@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y201: (2018-01-28 )
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITNEIKEKIMRAAKMTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGTDNVMYIHTTLIPYLKAAGEMKTKPTQHSVKELRGLGIQPNILVVRTEQPVSQSVKNKLAQFCDVEPEAVIESPDVDTLYSIPLVLQAQGMDQIVCDHLKLDTPEADMTEWKELEERVLNLKKKVRIALVGKYVELPDAYISVVEALKHSGFAYNSDIEIDWIKAQELTRENVEERLKDADGILVPGGFGDRGVEGKIEAIRYARENDVPFLGICLGMQMACVEFARNVVGLEDASSAETNPDTANNIIDLMADQENIENLGGTLRLGLYPCKIKKGTKTAEAYDGADVVQERHRHRYEFNNKYRQLFEEQGLVFSGVSPDNRLVEIVELPEKKFFVGCQFHPELISRPNRPQKLIKAFVGASLADHETK
Atome Classification :
(20 SA)
.-........10........20........30........40........50........60........70........80........90........100.......110.......120.......130----..------....-----...140.......150.......160.......170.......180.-.----------.....190.......200.......210.......220.......230.......240.......250.......260.......---270........280..--.--....290.......300........310.......320.......330..-..----------.--.----------.340---------...---.....350.......360.......370.......380.......390.......400.......410.......420----.-------..-....430.......440-........450.......460.......470.......480...----....490......--.500.........510.......520.......530....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M-
T
K
Y
I
F
VTG
G
V
V
S
S
I
G
K
G
I
V
A
A
S
L
G
R
L
L
K
NRG
L
K
V
T
I
Q
KFD
P
Y
I
NVDPGTMSPYQHG
E
V
F
V
TDDGAETDLDLGH
Y
E
R
F
I
D
I
NLNKYSNVT
T
G
K
I
Y
S
E
V
L
R
K
E
RKGEYLG
A
T
V
Q
V
I
P
H
I
T
N
E
I
K
E
K
I
M
R
A
A------KM------TDS
D
-----
V
I
I
T
EVGGTVGDIES
L
P
F
L
E
A
L
R
Q
M
K
A
DVGTD
N
V
M
Y
I
H
T
T
L
I
P
Y
L
K
A-A----------GEMKTKPT
Q
H
S
V
K
E
L
RGLGIQP
N
I
L
V
V
RTEQP
V
S
Q
S
V
K
N
K
L
A
Q
F
CDV
E
P
E
AVIESPDVD
T
L
YSI
P
L
V
L
QAQG
M
D
Q
I
V
C
D
H
LKLDT---P-E
A
D
M
T
E
W
K
E
L
E
E
R
V
--
L
--
N
L
K
K
K
V
R
I
A
L
V
G
K
YVE-L
P
D
A
Y
I
S
V
V
E
A
L
K
HSGFAYNSD
I
E
I
D
W
I
K
A
Q
E
L
-
T
R
----------
E
--
N
----------
V
E
E
----------
R
L
K---DAD
G
I
L
VPGGFGDRGVEG
K
I
E
A
I
R
YARENDVP
F
L
G
I
C
L
G
M
Q
M
A
C
V
E
F
A
R
N
VVGLEDASSAETNPDT
A
N
N
I
I
D
L
MA
D
Q
E
----
N
-------
I
E
-NLGG
T
L
R
L
G
L
Y
P
C
K
I-K-KGTKTAEAYD
G
A
D
V
V
Q
E
R
H
R
H
RYEF
N
N
K
Y
R
Q
L
F
E
EQG
L
V
F
SGVS----PDNR
L
V
E
I
VELPE--K
K
--
F
F
V
G
C
Q
F
H
P
E
L
ISRPN
R
P
Q
K
L
I
K
A
F
VGASLADHETK-
29
PsiBlast_CBE
87.38
53%
-62
- C3 -
-
5TKV
7
PYRG_ECOLI
B:
[23-556]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
------
E
--------
G
H
D
-----
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
-
S
----------
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
A
---
P
-
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
-
E
T
----------
R
--
G
----------
V
-
E
----------
I
L
K
---
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
DENG
N
-------
V
E
V----
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
-
D
D
S
L
V
R
Q
L
Y
N
A
P
T
I
V
-
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
----
G
D
D
Q
L
V
E
I
I
E
V
P
N
--
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
--------
52
HHSearch
87.30
53%
-57
* C3 *
-
2AD5
4
PYRG_ECOLI
B:
[2-542]
T
-
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
------
E
--------
G
H
D
-----
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
-
S
----------
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
---
P
-
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
-
E
T
----------
R
-------------
G
V
E
----------
I
L
K
---
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
----
D
ENGNVEV-------
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
-
D
D
S
L
V
R
Q
L
Y
N
A
-
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
----
G
D
D
Q
L
V
E
I
I
E
V
P
N
--
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
--
30
PsiBlast_CBE
86.65
53%
-61
- C3 -
-
2AD5
4
PYRG_ECOLI
B:
[3-536]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
------
E
--------
G
H
D
-----
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
-
S
----------
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
---
P
-
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
-
E
T
----------
R
--
G
----------
V
-
E
----------
I
L
K
---
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
DENG
N
-------
V
E
V----
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
-
D
D
S
L
V
R
Q
L
Y
N
A
P
T
I
V
-
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
----
G
D
D
Q
L
V
E
I
I
E
V
P
N
--
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
--------
31
PsiBlast_CBE
84.56
53%
-60
- C3 -
-
1S1M
2
PYRG_ECOLI
B:
[3-536]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
------
E
--------
G
H
D
-----
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
-
S
----------
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
---
P
-
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
-
E
T
----------
R
--
G
----------
V
-
E
----------
I
L
K
---
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
DENG
N
-------
V
E
V----
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
-
D
D
S
L
V
R
Q
L
Y
N
A
P
T
I
V
-
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
----
G
D
D
Q
L
V
E
I
I
E
V
P
N
--
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
--------
4
PsiBlast_PDB
81.23
51%
-
- C3 -
-
3NVA
-
PYRG_SULSO
A:
[4-531]
---
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
S
------
K
I
------
N
N
A
E
-----
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
-
T
----------
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
---
R
-
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
G
I
--
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
-
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
L
-
E
S
----------
D
TK
N
----------
L
N
E
----------
I
L
G
---
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
----
N
-------
V
T
-
Q
L
G
G
T
M
R
L
G
A
Q
K
I
I
L
-
K
-
E
G
T
I
A
Y
Q
L
Y
-
G
K
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
-----
E
N
G
L
V
E
I
I
E
L
P
S
--
N
K
--
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
---------
53
HHSearch
80.59
50%
-
- C3 -
-
3NVA
-
PYRG_SULSO
B:
[2-534]
P
-
N
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
S
KI----
N
--------
N
A
E
-----
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
-----------
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
IALVEYLSVT
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
----
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
--
K
GI
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
-
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
L
-
E
S
----------
D
--
T
KN--------
L
N
E
----------
I
L
G
---
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
----
N
-------
V
T
-
Q
L
G
G
T
M
R
L
G
A
Q
K
I
I
L
-
K
-
E
G
T
I
A
Y
Q
L
Y
G
K
-
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
----
E
N
G
-
L
V
E
I
I
E
L
P
S
--
N
K
--
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
47
HHSearch
80.51
55%
3
- C3 -
-
4ZDJ
3
PYRG_MYCTU
A:
[9-552]
A
-
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
------
Q
P
DADG--
N
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
-
E
T
----------
T
--
S
G
---------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
DR
H
P
--
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
--
3
PsiBlast_PDB
80.11
54%
2
- C3 -
-
4ZDJ
3
PYRG_MYCTU
A:
[10-547]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
------
Q
P
DADG--
N
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
T
----------
S
--
G
----------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
-
V
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
T
Q
-
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
--
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
-------
21
PsiBlast_CBE
79.86
54%
2
- C3 -
-
4ZDK
3
PYRG_MYCTU
B:
[9-546]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
------
Q
P
DADG--
N
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
T
----------
S
--
G
----------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
-
V
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
T
Q
-
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
--
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
-------
1
PsiBlast_PDB
79.34
54%
3
- C3 -
-
4ZDK
3
PYRG_MYCTU
A:
[9-546]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
------
Q
P
DADG--
N
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
T
----------
S
--
G
----------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
-
V
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
T
Q
-
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
--
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
-------
2
PsiBlast_PDB
78.96
54%
4
- C3 -
-
4ZDI
-
PYRG_MYCTU
A:
[10-547]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
------
Q
P
DADG--
N
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
T
----------
S
--
G
----------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
-
V
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
T
Q
-
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
--
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
-------
38
Fugue
77.79
53%
3
- C3 -
-
1S1M
-
PYRG_ECOLI
A:
[1-544]
M
T
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
------
E
--------
G
H
D
-----
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
-
S
----------
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
---
P
-
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
-
E
T
----------
R
--
G
----------
V
E
I
-----------
L
K
---
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
----
D
-------
E
N
-
G
N
V
E
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
-
D
D
S
L
V
R
Q
L
Y
-
N
A
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
----
G
D
D
Q
L
V
E
I
I
E
V
P
N
--
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
48
HHSearch
77.15
56%
25
- C3 -
-
4ZDK
3
PYRG_MYCTU
B:
[8-550]
A
-
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
QPDADG
N
--------
R
P
D
-----
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
-
S
----------
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
---
R
-
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
-
E
T
----------
T
--
S
G---------
A
A
A
----------
A
L
G
---
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
-
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
----
P
D
G
H
L
V
E
F
V
E
Y
P
P
DR
H
P
--
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
49
HHSearch
76.18
50%
14
- C3 -
-
5U03
4
PYRG1_HUMAN
C:
[1-551]
--
M
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
------
L
I
PVDEDG
L
E
P
Q
-----
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
-
T
----------
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
ERQ
P
-
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
D
L
-
E
P
----------
I
--
T
SQEEPVRYHE
A
W
Q
----------
K
L
C
---
S
A
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
N
------------
P
G
-
Q
M
G
G
T
M
R
L
G
K
R
R
T
L
F
-
Q
T
K
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
E
E
Q
G
L
K
F
V
G
Q
D
----
V
E
G
E
R
M
E
I
V
E
L
E
D
--
H
P
--
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
R
L
----
34
PsiBlast_CBE
73.62
49%
17
- C3 -
-
5U03
4
PYRG1_HUMAN
B:
[2-549]
---
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
------
L
I
P-----
V
D
E
D
GLEPQ
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
-
T
----------
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
ERQ
P
-
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
D
L
-
E
P
----------
I
--
T
----------
S
Q
E
EPVRYHEAWQ
K
L
C
---
S
A
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
-----
N
-------
P
G
-
Q
M
G
G
T
M
R
L
G
K
R
R
T
L
F
-
Q
T
K
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
E
E
Q
G
L
K
F
V
G
Q
D
----
V
E
G
E
R
M
E
I
V
E
L
E
D
--
H
P
--
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
------
32
PsiBlast_CBE
73.56
49%
17
- C3 -
-
5U03
4
PYRG1_HUMAN
D:
[2-549]
---
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
------
L
I
P-----
V
D
E
D
GLEPQ
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
-
T
----------
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
ERQ
P
-
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
D
L
-
E
P
----------
I
--
T
----------
S
Q
E
EPVRYHEAWQ
K
L
C
---
S
A
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
-----
N
-------
P
G
-
Q
M
G
G
T
M
R
L
G
K
R
R
T
L
F
-
Q
T
K
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
E
E
Q
G
L
K
F
V
G
Q
D
----
V
E
G
E
R
M
E
I
V
E
L
E
D
--
H
P
--
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
------
33
PsiBlast_CBE
73.46
49%
17
- C3 -
-
5U03
4
PYRG1_HUMAN
C:
[2-549]
---
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
------
L
I
P-----
V
D
E
D
GLEPQ
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
-
T
----------
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
ERQ
P
-
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
D
L
-
E
P
----------
I
--
T
----------
S
Q
E
EPVRYHEAWQ
K
L
C
---
S
A
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
-----
N
-------
P
G
-
Q
M
G
G
T
M
R
L
G
K
R
R
T
L
F
-
Q
T
K
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
E
E
Q
G
L
K
F
V
G
Q
D
----
V
E
G
E
R
M
E
I
V
E
L
E
D
--
H
P
--
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
------
5
PsiBlast_PDB
73.18
49%
17
- C3 -
-
5U03
4
PYRG1_HUMAN
A:
[2-549]
---
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
------
L
I
P-----
V
D
E
D
GLEPQ
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
-
T
----------
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
E
R
Q
P
-
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
D
L
-
E
P
----------
I
--
T
----------
S
Q
E
E
P
V
R
Y
H
E
A
W
Q
K
L
C
---
S
A
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
-----
N
-------
P
G
-
Q
M
G
G
T
M
R
L
G
K
R
R
T
L
F
-
Q
T
K
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
E
E
Q
G
L
K
F
V
G
Q
D
----
V
E
G
E
R
M
E
I
V
E
L
E
D
--
H
P
--
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
------
8
PsiBlast_PDB
46.76
39%
11
- C3 -
-
5N29
-
?
A:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
A
F
V
G
K
Y
L
Q
D
A
G
D
T
Y
F
S
V
L
Q
C
F
E
H
C
Q
I
A
L
Q
V
R
L
D
I
L
Y
V
D
S
E
E
L
-
E
G
----------
P
--
N
----------
A
D
E
----------
A
R
K
A
L
L
G
C
D
G
I
F
V
P
G
G
F
G
N
R
G
V
D
G
K
C
A
A
A
Q
V
A
R
M
N
N
I
P
Y
F
G
V
-
L
G
M
Q
V
A
V
I
E
L
S
R
N
V
V
G
W
S
D
A
N
S
E
E
F
N
K
E
S
T
H
Q
V
V
R
I
M
D
C
D
R
----
N
----------
K
M
G
A
N
M
H
L
G
A
C
D
V
Y
I
V
E
-
K
S
S
I
M
A
K
I
Y
S
K
S
N
I
V
V
E
R
H
R
H
R
Y
E
V
N
T
A
Y
F
E
D
L
R
K
A
G
L
C
I
S
A
V
T
DPTF
S
S
R
C
R
V
E
A
V
E
N
P
S
--
L
R
--
F
F
L
A
V
Q
F
H
P
E
F
I
S
T
P
M
D
P
A
P
T
Y
L
S
F
M
A
A
A
--------
6
PsiBlast_PDB
46.68
42%
-11
- C3 -
-
2VKT
-
PYRG2_HUMAN
A:
[297-537]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
C
S
I
A
L
V
G
K
Y
-
K
-
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
L
-
E
K
I
T
E
T
E
D
P
V
K
F
H
--
E
----------
A
W
Q
----------
K
L
C
---
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
C
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
--------------------
T
M
R
L
G
I
R
R
T
V
F
-
K
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
----
V
D
G
D
R
M
E
I
I
E
L
A
N
--
H
P
--
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
------------------