@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y1T4: (2018-01-27 )
MIKEYRTIGEVVGPLMAVEKVAGVKYEELIEVRMQNGEIRRGQVLEVQEDKAMVQIFEGTSGINLRDSSVRFLGHPLELGVSEDMIGRVFDGLGRPKDNGPEILPEKHLDINGEVINPVARDYPDEFIQTGISAIDHLNTLVRGQKLPVFSGSGLPHKELAAQIARQATVLDSSDDFAVVFAAIGITFEEAEFFMEDFRQTGAIDRSVMFMNLANDPAIERIATPRMALTAAEYLAYEKGMHVLVIMTDMTNYAEALREISAARREVPGRRGYPGYLYTNLATLFERAGRIRGLKGSVTQIPILTMPEDDKTHPIPDLTGYITEGQIILTRELYKSGIQPPIDVLPSLSRLKDKGTGPGKTREDHAATMNQLFAAYAQGKQAKELAVVLGESALSDVDKIYAKFAERFEKEYVNQGFYTNRSITETLDLGWELLSMLPRTELKRIKDDMLDKYLPEGK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60...-.....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
K
E
Y
R
T
I
G
E
V
V
G
P
L
M
A
V
E
K
V
AGV
K
Y
E
E
L
I
E
V
R
MQNGEIRR
G
Q
V
L
E
VQED
K
A
M
V
Q
I
FEGTSGIN-LRDS
S
V
R
FLGHPLELGVS
E
D
M
I
G
R
V
F
D
GLGRPKDNGPEILPEKHLDING
E
V
I
N
P
V
A
R
DY
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
VRGQKLPVFSGSGL
P
H
K
E
L
A
A
Q
I
A
R
Q
ATVLDSSD
D
F
A
V
V
F
A
A
IGI
T
F
E
E
A
E
F
F
M
E
D
F
R
QTGAIDR
S
V
M
F
M
NLANDP
A
I
E
R
IATP
R
M
A
L
T
A
A
E
Y
L
A
Y
EKG
M
H
V
L
V
I
MTD
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
EVPGRRGYP
G
Y
L
Y
T
N
L
A
T
L
F
E
RAGRIRGLKGSV
T
Q
I
P
I
L
TMPEDDKTHPIPDL
T
G
Y
ITE
G
Q
I
I
L
T
R
E
L
Y
KSGIQ
P
P
I
D
V
L
P
S
L
S
R
L
KDKGTGPGKTR
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
AQGK
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
V
D
K
I
Y
A
K
F
A
E
R
F
E
K
E
Y
V
NQGFYTNRS
I
T
E
T
L
D
L
G
W
E
L
L
S
ML
P
R
T
E
L
K
R
I
K
D
D
M
L
D
K
YLPEGK
25
PsiBlast_CBE
98.43
97%
-85
- C6 -
-
5KNB
2
NTPB_ENTHA
E:
[9-462]
-
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
21
PsiBlast_CBE
98.08
97%
-83
- C6 -
-
5KND
2
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
3
PsiBlast_PDB
97.91
97%
-84
- C6 -
-
5KNC
1
NTPB_ENTHA
D:
[8-461]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
----
2
PsiBlast_PDB
97.84
97%
-81
- C6 -
-
5KNB
-
NTPB_ENTHA
D:
[10-462]
--
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
4
PsiBlast_PDB
97.75
97%
-83
- C6 -
-
5KND
-
NTPB_ENTHA
D:
[11-462]
---
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
24
PsiBlast_CBE
97.40
97%
-83
- C6 -
-
5KNB
1
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
27
PsiBlast_CBE
97.31
97%
-84
- C6 -
-
3VR6
1
NTPB_ENTHA
E:
[11-462]
---
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
26
PsiBlast_CBE
97.07
97%
-79
- C6 -
-
3VR6
1
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
22
PsiBlast_CBE
96.41
97%
-84
- C6 -
-
5KNC
4
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
23
PsiBlast_CBE
96.39
97%
-79
- C6 -
-
5KNC
3
NTPB_ENTHA
E:
[10-462]
--
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
1
PsiBlast_PDB
96.35
97%
-81
- C6 -
-
3VR6
-
NTPB_ENTHA
D:
[11-461]
---
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
----
5
PsiBlast_PDB
95.77
94%
-81
- C6 -
-
3VR4
2
NTPB_ENTHA
D:
[11-462]
---
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
-
L
K
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
66
HHSearch
88.98
97%
-20
- C6 -
-
3VR4
5
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
L
K
-
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
67
HHSearch
86.88
97%
-16
- C6 -
-
5KNB
1
NTPB_ENTHA
F:
[8-462]
M
I
K
E
Y
R
T
I
K
E
V
V
G
P
L
M
A
V
E
K
V
S
G
V
K
Y
E
E
L
I
E
V
R
M
Q
N
G
E
I
R
R
G
Q
V
L
E
V
Q
E
D
K
A
M
V
Q
I
F
E
G
T
S
G
I
N
L
K
-
N
S
S
V
R
F
L
G
H
P
L
Q
L
G
V
S
E
D
M
I
G
R
V
F
D
G
L
G
R
P
K
D
N
G
P
E
I
L
P
E
K
Y
L
D
I
N
G
E
V
I
N
P
I
A
R
D
Y
P
D
E
F
I
Q
T
G
I
S
A
I
D
H
L
N
T
L
V
R
G
Q
K
L
P
V
F
S
G
S
G
L
P
H
K
E
L
A
A
Q
I
A
R
Q
A
T
V
L
D
S
S
D
D
F
A
V
V
F
A
A
I
G
I
T
F
E
E
A
E
F
F
M
E
D
F
R
Q
T
G
A
I
D
R
S
V
M
F
M
N
L
A
N
D
P
A
I
E
R
I
A
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
K
G
M
H
V
L
V
I
M
T
D
M
T
N
Y
A
E
A
L
R
E
I
S
A
A
R
R
E
V
P
G
R
R
G
Y
P
G
Y
L
Y
T
N
L
A
T
L
F
E
R
A
G
R
I
R
G
L
K
G
S
V
T
Q
I
P
I
L
T
M
P
E
D
D
K
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
I
L
T
R
E
L
Y
K
S
G
I
Q
P
P
I
D
V
L
P
S
L
S
R
L
K
D
K
G
T
G
A
G
K
T
R
E
D
H
A
A
T
M
N
Q
L
F
A
A
Y
A
Q
G
K
Q
A
K
E
L
A
V
V
L
G
E
S
A
L
S
D
I
D
K
I
Y
A
K
F
A
E
R
F
E
N
E
Y
V
N
Q
G
F
Y
T
N
R
T
I
T
E
T
L
D
L
G
W
E
L
L
A
M
L
P
R
T
E
L
K
R
I
K
D
D
L
L
D
K
Y
L
P
---
33
PsiBlast_CBE
82.96
59%
-82
- C6 -
-
3TGW
7
VATB_METMA
B:
[10-454]
---------
Q
I
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
E
G
T
G
--------
G
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
A
N
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
A
A
----
P
G
R
R
G
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
---
70
HHSearch
82.75
60%
-79
- C6 -
-
3TGW
9
VATB_METMA
A:
[11-456]
----------
I
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
E
G
T
G
G
-----
D
C
G
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
A
N
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
A
A
R
N
E
V
P
G
R
R
G
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
A
H
-
65
HHSearch
82.35
60%
-87
- C6 -
-
2C61
-
VATB_METMA
B:
[13-456]
------------
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
--------------
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
H
N
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
-----------
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
A
H
-
30
PsiBlast_CBE
82.11
60%
-91
- C6 -
-
3TIV
8
VATB_METMA
B:
[11-454]
----------
I
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
E
G
-----------
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
H
A
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
-----------
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
---
13
PsiBlast_PDB
82.07
59%
-80
- C6 -
-
3TGW
9
VATB_METMA
A:
[11-454]
----------
I
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
E
G
T
G
G
-----
D
C
G
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
A
N
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
A
A
R
N
E
V
P
G
R
R
G
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
---
10
PsiBlast_PDB
81.92
60%
-84
- C6 -
-
3TIV
10
VATB_METMA
A:
[12-454]
-----------
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
E
G
-----------
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
H
A
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
A
A
R
N
E
V
P
G
R
R
G
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
---
32
PsiBlast_CBE
81.73
60%
-87
- C6 -
-
3SSA
10
VATB_METMA
B:
[12-454]
-----------
A
G
P
L
I
F
V
E
K
T
E
P
V
G
Y
N
E
I
V
N
I
K
M
G
D
G
T
V
R
R
G
Q
V
L
D
S
S
A
D
I
V
V
V
Q
V
F
-------------
V
I
F
T
G
E
T
L
K
L
P
A
S
V
D
L
L
G
R
I
L
S
G
S
G
E
P
R
D
G
G
P
R
I
V
P
D
Q
L
L
D
I
N
G
A
A
M
N
P
Y
A
R
L
P
P
K
D
F
I
Q
T
G
I
S
T
I
D
G
T
N
T
L
V
R
G
Q
K
L
P
I
F
S
A
S
G
L
P
H
T
E
I
A
L
Q
I
A
R
Q
A
S
V
P
G
S
E
S
A
F
A
V
V
F
A
A
M
G
I
T
N
E
E
A
Q
Y
F
M
S
D
F
E
K
T
G
A
L
E
R
A
V
V
F
L
N
L
A
D
D
P
A
V
E
R
I
V
T
P
R
M
A
L
T
A
A
E
Y
L
A
Y
E
H
G
M
H
V
L
V
I
L
T
D
I
T
N
Y
A
E
A
L
R
Q
M
G
-----------
Y
P
G
Y
M
Y
T
D
L
A
T
L
Y
E
R
A
G
I
V
K
G
A
K
G
S
V
T
Q
I
P
I
L
S
M
P
G
D
D
I
T
H
P
I
P
D
L
S
G
Y
I
T
E
G
Q
I
V
V
A
R
E
L
H
R
K
G
I
Y
P
P
I
N
V
L
P
S
L
S
R
L
M
N
S
G
I
G
A
G
K
T
R
E
D
H
K
A
V
S
D
Q
M
Y
A
G
Y
A
E
G
R
D
L
R
G
L
V
A
I
V
G
K
E
A
L
S
E
R
D
T
K
F
L
E
F
A
D
L
F
E
D
K
F
V
R
Q
G
R
N
E
N
R
T
I
E
D
T
L
E
I
G
W
Q
I
L
T
H
L
P
E
N
Q
L
G
R
I
D
N
K
Y
I
Q
K
Y
H
P
---