@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y1X4: (2018-01-28 )
MKKLVAGLLTAVALLAMSACGADQKNTAQTSSSTKESAEVSSGASEQVYTDPKEMKESYDVVIIGAGGAGMAAAIEAKDAGLNPVILEKMPVAGGNTSKSSSGMNASETKFQKEEGIKDSNDAFYEETLKGGGGTNDKEMLRYFVDHSADAVDWLDQNGIKLDNLTITGGMSEKRTHRPSDGSAIGGYLVEGLLNNVHEREIPIFVNADVTDIKKNGETVNEVTVHVQGEEPKEVTGKAIVVTTGGFGASKEFIEKYRPDLADYITTNQEGSTGDGITMIEKLGGQTVDMDKIQIHPTVQQDEGVLIGEVVRGEGAILVDQEGKRFVNEMDTRDKVSAAITALPEKSAYLIFDQGVRDRATAIEFYDQKGYVTTGKTMEELAEKIDLPKETLAKTVDGWNTDVAEKKDAQFNRATAMEHDLSSPNYYAIKIAPGIHYTMGGVKINTNTEVLDKENQPIRGLYAAGEVTGGLHGNNRIGGNSVAEIIIFGRQAGIQAARFASENE
Atome Classification :
(20 SA)
---------------------------------------------------------.........10..-----------......20--.........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210....--..-.220..-..-...230..--.....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..-......460.......470.......480.......490.......500..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------
M
K
K
L
V
A
G
L
L
T
A
V
A
-----------
L
L
A
M
S
AC---GADQKNTAQTSSSTKESAEVSSGASEQVYT
D
P
K
E
M
KESY
D
V
V
I
IGAGGAG
M
A
A
A
I
E
AKDAGLN
P
V
I
L
EKMPVAGGNTSKSSSGMNA
S
E
T
K
F
Q
K
EEGIKDS
N
D
A
F
Y
E
E
T
LKGGGGT
N
D
K
E
M
L
R
Y
F
V
DHSA
D
A
V
D
W
LDQNG
I
K
LD
N
L
T
ITGGMSEKRTHRPSDGS
A
I
G
G
Y
L
V
E
G
L
L
NNVHEREI
P
I
F
V
NAD
V
T
DIKKN--GE-T
V
N
E
V
T
-
V
H
-
V
QGEEPKE--VTG
K
A
I
V
V
T
TGGFG
A
S
K
E
F
I
E
K
YR
P
D
L
A
D
Y
ITTNQEGSTGD
G
I
T
M
I
E
K
LGGQ
T
V
DM
D
K
I
Q
I
HPTVQQDE
G
V
L
I
G
E
V
VRGE
G
A
I
L
VDQE
G
K
R
F
V
N
E
MD
T
R
D
K
V
S
A
A
I
TALPEK
S
A
Y
L
I
F
DQGVRDRA
T
A
I
E
F
YDQKGYVTT
G
K
T
M
E
E
L
A
E
K
IDL
P
K
E
T
L
A
K
T
VDGWNTDVAEKKDAQFNR
A
T
A
MEHDLSSP
N
Y
Y
A
I
K
IAPG
I
H
Y
T
MG
G
V
K
INTNT
E
V
-LDK-ENQP
I
R
G
L
Y
AAGEVTGGLHGNNRIGG
N
S
V
A
E
I
I
I
F
GRQAGIQ
A
A
RFASENE
96
HHSearch
93.18
45%
0
- C- -
-
1D4C
3
FRDA_SHEON
A:
[121-571]
---------------------------------------------------------------------------------------------------------------------------
A
G
V
K
E
T
T
D
V
V
I
I
G
S
G
G
A
G
L
A
A
A
V
S
A
R
D
A
G
A
K
V
I
L
L
E
K
E
P
I
P
G
G
N
T
K
L
A
A
G
G
M
N
A
A
E
T
K
P
Q
A
K
L
G
I
E
D
K
K
Q
I
M
I
D
D
T
M
K
G
G
R
N
I
N
D
P
E
L
V
K
V
L
A
N
N
S
S
D
S
I
D
W
L
T
S
M
G
A
D
M
T
D
V
G
R
M
G
G
A
S
V
N
R
S
H
R
P
T
G
G
A
G
V
G
A
H
V
A
Q
V
L
W
D
N
A
V
K
R
G
T
D
I
R
L
N
S
R
V
V
R
I
L
E
D
A
S
G
K
--
V
T
G
V
L
-
V
K
G
E
Y
T
-
G
Y
Y
V
--
I
K
A
D
A
V
V
I
A
A
G
G
F
A
K
N
N
E
R
V
S
K
Y
D
P
K
L
K
G
F
K
A
T
N
H
P
G
A
T
G
D
G
L
D
V
A
L
Q
A
G
A
A
T
R
D
L
E
Y
I
Q
A
H
P
T
Y
S
P
A
G
G
V
M
I
T
E
A
V
R
G
N
G
A
I
V
V
N
R
E
G
N
R
F
M
N
E
I
T
T
R
D
K
A
S
A
A
I
L
Q
Q
K
G
E
S
A
Y
L
V
F
D
D
S
I
R
K
S
L
K
A
I
E
G
Y
V
H
L
N
I
V
K
E
G
K
T
I
E
E
L
A
K
Q
I
D
V
P
A
A
E
L
A
K
T
V
T
A
Y
N
G
F
V
K
S
G
K
D
A
Q
F
E
R
P
D
L
-
P
R
E
L
V
V
A
P
F
Y
A
L
E
I
A
P
A
V
H
H
T
M
G
G
L
V
I
D
T
K
A
E
V
-
K
S
E
K
T
G
K
P
I
T
G
L
Y
A
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
V
T
Y
G
R
I
A
G
A
S
A
A
K
F
A
K
D
--
23
PsiBlast_CBE
92.08
45%
0
- C- -
-
1D4C
5
FRDA_SHEON
B:
[123-571]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
T
T
D
V
V
I
I
G
S
G
G
A
G
L
A
A
A
V
S
A
R
D
A
G
A
K
V
I
L
L
E
K
E
P
I
P
G
G
N
T
K
L
A
A
G
G
M
N
A
A
E
T
K
P
Q
A
K
L
G
I
E
D
K
K
Q
I
M
I
D
D
T
M
K
G
G
R
N
I
N
D
P
E
L
V
K
V
L
A
N
N
S
S
D
S
I
D
W
L
T
S
M
G
A
D
M
T
D
V
G
R
M
G
G
A
S
V
N
R
S
H
R
P
T
G
G
A
G
V
G
A
H
V
A
Q
V
L
W
D
N
A
V
K
R
G
T
D
I
R
L
N
S
R
V
V
R
I
L
E
D
--
A
S
---
G
K
V
T
G
V
L
-
V
K
G
E
Y
T
G
Y
Y
V
I
K
A
D
A
V
V
I
A
A
G
G
F
A
K
N
N
E
R
V
S
K
Y
D
P
K
L
K
G
F
K
A
T
N
H
P
G
A
T
G
D
G
L
D
V
A
L
Q
A
G
A
A
T
R
D
L
E
Y
I
Q
A
H
P
T
Y
S
P
A
G
G
V
M
I
T
E
A
V
R
G
N
G
A
I
V
V
N
R
E
G
N
R
F
M
N
E
I
T
T
R
D
K
A
S
A
A
I
L
Q
Q
K
G
E
S
A
Y
L
V
F
D
D
S
I
R
K
S
L
K
A
I
E
G
Y
V
H
L
N
I
V
K
E
G
K
T
I
E
E
L
A
K
Q
I
D
V
P
A
A
E
L
A
K
T
V
T
A
Y
N
G
F
V
K
S
G
K
D
A
Q
F
E
R
P
D
-
L
P
R
E
L
V
V
A
P
F
Y
A
L
E
I
A
P
A
V
H
H
T
M
G
G
L
V
I
D
T
K
A
E
V
K
S
E
K
-
T
G
K
P
I
T
G
L
Y
A
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
V
T
Y
G
R
I
A
G
A
S
A
A
K
F
A
K
D
--
22
PsiBlast_CBE
92.08
45%
0
- C- -
-
1D4C
5
FRDA_SHEON
C:
[123-571]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
T
T
D
V
V
I
I
G
S
G
G
A
G
L
A
A
A
V
S
A
R
D
A
G
A
K
V
I
L
L
E
K
E
P
I
P
G
G
N
T
K
L
A
A
G
G
M
N
A
A
E
T
K
P
Q
A
K
L
G
I
E
D
K
K
Q
I
M
I
D
D
T
M
K
G
G
R
N
I
N
D
P
E
L
V
K
V
L
A
N
N
S
S
D
S
I
D
W
L
T
S
M
G
A
D
M
T
D
V
G
R
M
G
G
A
S
V
N
R
S
H
R
P
T
G
G
A
G
V
G
A
H
V
A
Q
V
L
W
D
N
A
V
K
R
G
T
D
I
R
L
N
S
R
V
V
R
I
L
E
D
--
A
S
---
G
K
V
T
G
V
L
-
V
K
G
E
Y
T
G
Y
Y
V
I
K
A
D
A
V
V
I
A
A
G
G
F
A
K
N
N
E
R
V
S
K
Y
D
P
K
L
K
G
F
K
A
T
N
H
P
G
A
T
G
D
G
L
D
V
A
L
Q
A
G
A
A
T
R
D
L
E
Y
I
Q
A
H
P
T
Y
S
P
A
G
G
V
M
I
T
E
A
V
R
G
N
G
A
I
V
V
N
R
E
G
N
R
F
M
N
E
I
T
T
R
D
K
A
S
A
A
I
L
Q
Q
K
G
E
S
A
Y
L
V
F
D
D
S
I
R
K
S
L
K
A
I
E
G
Y
V
H
L
N
I
V
K
E
G
K
T
I
E
E
L
A
K
Q
I
D
V
P
A
A
E
L
A
K
T
V
T
A
Y
N
G
F
V
K
S
G
K
D
A
Q
F
E
R
P
D
-
L
P
R
E
L
V
V
A
P
F
Y
A
L
E
I
A
P
A
V
H
H
T
M
G
G
L
V
I
D
T
K
A
E
V
K
S
E
K
-
T
G
K
P
I
T
G
L
Y
A
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
V
T
Y
G
R
I
A
G
A
S
A
A
K
F
A
K
D
--
21
PsiBlast_CBE
92.08
45%
0
- C- -
-
1D4C
3
FRDA_SHEON
D:
[123-571]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
T
T
D
V
V
I
I
G
S
G
G
A
G
L
A
A
A
V
S
A
R
D
A
G
A
K
V
I
L
L
E
K
E
P
I
P
G
G
N
T
K
L
A
A
G
G
M
N
A
A
E
T
K
P
Q
A
K
L
G
I
E
D
K
K
Q
I
M
I
D
D
T
M
K
G
G
R
N
I
N
D
P
E
L
V
K
V
L
A
N
N
S
S
D
S
I
D
W
L
T
S
M
G
A
D
M
T
D
V
G
R
M
G
G
A
S
V
N
R
S
H
R
P
T
G
G
A
G
V
G
A
H
V
A
Q
V
L
W
D
N
A
V
K
R
G
T
D
I
R
L
N
S
R
V
V
R
I
L
E
D
--
A
S
---
G
K
V
T
G
V
L
-
V
K
G
E
Y
T
G
Y
YV
I
K
A
D
A
V
V
I
A
A
G
G
F
A
K
N
N
E
R
V
S
K
Y
D
P
K
L
K
G
F
K
A
T
N
H
P
G
A
T
G
D
G
L
D
V
A
L
Q
A
G
A
A
T
R
D
L
E
Y
I
Q
A
H
P
T
Y
S
P
A
G
G
V
M
I
T
E
A
V
R
G
N
G
A
I
V
V
N
R
E
G
N
R
F
M
N
E
I
T
T
R
D
K
A
S
A
A
I
L
Q
Q
K
G
E
S
A
Y
L
V
F
D
D
S
I
R
K
S
L
K
A
I
E
G
Y
V
H
L
N
I
V
K
E
G
K
T
I
E
E
L
A
K
Q
I
D
V
P
A
A
E
L
A
K
T
V
T
A
Y
N
G
F
V
K
S
G
K
D
A
Q
F
E
R
P
D
-
L
P
R
E
L
V
V
A
P
F
Y
A
L
E
I
A
P
A
V
H
H
T
M
G
G
L
V
I
D
T
K
A
E
V
K
S
E
K
-
T
G
K
P
I
T
G
L
Y
A
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
V
T
Y
G
R
I
A
G
A
S
A
A
K
F
A
K
D
--
1
PsiBlast_PDB
92.08
45%
0
- C- -
-
1D4C
3
FRDA_SHEON
A:
[123-571]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
T
T
D
V
V
I
I
G
S
G
G
A
G
L
A
A
A
V
S
A
R
D
A
G
A
K
V
I
L
L
E
K
E
P
I
P
G
G
N
T
K
L
A
A
G
G
M
N
A
A
E
T
K
P
Q
A
K
L
G
I
E
D
K
K
Q
I
M
I
D
D
T
M
K
G
G
R
N
I
N
D
P
E
L
V
K
V
L
A
N
N
S
S
D
S
I
D
W
L
T
S
M
G
A
D
M
T
D
V
G
R
M
G
G
A
S
V
N
R
S
H
R
P
T
G
G
A
G
V
G
A
H
V
A
Q
V
L
W
D
N
A
V
K
R
G
T
D
I
R
L
N
S
R
V
V
R
I
L
E
D
--
A
S
---
G
K
V
T
G
V
L
-
V
K
G
E
Y
T
G
Y
Y
V
I
K
A
D
A
V
V
I
A
A
G
G
F
A
K
N
N
E
R
V
S
K
Y
D
P
K
L
K
G
F
K
A
T
N
H
P
G
A
T
G
D
G
L
D
V
A
L
Q
A
G
A
A
T
R
D
L
E
Y
I
Q
A
H
P
T
Y
S
P
A
G
G
V
M
I
T
E
A
V
R
G
N
G
A
I
V
V
N
R
E
G
N
R
F
M
N
E
I
T
T
R
D
K
A
S
A
A
I
L
Q
Q
K
G
E
S
A
Y
L
V
F
D
D
S
I
R
K
S
L
K
A
I
E
G
Y
V
H
L
N
I
V
K
E
G
K
T
I
E
E
L
A
K
Q
I
D
V
P
A
A
E
L
A
K
T
V
T
A
Y
N
G
F
V
K
S
G
K
D
A
Q
F
E
R
P
D
-
L
P
R
E
L
V
V
A
P
F
Y
A
L
E
I
A
P
A
V
H
H
T
M
G
G
L
V
I
D
T
K
A
E
V
K
S
E
K
-
T
G
K
P
I
T
G
L
Y
A
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
V
T
Y
G
R
I
A
G
A
S
A
A
K
F
A
K
D
--
2
PsiBlast_PDB
68.46
41%
-3
- C2 -
-
1QO8
3
FRD2_SHEFN
A:
[120-563]
-------------------------------------------------------------------------------------------------------------------------------
E
T
T
Q
V
L
V
V
G
A
G
S
A
G
F
N
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
N
A
V
G
T
K
Q
Q
T
A
H
G
V
E
D
K
V
E
W
F
I
E
D
A
M
K
G
G
R
Q
Q
N
D
I
K
L
V
T
I
L
A
E
Q
S
A
D
G
V
Q
W
L
E
S
L
G
A
N
L
D
D
L
K
R
S
G
G
A
R
V
D
R
T
H
R
P
H
G
G
K
S
S
G
P
E
I
I
D
T
L
R
K
A
A
K
E
Q
G
I
D
T
R
L
N
S
R
V
V
K
L
V
V
N
--
D
D
H
S
V
V
G
A
V
-
V
H
-
G
K
H
T
G
Y
Y
M
--
I
G
A
K
S
V
V
L
A
T
G
G
Y
G
M
N
K
E
M
I
A
Y
Y
R
P
T
M
K
D
M
T
S
S
N
N
I
T
A
T
G
D
G
V
L
M
A
K
E
I
G
A
S
M
T
D
I
D
W
V
Q
A
H
P
T
V
G
K
D
S
R
I
L
I
S
E
T
V
R
G
V
G
A
V
M
V
N
K
D
G
N
R
F
I
S
E
L
T
T
R
D
K
A
S
D
A
I
L
K
Q
P
G
Q
F
A
W
I
I
F
D
N
Q
L
Y
K
K
A
K
M
V
R
G
Y
D
H
L
E
M
L
Y
K
G
D
T
V
E
Q
L
A
K
S
T
G
M
K
V
A
D
L
A
K
T
V
S
D
Y
N
G
Y
V
A
S
G
K
D
T
A
F
G
R
A
D
-
M
P
L
N
M
T
Q
S
P
Y
Y
A
V
K
V
A
P
G
I
H
H
T
M
G
G
V
A
I
N
T
T
A
S
V
-
L
D
L
-
Q
S
K
P
I
D
G
L
F
A
A
G
E
V
T
G
G
V
H
G
Y
N
R
L
G
G
N
A
I
A
D
T
V
V
F
G
R
I
A
G
D
N
A
A
K
H
A
----
24
PsiBlast_CBE
67.55
41%
-7
- C2 -
-
1QO8
3
FRD2_SHEFN
D:
[120-563]
-------------------------------------------------------------------------------------------------------------------------------
E
T
T
Q
V
L
V
V
G
A
G
S
A
G
F
N
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
N
A
V
G
T
K
Q
Q
T
A
H
G
V
E
D
K
V
E
W
F
I
E
D
A
M
K
G
G
R
Q
Q
N
D
I
K
L
V
T
I
L
A
E
Q
S
A
D
G
V
Q
W
L
E
S
L
G
A
N
L
D
D
L
K
R
S
G
G
A
R
V
D
R
T
H
R
P
H
G
G
K
S
S
G
P
E
I
I
D
T
L
R
K
A
A
K
E
Q
G
I
D
T
R
L
N
S
R
V
V
K
L
V
V
N
--
D
D
H
S
V
V
G
A
V
-
V
H
-
G
K
H
T
G
Y
Y
M
--
I
G
A
K
S
V
V
L
A
T
G
G
Y
G
M
N
K
E
M
I
A
Y
Y
R
P
T
M
K
D
M
T
S
S
N
N
I
T
A
T
G
D
G
V
L
M
A
K
E
I
G
A
S
M
T
D
I
D
W
V
Q
A
H
P
T
V
G
K
D
S
R
I
L
I
S
E
T
V
R
G
V
G
A
V
M
V
N
K
D
G
N
R
F
I
S
E
L
T
T
R
D
K
A
S
D
A
I
L
K
Q
P
G
Q
F
A
W
I
I
F
D
N
Q
L
Y
K
K
A
K
M
V
R
G
Y
D
H
L
E
M
L
Y
K
G
D
T
V
E
Q
L
A
K
S
T
G
M
K
V
A
D
L
A
K
T
V
S
D
Y
N
G
Y
V
A
S
G
K
D
T
A
F
G
R
A
D
-
M
P
L
N
M
T
Q
S
P
Y
Y
A
V
K
V
A
P
G
I
H
H
T
M
G
G
V
A
I
N
T
T
A
S
V
-
L
D
L
-
Q
S
K
P
I
D
G
L
F
A
A
G
E
V
T
G
G
V
H
G
Y
N
R
L
G
G
N
A
I
A
D
T
V
V
F
G
R
I
A
G
D
N
A
A
K
H
A
----
95
HHSearch
66.60
43%
14
* C2 *
-
1Y0P
4
FRDA_SHEFR
A:
[119-568]
-------------------------------------------------------------------------------------------------------------------------
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
DK
G
T
--
V
K
G
I
L
-
V
K
G
M
Y
K
-
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
L
-
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
97
HHSearch
66.51
43%
14
- C2 -
-
1KSU
4
FRDA_SHEFR
A:
[118-568]
------------------------------------------------------------------------------------------------------------------------
A
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
DK
G
T
--
V
K
G
I
L
-
V
K
G
M
Y
K
-
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
Y
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
114
Fugue
66.44
39%
45
- C2 -
-
1JRX
6
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNA
H
A
S
H
F
P
G
E
V
A
C
T
S
CHSAH
E
K
S
---
M
V
Y
C
D
S
C
HSF
D
F
N
M
P
Y
A
K
K
W
L
R
D
E
P
T
I
A
E
L
A
K
D
K
S
E
R
Q
A
A
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
115
Fugue
66.38
39%
45
- C2 -
-
1QJD
7
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNA
H
A
S
H
F
P
G
E
V
A
C
T
S
CHSAH
E
K
S
M
V
Y
C
D
S
C
H
S
F
---
D
F
N
M
P
Y
A
K
K
W
L
R
D
E
P
T
I
A
E
L
A
K
D
K
S
E
R
Q
A
A
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
94
HHSearch
65.56
41%
7
- C2 -
-
1QO8
3
FRD2_SHEFN
D:
[113-565]
------------------------------------------------------------------------------------------------------------------------
A
I
A
A
G
P
S
E
T
T
Q
V
L
V
V
G
A
G
S
A
G
F
N
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
N
A
V
G
T
K
Q
Q
T
A
H
G
V
E
D
K
V
E
W
F
I
E
D
A
M
K
G
G
R
Q
Q
N
D
I
K
L
V
T
I
L
A
E
Q
S
A
D
G
V
Q
W
L
E
S
L
G
A
N
L
D
D
L
K
R
S
G
G
A
R
V
D
R
T
H
R
P
H
G
G
K
S
S
G
P
E
I
I
D
T
L
R
K
A
A
K
E
Q
G
I
D
T
R
L
N
S
R
V
V
K
L
V
V
N
DD
H
S
--
V
V
G
A
V
-
V
H
G
K
H
T
-
G
Y
Y
M
--
I
G
A
K
S
V
V
L
A
T
G
G
Y
G
M
N
K
E
M
I
A
Y
Y
R
P
T
M
K
D
M
T
S
S
N
N
I
T
A
T
G
D
G
V
L
M
A
K
E
I
G
A
S
M
T
D
I
D
W
V
Q
A
H
P
T
V
G
K
D
S
R
I
L
I
S
E
T
V
R
G
V
G
A
V
M
V
N
K
D
G
N
R
F
I
S
E
L
T
T
R
D
K
A
S
D
A
I
L
K
Q
P
G
Q
F
A
W
I
I
F
D
N
Q
L
Y
K
K
A
K
M
V
R
G
Y
D
H
L
E
M
L
Y
K
G
D
T
V
E
Q
L
A
K
S
T
G
M
K
V
A
D
L
A
K
T
V
S
D
Y
N
G
Y
V
A
S
G
K
D
T
A
F
G
R
A
D
M
P
L
-
N
M
T
Q
S
P
Y
Y
A
V
K
V
A
P
G
I
H
H
T
M
G
G
V
A
I
N
T
T
A
S
V
-
L
D
L
-
Q
S
K
P
I
D
G
L
F
A
A
G
E
V
T
G
G
V
H
G
Y
N
R
L
G
G
N
A
I
A
D
T
V
V
F
G
R
I
A
G
D
N
A
A
K
H
A
L
D
--
29
PsiBlast_CBE
63.73
42%
12
- C2 -
-
1M64
4
FRDA_SHEFR
B:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
F
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
17
PsiBlast_PDB
63.72
41%
14
- C2 -
-
1LJ1
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
F
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
10
PsiBlast_PDB
63.47
42%
17
- C2 -
-
1KSS
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
A
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
5
PsiBlast_PDB
63.45
42%
16
- C2 -
-
1P2E
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
11
PsiBlast_PDB
63.40
42%
15
- C2 -
-
1JRY
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
K
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
15
PsiBlast_PDB
63.36
42%
14
- C2 -
-
1M64
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
F
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
9
PsiBlast_PDB
63.35
42%
16
- C2 -
-
2B7R
3
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
D
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----
8
PsiBlast_PDB
63.35
42%
17
- C2 -
-
1Y0P
4
FRDA_SHEFR
A:
[139-568]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
G
A
S
V
N
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
--
D
K
G
T
V
K
G
I
L
-
V
K
-
G
M
Y
K
G
Y
Y
W
--
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
-
M
N
A
-
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----