@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2G6: (2018-01-30 )
MRLTDFSAIHLPAVEKEILSFLDEHTTDRGLYDAMSYSVKAGGKRIRPLLLLTAVASFDEPIDVPVYQVAAALEMVHTYSLIHDDLPAMDNDDLRRGKPTNHKVFGEALAILAGDGLLTGAFQLISMAHLGNSPKLLLLQQLAVCAGSQGMVAGQAADIEGESKKLSLEELAFIHERKTGHLIRYALLAGGILAKQPEEILLLLQRLAEHLGLAFQIRDDLLDVIGTTKTLGKTAGKDERMEKNTYPRLLGLEKTREALEIELLSANKIIDKLEEDVFSFDGGLMRQMIKQFDVEK
Atome Classification :
(46 SA)
.........10........20....-.-...30.....-..-.40........50....--...---.60------....-----.--...70........80........90........100.......110.......120....---.-..130-.--.---..----...--.--.140.-----......150......------.160------.---..--....170...--....180.......190..-.-.-.-.-.200.......210.......220.......230.......240.......250...--.---...260.......270...-....280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRLTDFSAIHL
P
A
V
E
K
E
I
L
S
F
L
D
EH-T-TDR
G
L
Y
D
A
M
S
-
Y
S
-VKAGG
K
R
I
R
P
L
L
L
L
T
A
V
--ASF---DEP------ID
V
P
-----
V
--
Y
Q
V
A
A
A
L
E
M
V
H
T
Y
S
L
I
HDDLPAMDNDDLRRGKPTN
H
K
V
F
G
E
A
L
A
I
LAGD
G
L
L
T
G
A
F
Q
L
I
S
---
M
-
A
HL---G--N---S
P
----
K
L
L
--
L
--
L
Q
Q
L
A
-----
V
CAGSQGMVAGQAAD------IEGE------S---KK--L
S
L
E
E
L
A
F
I
H
--ERKT
G
H
L
I
R
Y
A
L
LAG
G
I
LA-K-Q-
P
-
E
-
E
I
L
L
L
L
Q
R
L
A
E
HL
G
L
A
F
Q
I
R
D
D
L
L
D
V
IGT
T
K
T
L
GKTAGKDERMEKNTYPRLLG
L
E
K
T--R---
E
A
L
E
I
E
L
L
S
A
N
K
I
I
D
K
L
E
E
-
D
V
F
SF
D
G
G
L
M
R
Q
M
I
K
Q
FDVEK
1
PsiBlast_PDB
99.96
58%
-112
- C- -
-
3P8L
-
?
A:
[1-292]
--
L
T
N
F
S
Q
Q
H
L
P
L
V
E
K
V
M
V
D
F
I
A
E
Y
-
T
-
E
N
E
R
L
K
E
A
M
L
-
Y
S
-
I
H
A
G
G
K
R
L
R
P
L
L
V
L
T
T
V
--
A
A
F
---
Q
K
E
------
M
E
T
Q
-----
D
--
Y
Q
V
A
A
S
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
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A
T
A
I
L
A
G
D
G
L
L
T
G
A
F
Q
L
L
S
---
L
-
S
Q
L
---
G
--
L
---
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----
K
V
L
--
L
--
M
Q
Q
L
A
-----
K
A
A
G
N
Q
G
M
V
S
G
Q
M
G
D
------
I
E
G
E
------
K
---
V
S
--
L
T
L
E
E
L
A
A
V
H
--
E
K
K
T
G
A
L
I
E
F
A
L
I
A
G
G
V
L
A
-
N
-
Q
-
T
-
E
-
E
V
I
G
L
L
T
Q
F
A
H
H
Y
G
L
A
F
Q
I
R
D
D
L
L
D
A
T
S
-----------------
S
T
Y
P
A
L
L
G
I
A
G
A
--
K
---
D
A
L
T
H
Q
L
A
E
G
S
A
V
L
E
K
I
K
A
-
N
V
P
N
F
S
E
E
H
L
A
N
L
L
T
Q
L
Q
L
--
80
HHSearch
83.93
61%
-64
- C- -
-
3P8L
-
?
A:
[4-274]
-----
F
S
Q
Q
H
L
P
L
V
E
K
V
M
V
D
F
I
A
E
Y
-
T
-
E
N
E
R
L
K
E
A
M
L
-
Y
S
-
I
H
A
G
G
K
R
L
R
P
L
L
V
L
T
T
V
--
A
A
F
---
Q
K
E
M-----
E
T
Q
------
D
--
Y
Q
V
A
A
S
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
T
A
I
L
A
G
D
G
L
L
T
G
A
F
Q
L
L
S
---
L
-
S
Q
L
---
G
--
L
---
S
E
----
K
V
L
--
L
--
M
Q
Q
L
A
-----
K
A
A
G
N
Q
G
M
V
S
G
Q
M
G
D
------
I
E
G
E
------
K
---
V
S
--
L
T
L
E
E
L
A
A
V
H
--
E
K
K
T
G
A
L
I
E
F
A
L
I
A
G
G
V
L
A
-
N
-
Q
-
T
-
E
-
E
V
I
G
L
L
T
Q
F
A
H
H
Y
G
L
A
F
Q
I
R
D
D
L
L
D
A
T
S
-----------------
S
T
Y
P
A
L
L
G
I
A
G
A
--
K
---
D
A
L
T
H
Q
L
A
E
G
S
A
V
L
E
K
I
K
A
-
N
--------------------
81
HHSearch
80.45
61%
-59
- C- -
-
3P8L
-
?
B:
[4-274]
-----
F
S
Q
Q
H
L
P
L
V
E
K
V
M
V
D
F
I
A
E
Y
-
T
-
E
N
E
R
L
K
E
A
M
L
-
Y
S
-
I
H
A
G
G
K
R
L
R
P
L
L
V
L
T
T
V
--
A
A
F
---
Q
K
E
M-----
E
T
Q
------
D
--
Y
Q
V
A
A
S
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
T
A
I
L
A
G
D
G
L
L
T
G
A
F
Q
L
L
S
---
L
-
S
Q
L
---
G
--
L
---
S
E
----
K
V
L
--
L
--
M
Q
Q
L
A
-----
K
A
A
G
N
Q
G
M
V
S
G
Q
M
G
D
------
I
E
G
E
------
K
---
V
S
--
L
T
L
E
E
L
A
A
V
H
--
E
K
K
T
G
A
L
I
E
F
A
L
I
A
G
G
V
L
A
-
N
-
Q
-
T
-
E
-
E
V
I
G
L
L
T
Q
F
A
H
H
Y
G
L
A
F
Q
I
R
D
D
L
L
D
A
T
S
------------------
T
Y
P
A
L
L
G
I
A
G
A
--
K
---
D
A
L
T
H
Q
L
A
E
G
S
A
V
L
E
K
I
K
A
-
N
--------------------
5
PsiBlast_PDB
71.24
43%
-112
- C1 -
-
4LFE
1
?
A:
[12-272]
--------
I
H
A
F
Y
C
E
K
A
V
I
S
----------
E
K
L
N
E
A
V
L
-
Y
S
-
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
--
E
A
L
---
Q
I
P
------
L
T
E
S
-----
H
--
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
---
E
-
T
D
F
---
P
--
T
---
D
V
----
T
V
D
--
L
--
V
R
S
L
S
-----
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
------
M
A
A
E
------
G
---
K
K
--
L
N
L
K
N
L
Q
L
I
H
--
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
-
Q
-
L
-
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
----------------
K
M
T
Y
P
H
L
L
G
L
N
E
S
--
Y
---
Q
I
L
D
E
S
L
D
Q
A
E
A
I
L
R
K
L
S
D
-
E
I
-------------------
29
PsiBlast_CBE
69.80
43%
-89
- C1 -
-
4LFG
2
?
B:
[12-272]
--------
I
H
A
F
Y
C
E
K
A
V
I
S
----------
E
K
L
N
E
A
V
L
-
Y
S
-
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
--
E
A
L
---
Q
I
P
------
L
T
E
S
-----
H
--
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
---
E
-
T
D
F
---
P
--
T
---
D
V
----
T
V
D
--
L
--
V
R
S
L
S
-----
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
------
M
A
A
E
------
G
---
K
K
--
L
N
L
K
N
L
Q
L
I
H
--
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
-
Q
-
L
-
D
-
E
-
N
L
L
A
T
F
L
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I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--
Y
---
Q
I
L
D
E
S
L
D
Q
A
E
A
I
L
R
K
L
S
D
-
E
I
-------------------
76
HHSearch
68.76
50%
-68
- C1 -
-
5AYP
-
ISPA_GEOSE
B:
[4-280]
L
S
V
E
Q
F
L
N
E
Q
K
Q
A
V
E
T
A
L
S
R
Y
I
E
R
L
-
E
-
G
P
A
K
L
K
K
A
M
A
-
Y
S
-
L
E
A
G
G
K
R
I
R
P
L
L
L
L
S
T
V
--
R
A
L
---
G
K
D
------
P
A
V
------
G
--
L
P
V
A
C
A
I
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
S
M
--------
K
P
T
N
H
K
V
F
G
E
A
M
A
I
L
A
G
D
G
L
L
T
Y
A
F
Q
L
I
T
---
E
-
I
D
D
ERI
P
--
P
---
S
V
----
R
L
R
--
L
--
I
E
R
L
A
-----
K
A
A
G
P
E
G
M
V
A
G
Q
A
A
D
------
M
E
G
E
------
G
---
K
T
--
L
T
L
S
E
L
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Y
I
H
--
R
H
K
T
G
K
M
L
Q
Y
S
V
H
A
G
A
L
I
G
-
G
-
A
-
D
-
A
-
R
Q
T
R
E
L
D
E
F
A
A
H
L
G
L
A
F
Q
I
R
D
D
I
L
D
---------------------
T
Y
P
A
L
L
S
L
A
G
A
--
K
---
E
K
L
A
F
H
I
E
A
A
Q
R
H
L
R
N
A
D
V
----------------------
70
HHSearch
68.25
41%
-58
- C- -
-
1RTR
-
?
A:
[5-289]
-----
P
M
N
K
L
I
D
E
V
N
N
E
L
S
V
A
I
N
K
S
-
V
-
M
D
T
Q
L
E
E
S
M
L
-
Y
S
-
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
L
--
D
S
L
---
N
T
E
------
Y
E
L
------
G
--
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
D
A
L
L
T
K
A
F
E
L
I
S
---
S
-
D
D
R
L--
T
--
D
---
E
V
----
K
I
K
--
V
--
L
Q
R
L
S
-----
I
A
S
G
H
V
G
M
V
G
G
Q
M
L
D
------
M
Q
S
E
------
G
---
Q
P
--
I
D
L
E
T
L
E
M
I
H
--
K
T
K
T
G
A
L
L
T
F
A
V
M
S
A
A
D
I
A
-
N
-
V
-
D
-
D
-
T
T
K
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
--
E
---
D
K
L
T
Y
H
R
D
A
A
V
D
E
L
T
Q
I
D
E
-
Q
F
N
T
K
H
L
L
E
I
V
D
L
F
Y
------
30
PsiBlast_CBE
67.89
43%
-89
- C1 -
-
4LFE
2
?
B:
[12-272]
--------
I
H
A
F
Y
C
E
K
A
V
I
S
----------
E
K
L
N
E
A
V
L
-
Y
S
-
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
--
E
A
L
---
Q
I
P
------
L
T
E
S
-----
H
--
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
---
E
-
T
D
F
---
P
--
T
---
D
V
----
T
V
D
--
L
--
V
R
S
L
S
-----
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
------
M
A
A
E
------
G
---
K
K
--
L
N
L
K
N
L
Q
L
I
H
--
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
-
Q
-
L
-
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--
Y
---
Q
I
L
D
E
S
L
D
Q
A
E
A
I
L
R
K
L
S
D
-
E
I
-------------------
6
PsiBlast_PDB
67.62
43%
-87
- C1 -
-
4LFG
2
?
A:
[12-272]
--------
I
H
A
F
Y
C
E
K
A
V
I
S
----------
E
K
L
N
E
A
V
L
-
Y
S
-
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
--
E
A
L
---
Q
I
P
------
L
T
E
S
-----
H
--
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
---
E
-
T
D
F
---
P
--
T
---
D
V
----
T
V
D
--
L
--
V
R
S
L
S
-----
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
------
M
A
A
E
------
G
---
K
K
--
L
N
L
K
N
L
Q
L
I
H
--
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
-
Q
-
L
-
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--
Y
---
Q
I
L
D
E
S
L
D
Q
A
E
A
I
L
R
K
L
S
D
-
E
I
-------------------
21
PsiBlast_CBE
65.39
47%
-53
- C1 -
-
3PDE
2
?
D:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
63
HHSearch
64.58
44%
-32
* C1 *
-
3PDE
2
?
D:
[10-290]
----
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
FV----
P
E
R
------
H
--
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
P
T
-
S
T
Q
R
D
D
L
A
A
------------
24
PsiBlast_CBE
64.53
47%
-49
- C1 -
-
3M9U
3
?
B:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
8
PsiBlast_PDB
63.82
46%
-66
- C- -
-
1RTR
-
?
A:
[10-258]
----------
I
D
E
V
N
N
E
L
S
V
A
I
N
K
S
-
V
-
M
D
T
Q
L
E
E
S
M
L
-
Y
S
-
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
L
--
D
S
L
---
N
T
E
------
Y
E
L
G
-----
M
---
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
D
A
L
L
T
K
A
F
E
L
I
S
---
S
D
D
R
L
---
T
--
D
---
E
V
----
K
I
K
--
V
--
L
Q
R
L
S
-----
I
A
S
G
H
V
G
M
V
G
G
Q
M
L
D
------
M
Q
S
E
------
G
---
Q
P
--
I
D
L
E
T
L
E
M
I
H
--
K
T
K
T
G
A
L
L
T
F
A
V
M
S
A
A
D
I
A
-
N
-
V
-
D
-
D
-
T
T
K
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
--
E
---
D
K
L
--------------------------------------
23
PsiBlast_CBE
63.79
47%
-50
- C1 -
-
3M9U
6
?
C:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
--------------
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
4
PsiBlast_PDB
63.63
47%
-53
- C1 -
-
3PDE
2
?
A:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
3
PsiBlast_PDB
63.48
47%
-51
- C1 -
-
3M9U
4
?
A:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
72
HHSearch
63.32
40%
-88
- C1 -
-
3M0G
-
?
B:
[2-272]
-
S
L
S
E
R
L
K
E
V
Q
D
A
V
E
T
A
M
A
A
A
I
G
R
L
---
P
A
G
D
L
R
D
A
M
A
-
Y
A
-
A
-
Q
G
G
K
R
L
R
A
F
L
A
I
E
S
A
--
A
I
H
---
G
I
S
------
M
A
Q
------
A
--
M
P
A
A
L
A
V
E
A
L
H
A
Y
S
L
V
H
D
D
M
P
C
M
D
N
D
D
L
R
R
G
L
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
C
T
---
D
-
P
V
L
G--
S
--
A
---
E
N
----
R
V
A
--
L
--
V
A
A
L
A
-----
Q
A
S
G
A
E
G
M
V
Y
G
Q
A
L
D
------
I
A
A
E
------
T
---
A
A
VP
L
T
L
D
E
I
I
R
L
Q
--
A
G
K
T
G
A
L
I
S
F
A
A
Q
A
G
A
I
L
A
-
G
-
A
-
D
-
R
----
G
P
L
T
A
Y
A
T
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
------------------
K
A
T
F
V
S
L
L
G
L
A
G
A
--
K
---
S
R
A
A
D
L
V
A
E
A
E
A
A
L
A
P
Y
G
E
----------------------
75
HHSearch
63.20
50%
-59
- C1 -
-
5AYP
-
ISPA_GEOSE
A:
[4-280]
L
S
V
E
Q
F
L
N
E
Q
K
Q
A
V
E
T
A
L
S
R
Y
I
E
R
L
-
E
-
G
P
A
K
L
K
K
A
M
A
-
Y
S
-
L
E
A
G
G
K
R
I
R
P
L
L
L
L
S
T
V
--
R
A
L
---
G
K
D
------
P
A
V
------
G
--
L
P
V
A
C
A
I
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
S
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
M
A
I
L
A
G
D
G
L
L
T
Y
A
F
Q
L
I
T
---
E
---
D
ERI
P
--
P
---
S
V
----
R
L
R
--
L
--
I
E
R
L
A
-----
K
A
A
G
P
E
G
M
V
A
G
Q
A
A
D
------
M
E
G
E
------
G
---
K
T
--
L
T
L
S
E
L
E
Y
I
H
--
R
H
K
T
G
K
M
L
Q
Y
S
V
H
A
G
A
L
I
G
-
G
-
A
-
D
-
A
-
R
Q
T
R
E
L
D
E
F
A
A
H
L
G
L
A
F
Q
I
R
---------------------------------
L
A
G
A
--
K
---
E
K
L
A
F
H
I
E
A
A
Q
R
H
L
R
N
A
D
V
----------------------
22
PsiBlast_CBE
62.41
47%
-52
- C1 -
-
3PDE
2
?
B:
[7-265]
-
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
------
F
-
V
P
-----
E
RH
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
--------------------------------------
64
HHSearch
62.40
44%
-34
- C1 -
-
3PDE
3
?
A:
[10-290]
----
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
L
A
A
A
M
T
-
Y
S
-
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
--
Q
S
L
---
G
V
T
F
V
----
P
E
R
------
H
--
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
-
T
D
L
---
P
--
A
---
T
M
----
Q
A
A
--
L
--
V
Q
A
L
A
-----
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
------
I
Q
S
E
------
H
---
V
N
--
L
P
L
S
Q
L
R
V
L
H
--
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
-
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
--
N
---
Q
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
P
T
-
S
T
Q
R
D
D
L
A
A
------------
73
HHSearch
62.05
39%
-60
- C1 -
-
3OAB
2
?
D:
[3-290]
-
D
F
D
G
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
V
Q
M
K
---
E
P
L
K
I
H
E
S
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
--
E
L
V
---
G
G
D
------
E
S
T
------
A
--
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
-
A
T
K
---
G
AP
P
---
E
R
----
I
V
R
--
V
--
L
G
E
L
A
-----
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
------
V
C
S
E
------
G
---
M
A
E-
V
G
L
D
H
L
E
F
I
H
--
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
-
G
-
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
--
K
---
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
-
H
R
A
A
-
P
L
I
A
L
A
N
Y
I
-------
83
HHSearch
58.64
40%
2
- C1 -
-
1RQJ
2
ISPA_ECOLI
A:
[1-290]
M
D
F
P
Q
Q
L
E
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
-
P
F
Q
N
T
P
V
V
E
T
M
Q
-
Y
G
-
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
--
H
M
F
---
G
V
S
------
T
N
T
------
L
--
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
-
A
D
M
---
P
--
E
VS
D
R
D
----
R
I
S
--
M
--
I
S
E
L
A
-----
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
------
L
D
A
E
------
G
---
K
H
--
V
P
L
D
A
L
E
R
I
H
--
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
-
D
-
K
-
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
--
R
---
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
L
-----------
66
HHSearch
55.90
42%
-69
- C1 -
-
4F62
1
?
B:
[3-278]
M
N
L
K
Q
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
-
A
-
P
A
N
Q
L
H
N
A
M
R
-
Y
S
-
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
A
--
Q
L
V
---
G
D
I
------
S
S
L
------
T
--
D
A
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
---------------
F
D
E
A
T
A
I
L
A
G
D
A
L
Q
T
F
A
F
E
L
L
S
---
N
-
P
T
S
---
A
--
Q
P
--
E
L
----
A
I
K
--
L
--
I
Q
E
L
V
-----
V
A
S
G
R
N
G
M
I
T
G
Q
M
I
D
------
L
S
S
E
------
N
-------
I
S
L
A
E
L
E
Q
M
H
--
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
T
-
G
-
Q
V
K
-
P
-
E
Q
L
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
------------------
K
A
T
Y
P
K
L
L
G
L
D
G
A
--
K
---
A
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
G
D
----------------------
67
HHSearch
55.46
42%
-64
- C1 -
-
4F62
1
?
A:
[3-278]
M
N
L
K
Q
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
-
A
-
P
A
N
Q
L
H
N
A
M
R
-
Y
S
-
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
A
--
Q
L
V
---
G
D
I
------
S
S
L
------
T
--
D
A
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
N
-------
P
T
C
H
I
Q
F
D
E
A
T
A
I
L
A
G
D
A
L
Q
T
F
A
F
E
L
L
S
---
N
-
P
T
S
---
A
--
Q
P
--
E
L
----
A
I
K
--
L
--
I
Q
E
L
V
-----
V
A
S
G
R
N
G
M
I
T
G
Q
M
I
D
------
L
S
S
E
------
N
---
K
N
--
I
S
L
A
E
L
E
Q
M
H
--
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
T
-
G
-
Q
V
K
-
P
-
E
Q
L
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
G
L
D
G
A
--
K
---
A
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
G
D
----------------------
82
HHSearch
54.76
34%
-31
- C1 -
-
3Q1O
2
?
B:
[17-302]
-----
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
L
E
S
-
F
H
P
Y
L
E
K
A
F
F
-
E
M
-
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
--
C
A
L
---
V
G
Q
K
D
Y
S
N
Q
Q
T
E
------
Y
--
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
-
A
L
L
---
E
--
S
---
H
I
----
I
V
E
--
L
--
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
------
C
Y
F
E
------
N
---
T
P
--
L
N
L
E
Q
L
T
F
L
H
--
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
-
I
-
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
--
T
H
L
D
S
A
K
N
S
F
V
N
L
L
G
L
E
R
A
--
N
---
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
------
A
Y
P
L
L
Q
E
N
L
N
A
-----
32
PsiBlast_CBE
47.68
47%
-5
- C1 -
-
1RQJ
2
ISPA_ECOLI
B:
[32-261]
--------------------------------
V
V
E
T
M
Q
-
Y
G
-
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
--
H
M
F
GVS
T
N
T
------
L
D
A
P
-----------
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
DAD
M
-
P
E
V
---
S
--
D
---
R
D
----
R
I
S
--
M
--
I
S
E
L
A
-----
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
------
L
D
A
E
------
G
---
K
H
--
V
P
L
D
A
L
E
R
I
H
--
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
D
-
K
-
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
--
R
---
K
----------------------------------------
33
PsiBlast_CBE
47.06
47%
-8
- C1 -
-
1RQI
2
ISPA_ECOLI
B:
[33-262]
--------------------------------
V
V
E
T
M
Q
-
Y
G
-
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
--
H
M
F
GVS
T
N
T
------
L
D
A
P
-----------
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
DAD
M
-
P
E
V
---
S
--
D
---
R
D
----
R
I
S
--
M
--
I
S
E
L
A
-----
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
------
L
D
A
E
------
G
---
K
H
--
V
P
L
D
A
L
E
R
I
H
--
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
D
-
K
-
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
--
R
---
K
----------------------------------------
11
PsiBlast_PDB
46.18
47%
-7
- C1 -
-
1RQJ
2
ISPA_ECOLI
A:
[32-261]
--------------------------------
V
V
E
T
M
Q
-
Y
G
-
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
--
H
M
F
GVS
T
N
T
------
L
D
A
P
-----------
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
DAD
M
-
P
E
V
---
S
--
D
---
R
D
----
R
I
S
--
M
--
I
S
E
L
A
-----
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
------
L
D
A
E
------
G
---
K
H
--
V
P
L
D
A
L
E
R
I
H
--
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
D
-
K
-
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
--
R
---
K
----------------------------------------
12
PsiBlast_PDB
45.98
47%
-7
- C1 -
-
1RQI
3
ISPA_ECOLI
A:
[33-262]
--------------------------------
V
V
E
T
M
Q
-
Y
G
-
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
--
H
M
F
GVS
T
N
T
------
L
D
A
P
-----------
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
AD
M
-
P
E
V
---
S
--
D
---
R
D
----
R
I
S
--
M
--
I
S
E
L
A
-----
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
------
L
D
A
E
------
G
---
K
H
--
V
P
L
D
A
L
E
R
I
H
--
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
D
-
K
-
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
--
R
---
K
----------------------------------------
62
PsiBlast_CBE
44.03
31%
-73
- C1 -
-
4GP2
2
?
A:
[17-244]
-------------
V
E
K
A
L
V
R
Y
L
S
I
G
-
L
-
A
E
-
D
F
R
E
A
V
L
-
Y
Q
-
V
K
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
--
E
A
V
---
S
G
Q
------
W
R
-
P
-----
A
--
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
----
I
W
Y
R
E
A
I
E
---
E
-
A
V
L
---
D
--
T
---
P
K
----
P
T
L
--
F
--
A
K
E
V
A
E
V
I
K
A
I
D
E
G
E
R
L
D
I
L
F
E
A
A
G
RSD
P
Y
F
V
Q
A
R
------
W
---
R
E
--
V
T
L
D
D
Y
I
K
M
V
--
S
L
K
T
G
A
L
I
A
A
A
A
K
W
G
V
L
S
V
-
S
-
D
-
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
----------------------------------------------------------------
61
PsiBlast_CBE
43.66
33%
-103
- C1 -
-
3Q2Q
3
?
A:
[62-275]
--------------------------------
L
V
D
I
V
M
-
H
L
-
T
R
A
G
G
K
R
F
R
P
M
F
A
L
L
A
S
--
E
F
G
---
E
K
P
------
L
S
E
N
-----
V
--
I
K
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
-----
M
-
S
Q
L
---
G
--
T
---
D
----------
T
--
V
A
H
F
A
-----
E
T
F
G
E
--
L
V
T
G
Q
M
R
E
------
T
V
G
P
------
R
---
D
T
--
D
P
I
E
H
Y
T
N
V
I
--
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
-
G
-
A
-
A
-
P
-
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
------------------------------------------------
27
PsiBlast_CBE
42.13
48%
3
- C1 -
-
3KRO
2
?
D:
[31-259]
--------------------------------
I
H
E
S
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
EL
V
G
G
---
D
E
S
------
T
A
M
P
-----
A
-----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
-
A
T
K
---
G
--
A
---
P
P
----
E
R
I
VR
V
--
L
G
E
L
A
-----
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
------
V
C
S
E
------
G
M--
A
E
--
V
G
L
D
H
L
E
F
I
H
--
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
-
G
-
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
--
K
---
E
----------------------------------------
35
PsiBlast_CBE
41.03
44%
-19
- C1 -
-
4LLS
3
?
B:
[51-275]
--------------------------------
I
V
E
A
M
A
-
H
A
-
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
--
R
L
H
---
D
I
A
------
A
G
E
A
-----
I
--
W
S
-
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
------
H
P
---
G
--
A
---
S
A
S
A
E
V
R
A
D
--
L
--
A
L
S
L
A
-----
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
------
I
A
A
E
------
T
---
A
R
AP
L
S
L
D
E
I
T
R
L
Q
--
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
-
A
-
D
-
T
-
A
A
---
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
--
R
--------------------------------------------
55
PsiBlast_CBE
40.91
34%
-68
- C1 -
-
3WJO
2
?
A:
[19-255]
-
K
I
N
E
L
T
A
Q
D
M
A
G
V
N
A
A
I
L
E
Q
L
N
-----
S
D
V
Q
L
I
N
Q
L
G
-
Y
Y
I
V
S
G
G
G
K
R
I
R
P
M
I
A
V
L
A
A
--
R
A
V
---
G
Y
E
------
G
N
A
H
-----
V
---
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
-----
M
-
T
S
L
---
G
------
S
L
----
K
V
L
--
E
--
V
M
S
E
A
-----
V
N
V
I
A
E
G
E
V
L
-
Q
L
M
N
----------------------------
N
Y
M
R
V
I
--
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
-
G
-
C
-
T
-
P
-
E
E
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
-----------------------------------------------------
26
PsiBlast_CBE
39.89
48%
11
- C1 -
-
3OAB
2
?
D:
[31-259]
--------------------------------
I
H
E
S
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
EL
V
G
G
---
D
E
S
------
T
A
M
P
-----
A
-----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
-
A
T
K
---
G
--
A
---
P
P
----
E
R
I
VR
V
--
L
G
E
L
A
-----
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
------
V
C
S
E
------
G
M--
A
E
--
V
G
L
D
H
L
E
F
I
H
--
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
-
G
-
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
--
K
---
E
----------------------------------------
25
PsiBlast_CBE
39.89
48%
9
- C1 -
-
3OAC
2
?
D:
[31-259]
--------------------------------
I
H
E
S
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
EL
V
G
G
---
D
E
S
------
T
A
M
P
-----
A
-----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
-
A
T
K
---
G
--
A
---
P
P
----
E
R
I
VR
V
--
L
G
E
L
A
-----
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
------
V
C
S
E
------
G
M--
A
E
--
V
G
L
D
H
L
E
F
I
H
--
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
-
G
-
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
--
K
---
E
----------------------------------------
28
PsiBlast_CBE
39.38
48%
5
- C1 -
-
3KRF
2
?
D:
[31-259]
--------------------------------
I
H
E
S
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
EL
V
G
G
---
D
E
S
------
T
A
M
P
-----
A
-----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
-
A
T
K
---
G
--
A
---
P
P
----
E
R
I
VR
V
--
L
G
E
L
A
-----
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
------
V
C
S
E
------
G
M--
A
E
--
V
G
L
D
H
L
E
F
I
H
--
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
-
G
-
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
--
K
---
E
----------------------------------------
13
PsiBlast_PDB
39.12
44%
-18
- C1 -
-
4LLS
3
?
A:
[51-275]
--------------------------------
I
V
E
A
M
A
-
H
A
-
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
--
R
L
H
---
D
I
A
------
A
G
E
A
-----
I
--
W
S
-
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
------
H
P
---
G
--
A
---
S
A
S
A
E
V
R
A
D
--
L
--
A
L
S
L
A
-----
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
------
I
A
A
E
------
T
---
A
R
A
P
L
S
L
D
E
I
T
R
L
Q
--
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
-
A
-
D
-
T
-
A
A
---
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
--
R
--------------------------------------------
9
PsiBlast_PDB
38.75
43%
-11
- C1 -
-
2J1P
2
GGPPS_SINAL
A:
[40-260]
--------------------------------
I
H
E
A
M
R
-
Y
S
-
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
C
E
L
V
G
G
---
E
E
S
------
L
A
M
P
-----
A
-----
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
L
A
---
S
-
A
T
S
---
S
--
E
V--
S
P
----
A
R
V
--
V
R
A
V
G
E
L
A
-----
K
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
------
I
S
---------LDL
N
N
--
V
G
L
E
H
L
K
F
I
H
--
L
H
K
T
A
A
L
L
E
A
S
A
V
L
G
G
I
I
G
-
G
-
G
-
S
-
D
-
E
E
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--
K
L
--------------
T
Y
P
K
L
M
G
L
E
K
S
--
R
---
E
F
A
E
-------------------------------------
34
PsiBlast_CBE
38.54
44%
-16
- C1 -
-
4LLT
2
?
B:
[51-275]
--------------------------------
I
V
E
A
M
A
-
H
A
-
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
--
R
L
H
---
D
I
A
------
A
G
E
A
-----
I
--
W
S
-
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
------
H
P
---
G
--
A
---
S
A
S
A
E
V
R
A
D
--
L
--
A
L
S
L
A
-----
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
------
I
A
A
E
------
T
---
A
R
A
P
L
S
L
D
E
I
T
R
L
Q
--
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
-
A
-
D
-
T
-
A
A
---
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
--
R
--------------------------------------------
14
PsiBlast_PDB
38.31
44%
-13
- C1 -
-
4LLT
2
?
A:
[51-275]
--------------------------------
I
V
E
A
M
A
-
H
A
-
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
--
R
L
H
---
D
I
A
------
A
G
E
A
-----
I
--
W
S
-
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
------
H
P
---
G
--
A
---
S
A
S
A
E
V
R
A
D
--
L
--
A
L
S
L
A
-----
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
------
I
A
A
E
------
T
---
A
R
AP
L
S
L
D
E
I
T
R
L
Q
--
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
-
A
-
D
-
T
-
A
A
---
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
--
R
--------------------------------------------
43
PsiBlast_CBE
36.63
39%
2
- C1 -
-
3Q1O
2
?
B:
[51-284]
------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
--
C
A
L
---
V
G
Q
------
K
D
Y
S
N
Q
Q
T
E
Y
--
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
-
A
L
L
---
E
--
S
---
H
I
----
I
V
E
--
L
--
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
------
C
Y
F
E
------
N
---
T
P
--
L
N
L
E
Q
L
T
F
L
H
--
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
-
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
--
N
N
Y
A
Q
T
L
K
T
E
V
L
N
--------------------------------
42
PsiBlast_CBE
36.33
39%
-4
- C1 -
-
3Q1O
2
?
C:
[51-284]
------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
--
C
A
L
---
V
G
Q
------
K
D
Y
S
NQQTE
Y
--
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
-
A
L
L
---
E
--
S
---
H
I
----
I
V
E
--
L
--
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
------
C
Y
F
E
------
N
---
T
P
--
L
N
L
E
Q
L
T
F
L
H
--
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
-
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
--
N
NYA
Q
T
L
K
T
E
V
L
N
--------------------------------
41
PsiBlast_CBE
34.78
39%
-2
- C1 -
-
3Q1O
2
?
D:
[51-284]
------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
--
C
A
L
---
V
G
Q
------
K
D
Y
S
NQQTE
Y
--
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
-
A
L
L
---
E
--
S
---
H
I
----
I
V
E
--
L
--
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
------
C
Y
F
E
------
N
---
T
P
--
L
N
L
E
Q
L
T
F
L
H
--
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
-
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
--
N
NYA
Q
T
L
K
T
E
V
L
N
--------------------------------
19
PsiBlast_PDB
34.05
39%
4
- C1 -
-
3Q1O
2
?
A:
[51-284]
------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
--
C
A
L
---
V
G
Q
------
K
D
Y
S
N
Q
Q
T
E
Y
--
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
-
A
L
L
---
E
--
S
---
H
I
----
I
V
E
--
L
--
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
------
C
Y
F
E
------
N
---
T
P
--
L
N
L
E
Q
L
T
F
L
H
--
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
-
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
--
N
N
Y
A
Q
T
L
K
T
E
V
L
N
--------------------------------
60
PsiBlast_CBE
29.22
34%
-3
- C1 -
-
3OYR
2
?
B:
[44-273]
----------------------
D
R
M
-
Q
-
S
D
V
A
I
I
P
A
L
A
E
H
L
-
I
A
A
G
G
K
R
L
R
P
L
M
T
V
A
A
---
A
R
L
---
A
G
A
------
D
N
D
H
-----
F
--
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
---
E
-
T
--------
N
---
S
-------------
M
K
A
L
E
-----
I
L
A
R
A
S
R
V
I
A
------------
E
G
E
V
L
Q
L
M
R
S
---
H
D
--
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
-
G
-
V
-
D
-
V
-
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
R
S
GP
R
---
E
A
---------------------------------------