@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y195: (2018-01-24 )
MIELGKKLNGRYQITGNIGSGGMANVFLAHDLILDRDVAVKVLRFDFQNDQTAIRRFQREALAATELVHPNIVSVYDVGEEDNMQYLVMEYVKGMDLKRYIQTHYPVPYETAVNIMQQILSAISLAHNHQIIHRDLKPQNVLIDNEGVVKITDFGIAIALSETSITQTNTMLGSVHYLSPEQARGSMATKQSDIYALGIILYEMLTGSVPFDGESAVTIALKHFQDDLPSIKALDPNVPQALENVILRATAKEPADRYKSAEEMSDDLSTVLSPARANEEKWQPHVMDNETKVITPLTEDAPMPDSFKSMPLPKDKPENETLPEEEEVLPDPKKKGQKKWWLILLAILAVLGIGTAVFFASGGRGEVVVPDVSDLSEASARETLAKAKLEVATKTEEIADDKIEEGNVVKTDPAAGTTVKQKREVTLYISSGTKKIKLDDYSGKSYEDAEASLKELGFSADLIQKEEEFSSEVESGMIISQSPSEDTEVDPKTDTITFTVSKGPETVTLSSHVGENYETVRNWLVTQGFNINNISATYDYSDTVPSGSIISQDPASGEVVAEETYINFVVSQGTEPKLNDISGYTKSEAQSYLASVGAEYIGHETSEYSNTVDKDKVIRTVPGAGTTITKGMVVNVIYSKGPDPASSSSEKDSSDSSSSSSSSSSTSNSSKEESSSSTSSSASTSESSK
Atome Classification :
(20 SA)
-----------------------------------------------------------------.........10........20........30....-....40........50--.........60........70........80-----..----......90........100----.......110.......120.......130.......140.......150.......160.......170.......180....-.-.-.190.......200.......210.......220.......230..-...-...240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------MIE
L
G
KKLN
G
R
Y
Q
I
T
G
NIGSGG
M
A
N
V
F
L
A
H
D
L
ILD-R
D
V
A
V
K
V
L
R
F
DFQN
D
---
Q
T
A
I
R
R
F
Q
R
E
A
L
A
A
T
ELVHP
N
I
V
S
V
Y
DVGEE-----D
N
----
M
Q
Y
L
V
M
E
Y
VKGM
D
L
K
R
Y
I
Q
----THYPV
P
Y
E
T
A
V
N
I
M
Q
Q
I
L
S
A
I
S
L
AHN
H
Q
I
I
HRDLKPQ
N
V
L
IDNE
G
V
V
K
I
TDF
G
I
A
I
A
L
SETSITQTN
T
M
L
G
S
V
H
YL
S
P
E
Q
ARGS-M-A-TKQS
D
I
Y
A
L
G
I
I
L
Y
E
M
LTGSVPFDGE
S
A
V
T
I
A
L
K
H
F
QDDLPS-IKA-LDP-N
V
P
Q
A
L
E
N
V
I
L
R
ATAKE
P
A
D
R
Y
K
S
A
E
E
M
S
D
D
L
S
T
V
LSPARAN
E
E
KWQPHVMDNE
T
K
V
I
TPLTEDAPMPDSFKSMPLPKDKPENETLP
E
E
E
EVLPDPKKKGQ
K
K
W
W
L
I
L
L
A
I
L
A
V
L
GIG
T
A
V
F
F
ASGGRG
E
V
V
VP
D
V
S
D
L
S
E
A
S
A
R
E
T
L
A
K
A
K
L
E
V
AT
K
T
E
E
IADDKIEEG
N
V
V
KTDPAAGT
T
V
K
Q
K
R
E
V
T
L
Y
ISSG
T
K
K
I
K
LDDYSGKSY
E
D
A
E
A
S
L
K
E
LGF
S
A
D
L
I
Q
K
E
E
E
F
S
S
E
V
ES
G
M
I
I
SQSPSEDTEVDPKT
D
T
I
T
F
TVSKGP
E
T
V
T
L
S
S
HVG
E
N
Y
E
T
V
R
N
W
L
V
TQGFNIN
N
I
S
A
T
YDYSDTVPSGSIISQDPASG
E
V
V
A
EE
T
Y
I
N
F
V
VSQGTEPKLNDISGY
T
K
S
E
A
Q
S
Y
L
A
S
V
G
A
E
Y
IGHETSEYSNTVDK
D
K
V
I
R
TVPGAG
T
T
I
TK
G
M
V
V
N
V
I
YSKGPDPASSSSEKDSSDSSSSSSSSSSTSNSSKEESSSSTSSSASTSESSK
21
PsiBlast_CBE
83.23
51%
-84
- C3 -
-
4EQM
1
?
F:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.61
51%
-84
- C3 -
-
4EQM
1
?
D:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.54
51%
-83
- C3 -
-
4EQM
1
?
E:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.80
51%
-87
- C3 -
-
4EQM
2
?
B:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.31
51%
-87
- C3 -
-
4EQM
2
?
C:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.51
51%
-85
- C3 -
-
4EQM
2
?
A:
[5-285]
--------------------------------------------------------------------
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
80.23
51%
-91
- C3 -
-
4EQM
2
?
C:
[4-276]
-------------------------------------------------------------------
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
---
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
----
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
-
A
-
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
V
P
N
V
T
T
D
-
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.66
43%
-17
- C3 -
-
3ORK
2
?
A:
[10-279]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.31
43%
-16
- C3 -
-
3F61
1
PKNB_MYCTU
A:
[10-279]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
-----------------
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.03
43%
-19
- C3 -
-
3ORP
1
?
A:
[10-279]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
--------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.46
43%
-12
- C3 -
-
3ORO
2
PKNB_MYCTU
A:
[12-279]
--------------------------------------------------------------------------
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.70
43%
-24
- C3 -
-
3ORM
1
?
A:
[13-279]
---------------------------------------------------------------------------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
A
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.62
43%
-13
- C3 -
-
3ORT
2
?
A:
[10-279]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
----------------
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.85
44%
-10
- C3 -
-
2FUM
-
PKNB_MYCTU
A:
[27-296]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
D
----------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.44
44%
-17
- C3 -
-
1O6Y
1
PKNB_MYCTU
A:
[27-296]
------------------------------------------------------------------------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
---
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
----
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
--------------
Q
Y
L
S
P
E
Q
A
R
G
D
-
S
-
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
-
P
S
A
-
R
H
E
-
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.42
34%
-117
- C3 -
-
5ISO
2
?
C:
[9-338]
---------------------------------------------------------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
-
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
-----
P
T
----
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
----
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
--
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
-
L
Y
A
-
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.95
32%
-80
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
-
R
E
V
A
I
K
I
I
D
-
K
T
Q
L
N
---
P
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
-----
E
K
----
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
----
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
A
N
I
K
I
A
D
F
G
F
S
N
---------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
-
K
-
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
-----
L
K
E
L
R
E
R
V
L
R
-
G
K
Y
-
R
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.90
34%
-116
- C3 -
-
5ISO
2
?
A:
[9-315]
---------------------------------------------------------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
-
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
-----
P
T
----
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
----
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
--
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
-
L
Y
A
-
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
58.07
18%
29
- C1 -
-
2PZI
5
PKNG_MYCTU
A:
[1-677]
GSHMLGGGL
V
E
I
P
R
A
PDIDPLEALMT
N
P
V
V
P
ESKRFCWNCGRPVGRSGAS
E
G
W
C
PYCG
S
P
Y
S
FLP
Q
L
N
P
G
D
I
V
A
G
Q
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
N
G
R
P
V
V
L
K
G
L
V
H
--
S
G
D
---
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
RHG
D
P
----
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
K
Q
----------
K
L
P
V
A
E
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
T
E
E
Q
-
L
K
L
I
D
L
G
A
V
-----
S
R
I
N
S
F
G
Y
L
Y
G
T
P
G
F
Q
A
P
E
I
V
R
T
G
---
P
-
T
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
T
R
N
G
R
Y
V
D
G
----------
L
P
-
E
D
D
-
P
V
L
-
K
T
Y
D
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
G
V
P
R
P
G
L
S
T
I
F
S
P
S
R
S
T
F
G
V
D
L
L
V
A
H
T
D
V
Y
L
D
G
Q
V
H
A
E
K
L
T
A
N
E
I
V
T
A
L
S
V
P
L
V
D
P
T
D
V
-------------------------
A
A
S
V
L
Q
A
T
V
L
S
Q
P
V
Q
T
L
D
S
L
R
A
A
R
H
G
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
G
D
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
---------
P
G
E
L
A
P
K
L
A
L
A
A
T
A
E
L
A
G
N
T
D
E
------------
H
K
F
Y
Q
T
V
W
S
T
N
D
G
V
I
S
A
A
F
G
L
A
R
A
R
S
A
E
G
D
R
V
G
A
V
R
T
L
D
E
V
P
P
T
S
------------
R
H
F
T
T
A
R
L
T
S
A
V
T
L
L
V
T
E
E
Q
I
R
D
A
A
R
R
V
E
A
L
P
P
T
E
P
R
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
K
A
S
T
N
H
I
L
G
F
P
F
T
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
A
P
T
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
R
P
-----------------------
86
PsiBlast_CBE
57.22
34%
-36
- C3 -
-
3QZI
1
CDK2_HUMAN
A:
[12-225]
----------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----
T
E
GVP
S
T
A
I
R
----
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
N
----
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
AL
T
G
I
P
L
P
--
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
-
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------