@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y285: (2018-01-29 )
MEKIKVVIVGASHGGHQSILELLTRYGENVDITLFEAGDYISFMSCGMELYLEDKVTDVNDVRNFRPENFPQSNVHILNNHEVKTIDADKKTVTVTSASDNETKEYPYDKLILSSGVKPNNLPVPGADLENVYLMRGYNWATKIKEKLNDPAIKKIAVVGAGYIGIEAAEASRKAGKEVVLLDVIDRPLGTYLDAEMTDILEQHLNENGIEVLTNAKIEAFTGNGKVEAIKTSEKEIPADLVIQAAGVKANTEWLKGIVDLDERGWIQTNEYLQTNLPDVYAVGDATLAYSIPARKKMPIALATVARREARYVVKHLFEEVPNKPFGGVVGSSALSVFDYHFAASGLNSFTAAKAGVDVRVSYYEDTLRPKYVPEEQGNPKVSIQLFSDPMTHQLLGGAVLSTYDVTGQGNVLALAIQNKLTLEELAEADFFFQPGFDRQWSMLNLAAQQALGEEPFVE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70-........80........90........100.......110.......120......-----------.-130.......140.......150.......160.......170.......180.......190.......200.......210.......220...--------------------....230.......240.......250.....-..260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360........370.......380.......390.......400.......410.......420.......430.......440.......450.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
K
I
K
V
V
I
V
GASHG
G
H
Q
S
I
L
E
L
L
T
RYGENV
D
I
T
L
FEAG
D
Y
I
S
F
M
SCG
M
E
L
Y
L
EDKVT
D
V
N
D
V
RNFRPENFP-QS
N
V
H
I
LNNH
E
V
K
T
IDADK
K
T
V
T
V
T
SASDNETKEYPY
D
K
L
I
L
SSGVKPNNLPVPGAD-----------L-
E
N
V
Y
L
MRGY
N
W
A
T
K
I
K
E
KLNDPA
I
K
K
I
A
V
V
GA
G
Y
I
G
I
E
A
A
E
A
S
R
KAG
K
E
V
V
L
L
DVIDR
P
L
G
T
Y
L
D
A
E
M
T
D
I
L
E
Q
H
LNENG
I
E
V
L
TN
A
K
I
E
A
F
TGNG--------------------
K
V
E
A
I
KTSEKEI
P
A
D
L
V
I
Q
AAGVKA
N
T
E
W
L
K
G
-
I
VDLDERGWIQT
N
E
Y
L
QTNLP
D
V
Y
AVGD
A
T
L
A
Y
SIPARKKMP
I
A
L
A
T
V
A
R
R
E
A
R
Y
V
V
K
H
L
F
E
EVPNKPFGGVV
G
S
S
A
L
S
V
F
D
Y
H
F
A
ASGL
N
S
F
TAAKA
G
V
D
V
R
-
V
S
Y
Y
EDTLRPKYVPEEQGN
P
K
V
S
I
Q
LFSDP
M
T
H
Q
LLG
G
A
V
L
S
T
Y
DVTGQG
N
V
L
A
L
A
IQNKL
T
L
E
E
L
AEA
D
F
F
FQPGFDR
Q
W
S
M
L
N
L
A
A
Q
Q
ALGEEPFVE
52
HHSearch
97.83
46%
-106
- C1 -
-
1NHP
1
NAPE_ENTFA
A:
[1-445]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
A
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
--
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
-
A
V
T
V
V
E
D
Y
L
M
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
-----
7
PsiBlast_PDB
96.59
46%
-87
- C1 -
-
1NHS
2
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
C
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
5
PsiBlast_PDB
95.13
46%
-83
- C1 -
-
1NPX
2
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
2
PsiBlast_PDB
94.97
46%
-85
- C1 -
-
1NHP
1
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
A
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
53
HHSearch
94.63
46%
-101
- C1 -
-
1JOA
1
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
--
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
-
A
V
T
V
V
E
D
Y
L
M
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
3
PsiBlast_PDB
94.30
46%
-85
- C1 -
-
1NHQ
1
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
S
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
6
PsiBlast_PDB
94.24
46%
-85
- C1 -
-
2NPX
3
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
1
PsiBlast_PDB
93.80
46%
-85
- C1 -
-
1NHR
1
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
C
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
4
PsiBlast_PDB
91.81
46%
-82
- C1 -
-
1JOA
1
NAPE_ENTFA
A:
[1-446]
---
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
-
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
V
R
Y
M
T
G
E
K
M
E
-
S
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
G
E
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
-----------
L
-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
G
--------------------
R
V
Q
K
V
V
T
D
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
--
E
E
P
V
K
P
F
P
G
V
Q
G
S
S
G
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
D
Y
L
M
-
D
F
N
P
D
K
Q
---
K
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
S
K
A
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
----
38
HHSearch
87.82
36%
-110
* C1 *
-
5ER0
9
?
B:
[50-494]
--
S
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
-
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
Q
-
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
T
V
T
V
E
D
L
T
N
H
A
Q
T
T
E
S
Y
D
K
L
V
M
T
S
G
S
W
P
I
V
P
K
I
P
G
I
D
-----------
S
-
D
R
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
K
E
--
A
K
R
I
T
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
S
T
T
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
K
Y
F
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
A
L
G
E
T
V
E
S
F
T
D
S
A
--------------------
T
G
L
T
I
K
T
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
P
--
T
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
-
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
---
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
K
Y
D
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
L
A
Q
A
A
Q
A
K
V
----
22
PsiBlast_CBE
84.44
35%
-109
- C1 -
-
5ER0
9
?
C:
[51-485]
---
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
-
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
Q
-
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
T
V
T
V
E
D
L
T
N
H
A
Q
T
T
E
S
Y
D
K
L
V
M
T
S
G
S
W
P
I
V
P
K
I
P
G
I
D
-----------
S
-
D
R
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
K
E
A
--
K
R
I
T
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
S
T
T
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
K
Y
F
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
A
L
G
E
T
V
E
S
F
T
D
S
A
--------------------
T
G
L
T
I
K
T
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
--
P
T
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
-
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
---
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
K
Y
D
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
-------------
8
PsiBlast_PDB
83.80
35%
-110
- C1 -
-
5ER0
9
?
A:
[51-485]
---
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
-
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
Q
-
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
T
V
T
V
E
D
L
T
N
H
A
Q
T
T
E
S
Y
D
K
L
V
M
T
S
G
S
W
P
I
V
P
K
I
P
G
I
D
-----------
S
-
D
R
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
K
E
A
--
K
R
I
T
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
S
T
T
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
K
Y
F
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
A
L
G
E
T
V
E
S
F
T
D
S
A
--------------------
T
G
L
T
I
K
T
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
--
P
T
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
-
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
---
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
K
Y
D
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
-------------
23
PsiBlast_CBE
83.78
35%
-110
- C1 -
-
5ER0
9
?
B:
[51-485]
---
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
-
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
Q
-
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
T
V
T
V
E
D
L
T
N
H
A
Q
T
T
E
S
Y
D
K
L
V
M
T
S
G
S
W
P
I
V
P
K
I
P
G
I
D
-----------
S
-
D
R
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
K
E
A
--
K
R
I
T
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
S
T
T
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
K
Y
F
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
A
L
G
E
T
V
E
S
F
T
D
S
A
--------------------
T
G
L
T
I
K
T
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
--
P
T
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
-
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
---
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
K
Y
D
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
-------------
21
PsiBlast_CBE
83.52
35%
-111
- C1 -
-
5ER0
8
?
D:
[51-485]
---
M
K
V
T
V
V
G
C
T
H
A
G
T
F
A
I
K
Q
I
L
A
E
H
-
P
D
A
E
V
T
V
Y
E
R
N
D
V
I
S
F
L
S
C
G
I
A
L
Y
L
G
G
K
V
A
D
P
Q
G
L
F
Y
S
S
P
E
E
L
Q
-
K
L
G
A
N
V
Q
M
N
H
N
V
L
A
I
D
P
D
Q
K
T
V
T
V
E
D
L
T
N
H
A
Q
T
T
E
S
Y
D
K
L
V
M
T
S
G
S
W
P
I
V
P
K
I
P
G
I
D
-----------
S
-
D
R
V
K
L
C
K
N
W
A
H
A
Q
A
L
I
E
D
A
K
E
A
--
K
R
I
T
V
I
G
A
G
Y
I
G
A
E
L
A
E
A
Y
S
T
T
G
H
D
V
T
L
I
D
A
M
A
R
V
M
P
K
Y
F
D
A
D
F
T
D
V
I
E
Q
D
Y
R
D
H
G
V
Q
L
A
L
G
E
T
V
E
S
F
T
D
S
A
--------------------
T
G
L
T
I
K
T
D
K
N
S
Y
E
T
D
L
A
I
L
C
I
G
F
R
P
N
T
D
L
L
K
G
-
K
V
D
M
A
P
N
G
A
I
I
T
D
D
Y
M
R
S
S
N
P
D
I
F
A
A
G
D
S
A
A
V
H
Y
N
P
T
H
Q
N
A
Y
I
P
L
A
T
N
A
V
R
Q
G
I
L
V
G
K
N
L
V
K
--
P
T
V
K
Y
M
G
T
Q
S
S
S
G
L
A
L
Y
D
R
T
I
V
S
T
G
L
T
L
A
A
A
K
Q
Q
G
L
N
A
E
-
Q
V
I
V
E
D
N
Y
R
P
E
F
M
P
S
T
E
---
P
V
L
M
S
L
V
F
D
P
D
T
H
R
I
L
G
G
A
L
M
S
K
Y
D
V
S
Q
S
A
N
T
L
S
V
C
I
Q
N
E
N
T
I
D
D
L
A
M
V
D
M
L
F
Q
P
N
F
D
R
P
F
N
Y
L
N
I
-------------
24
PsiBlast_CBE
71.87
34%
-19
- C1 -
-
2BCP
2
NAOX_STRP6
B:
[37-488]
----
K
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
L
F
Y
S
D
K
E
E
L
E
-
S
L
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
V
D
G
K
N
H
V
E
--
T
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
K
G
A
E
IKEGSLEFEAT
L
-
E
N
L
Q
F
V
K
L
Y
Q
N
S
A
D
V
I
A
K
L
E
N
K
D
I
K
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
G
I
Q
L
A
F
G
E
T
V
K
E
V
A
G
N
G
--------------------
K
V
E
K
I
I
T
D
K
N
E
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
-
I
V
A
A
H
N
A
C
G
T
D
L
E
G
I
-
G
V
Q
G
S
N
G
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
E
K
A
K
R
L
G
F
D
A
A
-
V
T
E
Y
T
D
N
Q
K
P
E
F
I
--
E
H
G
N
F
P
V
T
I
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
A
R
E
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
--------
9
PsiBlast_PDB
71.12
34%
-18
- C1 -
-
2BC1
2
NAOX_STRP6
A:
[37-488]
----
K
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
L
F
Y
S
D
K
E
E
L
E
-
S
L
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
V
D
G
K
N
H
V
E
--
T
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
K
G
A
E
IKEGSLEFEAT
L
-
E
N
L
Q
F
V
K
L
Y
Q
N
S
A
D
V
I
A
K
L
E
N
K
D
I
K
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
G
I
Q
L
A
F
G
E
T
V
K
E
V
A
G
N
G
--------------------
K
V
E
K
I
I
T
D
K
N
E
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
-
I
V
A
A
H
N
A
C
G
T
D
L
E
G
I
-
G
V
Q
G
S
N
G
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
E
K
A
K
R
L
G
F
D
A
A
-
V
T
E
Y
T
D
N
Q
K
P
E
F
I
--
E
H
G
N
F
P
V
T
I
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
A
R
E
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
--------
25
PsiBlast_CBE
71.02
34%
-21
- C1 -
-
2BC1
2
NAOX_STRP6
B:
[37-488]
----
K
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
L
F
Y
S
D
K
E
E
L
E
-
S
L
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
V
D
G
K
N
H
V
E
--
T
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
K
G
A
E
IKEGSLEFEAT
L
-
E
N
L
Q
F
V
K
L
Y
Q
N
S
A
D
V
I
A
K
L
E
N
K
D
I
K
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
G
I
Q
L
A
F
G
E
T
V
K
E
V
A
G
N
G
--------------------
K
V
E
K
I
I
T
D
K
N
E
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
-
I
V
A
A
H
N
A
C
G
T
D
L
E
G
I
-
G
V
Q
G
S
N
G
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
E
K
A
K
R
L
G
F
D
A
A
-
V
T
E
Y
T
D
N
Q
K
P
E
F
I
--
E
H
G
N
F
P
V
T
I
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
A
R
E
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
--------
10
PsiBlast_PDB
70.00
34%
-21
- C1 -
-
2BCP
2
NAOX_STRP6
A:
[37-488]
----
K
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
L
F
Y
S
D
K
E
E
L
E
-
S
L
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
V
D
G
K
N
H
V
E
--
T
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
K
G
A
E
IKEGSLEFEAT
L
-
E
N
L
Q
F
V
K
L
Y
Q
N
S
A
D
V
I
A
K
L
E
N
K
D
I
K
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
G
I
Q
L
A
F
G
E
T
V
K
E
V
A
G
N
G
--------------------
K
V
E
K
I
I
T
D
K
N
E
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
-
I
V
A
A
H
N
A
C
G
T
D
L
E
G
I
-
G
V
Q
G
S
N
G
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
E
K
A
K
R
L
G
F
D
A
A
-
V
T
E
Y
T
D
N
Q
K
P
E
F
I
--
E
H
G
N
F
P
V
T
I
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
A
R
E
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
--------
47
HHSearch
63.97
26%
-8
- C1 -
-
3NTD
4
?
A:
[1-467]
--
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
-
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
L
L
D
G
S
E
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
P
I
P
G
V
D
-----------
N
-
P
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
M
N
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
L
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
P
-
V
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
L
T
L
S
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
--
E
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
-
K
V
Y
V
H
T
A
S
H
A
S
Y
Y
P
G
A
E
---
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
K
D
G
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
-----
51
HHSearch
63.89
28%
-1
- C1 -
-
3ICT
4
?
A:
[35-483]
-
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
-
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
N
V
T
T
N
E
T
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
I
P
G
I
E
-----------
E
A
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
R
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
P
-
I
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
G
---------------------
A
V
V
R
L
K
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
-
D
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
-
V
V
H
V
Q
A
N
S
H
A
G
Y
Y
P
N
A
T
---
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
R
D
G
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
-----