@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y175: (2018-01-24 )
MNKKNNGMMKNALYYVLVILAMVMVVYFIFGNNGQRSSDIEYSKFTEQLQAGKIKEFEVQPANGVYKITGEYKEQQTVANSGGLAILGSTDTTTTHFTTIILPNDTTLSQVTELAKENKVATTVKEESSSGIWVSLLLSFLPIVIIIFFFYMMMGQQGGGGGGGGRVMNFGKSKAKEADKKANRVRFSDVAGAEEEKQELVEVVEFLKDPRRFVELGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFETAKKNAPAIIFIDEIDAVGRQRGAGMGGGHDEREQTLNQLLVEMDGFDGNEGVIVIAATNRSDVLDPALLRPGRFDRQILVGRPDVKGREAILRVHARNKPMADDVDLKVVAQQTPGFAGADLENVLNEAALVAARRNKKKIDASDIDEAEDRVIAGPAKKDRVISKKEREMVAYHEAGHTIVGLVLSRARVVHKVTIIPRGRAGGYMIALPKEDQFLMTKEDMFEQIVGLLGGRTAEEIIFNVQSTGASNDFEQATALARSMVTEYGMSDRLGPVQYEGNHQVFVGRDYGQTKAYSEQVAFEIDQEVRKILMEAHDKAREIIEAHRAQHKLIAEKLLEFETLDAKAIKSLFEHGVMPEGTESNDYPSEKEAKTFEEAKRALEEKDAEKQAEEKRDFEEAKHELNEENKAEHDSDSQQSEDNHSDDQYK
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200....-...210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.-......330.......340.......350.......360.......370.......380--.......390.......400.......410.......420.......430.......440.......450.......460.......470....-.-..480.......490.......500.......510.......--520.......530.......540.......550.......560.......570.........580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNKKNNG
M
M
K
N
A
L
Y
Y
V
L
V
I
L
A
M
V
M
V
V
Y
F
I
FGNNGQRSSDI
E
Y
S
K
F
T
E
Q
L
QAGK
I
K
E
F
E
VQPAN
G
V
Y
K
ITGEYK
E
Q
Q
TVANSG
G
L
A
I
LGSTDT
T
T
T
H
F
T
T
I
I
LPNDT
T
L
S
Q
V
T
E
L
A
KENK
V
A
T
T
V
KEESSS
G
I
W
V
S
L
L
L
S
F
L
P
I
V
I
I
I
F
F
F
Y
M
M
MGQQGGGGGGGGRVMNFG
K
S
K
A
K
E
A
DKKAN
R
V
R
FSDVAG
A
E
E
E
K
Q
E
L
V
E
V
V
E
F
-
L
KD
P
R
R
F
V
E
L
GARIPA
G
V
L
L
EGPPGT
G
K
T
L
L
A
K
A
VAGEAGV
P
F
Y
SIS
G
S
D
F
V
E
M
F
V
GV
G
A
S
R
V
R
D
L
F
E
T
A
KKNA
P
A
I
I
F
I
DE
I
D
AVGRQRGAGMGGG
H
D
E
R
E
Q
T
L
N
Q
L
L
V
EMDGFDG-NE
G
V
I
V
I
A
ATNRSDVL
D
P
A
LLRPGRFD
R
Q
I
L
VGRPDVK
G
R
E
A
I
L
R
V
HARNKPMADDV
D
L
--
K
V
V
A
QQTPGFAG
A
D
L
E
N
V
L
N
E
A
A
L
V
A
ARRNKKKIDASDIDEAED
R
V
IAGPAKK
D
R
V
I
S
K
K
E
R
E
M
V
A
Y
HEAG
H
T
I
V
G
L
V
L
S
R
A
R
V
V
H
K
V
T
I
I
PRG-R-AG
G
Y
M
I
A
LPKED
Q
F
LM
T
K
E
D
M
F
E
Q
I
V
G
L
LGGR
T
A
E
E
I
I
F
N
V
Q--STGASN
D
F
E
Q
A
T
A
L
A
R
S
M
V
T
EYGMSDRLG
P
V
Q
YEGN
H
Q
V
F
V
GRDYGQT
K
A
Y
--
S
E
Q
V
A
F
E
I
D
Q
E
V
R
K
I
L
M
E
A
H
D
K
A
R
E
I
I
E
A
H
R
A
Q
H
K
L
I
A
E
K
L
L
E
FETL
D
A
K
A
I
K
S
L
F
EHGVMPEGTESNDYPS
E
K
E
A
K
T
F
E
E
A
K
R
A
L
E
E
K
D
A
E
K
Q
A
E
E
KR
D
F
E
E
A
K
H
ELNEENKAEHDSDSQQSEDNHSDDQYK
146
Fugue
89.60
58%
-99
- C1 -
-
2CE7
-
FTSH_THEMA
A:
[5-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
H
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
------------------
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
------------
G
K
L
R
N
Y
--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
----------------------------------------------------------------------------
115
HHSearch
88.06
58%
-59
- C1 -
-
3KDS
1
FTSH_THEMA
E:
[11-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
-
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
-----------
R
L
R
N
Y
--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
---------------------------------------------------------------------------
1
PsiBlast_PDB
87.87
58%
-60
- C1 -
-
3KDS
1
FTSH_THEMA
E:
[12-456]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
-
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
-----------
R
L
R
N
Y
--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
-----------------------------------------------------------------------------
33
PsiBlast_CBE
86.58
57%
-91
- C1 -
-
2DHR
1
FTSH_THET8
E:
[18-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
117
HHSearch
86.32
58%
-92
- C1 -
-
2DHR
1
FTSH_THET8
E:
[24-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
G
--
Y
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
--------------------------------------------------------------------
35
PsiBlast_CBE
86.09
57%
-90
- C1 -
-
2DHR
1
FTSH_THET8
C:
[18-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
2
PsiBlast_PDB
86.04
57%
-84
- C1 -
-
4EIW
1
FTSH_THET8
A:
[27-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
30
PsiBlast_CBE
85.81
57%
-83
- C1 -
-
4EIW
1
FTSH_THET8
C:
[27-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
39
PsiBlast_CBE
85.57
57%
-81
- C1 -
-
4WW0
2
FTSH_AQUAE
C:
[9-459]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
----------------
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
---------------
A
V
DT
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------------------------------------------------------
28
PsiBlast_CBE
85.15
57%
-83
- C1 -
-
4EIW
1
FTSH_THET8
E:
[27-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
5
PsiBlast_PDB
84.70
57%
-72
- C1 -
-
4Z8X
1
FTSH_AQUAE
A:
[5-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
----------------DT
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------------------------------------------------------
3
PsiBlast_PDB
84.61
57%
-90
- C1 -
-
2DHR
1
FTSH_THET8
A:
[18-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
40
PsiBlast_CBE
84.55
57%
-70
- C1 -
-
4WW0
1
FTSH_AQUAE
B:
[3-459]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
K
V
Y
I
E
--
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
--------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
R
G
-
M
-
A
L
--------
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-----------------DT
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------------------------------------------------------
37
PsiBlast_CBE
84.30
57%
-74
- C1 -
-
4Z8X
1
FTSH_AQUAE
C:
[5-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
----------------DT
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------------------------------------------------------
4
PsiBlast_PDB
84.21
57%
-78
- C1 -
-
4WW0
1
FTSH_AQUAE
A:
[4-459]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
----------------DT
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------------------------------------------------------
116
HHSearch
84.10
58%
-61
- C1 -
-
2CE7
-
FTSH_THEMA
C:
[9-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
-
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
R
N
Y
--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
------------------------------------------------------------------------
34
PsiBlast_CBE
80.35
57%
-85
- C1 -
-
2DHR
1
FTSH_THET8
D:
[23-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
32
PsiBlast_CBE
80.08
57%
-81
- C1 -
-
2DHR
1
FTSH_THET8
F:
[18-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
-
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
29
PsiBlast_CBE
79.86
57%
-84
- C1 -
-
4EIW
1
FTSH_THET8
D:
[31-476]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
27
PsiBlast_CBE
79.51
57%
-82
- C1 -
-
4EIW
1
FTSH_THET8
F:
[31-476]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
-
G
Y
-
D
V
R
Q
Y
--
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------------------------------------------------------
12
PsiBlast_PDB
73.20
72%
-106
- C1 -
-
1IY1
1
FTSH_THET8
A:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.55
72%
-100
- C1 -
-
1IY0
1
FTSH_THET8
A:
[9-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
-------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.35
65%
-56
- C1 -
-
2R65
1
FTSH_HELPY
D:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.59
50%
-95
- C1 -
-
2QZ4
1
A:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
Q
S
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
--------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.04
65%
-62
- C1 -
-
2R65
1
FTSH_HELPY
A:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.14
65%
-51
- C1 -
-
2R65
1
FTSH_HELPY
E:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
57.94
65%
-42
- C1 -
-
2R65
1
FTSH_HELPY
C:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
57.72
65%
-50
- C1 -
-
2R65
1
FTSH_HELPY
B:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
55.34
44%
8
- C1 -
-
3HU3
2
TERA_HUMAN
B:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
55.01
44%
6
- C1 -
-
3HU3
1
TERA_HUMAN
A:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.68
44%
7
- C1 -
-
4KO8
1
TERA_HUMAN
A:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
54.32
44%
8
- C1 -
-
4KO8
2
TERA_HUMAN
B:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
52.54
49%
17
- C1 -
-
3H4M
1
PAN_METJA
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
-
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
52.21
49%
14
- C1 -
-
3H4M
1
PAN_METJA
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
-
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
51.45
50%
23
- C1 -
-
5EQT
1
PAN_PYRHO
A:
[2-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
Y
N
D
I
G
G
L
K
K
Q
L
Q
E
L
R
E
A
I
E
L
P
L
K
H
P
E
L
F
E
E
V
G
I
D
P
P
K
G
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
L
A
H
E
V
N
A
T
F
I
R
V
V
G
S
E
L
V
R
K
Y
I
G
E
G
A
R
L
V
H
E
L
F
E
L
A
K
E
K
A
P
T
I
I
F
I
D
E
I
D
A
I
G
A
K
--------
E
R
E
V
N
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
P
-
R
G
N
V
K
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
L
I
E
V
P
L
P
D
F
E
G
R
L
E
I
L
K
V
H
T
R
R
M
K
L
-
K
G
V
D
L
--
R
A
I
A
E
M
T
E
G
A
S
G
A
D
L
K
A
I
A
T
E
A
G
M
F
A
I
R
E
R
R
T
Y
V
T
Q
E
D
F
L
K
A
V
D
K
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
50.42
49%
26
- C1 -
-
3H4M
1
PAN_METJA
C:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
-
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
49.75
44%
0
- C1 -
-
5DYG
1
TERA_HUMAN
A:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
W
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
49.18
45%
4
- C1 -
-
1E32
1
TERA_MOUSE
A:
[190-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
49.14
45%
3
- C1 -
-
1R7R
1
TERA_MOUSE
A:
[190-468]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------