
Q
S
A
G
H
M
E
V
N
V
K
K
L
H
A
D
F
L
A
F
S
G
H
K
G
P
M
-
G
P
T
G
I
G
V
L
Y
I
R
E
E
F
F
D
T
F
E
P
P
L
I
G
G
G
T
I
E
D
V
S
L
D
G
-
Y
K
L
T
E
P
P
E
R
F
E
A
G
T
P
N
I
G
G
A
I
G
L
A
A
G
I
R
Y
I
E
R
I
G
L
G
R
I
E
R
Q
E
H
K
L
---
V
K
R
T
T
E
G
L
D
E
L
E
V
P
W
Y
G
P
R
N
L
K
K
--
H
A
G
V
V
S
F
N
V
P
G
L
H
P
H
D
V
A
A
I
L
D
D
H
S
I
M
V
R
S
G
H
H
-
A
L
P
V
M
K
K
L
G
I
N
G
T
V
R
A
S
F
H
V
Y
N
S
L
E
E
V
E
T
F
L
---------------