@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2W4: (2018-02-02 )
MNTVTVIGSINMDTTLRLTNMPKPGETMHAHEIFHAGGGKGANQAVAAKRSGARTSFIGGVGADSEGQQLLDLLTKENIDTSGIAEIQGATTGQAMIMVDAAGENSILIHAGANNAFHEQEVLKNKQLITNSDFIIAQFESSLDATILAFSIAKDAGKTTILNPAPARETIPTELLEKTDIIIPNETETEIITGIRVTDHNSLVAAAEKLHELGIGTVIITLGSAGAFYHTEKEHGIVPAFKVDAVDTTAAGDTFIGALSSTLQPDLSNLKEAILYGNLASSVAVQSYGAQPSIPYREALEQSAV
Atome Classification :
(27 SA)
.........10........20........30--.........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....---..--170.......180.......190.......200.......210.......220.......230.......240.......250.......260....-------.-.----.270.......280.......290.......300...--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
T
V
T
V
I
G
SINM
D
T
T
L
R
LTNMPKPGETMH
A
---
H
E
I
F
HAGGGKGA
N
Q
A
V
A
AKRSGART
S
F
I
GGVGADS
E
G
Q
Q
L
L
D
L
L
T
KENIDTSG
I
A
E
I
QGATTG
Q
A
M
I
M
V
DAAGE
N
S
I
L
I
H
AGANNA
F
H
E
Q
E
V
L
KNKQLITNS
D
F
I
I
A
Q
F
ESSLD
A
T
I
L
A
F
S
IAKDAGK
T
T
ILNPAPA---RE--TI
P
T
E
L
L
EKT
D
I
IIPNETE
T
E
I
I
T
G
I
R
VTDH
N
S
L
V
A
A
A
E
K
L
H
E
LGI
G
T
V
I
I
T
LGSAG
A
F
Y
H
TEKEHGIV
P
A
F
K
V
D
A
V
DTTAAG
D
T
F
I
G
A
L
S
S
TLQP
D
-------
L
-
S
----
N
L
K
E
A
I
L
YG
N
L
A
S
S
V
A
V
Q
SYGAQPSI
P
Y
R
E
A
L
E
Q
SAV--
26
PsiBlast_CBE
84.92
47%
-75
- C1 -
-
1GQT
2
RBSK_ECOLI
B:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
25
PsiBlast_CBE
84.78
47%
-75
- C1 -
-
1GQT
2
RBSK_ECOLI
C:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
23
PsiBlast_CBE
84.67
47%
-74
- C1 -
-
1RK2
2
RBSK_ECOLI
B:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
5
PsiBlast_PDB
84.44
47%
-75
- C1 -
-
1GQT
2
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
2
PsiBlast_PDB
84.25
47%
-72
- C1 -
-
1RK2
2
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
22
PsiBlast_CBE
84.11
47%
-72
- C1 -
-
1RK2
2
RBSK_ECOLI
C:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
3
PsiBlast_PDB
84.09
47%
-75
- C1 -
-
1RKA
-
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
6
PsiBlast_PDB
83.97
47%
-76
- C1 -
-
1RKD
2
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
24
PsiBlast_CBE
83.59
47%
-74
- C1 -
-
1GQT
2
RBSK_ECOLI
D:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
21
PsiBlast_CBE
83.48
47%
-72
- C1 -
-
1RK2
2
RBSK_ECOLI
D:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
4
PsiBlast_PDB
82.84
47%
-78
- C1 -
-
1RKS
1
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
---
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
E
---------
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
------
31
PsiBlast_CBE
82.59
43%
-69
- C1 -
-
4XCK
2
?
C:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
28
PsiBlast_CBE
81.70
43%
-69
- C1 -
-
4XDA
2
?
C:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
27
PsiBlast_CBE
81.05
43%
-70
- C1 -
-
4XDA
2
?
D:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
32
PsiBlast_CBE
81.04
43%
-72
- C1 -
-
4XCK
2
?
B:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
29
PsiBlast_CBE
80.51
43%
-72
- C1 -
-
4XDA
2
?
B:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
8
PsiBlast_PDB
80.43
43%
-69
- C1 -
-
4XCK
3
?
A:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
9
PsiBlast_PDB
80.34
43%
-71
- C1 -
-
4XDA
3
?
A:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
30
PsiBlast_CBE
79.81
43%
-69
- C1 -
-
4XCK
1
?
D:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
---
R
N
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
E
---
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
E
-------
M
-
P
-----
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
------
83
HHSearch
79.02
47%
9
- C1 -
-
1GQT
2
RBSK_ECOLI
B:
[4-305]
A
G
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
--
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
---
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
--------
E
-
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
---
84
HHSearch
78.34
47%
10
- C1 -
-
1RKD
2
RBSK_ECOLI
A:
[4-305]
A
G
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
--
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
L
I
F
V
N
G
E
G
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
---
R
---
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
--------
E
-
K
----
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
---
80
HHSearch
75.88
47%
2
- C1 -
-
3RY7
2
?
A:
[2-303]
T
N
K
V
V
I
L
G
S
T
N
V
D
Q
F
L
T
V
E
R
Y
A
Q
P
G
E
T
L
H
V
EE
A
Q
K
A
F
G
--
G
G
K
G
A
N
Q
A
I
A
T
A
R
M
Q
A
D
T
T
F
I
T
K
I
G
T
D
G
V
A
D
F
I
L
E
D
F
K
V
A
H
I
D
T
S
Y
I
I
K
T
A
E
A
K
T
G
Q
A
F
I
T
V
N
A
E
G
Q
N
T
I
Y
V
Y
G
G
A
N
M
T
M
T
P
E
D
V
I
N
A
K
D
A
I
I
N
A
D
F
V
V
A
Q
L
E
V
P
I
P
A
I
I
S
A
F
E
I
A
K
A
H
G
V
T
T
V
L
N
P
A
P
A
---
K
---
A
L
P
N
E
L
L
S
L
I
D
I
I
V
P
N
E
T
E
A
E
L
L
S
G
I
K
V
T
N
E
Q
S
M
K
D
N
A
N
Y
F
L
S
I
G
I
K
T
V
L
I
T
L
G
K
Q
G
T
Y
F
A
T
K
N
Q
S
Q
H
I
E
A
Y
K
V
N
A
I
D
T
T
A
A
G
D
T
F
I
G
A
F
V
S
R
L
N
K
--------
S
Q
D
----
N
L
A
D
A
I
D
F
G
N
K
A
S
S
L
T
V
Q
K
H
G
A
Q
A
S
I
P
L
L
E
E
V
N
Q
-----
82
HHSearch
75.55
44%
5
- C1 -
-
4XDA
2
?
B:
[4-304]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
RN-
Y
Q
V
I
P
--
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
K
L
Q
P
N
C
P
T
G
I
A
M
I
Q
V
S
D
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
---
R
---
E
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
A
D
A
L
H
C
K
G
I
E
I
V
I
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
G
Q
R
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
Q
--------
E
-
M
----
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
----
57
PsiBlast_CBE
60.96
33%
-53
- C1 -
-
3GO6
1
?
A:
[22-286]
---
V
C
V
V
G
S
V
N
M
D
L
T
F
V
V
D
A
L
P
R
P
G
E
T
V
L
A
---
A
S
L
T
R
T
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
A
G
A
Q
V
Q
F
S
G
A
F
G
D
D
P
A
A
A
Q
L
R
A
H
L
R
A
N
A
V
G
L
D
R
T
V
T
V
P
G
-
P
S
G
T
A
I
I
V
V
D
A
S
A
E
N
T
V
L
V
A
P
G
A
N
--
A
H
L
T
P
V
---
P
S
A
V
A
N
C
D
V
L
L
T
Q
L
E
I
P
V
A
T
A
L
A
A
A
R
A
A
Q
S
A
D
A
V
V
M
V
N
A
S
P
A
GQD
R
S
--
S
L
-
Q
D
L
A
A
I
A
D
V
V
I
A
N
E
H
E
A
N
--------
D
W
P
S
-----
P
P
T
H
------
F
V
I
T
L
G
V
R
G
A
R
Y
V
G
A
D
G
V
F
E
V
P
A
P
T
V
T
P
V
D
T
A
G
A
G
D
V
F
A
G
V
L
A
A
N
W
P
R
N
PGS
P
A
E
R
L
-
R
----
A
L
R
R
A
C
A
A
G
A
L
A
T
L
V
S
-----------------------
55
PsiBlast_CBE
60.36
33%
-51
- C1 -
-
3GO7
1
?
A:
[22-286]
---
V
C
V
V
G
S
V
N
M
D
L
T
F
V
V
D
A
L
P
R
P
G
E
T
V
L
A
---
A
S
L
T
R
T
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
A
G
A
Q
V
Q
F
S
G
A
F
G
D
D
P
A
A
A
Q
L
R
A
H
L
R
A
N
A
V
G
L
D
R
T
V
T
V
P
G
-
P
S
G
T
A
I
I
V
V
D
A
S
A
E
N
T
V
L
V
A
P
G
A
N
--
A
H
L
T
P
V
---
P
S
A
V
A
N
C
D
V
L
L
T
Q
L
E
I
P
V
A
T
A
L
A
A
A
R
A
A
Q
S
A
D
A
V
V
M
V
N
A
S
P
A
GQD
R
S
--
S
L
-
Q
D
L
A
A
I
A
D
V
V
I
A
N
E
H
E
A
N
--------
D
W
P
S
-----
P
P
T
H
------
F
V
I
T
L
G
V
R
G
A
R
Y
V
G
A
D
G
V
F
E
V
P
A
P
T
V
T
P
V
D
T
A
G
A
G
D
V
F
A
G
V
L
A
A
N
W
P
R
N
PGS
P
A
E
R
L
-
R
----
A
L
R
R
A
C
A
A
G
A
L
A
T
L
V
S
-----------------------
100
Fugue
60.33
32%
-38
- C1 -
-
3GO6
1
?
A:
[19-305]
A
P
R
V
C
V
V
G
S
V
N
M
D
L
T
F
V
V
D
A
L
P
R
P
G
E
T
V
L
A
---
A
S
L
T
R
T
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
A
G
A
Q
V
Q
F
S
G
A
F
G
D
D
P
A
A
A
Q
L
R
A
H
L
R
A
N
A
V
G
L
D
R
T
V
T
V
P
G
-
P
S
G
T
A
I
I
V
V
D
A
S
A
E
N
T
V
L
V
A
P
G
A
N
A
H
L
T
P
V
P
-----
S
A
V
A
N
C
D
V
L
L
T
Q
L
E
I
P
V
A
T
A
L
A
A
A
R
A
A
Q
S
A
D
A
V
V
M
V
N
A
S
P
A
GQ-
D
R
--
S
S
L
Q
D
L
A
A
I
A
D
V
V
I
A
N
E
H
E
A
N
D
W
P
S
-------------------
P
P
T
H
F
V
I
T
L
G
V
R
G
A
R
Y
V
G
A
D
G
V
F
E
V
P
A
P
T
V
T
P
V
D
T
A
G
A
G
D
V
F
A
G
V
L
A
A
N
W
P
R
N
-------
P
-
G
S
P
A
-
E
R
L
R
A
L
R
R
A
C
A
A
G
A
L
A
T
L
V
S
G
V
G
D
C
A
P
A
A
A
A
I
D
A
A
L
R
A
N
90
HHSearch
58.18
32%
0
- C1 -
-
3GO6
1
?
A:
[19-302]
A
P
R
V
C
V
V
G
S
V
N
M
D
L
T
F
V
V
D
A
L
P
R
P
G
E
T
V
L
A
A
S
-
L
T
R
T
P
--
G
G
K
G
A
N
Q
A
V
A
A
A
R
A
G
A
Q
V
Q
F
S
G
A
F
G
D
D
P
A
A
A
Q
L
R
A
H
L
R
A
N
A
V
G
L
D
R
T
V
T
V
P
-
G
P
S
G
T
A
I
I
V
V
D
A
S
A
E
N
T
V
L
V
A
P
G
A
N
A
H
L
T
P
V
P
-----
S
A
V
A
N
C
D
V
L
L
T
Q
L
E
I
P
V
A
T
A
L
A
A
A
R
A
A
Q
S
A
D
A
V
V
M
V
N
A
S
P
A
---
G
Q
D
R
S
S
L
Q
D
L
A
A
I
A
D
V
V
I
A
N
E
H
E
A
N
D
W
P
-------------------
S
P
P
T
H
F
V
I
T
L
G
V
R
G
A
R
Y
V
G
A
D
G
V
F
E
V
P
A
P
T
V
T
P
V
D
T
A
G
A
G
D
V
F
A
G
V
L
A
A
N
W
P
R
--------
N
-
P
GS
P
A
E
R
L
R
A
L
R
R
A
C
A
A
G
A
L
A
T
L
V
S
G
V
G
D
C
A
P
A
A
A
A
I
D
A
A
L
---