@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y289: (2018-01-29 )
MWANQNPVFVYEKEPSRDILCIDCKSFYASVECVEKDLDPLTTKLVVMSYPSDSTETRGSGLILASSPAAKKAYGITNISRARDLPFPYPSDLYIVAPRMAYYMEKNREINSIYKKYADEANHHVYSVDESFLDVTNSMALFGKTNAYDMAKLIHKDVFEQTGIYTTIGIGDNPLLAKLALDNGSKDGKQMFAEWRYEDVPEKLWKISDITDFWGIGKRTAKRLKQMGIHSVYDLAHADYYHLKSKLGVIGTQLYAHAWGIDRSFLGQEYTPKSKSIGNSQILDRDYTRREEIEIVIKEMADQVGTRLRRSAAKTQVVSLWVGYSLGYLDPNGKTGFHQQMKIEATNASRDLADALLTIFHQHYHYQDIRRVGVNCSDLVYATGLQLNLFEDPEKQINEAKVDFVVDTIRKKYGFQSIIHAHSLLQGGRAIARSSLVGGHAGGMSGLEGGKDETDSKKIH
Atome Classification :
(20 SA)
.........10........20........30........40.........50........60........70.....---...80........90......-------..100.......110.......120.......130.......140----..--------------.---------------------------------------.....150.......160.......170.......180.......190.......200.......210.......220.-......230.......240.......-250.......260.......270........280....--...290.......300......-.310---.--.......320.......330.......340...-....350.......360.-------..--....370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MWANQN
P
V
F
V
YEKEPSR
D
I
L
C
I
D
C
K
S
F
Y
A
S
V
E
C
V
E
KDLDP-L
T
T
K
L
V
V
M
SYPSDSTETRGS
G
L
I
L
ASSPAAKKAYGI---TNISRARDLPFPYPS
D
L
Y
I
VA-------
P
R
M
A
Y
Y
M
E
KNR
E
I
N
S
I
Y
K
K
Y
A
DEAN
H
H
V
YSV
D
E
S
F
L
D
V
T
NS
M
A
L
-----FG--------------K---------------------------------------T
N
A
Y
D
M
A
K
L
I
H
K
D
V
F
E
QTG
I
Y
T
T
IGIGDN
P
L
L
A
K
L
ALDNGSK
D
G
K
Q
M
F
A
E
W
R
Y
E
D
V
P
E
K
L
W
KISD
I
T
D
F
W
G
I
G
K
R
T
A
K
R
-
L
K
Q
MG
I
H
S
V
Y
D
L
A
H
A
D
Y
Y
H
L
K
S
K
L
G
V
-
I
G
T
Q
L
Y
A
H
AWGI
D
R
S
F
LGQEY-TPKSKSIGNSQILDRD--YT
R
R
E
E
I
E
I
V
I
K
E
M
A
D
Q
V
G
T
R
L
-
R
R
S
----A--AK
T
Q
V
V
S
L
W
V
G
Y
S
LGYLDPNGKTGF
H
Q
Q
M
K
I
E
A-TNAS
R
D
L
A
D
A
L
L
T
I
F
H
QH-------Y
H
--
Y
Q
D
I
R
R
VGV
N
C
S
D
L
V
Y
ATG
L
Q
L
N
LFE
D
P
E
K
Q
I
N
E
A
K
V
D
F
V
V
D
T
I
R
K
KY
G
F
Q
S
I
I
H
A
H
S
L
L
QG
G
R
A
I
A
R
SSLVGGHAGGMSGLEGGKDETDSKKIH
34
HHSearch
80.45
23%
-94
- C1 -
-
5C5J
5
?
A:
[2-342]
---------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
-
P
A
L
-
R
D
I
P
I
A
I
G
G
S
R
E
R
-----
R
-
G
V
I
S
T
A
N
Y
P
A
R
K
-
F
G
V
---
R
S
A
M
P
T
G
M
A
L
K
L
C
P
-
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
--
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-----
H
G
--------------
S
-----------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
---
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
-
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
-
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
---
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
-
A
K
V
----
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
-------
Q
T
T
Q
E
H
V
W
P
--
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
-------
R
G
--
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-------------------------------------------------------------------------------
33
HHSearch
79.91
22%
-102
* C1 *
-
4IRD
5
DPO4_ECOLI
A:
[2-342]
---------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
-
P
A
L
-
R
D
I
P
I
A
I
G
G
S
R
E
R
-----
R
-
G
V
I
S
T
A
N
Y
P
A
R
K
-
F
G
V
---
R
S
A
M
P
T
G
M
A
L
A
L
C
P
-
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
--
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-----
H
G
--------------
S
-----------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
---
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
-
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
-
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
---
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
-
A
K
V
----
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
-------
Q
T
T
Q
E
H
V
W
P
--
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
-------
R
G
--
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-------------------------------------------------------------------------------
47
HHSearch
76.85
20%
-26
- C1 -
-
4ED6
4
POLH_HUMAN
A:
[6-434]
------------
T
G
Q
D
R
V
V
A
L
V
D
M
D
C
F
F
V
Q
V
E
Q
R
Q
N
-
P
H
L
-
R
N
K
P
C
A
V
V
Q
Y
K
S
W
----
K
G
-
G
G
I
I
A
V
S
Y
E
A
R
A
-
F
G
V
---
T
R
S
M
W
A
D
D
A
K
K
L
C
P
-
D
L
L
L
A
Q
V
R
ESRGK
A
N
L
T
K
Y
R
E
A
S
V
E
V
M
E
I
M
S
R
F
A
---
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
T
S
A
V
Q
E
R
L
Q
K
L
Q
G
Q
P
I
S
ADLLPS
T
Y
I
E
G
LPQGPEETVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
V
-
G
A
V
I
V
E
E
M
R
A
A
I
E
R
E
T
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
P
---
N
R
Q
T
L
V
S
H
G
S
V
P
Q
L
F
S
Q
-
M
P
I
R
K
I
R
S
L
G
G
K
L
G
A
S
V
I
E
I
L
G
I
E
Y
M
G
E
L
T
Q
F
T
E
S
Q
L
Q
S
H
F
G
E
K
N
G
S
W
L
Y
A
M
C
R
G
I
E
H
D
P
V
K
P
R
---
Q
L
P
K
T
I
G
C
S
K
N
F
P
G
K
TA
L
A
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
E
E
R
L
-
T
K
D
R
N
D
N
D
--
R
V
A
T
Q
L
V
V
S
I
R
V
Q
G
D
K
R
L
----
S
S
L
R
R
C
C
A
L
T
--
R
Y
D
A
H
K
M
S
H
D
A
F
T
V
I
K
N
C
NTSGIQT
E
W
--
S
P
P
L
T
M
L
F
L
C
A
T
K
F
S
A
-------------------------------------------------------------------------------
10
PsiBlast_PDB
75.24
26%
-6
- C1 -
-
1JXL
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
20
PsiBlast_PDB
74.97
26%
-5
- C1 -
-
1S9F
4
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
48
HHSearch
74.80
20%
-33
- C1 -
-
5KFZ
7
POLH_HUMAN
A:
[6-434]
------------
T
G
Q
D
R
V
V
A
L
V
D
M
D
C
F
F
V
Q
V
E
Q
R
Q
N
-
P
H
L
-
R
N
K
P
C
A
V
V
Q
Y
K
S
W
----
K
G
-
G
G
I
I
A
V
S
Y
E
A
R
A
-
F
G
V
---
T
R
S
M
W
A
D
D
A
K
K
L
C
P
-
D
L
L
L
A
Q
V
R
ESRGK
A
N
L
T
K
Y
R
E
A
S
V
E
V
M
E
I
M
S
R
F
A
---
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
T
S
A
V
Q
E
R
L
Q
K
L
Q
G
Q
P
I
S
ADLLPS
T
Y
I
E
G
LPQGPTVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
--
V
-
G
A
V
I
V
E
E
M
R
A
A
I
E
R
E
T
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
P
---
N
R
Q
T
L
V
S
H
G
S
V
P
Q
L
F
S
Q
-
M
P
I
R
K
I
R
S
L
G
G
K
L
G
A
S
V
I
E
I
L
G
I
E
Y
M
G
E
L
T
Q
F
T
E
S
Q
L
Q
S
H
F
G
E
K
N
G
S
W
L
Y
A
M
C
R
G
I
E
H
D
P
V
K
P
R
---
Q
L
P
K
T
I
G
C
S
K
N
F
P
G
K
TA
L
A
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
E
E
R
L
-
T
K
D
R
N
D
N
D
--
R
V
A
T
Q
L
V
V
S
I
R
V
Q
G
D
K
R
L
----
S
S
L
R
R
C
C
A
L
T
--
R
Y
D
A
H
K
M
S
H
D
A
F
T
V
I
K
N
C
NTSGIQT
E
W
--
S
P
P
L
T
M
L
F
L
C
A
T
K
F
S
A
-------------------------------------------------------------------------------
13
PsiBlast_PDB
74.33
26%
-4
- C1 -
-
1RYR
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
17
PsiBlast_PDB
73.63
26%
-6
- C1 -
-
1S0O
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
18
PsiBlast_PDB
73.62
26%
-5
- C1 -
-
1S10
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
3
PsiBlast_PDB
73.36
26%
-7
- C1 -
-
2ASD
4
DPO4_SULSO
A:
[11-349]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
5
PsiBlast_PDB
73.30
26%
-6
- C1 -
-
2ASL
2
DPO4_SULSO
A:
[11-349]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
12
PsiBlast_PDB
73.27
26%
-5
- C1 -
-
1N56
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
8
PsiBlast_PDB
73.13
26%
-6
- C1 -
-
3QZ7
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
9
PsiBlast_PDB
73.09
26%
-3
- C1 -
-
3QZ8
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
14
PsiBlast_PDB
73.04
26%
-4
- C1 -
-
1RYS
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
4
PsiBlast_PDB
72.56
26%
-9
- C1 -
-
2ASJ
2
DPO4_SULSO
A:
[11-349]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
7
PsiBlast_PDB
72.14
26%
-6
- C1 -
-
2AU0
2
DPO4_SULSO
A:
[11-349]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
16
PsiBlast_PDB
72.06
26%
-6
- C1 -
-
1S0N
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
37
HHSearch
72.01
21%
-85
- C1 -
-
3RAX
3
DPO4_SULSO
B:
[1-341]
----------------
G
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
-
P
S
L
-
K
G
K
P
V
V
V
C
V
F
S
G
R
F
--
E
D
S
-
G
A
V
A
T
A
N
Y
E
A
R
K
-
F
G
V
---
K
A
G
I
P
I
V
E
A
K
K
I
L
P
-
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
R
--------------
E
-----------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
---
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
-
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
----
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
-
D
K
R
----
I
----
P
K
A
I
H
V
V
A
V
T
E
D
L
D
-------
I
V
S
R
G
R
T
F
P
H
G
I
S
-
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-------
L
E
ED
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------
19
PsiBlast_PDB
71.98
26%
-8
- C1 -
-
1S97
3
DPO4_SULSO
A:
[3-341]
------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
---
V
A
T
A
N
Y
E
A
R
K
F
G
V
KAG
I
P
I
V
E
A
K
K
I
---
L
P
N
A
V
Y
L
-
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
--
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-------------------------------------------------------
R
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
---
E
E
V
-
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
-
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
--
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
---
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
-
Y
S
E
S
V
K
L
L
Q
K
I
L
-----
E
-------
E
D
--
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------------------------