@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y281: (2018-01-29 )
MREIDTCIVGATGLVGQTMLKVLEEYDFPVGRLKLLASKRSAGKVCVFKKKKHTVQELTETSFEGYDLALFSAGASVSKEFAPIARSQGLFVIDNSSAWREDSDIPLIVPEVNLEDYTLNRLIANPNCSTIQAVLPLKALQEAFGIQRVNYSTYQAVSGSGQKGIEDLHRTQNDEEPVLYPYNISQTVIPEIDQPLENGYTKEEQKMINETRKILHQPALPVSATCVRVPIENGHGVSVAVQLQKEFTTEEIRECLSQFPGIQLEDDLAAHKYPTSILARGTDMVYVGRIRKDTSLENGLLFYTTADNIRKGAAANAVQIAAALMQKIAEVAR
Atome Classification :
(35 SA)
.........10........20.......--.30........40........50........60........70........80........90........100.......110...---...---.-120--........130.......140.......150.......160...----....170----..-----------------.----------------...-----.180------.-------..-----......190......--.200.........210.......220.......230.......240.......250.......260.......270......-.280.......290....--..--.300.......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRE
I
D
T
C
I
VGAT
G
L
V
G
Q
T
M
L
K
V
L
E
EYDF--
P
V
G
R
L
K
L
L
ASKRSAG
K
V
C
V
F
KKKK
H
T
V
Q
E
L
T
E
TSFEG
Y
D
L
A
L
FSAGA
S
V
S
K
E
F
APIARSQ
G
L
F
V
IDNSSAWREDSDI
P
L
I
V
PEVNLE---D
Y
T
---
L
-
N
R
---
L
IANPNC
S
T
I
Q
A
VL
P
L
K
A
L
Q
E
A
FGIQRVNY
S
T
Y
QAVSGSGQK
G
I
----
E
D
L
H
RTQ----ND-----------------E----------------E
P
V
-----
L
Y--------P-------YN-----ISQTVIPEIDQ
P
L
EN--GY--
T
K
E
E
Q
K
M
I
N
E
T
R
K
I
L
HQPALPVS
A
T
C
V
R
V
PIENGHG
V
S
V
A
V
Q
L
Q
K
EF
T
T
E
E
I
R
E
C
L
S
QFPG
I
Q
LEDDLAAHKY
P
T
S
I
L
-ARGT
D
M
V
Y
V
GRIRKDTSL--EN--
G
L
L
F
Y
TT
A
D
NIRKGAAA
N
A
V
Q
I
A
A
A
L
M
Q
K
I
A
E
VAR
1
PsiBlast_PDB
93.60
45%
-34
- C2 -
-
2QZ9
-
DHAS2_VIBCH
A:
[4-335]
-
Q
Q
F
N
V
A
I
F
G
A
T
G
A
V
G
E
T
M
L
E
V
L
Q
E
R
E
F
--
P
V
D
E
L
F
L
L
A
S
E
R
S
E
G
K
T
Y
R
F
N
G
K
T
V
R
V
Q
N
V
E
E
F
D
W
S
Q
V
H
I
A
L
F
S
A
G
G
E
L
S
A
K
W
A
P
I
A
A
E
A
G
V
V
V
I
D
N
T
S
H
F
R
Y
D
Y
D
I
P
L
V
V
P
E
V
N
P
E
AIA
E
F
R
---
N
-
R
N
---
I
I
A
N
P
N
C
S
T
I
Q
M
L
V
A
L
K
P
I
Y
D
A
V
G
I
E
R
I
N
V
T
T
Y
Q
S
V
S
G
A
G
K
A
G
I
----
D
E
L
A
G
Q
T
----
A
K
L
L
N
G
Y
P
-----------
A
----------------
E
T
N
-----
T
F
--------
S
-------
Q
Q
-----
I
A
F
N
C
I
P
Q
I
D
Q
F
M
D
N
--
G
Y
--
T
K
E
E
M
K
M
V
W
E
T
Q
K
I
F
N
D
P
S
I
M
V
N
P
T
C
V
R
V
P
V
F
Y
G
H
A
E
A
V
H
V
E
T
R
A
P
I
D
A
E
Q
V
M
D
M
L
E
Q
T
D
G
I
E
L
---
F
R
G
A
D
F
P
T
Q
V
R
D
A
G
G
K
D
H
V
L
V
G
R
V
R
N
D
I
S
H
--
H
S
--
G
I
N
L
W
V
V
A
D
N
V
R
K
G
A
A
T
N
A
V
Q
I
A
E
L
L
V
R
-------
2
PsiBlast_PDB
90.23
45%
-61
- C2 -
-
2R00
-
DHAS2_VIBCH
A:
[2-333]
-
Q
Q
F
N
V
A
I
F
G
A
T
G
A
V
G
E
T
M
L
E
V
L
Q
E
R
E
F
--
P
V
D
E
L
F
L
L
A
S
E
R
S
E
G
K
T
Y
R
F
N
G
K
T
V
R
V
Q
N
V
E
E
F
D
W
S
Q
V
H
I
A
L
F
S
A
G
G
E
L
S
A
K
W
A
P
I
A
A
E
A
G
V
V
V
I
D
N
T
S
H
F
R
Y
D
Y
D
I
P
L
V
V
P
E
V
N
P
E
AIA
E
F
R
---
N
-
R
N
---
I
I
A
N
P
N
C
S
T
I
Q
M
L
V
A
L
K
P
I
Y
D
A
V
G
I
E
R
I
N
V
T
T
Y
Q
S
V
S
G
A
G
K
A
G
I
----
D
-------------------------------------------------------------------------------------
P
Q
I
D
Q
F
M
D
N
--
G
Y
--
T
K
E
E
M
K
M
V
W
E
T
Q
K
I
F
N
D
P
S
I
M
V
N
P
T
C
V
R
V
P
V
F
Y
G
H
A
E
A
V
H
V
E
T
R
A
P
I
D
A
E
Q
V
M
D
M
L
E
Q
T
D
G
I
E
L
---
F
R
G
A
D
F
P
T
Q
V
R
D
A
G
G
K
D
H
V
L
V
G
R
V
R
N
D
I
S
H
--
H
S
--
G
I
N
L
W
V
V
A
D
N
V
R
K
G
A
A
T
N
A
V
Q
I
A
E
L
L
V
R
-------
40
PsiBlast_CBE
89.41
43%
-31
- C2 -
-
2GZ3
2
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
23
PsiBlast_CBE
88.46
43%
-31
* C2 *
-
4R51
7
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
25
PsiBlast_CBE
88.20
43%
-31
- C2 -
-
4R41
7
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
27
PsiBlast_CBE
87.92
43%
-31
- C2 -
-
4R3N
7
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
18
PsiBlast_PDB
87.85
43%
-30
- C2 -
-
4R51
9
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
39
PsiBlast_CBE
87.76
43%
-31
- C2 -
-
2GZ3
2
?
C:
[6-346]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
91
HHSearch
87.74
44%
-34
- C2 -
-
4R3N
4
?
A:
[2-346]
--
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
A
--
H
-
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
----
L
E
T
Q
R
E
L
----
R
E
V
----------------
L
NDGVKPCD
L
H
A
E
I
LPS
G
G
D
-----
K
K
--------
H
-------
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
----
14
PsiBlast_PDB
87.69
43%
-30
- C2 -
-
4R3N
4
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
15
PsiBlast_PDB
87.64
43%
-29
- C2 -
-
4R3W
6
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
90
HHSearch
87.57
44%
-34
- C2 -
-
3PYL
1
?
C:
[2-346]
--
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
A--
H
-
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
----
L
E
T
Q
R
E
L
----
R
E
V----------------
L
NDGVKPCDLHAEILPS
G
G
D
-----
K
K
--------
H
-------
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
----
7
PsiBlast_PDB
87.51
43%
-30
- C2 -
-
3PWK
7
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
22
PsiBlast_CBE
87.46
43%
-31
- C2 -
-
4R54
2
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
26
PsiBlast_CBE
87.37
43%
-30
- C2 -
-
4R3W
6
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
38
PsiBlast_CBE
87.36
43%
-32
- C2 -
-
2GZ3
3
?
D:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
9
PsiBlast_PDB
87.32
43%
-34
- C2 -
-
3PYL
1
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
21
PsiBlast_CBE
87.30
43%
-30
- C2 -
-
4R5H
6
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
16
PsiBlast_PDB
87.14
43%
-31
- C2 -
-
4R41
8
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
31
PsiBlast_CBE
87.02
43%
-31
- C2 -
-
3Q11
5
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
10
PsiBlast_PDB
87.00
43%
-30
- C2 -
-
3PYX
5
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
24
PsiBlast_CBE
86.99
43%
-30
- C2 -
-
4R4J
7
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
37
PsiBlast_CBE
86.98
43%
-29
- C2 -
-
3PWK
7
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
8
PsiBlast_PDB
86.82
43%
-30
- C2 -
-
3PWS
2
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
33
PsiBlast_CBE
86.67
43%
-29
- C2 -
-
3PYX
6
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
36
PsiBlast_CBE
86.49
43%
-28
- C2 -
-
3PWS
2
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
17
PsiBlast_PDB
86.40
43%
-29
- C2 -
-
4R4J
5
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
32
PsiBlast_CBE
86.30
43%
-28
- C2 -
-
3PZB
5
?
B:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
LETQ
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
DLHAE
I
L
--------
P
SGGDKKH
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
12
PsiBlast_PDB
86.25
43%
-32
- C2 -
-
3Q11
5
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
11
PsiBlast_PDB
86.25
43%
-32
- C2 -
-
3PZB
5
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
19
PsiBlast_PDB
86.14
43%
-29
- C2 -
-
4R54
2
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
20
PsiBlast_PDB
86.02
43%
-29
- C2 -
-
4R5H
7
?
A:
[6-344]
------
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
---
A
L
D
---
A
H
N
G
---
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
----
N
D
-----------------
G
V---------------
K
P
C
D
L
H
A
E
I
L
--------
P
SGGDK
K
H
Y
P
-----
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
-
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
------
44
PsiBlast_CBE
81.94
40%
-15
- C2 -
-
3VOS
3
DHAS_MYCTU
A:
[24-359]
-------
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
--
P
A
S
A
V
R
F
F
A
S
A
R
----
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
---
R
D
A
---
H
-
R
R
PKG
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
----
A
E
L
A
E
Q
A
R
A
V
I
G
G
-----------------
A
----------------
E
Q
L
-----
V
Y
DGGALEFP
P
-------
P
N
TYVAP
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
--
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
-
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
--
P
D
GR
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
--------
43
PsiBlast_CBE
79.59
40%
-11
- C2 -
-
3TZ6
4
DHAS_MYCTU
A:
[6-342]
-------
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
--
P
A
S
A
V
R
F
F
A
S
A
R
S
Q
G
R
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
---
R
D
A
---
H
-
R
R
PKG
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
----
A
E
L
A
E
Q
A
R
A
V
I
G
G
-----------------
A
----------------
E
Q
L
-----
V
Y
DGGALEFP
P
-------
P
N
TYVAP
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
--
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
-
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
--
P
D
GR
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
-------
86
HHSearch
77.76
42%
4
- C2 -
-
3TZ6
4
DHAS_MYCTU
A:
[1-342]
--
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
--
R
DF
P
A
S
A
V
R
F
F
A
S
A
R
S
Q
G
R
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
---
R
D
A
HRR
P
-
K
G
---
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
----
A
E
L
A
E
Q
A
----
R
A
V
IGGAEQLVYDGGALEF
P
----------------
P
P
N
-----
T
Y
--------
V
-------
A
P
-----
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
GS
G
E
--
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
-
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
PD
G
R
--
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
-------