@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0P7: (2018-01-21 )
MKIVIVGGVAGGMSAATRLRRLMEDAEIVVFEKGPYVSFANCGLPYYLSGEISERENLLVQTPESLSARFCLDVRPNHEVTAIFPENKTVEVVHEGQKHIEQYDALVLSPGAKPVVPSIPGITEADNVFSIRNVPDIDKVMHALEKQPKRAVIVGAGFIGLEMAENLKRRGLEVMVIEQAPHILPTLDEEMAAFIEKELSHQGVEVITSHAVAGFEDHGKRLRLDDGRTIPADLVILSIGVRPDNQLAVTAGIELGIRGGILVDERYQTNIPDIYAVGDAIVVKQQITGKDALISLASPANRQGRQVADTISGISRRNQGGIGTAIIRTFGMTAASTGLSERTAKENELSFEVIHVSGKDHASYYPEATDILLKLIFHPETGEIYGAQGVGAKGVDKRIDILATAIKGHLTIFDLPELELTYAPPFGSAKDPVNMLGYAAMNIAEGLSETVQWHELPTELAKGKILLDVRTAEELEKGKFKEAKHIPLNELRDRLNELDSQQEYIVSCHSGLRSYLAERILKQSGYHVKNLDGAFSLYQTVRPEELIYPNK
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80.......--.90.--..--.--....100--.......110..-.....120.....--..130.......140..-.-.-...150-.......160.....-..170........180...-.-.-..190.......200....------------...210--....-..--------------------.--220------..-.-.-....230.......240.......250.......260.......270.......280.......290.......300.......310.-..-....320.......330.......340.......350.......360.......370.......380.......390--...--.....400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
V
I
VGGVAG
G
M
S
A
A
T
R
L
R
R
L
MEDA
E
I
V
V
F
EKGP
Y
V
S
F
ANCGL
P
Y
Y
LSGEISERE
N
L
L
V
QTPESLS
A
R
F
C
L
DVRPNH
E
V
T
A
I
FPEN
K
--
T
V
E
V
--
V
H
--
E
--
G
Q
K
H
I
E
Q
--
Y
D
A
L
V
LSPGAKP-VVPSIPGITEAD
N
--
V
F
SIRNVP
D
I
D
K
V
M
H
A
L
-E-K-QPK
R
A
V
-
I
V
GAG
F
I
G
L
E
M
A
E
N
L
-
K
RR-G
L
E
V
M
V
IEQAPHILP-T-
L
-
D
E
E
M
A
A
F
I
E
K
E
L
SHQ
G
V
E
V
------------
I
T
S
HAV--AG
F
E
-DH--------------------G--
K
R
-------
L
R-L-D-DGRTIP
A
D
L
V
I
L
S
I
GVRPDN
Q
L
A
V
T
A
G
I
E
L
GIRG
G
I
L
V
DERYQTNIP
D
I
Y
AVG
D
A
I
V
V
K
QQITGK
D
A
L
ISLASPANRQG
R
Q
V
A
D
T
I
S
G
-
I
S
-RRNQGG
I
G
T
A
I
I
R
T
FGM
T
A
ASTGLSERTAKENE
L
S
F
E
V
I
H
VSGKDHASYYP
E
A
T
D
I
L
L
K
L
IFHPETG
E
I
YGAQGVG---AK
G
--
V
D
K
R
I
D
I
L
A
T
A
IKG
H
L
T
I
F
DLPE
L
E
L
T
YAPPFGSAK
D
P
V
N
M
L
G
Y
A
A
M
N
I
A
E
G
L
S
E
T
V
Q
W
H
EL
P
T
E
LAK
G
K
I
L
L
D
VR
T
A
E
E
L
E
KGKFKEAKHI
P
L
N
E
L
R
D
R
L
N
E
LD
S
Q
Q
E
Y
I
V
S
C
H
S
G
L
R
S
Y
L
A
E
R
I
L
K
QSGYHVKNLD
G
A
F
S
L
Y
Q
TV
R
P
E
E
LIYPNK
93
HHSearch
85.74
51%
-3
- C1 -
-
3ICT
4
?
A:
[37-586]
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
--
T
I
T
I
--
K
N
--
V
TT
N
E
T
Y
N
E
A
--
Y
D
V
L
I
L
S
P
G
A
K
P
-
I
V
P
S
I
P
G
I
E
E
A
K
A
--
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
-
D
E
K
-
K
P
R
H
A
T
-
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-
R
E
R
-
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
------------
V
F
E
D
G
V
--
D
A
L
E
-
E
N
--------------------
G
--
A
V
-------
V
R
-
L
-
K
-
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
-
H
T
D
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
---
R
D
G
--
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
T
V
Q
W
H
E
I
D
R
I
V
E
N
G
G
Y
L
I
D
V
R
E
P
N
E
L
K
Q
G
M
I
K
G
S
I
N
I
P
L
D
E
L
R
D
R
L
E
E
V
P
V
D
K
D
I
Y
I
T
C
Q
L
G
M
R
G
Y
V
A
A
R
M
L
M
E
K
G
Y
K
V
K
N
V
D
G
G
F
K
L
Y
G
T
V
L
P
E
R
I
-----
92
HHSearch
84.78
51%
-2
- C1 -
-
3ICS
5
?
B:
[37-586]
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
--
T
I
T
I
--
K
N
--
V
TT
N
E
T
Y
N
E
A
--
Y
D
V
L
I
L
S
P
G
A
K
P
-
I
V
P
S
I
P
G
I
E
E
A
K
A
--
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
-
D
E
K
-
K
P
R
H
A
T
-
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-
R
E
R
-
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
------------
V
F
E
D
G
V
--
D
A
L
E
-
E
N
--------------------
G
--
A
V
-------
V
R
-
L
-
K
-
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
-
H
T
D
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
---
R
D
G
--
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
T
V
Q
W
H
E
I
D
R
I
V
E
N
G
G
Y
L
I
D
V
R
E
P
N
E
L
K
Q
G
M
I
K
G
S
I
N
I
P
L
D
E
L
R
D
R
L
E
E
V
P
V
D
K
D
I
Y
I
T
C
Q
L
G
M
R
G
Y
V
A
A
R
M
L
M
E
K
G
Y
K
V
K
N
V
D
G
G
F
K
L
Y
G
T
V
L
P
E
R
I
-----
91
HHSearch
79.83
45%
-6
- C1 -
-
3NTD
4
?
A:
[2-564]
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
--
L
V
T
V
--
R
R
LL
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
D
-
N
P
L
--
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
------------
R
L
G
T
A
L
--
S
E
V
S
-
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
-
L
S
-------
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
L
-
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
S
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
F
A
----------
3
PsiBlast_PDB
78.73
49%
11
- C1 -
-
3ICT
4
?
A:
[54-588]
-----------------
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
--
T
I
T
I
K
N
V
T
--
T
--
N
E
T
Y
N
E
A
--
Y
D
V
L
I
L
S
P
G
A
K
P
-
I
V
P
S
I
P
G
I
E
E
A
K
A
--
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
-
K
-
K
P
R
H
A
T
-
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-
R
E
R
-
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
------------
V
F
E
D
G
V
--
D
A
L
E
-
E
N
--------------------
G
--
A
V
-------
V
R
-
L
-
K
-
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
-
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
---
R
D
G
--
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
T
V
Q
W
H
E
I
D
R
I
V
E
N
G
G
Y
L
I
D
V
R
E
P
N
E
L
K
Q
G
M
I
K
G
S
I
N
I
P
L
D
E
L
R
D
R
L
E
E
V
P
V
D
K
D
I
Y
I
T
C
Q
L
G
M
R
G
Y
V
A
A
R
M
L
M
E
K
G
Y
K
V
K
N
V
D
G
G
F
K
L
Y
G
T
V
L
P
E
R
I
V
Y
---
2
PsiBlast_PDB
78.43
49%
10
- C1 -
-
3ICS
4
?
A:
[54-588]
-----------------
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
--
T
I
T
I
K
N
V
T
--
T
--
N
E
T
Y
N
E
A
--
Y
D
V
L
I
L
S
P
G
A
K
P
-
I
V
P
S
I
P
G
I
E
E
A
K
A
--
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
-
K
-
K
P
R
H
A
T
-
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-
R
E
R
-
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
------------
V
F
E
D
G
V
--
D
A
L
E
-
E
N
--------------------
G
--
A
V
-------
V
R
-
L
-
K
-
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
-
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
---
R
D
G
--
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
T
V
Q
W
H
E
I
D
R
I
V
E
N
G
G
Y
L
I
D
V
R
E
P
N
E
L
K
Q
G
M
I
K
G
S
I
N
I
P
L
D
E
L
R
D
R
L
E
E
V
P
V
D
K
D
I
Y
I
T
C
Q
L
G
M
R
G
Y
V
A
A
R
M
L
M
E
K
G
Y
K
V
K
N
V
D
G
G
F
K
L
Y
G
T
V
L
P
E
R
I
V
Y
---
6
PsiBlast_PDB
78.40
43%
-16
- C1 -
-
3NTA
4
?
A:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
RLG
T
A
L
S
E
V
S
Y
Q
V
Q
T
H
V
A
S
D
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIK
G
H
L
S
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
C
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
1
PsiBlast_PDB
77.79
49%
13
- C1 -
-
3ICR
4
?
A:
[54-588]
-----------------
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
--
T
I
T
I
K
N
V
T
--
T
--
N
E
T
Y
N
E
A
--
Y
D
V
L
I
L
S
P
G
A
K
P
-
I
V
P
S
I
P
G
I
E
E
A
K
A
--
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
-
K
-
K
P
R
H
A
T
-
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-
R
E
R
-
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
------------
V
F
E
D
G
V
--
D
A
L
E
-
E
N
--------------------
G
--
A
V
-------
V
R
-
L
-
K
-
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
-
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
---
R
D
G
--
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
T
V
Q
W
H
E
I
D
R
I
V
E
N
G
G
Y
L
I
D
V
R
E
P
N
E
L
K
Q
G
M
I
K
G
S
I
N
I
P
L
D
E
L
R
D
R
L
E
E
V
P
V
D
K
D
I
Y
I
T
C
Q
L
G
M
R
G
Y
V
A
A
R
M
L
M
E
K
G
Y
K
V
K
N
V
D
G
G
F
K
L
Y
G
T
V
L
P
E
R
I
V
Y
---
22
PsiBlast_CBE
77.20
43%
-16
- C1 -
-
3NTD
4
?
B:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
LV
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
RLGTALSEVSYQ
V
Q
T
H
V
A
SD
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIKGHLS
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
S
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
5
PsiBlast_PDB
76.70
43%
-16
- C1 -
-
3NTD
4
?
A:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
RLGTALS
E
V
S
Y
Q
V
Q
T
H
V
A
S
D
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIK
G
H
L
S
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
S
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
7
PsiBlast_PDB
76.57
43%
-16
- C1 -
-
3NT6
4
?
A:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
S
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
RLG
T
A
L
S
E
V
S
Y
Q
V
Q
T
H
V
A
SD
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIK
G
H
L
S
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
S
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
21
PsiBlast_CBE
76.54
43%
-15
- C1 -
-
4OCG
4
?
B:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
LV
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
A
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
RLGTALSEVSYQ
V
Q
T
H
V
A
SD
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIKGHLS
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
C
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
4
PsiBlast_PDB
76.05
43%
-14
- C1 -
-
4OCG
4
?
A:
[3-562]
-
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
--
L
L
--
D
--
G
S
E
Y
Q
E
S
--
Y
D
T
L
L
L
S
P
G
A
A
P
-
I
V
P
P
I
P
G
V
---
D
N
PL
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
N
-
N
V
E
H
A
T
-
V
V
G
G
G
A
I
G
L
E
M
M
E
S
L
-
H
H
L
-
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
GTALS
E
V
S
Y
Q
V
Q
T
H
V
A
S
D
A
A
G
E
-
D
T
--------------------
A
--
H
Q
HIK
G
H
L
S
L
T
-
L
-
S
-
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
---
K
D
G
--
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
P
I
H
F
D
Q
I
D
N
-
L
S
E
D
Q
L
L
L
D
V
R
N
P
G
E
L
Q
N
G
G
L
E
G
A
V
N
I
P
V
D
E
L
R
D
R
M
H
E
L
P
K
D
K
E
I
I
I
F
C
Q
V
G
L
R
G
N
V
A
Y
R
Q
L
V
N
N
G
Y
R
A
R
N
L
I
G
G
Y
R
T
Y
K
------------
95
HHSearch
66.46
30%
-22
- C1 -
-
5ER0
9
?
B:
[51-494]
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
-
Q
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
--
T
V
T
V
--
E
D
LT
N
--
H
A
Q
T
T
E
S
--
Y
D
K
L
V
M
T
S
G
S
W
P
-
I
V
P
K
I
P
G
I
D
-
S
D
R
--
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
-
K
---
E
A
K
R
I
T
-
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
-
S
T
T
-
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
-
K
Y
F
-
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
------------
A
L
G
E
T
V
--
E
S
F
T
-
D
S
--------------------
A
--
T
G
-------
L
T
-
I
K
T
-
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
-
P
T
-
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
---
K
Y
D
--
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
L
A
Q
A
A
Q
A
K
V
-----------------------------------------------------------------------------------------------------------
103
HHSearch
62.59
35%
-2
- C1 -
-
3CGB
4
?
A:
[37-478]
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
Y
A
Q
C
G
L
P
Y
V
I
S
G
A
I
A
S
T
E
K
L
I
A
R
N
V
K
T
F
R
D
K
Y
G
I
D
A
K
V
R
H
E
V
T
K
V
D
T
E
K
K
--
I
V
Y
A
--
E
H
TK
T
--
K
D
V
F
E
F
S
--
Y
D
R
L
L
I
A
T
G
V
R
P
-
V
M
P
E
W
E
G
R
D
-
L
Q
G
--
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
-
E
T
N
-
K
V
E
D
V
T
-
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-
V
E
L
-
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
-
Y
-
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
------------
L
T
N
E
N
V
--
K
A
F
K
-
G
N
--------------------
E
R-
V
E
-------
A
V
-
E
-
T
-
D
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
L
E
G
T
N
I
R
T
N
H
K
G
A
I
E
V
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
I
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
-
K
R
-
R
A
F
K
G
T
L
G
T
G
I
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
K
E
A
K
G
L
H
I
P
Y
K
T
V
K
V
D
S
T
N
M
A
G
Y
Y
P
N
A
K
P
L
Y
L
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
G
---
E
E
G
--
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
Q
Q
A
A
R
R
----------------------------------------------------------------------------------------------------------------
101
HHSearch
62.57
35%
-13
- C1 -
-
3IWA
-
?
A:
[4-462]
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
D
P
E
A
H
V
T
M
I
D
Q
A
-------------------------------------
V
E
A
L
V
E
T
R
A
H
A
I
D
R
A
A
H
--
T
V
E
I
--
E
N
LR
T
--
G
E
R
R
T
L
K
--
Y
D
K
L
V
L
A
L
G
S
K
A
-
N
R
P
P
V
E
G
M
D
-
L
A
G
--
V
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
-
S
A
G
-
E
V
S
K
A
V
-
I
V
G
G
G
F
I
G
L
E
M
A
V
S
L
-
A
D
M
W
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
-
G
-
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
------------
H
T
G
E
K
V
--
V
R
L
E
-
G
E
--------------------
N
GK
V
A
-------
R
V
-
I
-
T
-
D
K
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
A
R
D
A
G
L
E
L
D
P
R
G
A
I
I
V
D
T
R
M
R
T
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
T
G
K
P
G
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
-
G
D
-
A
T
F
P
G
A
V
G
S
W
A
V
K
L
F
E
G
S
A
S
G
A
G
L
T
V
E
G
A
L
R
E
G
Y
D
A
V
N
V
H
V
E
Q
-----------
I
M
T
L
Q
L
V
V
D
R
P
T
R
R
V
L
G
I
Q
G
F
S
TL
G
D
A
---
L
T
A
R
I
N
A
V
A
T
M
L
A
S
K
P
T
V
E
D
I
S
N
A
E
V
V
--------
M
D
I
V
N
V
A
G
N
V
A
D
N
V
L
A
----------------------------------------------------------------------------------------------------------
104
HHSearch
62.11
35%
-3
- C1 -
-
3CGE
5
?
A:
[37-478]
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
Y
A
Q
C
G
L
P
Y
V
I
S
G
A
I
A
S
T
E
K
L
I
A
R
N
V
K
T
F
R
D
K
Y
G
I
D
A
K
V
R
H
E
V
T
K
V
D
T
E
K
K
--
I
V
Y
A
--
E
H
TK
T
--
K
D
V
F
E
F
S
--
Y
D
R
L
L
I
A
T
G
V
R
P
-
V
M
P
E
W
E
G
R
D
-
L
Q
G
--
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
-
E
T
N
-
K
V
E
D
V
T
-
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-
V
E
L
-
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
-
Y
-
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
------------
L
T
N
E
N
V
--
K
A
F
K
-
G
N
--------------------
E
R-
V
E
-------
A
V
-
E
-
T
-
D
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
L
E
G
T
N
I
R
T
N
H
K
G
A
I
E
V
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
I
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
-
K
R
-
R
A
F
K
G
T
L
G
T
G
I
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
K
E
A
K
G
L
H
I
P
Y
K
T
V
K
V
D
S
T
N
M
A
G
Y
Y
P
N
A
K
P
L
Y
L
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
G
---
E
E
G
--
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
Q
Q
A
A
R
R
----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.93
35%
-9
- C1 -
-
3IWA
-
?
A:
[6-462]
--
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
D
P
E
A
H
V
T
M
I
D
Q
A
-------------------------------------
V
E
A
L
V
E
T
R
A
H
A
I
D
R
A
A
H
--
T
V
E
I
E
N
L
R
--
T
--
G
E
R
R
T
L
K
--
Y
D
K
L
V
L
A
L
G
S
K
A
-
N
R
P
P
V
E
G
M
D
L
A
-
G
--
V
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
-
S
-
A
G
E
V
S
K
A
V
-
I
V
G
G
G
F
I
G
L
E
M
A
V
S
L
A
D
M
W
-
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
-
G
-
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
------------
H
T
G
E
K
V
--
V
R
L
E
G
E
N
--------------------
G
--
K
V
-------
A
R
V
I
-
T
-
D
K
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
A
R
D
A
G
L
E
L
D
P
R
G
A
I
I
V
D
T
R
M
R
T
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
T
G
K
P
G
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
-
G
D
-
A
T
F
P
G
A
V
G
S
W
A
V
K
L
F
E
G
S
A
S
G
A
G
L
T
V
E
G
A
L
R
E
G
Y
D
A
V
N
V
H
V
E
Q
-----------
I
M
T
L
Q
L
V
V
D
R
P
T
R
R
V
L
G
I
Q
G
F
S
---
T
L
G
D
A
L
T
A
R
I
N
A
V
A
T
M
L
A
S
K
P
T
V
E
D
I
S
N
A
E
V
V
--------
M
D
I
V
N
V
A
G
N
V
A
D
N
V
L
A
----------------------------------------------------------------------------------------------------------
96
HHSearch
61.54
34%
-10
- C1 -
-
4EQS
4
CDR_STAA3
B:
[1-434]
P
K
I
V
V
V
G
A
V
A
G
G
A
T
C
A
S
Q
I
R
R
L
D
K
E
S
D
I
I
I
F
E
K
D
R
D
M
S
F
A
N
C
A
L
P
Y
V
I
G
E
V
V
E
D
R
R
Y
A
L
A
Y
T
P
E
K
F
Y
D
R
K
Q
I
T
V
K
T
Y
H
E
V
I
A
I
N
D
E
R
Q
--
T
V
S
V
--
L
N
RK
T
--
N
E
Q
F
E
E
S
--
Y
D
K
L
I
L
S
P
G
A
S
A
-
N
S
L
G
F
E
S
----
D
I
--
T
F
T
L
R
N
L
E
D
T
D
A
I
D
Q
F
I
-
K
A
N
-
Q
V
D
K
V
L
-
V
V
G
A
G
Y
V
S
L
E
V
L
E
N
L
-
Y
E
R
-
G
L
H
P
T
L
I
H
R
S
D
K
I
N
K
-
L
-
M
-
D
A
D
M
N
Q
P
I
L
D
E
L
D
K
R
E
I
P
Y
------------
R
L
N
E
E
I
--
N
A
I
N
-
G
------------------------
N
E
-------
I
T
-
F
-
K
-
S
G
K
V
E
H
Y
D
M
I
I
E
G
V
G
T
H
P
N
S
K
F
I
E
S
S
N
I
K
L
D
R
K
G
F
I
P
V
N
D
K
F
E
T
N
V
P
N
I
Y
A
I
G
D
I
A
T
S
H
Y
R
H
V
D
L
P
A
S
V
P
L
A
W
G
A
H
R
A
A
S
I
V
A
E
Q
I
A
G
-
N
D
T
I
E
F
K
G
F
L
G
N
N
I
V
K
F
F
D
Y
T
F
A
S
V
G
V
K
P
N
E
L
K
Q
F
D
--
Y
K
M
V
E
V
T
Q
G
A
H
A
N
Y
Y
P
G
N
S
P
L
H
L
R
V
Y
Y
D
T
S
N
R
Q
I
L
R
A
A
A
V
G
---
K
E
G
--
A
D
K
R
I
D
V
L
S
M
A
M
M
N
Q
L
T
V
D
E
L
T
E
F
E
V
A
F
A
P
P
Y
S
H
P
K
D
L
I
N
M
I
G
Y
-----------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
61.38
35%
-6
- C1 -
-
3CGE
5
?
B:
[37-472]
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
Y
A
Q
C
G
L
P
Y
V
I
S
G
A
I
A
S
T
E
K
L
I
A
R
N
V
K
T
F
R
D
K
Y
G
I
D
A
K
V
R
H
E
V
T
K
V
D
T
E
K
K
--
I
V
Y
A
--
E
H
--
T
--
K
T
K
D
V
F
E
FS
Y
D
R
L
L
I
A
T
G
V
R
P
-
V
M
P
E
W
E
G
-
R
D
L
Q
G
--
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
-
E
-
T
-
N
K
V
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-
V
E
L
-
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
-
Y
-
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
------------
L
T
N
E
N
V
--
K
A
F
K
-
G
N
--------------------
E
--
R
V
-------
E
A
-
V
-
E
T
D
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
L
E
G
T
N
I
R
T
N
H
K
G
A
I
E
V
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
I
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
-
K
R
-
R
A
F
K
G
T
L
G
T
G
I
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
K
E
A
K
G
L
H
I
P
Y
K
T
V
K
V
D
S
T
N
M
A
G
Y
Y
P
N
A
K
P
L
Y
L
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
G
---
E
E
G
--
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
----------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.86
35%
-6
- C1 -
-
3CGD
5
?
B:
[37-472]
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
Y
A
Q
C
G
L
P
Y
V
I
S
G
A
I
A
S
T
E
K
L
I
A
R
N
V
K
T
F
R
D
K
Y
G
I
D
A
K
V
R
H
E
V
T
K
V
D
T
E
K
K
--
I
V
Y
A
--
E
H
--
T
--
K
T
K
D
V
F
E
FS
Y
D
R
L
L
I
A
T
G
V
R
P
-
V
M
P
E
W
E
G
-
R
D
L
Q
G
--
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
-
E
-
T
-
N
K
V
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-
V
E
L
-
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
-
Y
-
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
------------
L
T
N
E
N
V
--
K
A
F
K
-
G
N
--------------------
E
--
R
V
-------
E
A
-
V
-
E
T
D
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
L
E
G
T
N
I
R
T
N
H
K
G
A
I
E
V
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
I
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
-
K
R
-
R
A
F
K
G
T
L
G
T
G
I
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
K
E
A
K
G
L
H
I
P
Y
K
T
V
K
V
D
S
T
N
M
A
G
Y
Y
P
N
A
K
P
L
Y
L
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
G
---
E
E
G
--
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
----------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
49.04
34%
-56
- C1 -
-
4H4R
9
?
A:
[102-302]
----------------------------------------------------------------------------------------------------------------
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
M
--
P
--
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
-
P
-
Q
-
S
R
L
L
-
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
-
R
T
A
-
G
V
H
V
S
L
V
C
T
G
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
------------
R
F
E
R
S
V
--
T
G
S
V
-
D
------------------------
G
V
-------
V
L
-
L
-
D
-
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
--
L
A
C
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
48.68
34%
-45
- C1 -
-
4H4T
12
?
A:
[102-302]
----------------------------------------------------------------------------------------------------------------
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
M
--
P
--
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
-
P
-
Q
-
S
R
L
L
-
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
-
R
T
A
-
G
V
H
V
S
L
V
E
R
Q
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
------------
R
F
E
R
S
V
--
T
G
S
V
-
D
------------------------
G
V
-------
V
L
-
L
-
D
-
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
--
L
A
C
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
48.65
34%
-49
- C1 -
-
4H4P
8
?
A:
[102-302]
----------------------------------------------------------------------------------------------------------------
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
M
--
P
--
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
-
P
-
Q
-
S
R
L
L
-
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
-
R
T
A
-
G
V
H
V
S
L
V
Q
T
K
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
------------
R
F
E
R
S
V
--
T
G
S
V
-
D
------------------------
G
V
-------
V
L
-
L
-
D
-
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
--
L
A
C
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
48.00
34%
-51
- C1 -
-
4H4Z
9
?
A:
[102-302]
----------------------------------------------------------------------------------------------------------------
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
M
--
P
--
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
-
P
-
Q
-
S
R
L
L
-
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
-
R
T
A
-
G
V
H
V
S
L
V
Q
R
G
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
------------
R
F
E
R
S
V
--
T
G
S
V
-
D
------------------------
G
V
-------
V
L
-
L
-
D
-
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
--
L
A
C
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
47.77
34%
-51
- C1 -
-
4H4X
8
?
A:
[102-302]
----------------------------------------------------------------------------------------------------------------
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
M
--
P
--
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
-
P
-
Q
-
S
R
L
L
-
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
-
R
T
A
-
G
V
H
V
S
L
V
A
R
G
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
------------
R
F
E
R
S
V
--
T
G
S
V
-
D
------------------------
G
V
-------
V
L
-
L
-
D
-
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
--
L
A
C
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------