@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0S7: (2018-01-22 )
MEQFGMITATASVLPEKIITNNDLSKMMDTSDEWISSRTGIRERRCVTNQETSDLCILVAEKLIKQKNLNPKDLDFILVATMSPDYTTPSVAAQVQGKLGATHAIAFDISAACSGFVYALSMAEKMIRCGSTKGLVIGGETLSKLIDWSDRTTAVLFGDGAGGILLEANPQKKLLKEKLAADGTRSSSLTAGYQQNKNPFYSEDSEGSYYLQMTGRDIFDFAVRDVANNIQEVMKDKPVDYLLLHQANLRIIEKIARKVKMPQEKFLTNMDKYGNTSAASIPILLDEAVSSGKITLGKQQKVIFTGYGGGLTWGSILMEL
Atome Classification :
(30 SA)
.........10........20......-..30........40.......-.50---.-..-.....60........70........80........90........100.......110.......120.......130-..-.-.....140.......150.......160......--.170.....-..180.......190.......200..-.....210.......220.......230.-----.----.----.-----..-.-----240----........250.......260.....-.-.270.......280.......290......--..300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEQF
G
M
I
T
A
T
A
S
VL
P
E
K
IITN
N
D
L
S
K
M
-MDT
S
D
E
W
I
S
S
RTGI
R
E
RRCVT-NQE---T-S
D
-
L
C
I
L
V
A
E
K
L
I
K
QKNLNPKD
L
D
F
I
L
V
A
TMSPDYTTP
S
V
A
A
Q
V
QGKLG
A
T
H
A
I
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
M
I
RCG-S-TK-
G
-
L
V
I
G
G
E
T
L
S
K
L
IDWSD
R
T
T
A
V
L
F
GDGA
G
G
I
L
L
EA--N
P
Q
K
K
L
L
K
E
-
K
L
AADGTRSSSLTAGYQQNKNPFYSED-SEG
S
Y
Y
L
Q
MTGR
D
I
F
D
F
A
V
R
D
V
A
N
N
I
Q
E
V
-----
M
----K----D-----KP-V-----
D
Y
-----
L
L
LHQA
N
L
R
I
I
E
K
I
A
R
K
VKM
P
Q
E
K
F
L
-
T
-
N
M
D
KYGNTSAASI
P
I
L
L
D
EAVS-SG
K
I
T
LG--KQ
Q
K
V
I
F
T
GYGGGL
T
W
G
S
I
L
MEL
22
PsiBlast_CBE
98.62
62%
-60
- C2 -
-
3IL5
1
FABH_ENTFA
C:
[22-341]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
-
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
-
R
-
Y
Q
T
G
-
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
--
A
E
T
P
H
F
L
N
E
-
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
-
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
----
T
----
D
-----
E
T
-
V
-----
D
Y
-----
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
-
N
G
T
L
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
21
PsiBlast_CBE
98.37
62%
-63
- C2 -
-
3IL5
1
FABH_ENTFA
D:
[22-341]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
-
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
-
R
-
Y
Q
T
G
-
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
--
A
E
T
P
H
F
L
N
E
-
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
-
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
----
T
----
D
-----
E
T
-
V
-----
D
Y
-----
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
-
N
G
T
L
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
1
PsiBlast_PDB
98.03
62%
-65
- C2 -
-
3IL5
1
FABH_ENTFA
A:
[22-341]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
-
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
-
R
-
Y
Q
T
G
-
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
--
A
E
T
P
H
F
L
N
E
-
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
-
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
----
T
----
D
-----
E
T
-
V
-----
D
Y
-----
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
-
N
G
T
L
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
23
PsiBlast_CBE
95.90
62%
-57
- C2 -
-
3IL5
1
FABH_ENTFA
B:
[22-341]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
-
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
-
R
-
Y
Q
T
G
-
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
--
A
E
T
P
H
F
L
N
E
-
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
-
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
----
T
----
D
-----
E
T
-
V
-----
D
Y
-----
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
-
N
G
T
L
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
2
PsiBlast_PDB
93.78
61%
-61
- C2 -
-
3IL4
1
FABH_ENTFA
A:
[1-320]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
-
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
-
R
-
Y
Q
T
G
-
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
--
A
E
T
P
H
F
L
N
E
-
K
L
Q
A
D
G
Q
R
W
T
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
-
K
--
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
----
T
----
D
-----
E
T
-
V
-----
D
Y
-----
L
L
L
H
Q
A
S
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
-
N
G
T
L
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
84
HHSearch
88.28
54%
-42
- C2 -
-
5BQS
1
FABH_STRZP
B:
[1-323]
--
A
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
-
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
---
T
-
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
R
F
-
Q
K
-
G
-
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
--
S
E
Q
E
H
F
L
A
E
-
S
L
N
S
D
G
S
R
S
E
C
L
T
Y
G
H
S
G
L
H
S
P
F
S
D
Q
--
E
S
A
D
S
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
-----
I
----
D
----
E
SPIEV
T
D
-
L
-----
D
Y
-----
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
D
R
A
K
L
P
-
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
-
Q
G
--
L
I
P
LD
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
24
PsiBlast_CBE
87.97
53%
-40
- C2 -
-
5BQS
1
FABH_STRZP
B:
[2-323]
---
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
-
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
---
T
-
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
-
R
F
Q
K
-
G
-
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
--
S
E
Q
E
H
F
L
A
E
-
S
L
N
S
D
G
S
R
S
E
C
L
T
Y
G
H
S
G
L
H
S
P
F
S
D
Q
E
-
S
A
D
S
-
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
-----
I
----
D
----
E
-----
S
P
-
I
EVTDL
D
Y
-----
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
D
R
A
K
L
P
-
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
-
Q
G
L
I
P
L
D
--
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
3
PsiBlast_PDB
87.62
53%
-42
- C2 -
-
5BQS
1
FABH_STRZP
A:
[2-323]
---
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
-
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
---
T
-
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
-
R
F
Q
K
-
G
-
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
--
S
E
Q
E
H
F
L
A
E
-
S
L
N
S
D
G
S
R
S
E
C
L
T
Y
G
H
S
G
L
H
S
P
F
S
D
Q
E
-
S
A
D
S
-
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
-----
I
----
D
----
E
-----
S
P
-
I
EVTDL
D
Y
-----
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
D
R
A
K
L
P
-
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
-
Q
G
L
I
P
L
D
--
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
27
PsiBlast_CBE
84.70
41%
-27
- C2 -
-
4Z8D
1
FABH_ECOLI
B:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
ANNL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
19
PsiBlast_PDB
83.89
40%
-27
- C2 -
-
1EBL
1
FABH_ECOLI
A:
[2-317]
---
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
A
A
N
N
N
----
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
7
PsiBlast_PDB
83.83
41%
-25
- C2 -
-
1HND
1
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
28
PsiBlast_CBE
83.60
41%
-30
- C2 -
-
2GYO
1
FABH_ECOLI
B:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
ANNL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
13
PsiBlast_PDB
83.55
41%
-28
- C2 -
-
5BNM
1
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
10
PsiBlast_PDB
83.23
41%
-27
- C2 -
-
2EFT
2
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
31
PsiBlast_CBE
83.16
38%
-58
- C2 -
-
4X0O
1
FABH2_VIBCH
D:
[5-319]
---
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
-
I
S
-
H
V
N
---
T
-
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
C
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
-
H
-
Y
R
H
A
-
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
--
T
E
Q
K
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
-
N
-
G
Y
W
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
LARSG
L
----
S
----
T
-----
E
E
-
I
-----
D
V
-----
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
-
Q
G
K
I
K
----
P
H
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
-----
6
PsiBlast_PDB
83.14
41%
-24
- C2 -
-
1HN9
-
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
26
PsiBlast_CBE
83.08
41%
-29
- C2 -
-
5BNM
1
FABH_ECOLI
B:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
ANNL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
8
PsiBlast_PDB
83.00
41%
-29
- C2 -
-
1HNJ
1
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
12
PsiBlast_PDB
82.95
41%
-28
- C2 -
-
4Z8D
1
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
14
PsiBlast_PDB
82.87
41%
-28
- C2 -
-
5BNS
1
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
69
HHSearch
82.56
41%
-30
- C2 -
-
1HNJ
1
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
-
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
-
K
Y
-
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
----
A
N
NLDR
S
Q
-
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
--
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
40
PsiBlast_CBE
82.55
37%
-54
- C2 -
-
5V0P
2
FABH2_VIBCH
A:
[5-319]
---
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
-
I
S
-
H
V
N
---
T
-
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
-
H
-
Y
R
H
A
-
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
--
T
E
Q
K
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
-
N
-
G
Y
W
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
----
S
----
T
-----
E
E
-
I
-----
D
V
-----
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
-
Q
G
K
I
K
----
P
H
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
-----
25
PsiBlast_CBE
82.22
41%
-28
- C2 -
-
5BNS
1
FABH_ECOLI
B:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
ANNL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
11
PsiBlast_PDB
82.11
41%
-29
- C2 -
-
2GYO
2
FABH_ECOLI
A:
[5-317]
------
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
---
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
-
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
A
N
NL
D
-----
R
S
Q
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
39
PsiBlast_CBE
82.10
37%
-54
- C2 -
-
5V0P
2
FABH2_VIBCH
B:
[5-319]
---
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
-
I
S
-
H
V
N
---
T
-
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
-
H
-
Y
R
H
A
-
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
--
T
E
Q
K
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
-
N
-
G
Y
W
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
LARSG
L
----
S
----
T
-----
E
E
-
I
-----
D
V
-----
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
-
Q
G
K
I
K
----
P
H
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
-----
68
HHSearch
81.24
41%
-29
- C2 -
-
2GYO
2
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
-
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
-
K
Y
-
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
--
S
E
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
-------
E
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
----
A
N
NLDR
S
Q
-
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
-
D
G
--
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
41
PsiBlast_CBE
80.34
37%
-59
- C2 -
-
5KP2
2
FABH2_VIBCH
B:
[5-319]
---
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
-
I
S
-
H
V
N
---
T
-
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
-
H
-
Y
R
H
A
-
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
--
T
E
Q
K
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
-
N
-
G
Y
W
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
----
S
----
T
-----
E
E
-
I
-----
D
V
-----
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
-
Q
G
K
I
K
----
P
H
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
-----
53
Fugue
79.05
41%
-2
- C2 -
-
1HNJ
1
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V-
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
--NET
V
-
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
-
A
V
K
Y
-
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E--
E
P
G
I
I
S
T
-
H
L
H
A
D
G
S
Y
G
E
L
L
T
L
P
N
---
A
D
R
--
V
N
P
-
E
-
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
-----
L
----
A
----
A
N
NLDR
S
Q
-
L
-----
D
W
-----
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
-
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
-
G
R
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
50
PsiBlast_CBE
71.72
31%
-25
- C2 -
-
1MZJ
2
FABH_STRLI
B:
[9-324]
-
R
R
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
---
T
-
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
-
G
-
S
R
-
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
--
S
D
V
P
G
I
G
P
V
-
V
R
G
I
D
G
T
G
L
G
S
L
H
M
S
S
S
W
D
Q
---
Y
V
E
D
P
S
V
G
R
P
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
-----
L
----
E
----
V
-----
A
G
-
L
-----
T
V
GDLV
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
-
S
R
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
-
S
G
A
V
P
G
G
--
G
P
A
L
M
I
--
G
F
G
A
G
L
S
Y
-------
51
PsiBlast_CBE
71.52
31%
-28
- C2 -
-
1MZJ
2
FABH_STRLI
A:
[9-324]
-
R
R
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
---
T
-
I
Q
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-------