@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2A2: (2018-01-29 )
MTLKEEIIQESKRLGIDKIGFTTAEPFDSLKESLEEQKAAGHTSGFEHPNIDERLYPEMTFDQPKSIISIALAYPTRIHEEVPRDEKRGQFARASWGIDYHDILRDRLNRLIEFIQTRAEKWQKEEEWRLAPQVDTGELIDVAVAQRAGLGFIGRNGLLITEEFGSFVYLGEIVTNIVFEPDKPGEFGCGDCMRCVTACPTKALLGDGRMNAQRCLSYQTQTKGMMPEEYRKKMRNVIYGCDICQLVCPYNQGKDFHFHEEMEPKVDEIYPKLKPMLSMSNKDFKQQFGHLAGSWRGKKPLQRNALIALANLGDRTALPEISECLTDVRPVIRGTAAWAIGRLGTKEPEKWLDVLDEILAKETEEVVINELEHAQKLLRRKLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80-..--..-..-...90........100.......110.......120.......130.--......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...-.-...330.......340.......350.......360.-......370.......380.-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
L
K
E
E
I
I
Q
E
S
K
RLGIDKIGFTTAE
P
F
D
S
L
K
E
S
L
E
E
Q
K
AAGHTSGFEHPNI
D
E
R
LYPEMTFDQP
K
S
I
I
S
I
A
LAY
P
T
R
I
H
E
--EV--P
R
-
D
E
-KRGQFARASWGI
D
Y
H
D
I
L
R
D
R
L
N
R
L
I
E
F
I
Q
T
R
A
E
KW
Q
K
E
E
EWRLAPQ--VDT
G
E
L
I
D
V
A
V
A
Q
RAGLGFIGRN
G
L
L
I
T
E
EFG
S
F
V
Y
L
G
E
I
V
T
N
I
V
FEPDKPGEF
G
C
G
D
C
M
R
C
V
T
ACP
T
K
A
LLGDGRM
N
A
Q
R
C
L
S
Y
Q
TQTKGMM
P
E
E
Y
R
K
K
M
R
N
V
IYGC
D
I
C
Q
LVCPYNQGKDFH
F
H
EEMEP
K
V
D
E
I
Y
P
K
L
K
P
M
L
SMS
N
K
D
F
K
Q
Q
F
G
H
L
AGSWRGKKPLQRN
A
L
I
A
LANLGDRTA
L
P
E
I
S
E
C
L
-
T
-
D
V
R
P
V
I
RGT
A
A
W
AIGRLGTK
E
P
E
K
W
L
D
V
L
D
E
I
L
A
K
E
T
-
E
E
V
V
I
N
E
L
E
H
A
Q
K
L
L
R
R
KLK-
52
Fugue
78.95
49%
2
- C4 -
-
5D6S
3
?
A:
[28-399]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
------
N
F
E
Y
K
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
----
L
D
I
D
P
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
-
D
K
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
R
G
L
S
P
K
D
-------
E
H
S
Q
A
E
W
E
L
V
C
A
K
W
Q
I
32
HHSearch
78.19
53%
10
- C4 -
-
5D08
4
QUEG_BACSU
A:
[32-405]
Y
Q
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
--
A
P
R
S
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
--
K
------
H
E
D
I
R
T
K
S
M
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
-
H
K
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
D
P
A
---
Y
A
E
E
L
E
K
-
A
L
E
K
E
K
D
E
E
A
K
L
E
I
E
K
G
I
E
L
L
K
A
----
30
HHSearch
77.92
49%
-2
- C4 -
-
5D6S
3
?
B:
[28-398]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
T
E
F
-
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
------
N
F
E
Y
K
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
-
D
K
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
---
D
E
G
M
L
D
Y
M
R
G
L
S
P
K
D
E
H
S
Q
A
E
W
E
L
V
C
A
K
W
Q
-----
5
PsiBlast_PDB
77.75
50%
-4
- C4 -
-
5D6S
3
?
A:
[28-376]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
N
F
E
Y
K
------
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
D
K
-
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
------------------------------
29
PsiBlast_CBE
77.56
50%
-4
- C4 -
-
5D6S
3
?
B:
[28-376]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
N
F
E
Y
K
------
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
D
K
-
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
------------------------------
27
PsiBlast_CBE
77.33
50%
-3
- C4 -
-
5D6S
3
?
D:
[28-376]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
N
F
E
Y
K
------
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
D
K
-
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
------------------------------
26
PsiBlast_CBE
77.31
50%
-3
- C4 -
-
5D6S
3
?
E:
[28-376]
M
N
I
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
N
F
E
Y
K
------
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
D
K
-
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
------------------------------
31
HHSearch
77.14
53%
11
* C4 *
-
5D08
4
QUEG_BACSU
B:
[32-404]
Y
Q
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
--
A
P
RS
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
--
K
------
H
E
D
I
R
T
K
SM
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
-
H
K
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
D
P
A
---
Y
A
E
E
L
E
K
-
A
L
E
K
E
K
D
E
E
A
K
L
E
I
E
K
G
I
E
L
L
K
-----
28
PsiBlast_CBE
76.51
50%
-3
- C4 -
-
5D6S
3
?
C:
[31-376]
---
K
L
E
I
Q
K
M
A
K
E
I
G
I
S
K
I
G
F
T
T
A
D
D
F
D
Y
L
E
K
S
L
R
L
G
V
E
E
G
R
T
T
G
F
E
H
K
N
I
E
E
R
I
Y
P
K
L
S
L
E
S
A
K
T
I
I
S
I
A
V
A
Y
P
H
K
L
P
Q
--
Q
P
--
Q
K
-
T
E
F
K
R
G
K
I
T
P
N
S
W
G
L
D
Y
H
Y
V
L
Q
D
K
L
K
R
L
A
K
G
I
E
K
L
T
E
N
F
E
Y
K
------
G
M
--
V
D
T
G
A
L
V
D
T
A
V
A
K
R
A
G
I
G
F
I
G
K
N
G
L
V
I
S
K
E
Y
G
S
Y
M
Y
L
G
E
L
I
T
N
L
E
I
E
P
D
Q
E
V
D
Y
G
C
G
D
C
R
R
C
L
D
A
C
P
T
S
C
L
I
G
D
G
T
M
N
A
R
R
C
L
S
F
Q
T
Q
D
K
G
M
M
D
M
E
F
R
K
K
I
K
T
V
I
Y
G
C
D
I
C
Q
I
S
C
P
Y
N
R
G
I
D
N
P
L
--
D
I
D
P
--
D
L
A
M
P
E
L
L
P
F
L
E
L
T
N
K
S
F
K
E
T
F
G
M
I
A
G
S
W
R
G
K
N
I
L
Q
R
N
A
I
I
A
L
A
N
L
H
D
R
N
A
I
V
K
L
M
E
I
I
D
K
-
N
N
N
P
I
H
T
A
T
A
I
W
A
L
G
E
I
V
K
K
P
D
E
G
M
L
D
Y
M
------------------------------
4
PsiBlast_PDB
74.51
55%
11
- C4 -
-
5D08
4
QUEG_BACSU
A:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
A
P
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
E
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
23
PsiBlast_CBE
74.43
55%
11
- C4 -
-
5D0A
4
QUEG_BACSU
D:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
AP
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
-
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
22
PsiBlast_CBE
74.32
55%
8
- C4 -
-
5D0B
3
QUEG_BACSU
B:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
A
P
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
-
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
25
PsiBlast_CBE
73.78
55%
11
- C4 -
-
5D0A
5
QUEG_BACSU
B:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
AP
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
-
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
2
PsiBlast_PDB
73.74
55%
12
- C4 -
-
5D0B
5
QUEG_BACSU
A:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
A
P
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
E
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
1
PsiBlast_PDB
73.73
55%
12
- C4 -
-
5D0A
6
QUEG_BACSU
A:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
A
P
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
-
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
24
PsiBlast_CBE
73.60
55%
11
- C4 -
-
5D0A
4
QUEG_BACSU
C:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
AP
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
-
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
3
PsiBlast_PDB
72.57
55%
11
- C4 -
-
5T8Y
3
QUEG_BACSU
A:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
AP
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
E
D
I
R
T
K
S
M
--
V
D
T
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
21
PsiBlast_CBE
72.10
55%
15
- C4 -
-
5T8Y
4
QUEG_BACSU
B:
[34-372]
--
L
K
E
E
L
I
E
Y
A
K
S
I
G
V
D
K
I
G
F
T
T
A
D
T
F
D
S
L
K
D
R
L
I
L
Q
E
S
L
G
Y
L
S
G
F
E
E
P
D
I
E
K
R
V
T
P
K
L
L
L
P
K
A
K
S
I
V
A
I
A
L
A
Y
P
S
R
M
K
D
AP
R
S
--
T
R
-
T
E
-
R
R
G
I
F
C
R
A
S
W
G
K
D
Y
H
D
V
L
R
E
K
L
D
L
L
E
D
F
L
K
S
------
K
H
E
D
I
R
T
K
S
M
-----
G
E
L
S
D
R
A
V
A
E
R
A
G
I
G
F
S
A
K
N
C
M
I
T
T
P
E
Y
G
S
Y
V
Y
L
A
E
M
I
T
N
I
P
F
E
P
D
V
P
I
E
D
M
C
G
S
C
T
K
C
L
D
A
C
P
T
G
A
L
V
N
P
G
Q
L
N
A
Q
R
C
I
S
F
L
T
Q
T
K
G
F
L
P
D
E
F
R
T
K
I
G
N
R
L
Y
G
C
D
T
C
Q
T
V
C
P
L
N
K
G
K
D
F
H
L
H
P
E
M
E
P
D
P
E
I
A
K
P
L
L
K
P
L
L
A
I
S
N
R
E
F
K
E
K
F
G
H
V
S
G
S
W
R
G
K
K
P
I
Q
R
N
A
I
L
A
L
A
H
F
K
D
A
S
A
L
P
E
L
T
E
L
M
H
K
-
D
P
R
P
V
I
R
G
T
A
A
W
A
I
G
K
I
G
-----------------------------------------
9
PsiBlast_PDB
44.84
28%
-117
- C4 -
-
4XVP
-
?
D:
[92-166]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
S
E
A
A
L
A
L
G
K
I
G
D
E
R
A
V
E
P
L
I
K
A
L
-
K
-
D
E
D
R
Y
V
R
M
A
A
A
W
A
L
G
K
I
G
G
E
R
V
R
A
A
M
E
K
L
A
E
T
G
T
G
F
A
-
R
K
V
A
V
N
Y
L
E
T
H
K
---------
48
HHSearch
44.52
22%
-104
- C4 -
-
5DCQ
1
?
C:
[89-167]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
V
R
M
A
A
A
K
A
L
G
K
I
G
D
E
R
A
V
E
P
L
I
K
A
L
-
K
-
D
E
D
S
D
V
R
R
T
A
A
Y
A
L
G
E
I
G
G
E
R
---
V
R
A
A
M
E
K
-
L
A
E
T
G
-
T
G
F
A
R
K
V
A
V
N
Y
L
E
T
H
K
S
----