@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y176: (2018-01-24 )
MLEKDIERILISQEEIQVRCKELGKELTEIYQNTNPLVVGVLKGAVPFMADIVRSIDTYLELDFMDVSSYGNATVSSGEVKIVKDLDTNVEGRDLLIVEDIIDSGRTLAYLVDLFKYRKAKSVKIVTLLDKPEGRVVNIEADYVGFNVPNEFVVGYGLDYAEAYRNLPYIGVLKPSVYQSN
Atome Classification :
(98 SA)
.........10........20........30..-------..------.------.-.-.40........50.....---.---.---.---60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
E
K
D
I
E
R
I
LI
S
Q
E
E
I
Q
V
R
C
K
E
L
G
K
E
L
T
E
I
YQN-------TN------
P
------
L
-
V
-
V
G
V
L
KGA
V
P
F
M
A
D
I
V
R
S
I
---
D
---
T
---
Y
---
L
E
L
D
F
M
DVSSYGNATVSSG
E
V
K
I
V
K
DLDTNVEG
R
D
L
L
I
V
E
D
I
IDSG
R
T
L
A
Y
L
V
D
L
F
K
Y
RKAK
S
V
K
I
V
T
L
L
DKPEG
R
V
V
N
I
E
A
D
Y
VGFNVPNE
F
V
VGYGL
D
Y
A
E
A
YRNL
P
Y
I
GVLKPSVYQSN
23
PsiBlast_CBE
92.55
73%
-164
- C2 -
-
3KB8
2
?
B:
[25-204]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
N
-
1
PsiBlast_PDB
91.14
73%
-162
- C2 -
-
3H83
2
?
A:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
3
PsiBlast_PDB
90.65
73%
-163
- C2 -
-
3KB8
2
?
A:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
127
HHSearch
90.56
74%
-162
- C2 -
-
3KB8
2
?
A:
[26-203]
-
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
29
PsiBlast_CBE
89.81
73%
-156
- C2 -
-
3H83
1
?
B:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
6
PsiBlast_PDB
88.76
56%
-162
- C2 -
-
1YFZ
1
?
A:
[30-204]
---
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
G
-------
K
D
------
L
------
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---
P
---
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
---
26
PsiBlast_CBE
88.26
73%
-156
- C2 -
-
3HVU
1
?
B:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
2
PsiBlast_PDB
88.20
73%
-155
- C2 -
-
3HVU
1
?
A:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
30
PsiBlast_CBE
88.14
56%
-164
- C2 -
-
1YFZ
1
?
B:
[30-204]
---
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
G
-------
K
D
------
L
------
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---
P
---
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
---
25
PsiBlast_CBE
88.09
73%
-153
- C2 -
-
3HVU
1
?
C:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
24
PsiBlast_CBE
87.31
73%
-151
- C2 -
-
3HVU
1
?
D:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
128
HHSearch
87.21
74%
-151
- C2 -
-
3HVU
1
?
D:
[26-203]
-
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
5
PsiBlast_PDB
86.96
56%
-166
- C2 -
-
1R3U
-
?
A:
[30-204]
---
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
G
-------
K
D
------
L
------
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---
P
---
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
---
7
PsiBlast_PDB
86.74
56%
-168
- C2 -
-
2GEB
-
?
A:
[10-184]
---
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
G
-------
K
D
------
L
------
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---
P
---
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
---
21
PsiBlast_CBE
86.72
73%
-151
- C2 -
-
3KB8
1
?
D:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
130
HHSearch
86.70
57%
-168
- C2 -
-
2GEB
-
?
A:
[11-184]
----
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
G
-------
K
D
------
L
------
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---
P
---
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
---
22
PsiBlast_CBE
85.62
73%
-151
- C2 -
-
3KB8
1
?
C:
[25-203]
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
N
-------
T
V
------
P
------
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---
Y
---
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
--
126
HHSearch
85.50
54%
-162
- C2 -
-
4RQA
2
?
A:
[8-184]
-
M
H
N
D
L
K
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
G
-------
K
P
------
L
------
V
-
C
-
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---
H
---
L
S
I
D
F
M
D
V
S
S
Y
-----
S
T
G
E
V
Q
I
I
K
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
K
A
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
---
4
PsiBlast_PDB
85.04
53%
-165
- C2 -
-
4RQB
3
?
A:
[11-186]
----
D
L
K
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
G
-------
K
P
------
L
------
V
-
C
-
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---
H
---
L
S
I
D
F
M
D
V
S
S
Y
H
G
G
T
E
S
T
G
E
V
Q
I
I
K
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
K
A
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
S
N
-
125
HHSearch
84.54
54%
-165
- C2 -
-
4RQB
3
?
A:
[8-185]
-
M
H
N
D
L
K
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
G
-------
K
P
------
L
------
V
-
C
-
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---
H
---
L
S
I
D
F
M
D
V
S
S
Y
H
G
G
T
E
S
T
G
E
V
Q
I
I
K
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
K
A
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
S
--
50
PsiBlast_CBE
84.10
48%
-174
- C2 -
-
4QYI
1
?
C:
[7-173]
----
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
----------
123
HHSearch
83.36
46%
-175
- C2 -
-
4QYI
1
?
B:
[6-176]
---
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
V
-------
20
PsiBlast_PDB
82.23
48%
-180
- C2 -
-
3O7M
2
?
A:
[7-173]
----
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
----------
19
PsiBlast_PDB
81.33
48%
-175
- C2 -
-
4QYI
1
?
B:
[7-173]
----
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
----------
43
PsiBlast_CBE
80.90
48%
-185
- C2 -
-
3O7M
1
?
C:
[7-173]
----
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
----------
42
PsiBlast_CBE
79.20
48%
-185
- C2 -
-
3O7M
1
?
D:
[7-173]
----
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
G
-------
E
E
------
I
------
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---
D
---
V
T
I
D
F
I
S
A
S
S
Y
--------
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
----------
141
HHSearch
74.02
45%
-29
- C2 -
-
1TC1
2
?
B:
[5-189]
---
E
F
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPYV
N
P
------
L
------
V
-
L
-
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
F
N
V
---
P
---
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
76
PsiBlast_CBE
73.38
45%
-35
- C2 -
-
1TC2
2
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
88
PsiBlast_CBE
73.21
45%
-34
- C2 -
-
1I14
2
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
92
PsiBlast_CBE
72.93
45%
-37
- C2 -
-
1I0I
2
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
94
PsiBlast_CBE
72.90
45%
-36
- C2 -
-
1I13
3
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
74
PsiBlast_CBE
72.90
45%
-29
- C2 -
-
1TC1
2
?
B:
[8-189]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
82
PsiBlast_CBE
72.25
45%
-39
- C2 -
-
1P18
2
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
93
PsiBlast_CBE
71.84
45%
-31
- C2 -
-
1I0I
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
95
PsiBlast_CBE
71.54
45%
-29
- C2 -
-
1I13
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
89
PsiBlast_CBE
71.45
45%
-25
- C2 -
-
1I14
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
85
PsiBlast_CBE
71.39
45%
-29
- C2 -
-
1P17
1
?
C:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
---
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
90
PsiBlast_CBE
71.24
45%
-30
- C2 -
-
1I0L
2
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
83
PsiBlast_CBE
71.24
45%
-26
- C2 -
-
1P18
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
81
PsiBlast_CBE
69.80
45%
-26
- C2 -
-
1P19
1
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
--
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
87
PsiBlast_CBE
69.69
45%
-29
- C2 -
-
1P17
1
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
K
G
L
R
P
Y-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
---
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
77
PsiBlast_CBE
69.67
45%
-28
- C2 -
-
1TC2
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
91
PsiBlast_CBE
69.47
45%
-24
- C2 -
-
1I0L
2
?
A:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
142
HHSearch
69.17
44%
-29
- C2 -
-
1P17
1
?
B:
[4-191]
-
E
Y
E
F
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPYV
N
P
------
L
------
V
-
L
-
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
F
N
V
---
P
---
V
R
M
E
F
I
C
V
S
S
Y
------
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
--
86
PsiBlast_CBE
68.92
45%
-30
- C2 -
-
1P17
1
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
------
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
79
PsiBlast_CBE
68.91
45%
-18
- C2 -
-
1P19
1
?
C:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
----
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
78
PsiBlast_CBE
68.85
45%
-41
- C2 -
-
1P19
1
?
D:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
----------
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
138
HHSearch
68.06
47%
-56
- C2 -
-
5KNX
1
?
B:
[5-179]
--
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
SG-----
S
D
------
M
------
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
Y
G
S
G
M
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
------
84
PsiBlast_CBE
68.01
45%
-49
- C2 -
-
1P17
1
?
D:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
NVP
V
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
12
PsiBlast_PDB
67.61
49%
-60
- C2 -
-
5KNT
1
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
--------
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
75
PsiBlast_CBE
67.24
45%
-46
- C2 -
-
1TC1
2
?
A:
[8-187]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
-----
39
PsiBlast_CBE
66.64
48%
-60
- C2 -
-
1G9T
1
HPRT_ECOLI
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
14
PsiBlast_PDB
66.64
49%
-58
- C2 -
-
5KNV
1
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
121
HHSearch
66.16
50%
-12
- C2 -
-
4RHX
1
HPRT_MYCTU
A:
[18-200]
-
Y
P
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
LSATTG-
Q
D
------
L
------
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
----
S
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
11
PsiBlast_PDB
65.53
49%
-55
- C2 -
-
5KNS
2
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
56
PsiBlast_CBE
65.32
49%
-1
- C2 -
-
4RHY
1
HPRT_MYCTU
D:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
----------------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
58
PsiBlast_CBE
65.21
49%
-25
- C2 -
-
4RHY
1
HPRT_MYCTU
B:
[21-200]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-----------------GQ
D
L
--
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
63
PsiBlast_CBE
65.18
49%
-12
- C2 -
-
4RHX
1
HPRT_MYCTU
A:
[21-200]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
-------
L
S
------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
72
PsiBlast_CBE
65.02
49%
-40
- C2 -
-
4RHT
2
HPRT_MYCTU
B:
[21-199]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
----------------Q
D
L
---
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
----
61
PsiBlast_CBE
64.86
49%
-4
- C2 -
-
4RHX
1
HPRT_MYCTU
C:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
-------
L
S
------
A
T
T
GQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
68
PsiBlast_CBE
64.57
49%
5
- C2 -
-
4RHU
1
HPRT_MYCTU
B:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
-------
L
S
------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
--
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
59
PsiBlast_CBE
64.21
49%
-17
- C2 -
-
4RHY
1
HPRT_MYCTU
A:
[21-200]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
----------------GQ
D
L
--
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
13
PsiBlast_PDB
64.18
49%
-54
- C2 -
-
5KNU
2
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
33
PsiBlast_CBE
64.09
49%
-53
- C2 -
-
5KNV
1
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
80
PsiBlast_CBE
63.98
45%
-34
- C2 -
-
1P19
1
?
B:
[9-190]
------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
G
KGLRPY-
V
N
------
P
------
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
---
F
N
V
P
V
R
M
E
F
I
C
V
S
------------
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
---
32
PsiBlast_CBE
63.94
49%
-57
- C2 -
-
5KNX
1
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
Y
G
S
G
M
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
40
PsiBlast_CBE
63.58
48%
-57
- C2 -
-
1G9S
1
HPRT_ECOLI
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
DM----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
67
PsiBlast_CBE
63.53
49%
-5
- C2 -
-
4RHU
1
HPRT_MYCTU
C:
[21-198]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
-------
L
S
------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
-----
36
PsiBlast_CBE
63.35
49%
-56
- C2 -
-
5KNS
2
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
------
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
70
PsiBlast_CBE
63.31
49%
-40
- C2 -
-
4RHT
2
HPRT_MYCTU
D:
[21-197]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
------------------Q
D
L
---
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
---
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
------
10
PsiBlast_PDB
63.28
49%
-60
- C2 -
-
5KNR
1
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
Y
G
-----
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
15
PsiBlast_PDB
63.23
49%
-68
- C2 -
-
5KNX
1
?
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
Y
G
S
----
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
64
PsiBlast_CBE
63.02
49%
-21
- C2 -
-
4RHU
1
HPRT_MYCTU
F:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-----------------GQ
D
L
--
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
35
PsiBlast_CBE
63.02
49%
-54
- C2 -
-
5KNT
2
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
------
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
34
PsiBlast_CBE
62.71
49%
-66
- C2 -
-
5KNU
1
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
Y
-----
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
73
PsiBlast_CBE
62.44
49%
-22
- C2 -
-
4RHT
2
HPRT_MYCTU
A:
[21-198]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-----------------G
Q
D
L
--
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
-----
57
PsiBlast_CBE
62.25
49%
-2
- C2 -
-
4RHY
1
HPRT_MYCTU
C:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
----------------TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
------
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
17
PsiBlast_PDB
62.02
48%
-61
- C2 -
-
1G9T
1
HPRT_ECOLI
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
---------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
133
HHSearch
61.58
37%
-27
- C2 -
-
5JV5
1
HPRT_TRYBB
A:
[13-199]
--
Y
D
F
A
T
S
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
CNLKPLE
N
P
------
L
------
V
-
I
-
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
F
G
V
P
---
T
R
V
E
F
L
R
--------------------
L
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
--
16
PsiBlast_PDB
61.56
48%
-51
- C2 -
-
1G9S
1
HPRT_ECOLI
A:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
122
HHSearch
61.45
50%
-10
- C2 -
-
4RHX
1
HPRT_MYCTU
D:
[18-200]
-
Y
P
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
LSATTG-
Q
D
------
L
------
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
60
PsiBlast_CBE
61.18
49%
-12
- C2 -
-
4RHX
1
HPRT_MYCTU
D:
[21-200]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
-------
L
S
------
A
TTGQDL
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
---
37
PsiBlast_CBE
60.90
49%
-51
- C2 -
-
5KNR
1
?
B:
[11-175]
--------
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
D
-------
S
G
------
S
D
M
----
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---
S
---
H
E
V
D
F
M
T
A
S
S
-----
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
----------
65
PsiBlast_CBE
60.43
49%
-26
- C2 -
-
4RHU
1
HPRT_MYCTU
E:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-----------------TGQ
D
L
-
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
------------
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
69
PsiBlast_CBE
60.18
49%
-2
- C2 -
-
4RHU
1
HPRT_MYCTU
A:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
----------------TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
------
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
104
PsiBlast_CBE
58.95
38%
-32
- C2 -
-
5K51
1
HPRT_TRYBB
B:
[19-200]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
----------------------
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
T
-
99
PsiBlast_CBE
58.92
38%
-22
- C2 -
-
1PZM
1
?
A:
[25-202]
-------
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
D
FHLTA--
D
N
------
P
------
L
Y
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
A
D
E
G
---
V
---
P
---
V
K
V
E
F
I
C
A
S
-------------
M
L
L
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
E
-----
62
PsiBlast_CBE
58.48
49%
-5
- C2 -
-
4RHX
1
HPRT_MYCTU
B:
[21-201]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
---------
S
------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
Q
--
107
PsiBlast_CBE
58.03
38%
-29
- C2 -
-
5JV5
1
HPRT_TRYBB
A:
[19-200]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
R
--------------------
L
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
T
-
71
PsiBlast_CBE
57.55
49%
-0
- C2 -
-
4RHT
2
HPRT_MYCTU
C:
[23-195]
------
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-----------------TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--------
137
HHSearch
56.87
38%
-28
- C2 -
-
1PZM
1
?
B:
[22-201]
----
M
S
A
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
D
FHLTAD-
N
P
------
L
------
Y
-
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
---
A
---
D
E
G
V
P
---
V
K
V
E
F
I
C
A
------------
V
R
M
L
L
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
------
106
PsiBlast_CBE
56.80
38%
-29
- C2 -
-
5JV5
1
HPRT_TRYBB
B:
[19-200]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
-----------------------
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
T
-
100
PsiBlast_CBE
56.47
38%
-38
- C2 -
-
5KAP
1
HPRT_TRYBB
B:
[19-200]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
R
---------------------
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
T
-
66
PsiBlast_CBE
56.17
49%
-5
- C2 -
-
4RHU
1
HPRT_MYCTU
D:
[21-198]
----
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
---------------
A
TTGQ
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---
P
---
T
Q
F
E
F
M
A
V
S
S
Y
---------
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
-----
101
PsiBlast_CBE
56.09
38%
-35
- C2 -
-
5KAP
1
HPRT_TRYBB
A:
[19-198]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
R
-----------------------
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
---
102
PsiBlast_CBE
55.64
38%
-30
- C2 -
-
5K51
1
HPRT_TRYBB
D:
[19-200]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLE
N
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
-----------------------
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
E
T
-
98
PsiBlast_CBE
54.16
38%
-29
- C2 -
-
1PZM
1
?
B:
[25-201]
-------
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
D
FHLTA--
D
N
------
P
------
L
Y
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
A
D
E
G
---
V
---
P
---
V
K
V
E
F
I
C
A
------------
V
R
M
L
L
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
------
103
PsiBlast_CBE
53.24
38%
-31
- C2 -
-
5K51
1
HPRT_TRYBB
C:
[19-198]
--------
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
S
N
-------
C
N
LKPLEN
P
------
L
-
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
---
G
---
D
---
F
G
V
P
T
R
V
E
F
L
R
-------------------------
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
R
D
V
V
I
L
K
P
S
V
Y
---