@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2U7: (2018-02-01 )
MLQLKDIKKYYKVGETTTKALDGVSVAFRQKEFVAILGPSGSGKTTMLNVIGGLDNYDSGDMVINGKSTKDFKDSDWDAYRNNSIGFIFQSYNLIGHLGIIENVELGMTLSGVSKDEKRKRAEDALHRVGLTNHMHKKPNQLSGGQMQRVAIARALANDPDILLCDEPTGALDTETSIQIMELIQELSKEKLVIMVTHNPELAHQYADRIIEFSDGKILTDSHPHIERPKDDQFNLRRTKMSFWTALKLSFNNIRTKKGRTFLTSFASSIGIIGIAIVLSLSSGFQKQIDNTQAETMAKFPITISKVTTNQTRDDAGLGASKADYPDSKTITAKVSEEDKAQHTNKIDQTYVDYVTDIDPNLSNNIGFTRTTGINLLRDVNGKVQPVSFSNQNPDTESLSLSSTMSAMTGVGVSSFPTQLDTSKENFLKDNYSLLAGSYPASATDVVLIVDGNNNTNINALKNLGFDVKEDEKLDFDDIVGTTFKLVNNNTYYTKLPTGNFIPNTDYDAMYQNASDELKISGILRVKSSSTMNLLSPGIAYSDQLTTQIVNENKESEIVKAQRDSGVNVLTTEKVDENAKQTLLSYLGGDSLPSSIMIYPNNFEDKEKILDYLDDYNKGKSDEDKIIYTDLAGTMTELTGGLMDAITYVLIAFAGISLVTSMIMISIITYTSVIERTKEIGVLKALGARKKDITRVFDAETCILGISSGILGVFIAWLATFPINSILYNMTDLKNVAQLNPVHAIILVIVSTILTMLGGHLPARMAAKKDAAIALRAE
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70.......---.80..------......90-.........100..-...-..110--........120.......130...-...-.140.......150.......160.......170.......180.......--190..-.--......200.......210......--.220------...-------------.....230.......240-.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440------.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ML
Q
L
K
D
I
K
K
Y
Y
KVGE
T
T
T
K
ALDG
V
S
V
A
F
RQ
K
E
F
V
A
I
LGPSGSG
K
T
T
M
L
N
V
IGGLDNYDSG
D
M
V
I
NGKSTKDFKDSDWD---AYRNN------S
I
G
F
I
F
Q--SYNLIGHLG
I
I
ENV-EL
G
-
M
T
LS---GV
S
K
D
E
K
R
K
R
A
E
D
A
L
H
R
VGLTNHM-HKK-PNQLSGG
Q
M
Q
R
V
A
I
A
R
A
LANDP
D
I
L
L
CDEPTGALDTE
T
S
I
Q
I
M
E
L
I
Q
E
LSK--E--
K
L
-
V
--
I
M
V
TH
N
P
E
L
A
H
Q
Y
A
D
R
I
I
EFSD
G
K
I
--LTD-------SHP-------------HIERPKDDQFN
L
R
R
T
K
M
S
-
F
W
T
A
L
K
L
S
FNNIRTKKG
R
T
F
L
T
S
F
A
SSI
G
I
I
G
I
A
I
V
L
S
L
SS
G
F
Q
K
Q
IDN
T
Q
A
E
T
M
AKF
P
I
T
I
S
K
VTTNQTRDDAGLGASKADYPDS
K
T
I
T
A
KVSE
E
D
K
A
Q
HTN
K
I
D
Q
T
Y
V
D
Y
VTDIDPNLSNNIGFTRTTG
I
N
L
L
R
DVNG
K
V
Q
P
V
SFSNQNPDTESL
S
L
S
S
T
M
S
A
M
TGVGVSSFPTQLDT
S
K
E
N
F
L
KDN
Y
S
L
LAGSYPAS------
A
T
D
V
V
L
I
V
DGNNNT
N
I
N
A
L
K
NLGFDVKEDEKL
D
F
D
D
IVG
T
T
F
K
L
VNNN
T
Y
Y
T
KLPTGNFIPNT
D
Y
D
A
M
YQNASD
E
L
K
I
S
G
I
L
R
VKSSSTMNLLSPGIA
Y
S
D
Q
L
T
T
Q
I
VNENK
E
S
E
I
V
K
AQRDSG
V
N
V
L
T
T
E
K
VD
E
N
A
K
Q
T
L
L
S
Y
LGGDSLP
S
S
I
M
IYPNNF
E
D
K
E
K
I
L
D
Y
L
D
DYNKGKSDED
K
I
I
Y
TDLA
G
T
M
T
E
L
T
G
G
L
M
D
A
I
T
Y
V
L
I
A
F
A
G
I
S
L
V
T
S
M
I
M
I
S
I
I
T
Y
T
S
V
I
E
R
T
K
E
I
G
V
L
K
A
LGAR
K
K
D
I
T
R
V
FDAE
T
C
I
L
G
I
SS
G
I
L
G
V
F
I
A
W
L
A
TF
P
I
N
S
I
L
Y
N
M
T
D
L
K
N
V
A
QLN
P
V
H
A
I
I
L
V
I
V
S
T
I
L
T
M
LGGHL
P
A
R
M
AAKKD
A
A
I
A
L
RAE
126
HHSearch
78.20
28%
-38
- C2 -
-
5NIL
-
?
K:
[4-648]
L
L
E
L
K
D
I
R
R
S
Y
P
A
G
D
E
Q
V
E
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
Q
D
V
A
T
L
D
A
D
A
L
A
---
Q
L
R
R
E
------
H
F
G
F
I
F
Q
--
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
-
E
V
P
-
A
V
Y
A
---
G
L
E
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
R
L
G
L
E
D
R
T
-
E
Y
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
D
R-
G
--
H
T
-
V
--
I
I
V
T
H
D
P
Q
V
A
-
A
Q
A
E
R
V
I
E
I
R
D
G
E
I
--
V
R
N
-------
P
P
------------------------
G
W
R
Q
F
V
S
G
-
F
N
E
A
L
T
M
A
W
R
A
L
A
A
N
K
M
R
T
L
L
T
M
L
G
I
I
I
G
I
A
S
V
V
S
I
V
V
V
G
D
A
A
K
Q
M
V
L
A
D
I
R
S
I
-
G
T
N
T
I
D
V
Y
P
G
K
D
F
G
D
D
D
P
Q
Y
Q
--
Q
--
A
L
--
K
Y
D
-
D
-----------
L
I
A
I
Q
K
Q
--
P
W
V
A
S
--------
A
T
P
A
V
S
Q
N
L
R
L
-
R
Y
N
N
-
V
D
V
A
A
S
------------------
A
-
N
G
V
S
G
D
-----------
Y
F
N
V
Y
G
M
T
F
S
E
G
N
T
F
N
Q
EQLNGR
A
Q
V
V
V
L
D
S
N
T
R
R
Q
L
F
P
----------------
H
K
A
D
V
V
G
E
V
I
L
V
---------------------------
G
N
M
P
A
R
V
I
G
V
A
E
E
K
Q
S
M
F
G
S
-
S
K
V
L
R
V
W
L
P
--------
Y
S
T
M
S
G
R
V
----------------------------
M
G
Q
S
W
L
N
S
I
T
V
R
V
K
E
G
F
D
S
A
E
A
E
Q
Q
L
T
R
L
L
S
L
-
R
H
G
K
K
D
F
F
T
W
N
M
D
G
V
L
K
T
V
E
K
T
T
R
T
L
Q
L
F
L
T
L
V
A
V
I
S
L
V
V
G
G
I
G
V
M
N
I
M
L
V
S
V
T
E
R
T
R
E
I
G
I
R
M
A
V
G
A
R
A
S
D
V
L
Q
Q
F
L
I
E
A
V
L
V
C
L
V
G
G
A
L
G
I
T
L
S
L
L
I
A
F
T
L
Q
L
F
L
P
-----
G
W
E
I
G
F
S
P
L
A
L
L
L
A
F
L
C
S
T
V
T
G
I
L
F
G
W
L
P
A
R
N
A
A
R
L
D
P
V
D
A
L
A
R
E
19
PsiBlast_PDB
69.90
31%
-106
- C2 -
-
3TUZ
1
METN_ECOLI
C:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
68.97
31%
-105
- C2 -
-
3TUI
1
METN_ECOLI
H:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
68.75
32%
-105
- C2 -
-
3TUI
1
METN_ECOLI
C:
[24-251]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
-
R
R
------
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
RL
G
--
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
-------
D
T
V
-------------
S
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.38
31%
-97
- C2 -
-
3TUI
1
METN_ECOLI
C:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.61
31%
-103
- C2 -
-
3TUZ
1
METN_ECOLI
H:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
67.13
33%
-108
- C2 -
-
3PUV
2
MALK_ECOLI
A:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.93
31%
-103
- C2 -
-
3TUZ
1
METN_ECOLI
G:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.82
32%
-100
- C2 -
-
3DHW
-
METN_ECOLI
C:
[1-258]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
66.60
33%
-105
- C2 -
-
4KI0
3
MALK_ECOLI
A:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
66.35
33%
-106
- C2 -
-
2AWN
1
MALK_ECOLI
B:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
66.02
33%
-106
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
65.88
33%
-110
- C2 -
-
3DHW
-
METN_ECOLI
C:
[1-228]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
-
R
R
------
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
RL
G
--
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
-------
D
T
V
-------------
S
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
65.82
31%
-93
- C2 -
-
3TUI
1
METN_ECOLI
D:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.81
33%
-109
- C2 -
-
3PUY
2
MALK_ECOLI
A:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.63
30%
-98
- C2 -
-
3TUJ
-
METN_ECOLI
C:
[2-273]
-
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.59
33%
-107
- C2 -
-
3PUX
2
MALK_ECOLI
A:
[4-218]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
65.44
33%
-100
- C2 -
-
3RLF
2
MALK_ECOLI
B:
[4-219]
-
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
E
---------
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
LG
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
65.40
34%
-112
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[3-221]
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
---------
P
A
E
R
------
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
-
M
--
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
--
A
Q
V
-------
G
K
P
-------------
L
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
65.33
31%
-95
- C2 -
-
3TUI
1
METN_ECOLI
G:
[24-281]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
---
K
A
R
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
--
R
LG
L
T
-
I
--
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
--
I
E
Q
DTVSEVF
S
H
P
KTPLAQKFIQSTL
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.03
36%
-65
- C2 -
-
4YMV
1
?
A:
[1-220]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
N
I
N
---
K
V
R
Q
K
-------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
--
G
M
T
M
--
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
--
V
E
E
-------
G
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.78
46%
-18
- C2 -
-
1L2T
3
Y796_METJA
B:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
---
K
I
R
R
D
------
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
T
-
V
--
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
59.96
46%
-17
- C2 -
-
3TIF
4
Y796_METJA
B:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
---
K
I
R
R
D
------
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
T
-
V
--
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.47
36%
-61
- C2 -
-
4YMU
1
?
J:
[1-220]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
N
I
N
---
K
V
R
Q
K
-------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
--
G
M
T
M
--
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
--
V
E
E
-------
G
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.65
46%
-13
- C2 -
-
1F3O
1
Y796_METJA
A:
[2-223]
-
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
---
K
I
R
R
D
------
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
T
-
V
--
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
55.68
33%
-111
- C2 -
-
1VCI
1
?
A:
[27-233]
-------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
------
D
V
T
Y
L
---
P
P
K
D
R
------
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
-
A
F
P
-
L
--
K
---
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
--
K
--
L
K
-
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
--
L
Q
I
-------
G
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.15
34%
-49
- C2 -
-
5X40
2
CBIO_RHOCB
B:
[31-233]
------------------
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
T
A
T
G
H
S
R
-
K
D
L
T
---
G
W
R
R
R
-------
V
G
L
V
L
Q
D-
A
D
D
Q
L
F
A
T
T
V
F
E
D
V
-
S
F
G
-
P
L
N
L
---
G
L
S
E
A
E
A
R
A
R
V
E
E
A
L
A
A
L
S
I
S
D
L
R
-
D
R
P
-
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
--
A
--
G
M
T
L
--
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
--
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
54.15
34%
-44
- C2 -
-
5X40
2
CBIO_RHOCB
A:
[31-233]
------------------
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
T
A
T
G
H
S
R
-
K
D
L
T
---
G
W
R
R
R
-------
V
G
L
V
L
Q
D-
A
D
D
Q
L
F
A
T
T
V
F
E
D
V
-
S
F
G
-
P
L
N
L
---
G
L
S
E
A
E
A
R
A
R
V
E
E
A
L
A
A
L
S
I
S
D
L
R
-
D
R
P
-
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
--
A
--
G
M
T
L
--
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
--
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
53.26
37%
-12
- C2 -
-
1B0U
1
HISP_SALTY
A:
[7-237]
-
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
----
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
G
Q
LKV
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
---
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
--
E
G-
K
T
-
M
--
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
--
E
E
E
-------
G
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
45.49
33%
-22
- C2 -
-
4HLU
1
ECFA1_THEMA
C:
[27-233]
--------------------
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
S
P
A
D
P
F
---------
L
L
R
K
N
-------
V
G
Y
V
F
Q
NP
S
S
Q
I
I
G
A
T
-
V
E
E
D
V
-
A
F
S
-
L
E
I
M
---
G
L
D
E
S
E
M
R
K
R
I
K
K
V
L
E
L
V
G
L
S
G
L
A
-
A
A
D
-
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
--
E
G-
K
G
-
I
--
I
L
V
T
H
E
L
E
Y
L
D
D
-
M
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
-------
W
E
E
-------------
F
V
E
R
E
F
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
45.00
33%
-23
- C2 -
-
4HLU
1
ECFA1_THEMA
D:
[27-233]
--------------------
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
S
P
A
D
P
F
---------
L
L
R
K
N
-------
V
G
Y
V
F
Q
NP
S
S
Q
I
I
G
A
T
-
V
E
E
D
V
-
A
F
S
-
L
E
I
M
---
G
L
D
E
S
E
M
R
K
R
I
K
K
V
L
E
L
V
G
L
S
G
L
A
-
A
A
D
-
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
--
E
G-
K
G
-
I
--
I
L
V
T
H
E
L
E
Y
L
D
D
-
M
D
F
I
L
H
I
S
N
G
T
I
DF
C
G
S
-------
W
E
E
-------------
F
V
E
R
E
F
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------