@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y301: (2018-02-02 )
MSKTIAINAGSSSLKWQLYQMPEETVVAKGIVERIGLQDSIFTIKYGDNQKFEQIMDIENHEVAVKMLLDQLIELQILSSYDEITGVGHRVVHGGETYGDSVVIDEKVMDRIAELAEFAPLHNPANLMGIKAFKKILPDILSVAVFDTSFHSTMPKQNYLYSLPVSYYEDFKVRKYGFHGTSHRYVSERAAKLLNKPIEELKIITCHLGNGVSITAVDGGKSMDTSMGFTPLAGVTMGTRSGDIDPAVLPYLMEKLEIDIDEMINVLNKKSGLLGLTGLSSDMRDLEKNYEKEHIRLAYDIFVDRIRKYIGGYVTTMNGVDAIVFTAGIGENDGHVRSEIIKGMSWFGCEIDPALNELRGEEVDISTKESKVRVLVIPTDEELMIARDVERLRG
Atome Classification :
(34 SA)
.........10........20........-30........40........50........60........70..--..--....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290..--..--.....300.......310.......320.......330.......340.......350......---.--360--.-.-.....370.......380.......390..-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
K
T
I
A
INAGSS
S
L
K
W
Q
L
Y
QM
P
E
E
T
V
V
A
K
-
G
I
V
E
RIGLQD
S
I
F
T
I
K
YGDN
Q
K
F
E
Q
I
M
DIEN
H
E
V
A
V
K
M
L
L
D
Q
L
I
--
E
L
--
Q
I
L
S
SY
D
E
I
T
GVGH
R
V
VHGGETYG
D
S
V
V
I
D
E
K
V
M
D
R
I
A
E
L
A
E
FAPLHN
P
A
N
L
M
G
I
K
A
F
K
K
I
L
P
D
I
L
S
V
A
V
FDT
S
F
HSTMPKQN
Y
L
Y
SL
P
V
S
Y
Y
EDF
K
V
R
K
Y
GFHGT
S
H
R
Y
V
S
E
R
A
A
K
L
L
NK
P
I
E
E
L
K
I
I
T
C
HLGN
G
V
S
I
T
A
VDGGKSMDTSMGFTPLA
G
V
T
MGTRSGDID
P
A
V
L
P
Y
L
M
E
K
LEI
D
I
D
E
M
I
N
V
L
N
KKSG
L
L
GLTGL
S
S
D
M
R
D
L
E
K
NY--
E
K
--
E
H
--
I
R
L
A
Y
D
I
F
V
D
R
I
R
K
Y
I
G
G
Y
V
TTMNG
V
D
A
I
V
F
T
AGIGEND
G
H
V
R
S
E
I
I
KGMSWFGCEI
D
P
A
L
N
E
L---R--GEE--V-D-ISTKE
S
K
V
R
V
L
V
IPTD
E
E
L
M
I
A
R
D
V
E
R
LRG-
16
PsiBlast_PDB
88.97
41%
-77
- C8 -
-
1X3N
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
44
HHSearch
88.72
42%
-79
- C8 -
-
4FWM
4
TDCD_SALTY
A:
[17-406]
F
P
V
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
G
--
D
K
P
--
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
--
K
R
--
D
---
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
--
E
R
--
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
---
P
NS
H
G
E
--
R
-
I
-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
--
13
PsiBlast_PDB
88.56
41%
-76
- C8 -
-
4FWL
1
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
------
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
43
HHSearch
88.14
42%
-73
- C8 -
-
4XH4
3
TDCD_SALTY
A:
[18-407]
F
P
V
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
G
--
D
K
P
--
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
--
K
R
--
D
---
L
T
D
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
--
E
R
--
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
---
P
NS
H
G
E
--
R
-
I
-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
--
20
PsiBlast_PDB
88.06
41%
-77
- C8 -
-
4FWK
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
32
PsiBlast_CBE
87.73
41%
-78
- C8 -
-
4FWP
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
12
PsiBlast_PDB
87.64
42%
-72
- C8 -
-
4XH4
3
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
30
PsiBlast_CBE
87.44
41%
-75
- C8 -
-
4FWR
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
18
PsiBlast_PDB
87.44
41%
-76
- C8 -
-
2E1Z
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
14
PsiBlast_PDB
87.31
41%
-78
- C8 -
-
4FWM
4
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
42
HHSearch
87.23
44%
-74
- C8 -
-
4IJN
3
ACKA_MYCS2
A:
[22-397]
M
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
------------------
A
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
A
--
A
A
--
G
L
H
L
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
A
-
S
D
F
R
K
L
R
E
L
I
E
S
G
D
--
E
H
--
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
---
K
S-
D
E
P
--
R
-
L
-
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
---
33
PsiBlast_CBE
87.10
41%
-76
- C8 -
-
4FWO
4
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
31
PsiBlast_CBE
86.99
41%
-75
- C8 -
-
4FWQ
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
29
PsiBlast_CBE
86.85
41%
-75
- C8 -
-
4FWS
5
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
36
PsiBlast_CBE
86.84
41%
-76
- C8 -
-
4XH5
3
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
--
E
N
A
F
L
S
I
N
--
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
G
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
35
PsiBlast_CBE
86.80
41%
-76
- C8 -
-
4XH1
4
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
-
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
15
PsiBlast_PDB
86.75
41%
-75
- C8 -
-
1X3M
1
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
19
PsiBlast_PDB
86.70
41%
-73
- C8 -
-
2E20
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
34
PsiBlast_CBE
86.45
41%
-73
- C8 -
-
4FWN
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
K
P
I
N
---
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
---
F
--
E
L
--
E
K
R
D
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
S
S
D
L
R
V
L
E
K
A
W
--
H
E
--
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
PNS
H
--
G
E
R
--
I
---
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
8
PsiBlast_PDB
85.50
42%
-71
- C8 -
-
4IJN
3
ACKA_MYCS2
A:
[22-392]
M
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
A
------------------
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
A
--
A
A
--
G
L
H
L
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
-
A
S
D
F
R
K
L
R
E
L
I
--
E
S
GD
E
H
--
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
---
K
--
S
D
E
--
P
-
R
L
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
--------
28
PsiBlast_CBE
85.32
42%
-71
- C8 -
-
4IJN
2
ACKA_MYCS2
B:
[23-392]
-
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
A
------------------
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
A
--
A
A
--
G
L
H
L
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
-
A
S
D
F
R
K
L
R
E
L
I
--
E
S
GD
E
H
--
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
---
K
--
S
D
E
--
P
-
R
L
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
--------
57
Fugue
82.73
52%
2
- C8 -
-
1G99
1
ACKA_METTE
A:
[1-398]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
2
PsiBlast_PDB
82.18
52%
3
- C8 -
-
1G99
1
ACKA_METTE
A:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
4
PsiBlast_PDB
81.93
52%
5
- C8 -
-
1TUY
1
ACKA_METTE
A:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
46
HHSearch
81.13
53%
2
- C8 -
-
1G99
1
ACKA_METTE
B:
[1-396]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
--
D
D
EF
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
SK
G
N
--
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
--
48
HHSearch
80.97
53%
5
- C8 -
-
1TUU
1
ACKA_METTE
A:
[1-396]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
--
D
D
EF
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
--
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
--
21
PsiBlast_CBE
80.71
52%
3
- C8 -
-
1G99
1
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
3
PsiBlast_PDB
80.47
52%
7
- C8 -
-
1TUU
1
ACKA_METTE
A:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
23
PsiBlast_CBE
79.32
52%
9
- C8 -
-
1TUU
2
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
22
PsiBlast_CBE
78.83
52%
5
- C8 -
-
1TUY
3
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
--
G
V
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
S
N
D
F
R
D
L
D
E
A
A
--
S
K
GN
R
K
--
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
---
R
--
G
Q
E
--
I
-
D
-
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
45
HHSearch
77.37
45%
-19
* C8 *
-
3R9P
3
ACKA_MYCPA
A:
[12-389]
-
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
-
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
----------------
S
P
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
--
G
V
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
--
G
A
--
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
---
G
G-
K
G
A
--
R
-
Q
-
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
--
27
PsiBlast_CBE
76.56
43%
-15
- C8 -
-
3R9P
1
ACKA_MYCPA
B:
[13-390]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
-
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
----------------
E
--
S
P
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
--
G
V
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
-
R
D
F
R
R
L
R
E
L
I
--
E
S
GD
G
A
--
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
---
G
--
G
K
G
--
A
R
Q
-
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
7
PsiBlast_PDB
76.12
43%
-17
- C8 -
-
3R9P
3
ACKA_MYCPA
A:
[13-390]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
-
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
----------------
E
E
S
S
P
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
--
G
V
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
-
R
D
F
R
R
L
R
E
L
I
--
E
S
GD
G
A
--
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
---
G
--
G
K
G
--
A
R
Q
-
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
10
PsiBlast_PDB
74.01
44%
-9
- C8 -
-
4IZ9
6
ACKA_MYCA1
A:
[14-391]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
-
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
G
----------------
E
--
S
P
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
--
G
V
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
-
R
D
F
R
R
L
R
E
L
I
--
E
S
GD
G
A
--
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
-
L
---
P
--
G
A
K
GA
R
-
Q
-
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-