@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y316: (2018-02-03 )
MKIAIAGAGAMGSRFGLMLHQSGNEVLLIDGWAEHVQQIKEHGLQANFNGKEVEAKLPIVLQSEVEKEDQVDLIILFTKAMQLEKMLQDIQSLIKKDTEVLCLLNGIGHEDIIEKFVPMENIYIGNTMWTAGLEGPGQVKLFGSGSVELQNLGDGKEAAAKKLADKLSESGLNAHFSDNIHYSIYRKACVNGTMNGLCTILDVNMAELGKTSTAHKMVATIVNEFAKVAAVEKIELDVPEVIAHCESCFDPETIGLHYPSMYQDLIKNHRLTEIDYINGAISRKGKKYGVATPYCDFLTELVHAKEDSLNVK
Atome Classification :
(20 SA)
.........10........20........30........40........50.......-.60....-.-...70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250........260.......270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
A
I
AGAGAMGS
R
F
G
L
M
L
HQSG
N
E
V
L
L
ID
G
W
A
E
H
V
Q
Q
I
K
E
HGLQANFNG
K
E
V
E
AKL
P
-
I
V
L
Q
S
EV-E-KEDQV
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
KKDT
E
V
L
C
L
LNGI
G
H
E
D
I
I
E
K
FVPM
E
N
I
Y
IGN
T
M
W
TAGLEGP
G
Q
V
K
L
FGSG
S
V
E
L
QNLGD
G
K
E
A
A
A
K
K
L
A
D
K
L
S
ESGLNAHFSDN
I
H
Y
S
I
Y
R
K
A
C
VNGTMNG
L
C
T
I
L
DV
N
M
A
ELGKT
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
IELD
V
P
E
V
I
A
H
C
E
SCFDP-ETIGLHY
P
S
M
Y
Q
D
L
I
KNHRL
T
E
I
DYIN
G
A
I
SRKGKKYGVAT
P
Y
C
D
F
L
T
E
L
V
HAKEDSLNVK
3
PsiBlast_PDB
96.20
100%
-132
- C2 -
-
5X20
8
?
A:
[1-312]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
K
E
V
E
A
K
L
P
-
I
V
L
Q
S
E
V
-
E
-
K
E
D
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
K
24
PsiBlast_CBE
95.00
100%
-129
- C2 -
-
5X20
3
?
C:
[1-312]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
K
E
V
E
A
K
L
P
-
I
V
L
Q
S
E
V
-
E
-
K
E
D
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
K
26
PsiBlast_CBE
93.77
100%
-144
- C2 -
-
3WFJ
1
?
G:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
----
A
K
L
P
-
I
V
L
Q
----------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
29
PsiBlast_CBE
93.33
100%
-140
- C2 -
-
3WFJ
1
?
D:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
------
A
K
L
P
-
I
V
L
Q
S
E
-------
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
----
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
--
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
25
PsiBlast_CBE
93.33
100%
-131
- C2 -
-
5X20
5
?
B:
[1-311]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
K
E
V
E
A
K
L
P
-
I
V
L
Q
S
E
V
----
E
D
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
-
30
PsiBlast_CBE
92.51
100%
-146
- C2 -
-
3WFJ
1
?
C:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
----
V
E
A
K
L
P
-
I
V
L
Q
---------
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
--
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
--
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
2
PsiBlast_PDB
92.02
100%
-142
- C2 -
-
3WFJ
1
?
A:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
---
E
V
E
A
K
L
P
-
I
V
L
Q
S
E
V
--------
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
--
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
28
PsiBlast_CBE
91.79
100%
-141
- C2 -
-
3WFJ
1
?
E:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
----
V
E
A
K
L
P
-
I
V
L
Q
S
---------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
31
PsiBlast_CBE
91.43
100%
-146
- C2 -
-
3WFJ
1
?
B:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
---
V
E
A
K
L
P
-
I
V
L
Q
----------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
----
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
1
PsiBlast_PDB
84.65
100%
-
- C2 -
-
3WFI
-
?
A:
[1-311]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
K
E
V
E
A
K
L
P
-
I
V
L
Q
S
E
V
-
E
-
K
E
D
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
-
27
PsiBlast_CBE
83.36
100%
-159
- C2 -
-
3WFJ
1
?
F:
[4-310]
---
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
-------------------
L
P
-
I
V
L
--------------
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
-----
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
----
E
A
A
A
K
K
L
A
D
K
L
----
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
45
HHSearch
83.19
99%
-
- C2 -
-
3WFI
-
?
B:
[1-312]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
G
L
Q
A
N
F
N
G
K
E
V
E
A
K
L
P
I
V
L
Q
-
S
E
V
-
E
-
K
E
D
Q
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
G
H
E
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
G
S
V
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
L
D
V
N
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
L
D
V
P
E
V
I
A
H
C
E
S
C
F
D
P
-
E
T
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
K
46
HHSearch
70.23
60%
-35
- C2 -
-
2EW2
-
?
B:
[4-315]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
L
G
I
M
L
H
Q
G
G
N
D
V
T
L
I
D
Q
W
P
A
H
I
E
A
I
R
K
N
G
L
I
A
D
F
N
G
E
E
V
V
A
N
L
P
-
I
F
S
P
E
E
I
D
H
-
Q
N
E
Q
V
D
L
I
I
A
L
T
K
A
Q
Q
L
D
A
M
F
K
A
I
Q
P
M
I
T
E
K
T
Y
V
L
C
L
L
N
G
L
G
H
E
D
V
L
E
K
Y
V
P
K
E
N
I
L
V
G
I
T
M
W
T
A
G
L
E
G
P
G
R
V
K
L
L
G
D
G
E
I
E
L
E
N
I
D
P
S
G
K
K
F
A
L
E
V
V
D
V
F
Q
K
A
G
L
N
P
S
Y
S
S
N
V
R
Y
S
I
W
R
K
A
C
V
N
G
T
L
N
G
L
C
T
I
L
D
C
N
I
A
E
F
G
A
L
P
V
S
E
S
L
V
K
T
L
I
S
E
F
A
A
V
A
E
K
E
A
I
Y
L
D
Q
A
E
V
Y
T
H
I
V
Q
T
Y
D
P
-
N
G
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
V
W
R
K
G
Q
K
Y
N
V
A
T
P
F
C
A
M
L
T
Q
L
V
H
G
K
E
E
L
L
G
A
-
54
HHSearch
67.24
27%
-134
- C2 -
-
3HWR
3
?
A:
[20-316]
M
K
V
A
I
M
G
A
G
A
V
G
C
Y
Y
G
G
M
L
A
R
A
G
H
E
V
I
L
I
A
R
P
Q
-
H
V
Q
A
I
E
A
T
G
L
R
L
E
T
Q
S
F
D
E
Q
V
K
V
S
-
A
S
--
S
D
P
-
S
-
A
V
Q
G
A
D
L
V
L
F
C
V
K
S
T
D
T
Q
S
A
A
L
A
M
K
P
A
L
A
K
S
A
L
V
L
S
L
Q
N
G
V
E
N
A
D
T
L
R
S
L
L
E
Q
-
E
V
A
A
A
V
V
Y
V
A
T
E
M
A
G
P
G
H
V
R
H
H
G
R
G
E
L
V
I
E
P
T
S
-----
H
G
A
N
L
A
A
I
F
A
A
A
G
V
P
V
E
T
S
D
N
V
R
G
A
L
W
A
K
L
I
L
N
C
A
Y
N
A
L
S
A
I
T
Q
L
P
Y
G
R
L
V
R
G
E
G
V
E
A
V
M
R
D
V
M
E
E
C
F
A
V
A
R
A
E
G
V
K
L
P
D
-
D
V
A
L
A
I
R
R
I
A
E
---
T
M
P
R
Q
S
S
S
T
A
Q
D
L
A
-
R
G
K
R
S
E
I
D
H
L
N
G
L
I
V
R
R
G
D
A
L
G
I
P
V
P
A
N
R
V
L
H
A
L
V
R
L
I
E
D
K
Q
Q
--
53
HHSearch
65.54
27%
-130
- C2 -
-
3HWR
3
?
B:
[20-316]
M
K
V
A
I
M
G
A
G
A
V
G
C
Y
Y
G
G
M
L
A
R
A
G
H
E
V
I
L
I
A
R
P
Q
-
H
V
Q
A
I
E
A
T
G
L
R
L
E
T
Q
S
F
D
E
Q
V
K
V
S
-
A
S
--
S
D
P
-
S
-
A
V
Q
G
A
D
L
V
L
F
C
V
K
S
T
D
T
Q
S
A
A
L
A
M
K
P
A
L
A
K
S
A
L
V
L
S
L
Q
N
G
V
E
N
A
D
T
L
R
S
L
L
E
Q
-
E
V
A
A
A
V
V
Y
V
A
T
E
M
A
G
P
G
H
V
R
H
H
G
R
G
E
L
V
I
E
P
T
S
-----
H
G
A
N
L
A
A
I
F
A
A
A
G
V
P
V
E
T
S
D
N
V
R
G
A
L
W
A
K
L
I
L
N
C
A
Y
N
A
L
S
A
I
T
Q
L
P
Y
G
R
L
V
R
G
E
G
V
E
A
V
M
R
D
V
M
E
E
C
F
A
V
A
R
A
E
G
V
K
L
P
D
-
D
V
A
L
A
I
R
R
I
A
E
---
T
M
P
R
Q
S
S
S
T
A
Q
D
L
A
-
R
G
K
R
S
E
I
D
H
L
N
G
L
I
V
R
R
G
D
A
L
G
I
P
V
P
A
N
R
V
L
H
A
L
V
R
L
I
E
D
K
Q
Q
--
5
PsiBlast_PDB
65.08
31%
-88
- C2 -
-
5HWS
1
?
A:
[1-295]
M
R
I
Y
V
L
G
A
G
S
I
G
S
L
F
G
A
L
L
A
R
A
G
N
D
V
T
L
I
-
G
R
R
E
Q
V
D
A
I
N
K
N
G
L
H
V
-
F
G
A
E
E
F
T
V
K
P
K
-
A
T
I
Y
A
-----
P
E
E
P
P
D
L
L
I
L
A
V
K
S
Y
S
T
K
T
A
L
E
A
A
R
Q
C
I
G
R
N
T
W
V
L
S
I
Q
N
G
L
G
N
E
E
L
A
L
K
Y
T
P
--
N
V
M
G
G
V
T
T
N
G
A
M
L
V
E
W
G
K
V
L
W
A
G
K
G
I
T
V
I
G
R
Y
P
T
G
R
D
D
F
V
D
E
V
A
S
V
F
N
E
A
G
I
D
T
S
V
T
E
N
A
I
G
W
K
W
A
K
A
I
V
N
S
V
I
N
G
L
G
T
V
L
E
V
K
N
G
H
L
K
D
D
P
H
L
E
G
I
S
V
D
I
A
R
E
G
C
M
V
A
Q
Q
L
G
I
E
F
E
----
I
H
P
L
E
L
L
W
D
T
I
E
R
T
R
E
N
Y
N
S
T
L
Q
D
I
W
R
G
-
R
E
T
E
V
D
Y
I
H
G
K
I
V
E
Y
A
R
S
V
G
M
E
A
P
R
N
E
L
L
W
V
L
V
K
A
K
E
------
34
PsiBlast_CBE
64.17
31%
-87
- C2 -
-
5HWS
1
?
B:
[1-295]
M
R
I
Y
V
L
G
A
G
S
I
G
S
L
F
G
A
L
L
A
R
A
G
N
D
V
T
L
I
-
G
R
R
E
Q
V
D
A
I
N
K
N
G
L
H
V
-
F
G
A
E
E
F
T
V
K
P
K
-
A
T
I
Y
A
-----
P
E
E
P
P
D
L
L
I
L
A
V
K
S
Y
S
T
K
T
A
L
E
A
A
R
Q
C
I
G
R
N
T
W
V
L
S
I
Q
N
G
L
G
N
E
E
L
A
L
K
Y
T
P
--
N
V
M
G
G
V
T
T
N
G
A
M
L
V
E
W
G
K
V
L
W
A
G
K
G
I
T
V
I
G
R
Y
P
T
G
R
D
D
F
V
D
E
V
A
S
V
F
N
E
A
G
I
D
T
S
V
T
E
N
A
I
G
W
K
W
A
K
A
I
V
N
S
V
I
N
G
L
G
T
V
L
E
V
K
N
G
H
L
K
D
D
P
H
L
E
G
I
S
V
D
I
A
R
E
G
C
M
V
A
Q
Q
L
G
I
E
F
E
----
I
H
P
L
E
L
L
W
D
T
I
E
R
T
R
E
N
Y
N
S
T
L
Q
D
I
W
R
G
-
R
E
T
E
V
D
Y
I
H
G
K
I
V
E
Y
A
R
S
V
G
M
E
A
P
R
N
E
L
L
W
V
L
V
K
A
K
E
------
32
PsiBlast_CBE
64.06
31%
-82
- C2 -
-
5HWS
1
?
D:
[1-295]
M
R
I
Y
V
L
G
A
G
S
I
G
S
L
F
G
A
L
L
A
R
A
G
N
D
V
T
L
I
-
G
R
R
E
Q
V
D
A
I
N
K
N
G
L
H
V
-
F
G
A
E
E
F
T
V
K
P
K
-
A
T
I
Y
A
-----
P
E
E
P
P
D
L
L
I
L
A
V
K
S
Y
S
T
K
T
A
L
E
A
A
R
Q
C
I
G
R
N
T
W
V
L
S
I
Q
N
G
L
G
N
E
E
L
A
L
K
Y
T
P
--
N
V
M
G
G
V
T
T
N
G
A
M
L
V
E
W
G
K
V
L
W
A
G
K
G
I
T
V
I
G
R
Y
P
T
G
R
D
D
F
V
D
E
V
A
S
V
F
N
E
A
G
I
D
T
S
V
T
E
N
A
I
G
W
K
W
A
K
A
I
V
N
S
V
I
N
G
L
G
T
V
L
E
V
K
N
G
H
L
K
D
D
P
H
L
E
G
I
S
V
D
I
A
R
E
G
C
M
V
A
Q
Q
L
G
I
E
F
E
----
I
H
P
L
E
L
L
W
D
T
I
E
R
T
R
E
N
Y
N
S
T
L
Q
D
I
W
R
G
-
R
E
T
E
V
D
Y
I
H
G
K
I
V
E
Y
A
R
S
V
G
M
E
A
P
R
N
E
L
L
W
V
L
V
K
A
K
E
------
33
PsiBlast_CBE
63.51
31%
-85
- C2 -
-
5HWS
1
?
C:
[1-295]
M
R
I
Y
V
L
G
A
G
S
I
G
S
L
F
G
A
L
L
A
R
A
G
N
D
V
T
L
I
-
G
R
R
E
Q
V
D
A
I
N
K
N
G
L
H
V
-
F
G
A
E
E
F
T
V
K
P
K
-
A
T
I
Y
A
-----
P
E
E
P
P
D
L
L
I
L
A
V
K
S
Y
S
T
K
T
A
L
E
A
A
R
Q
C
I
G
R
N
T
W
V
L
S
I
Q
N
G
L
G
N
E
E
L
A
L
K
Y
T
P
--
N
V
M
G
G
V
T
T
N
G
A
M
L
V
E
W
G
K
V
L
W
A
G
K
G
I
T
V
I
G
R
Y
P
T
G
R
D
D
F
V
D
E
V
A
S
V
F
N
E
A
G
I
D
T
S
V
T
E
N
A
I
G
W
K
W
A
K
A
I
V
N
S
V
I
N
G
L
G
T
V
L
E
V
K
N
G
H
L
K
D
D
P
H
L
E
G
I
S
V
D
I
A
R
E
G
C
M
V
A
Q
Q
L
G
I
E
F
E
----
I
H
P
L
E
L
L
W
D
T
I
E
R
T
R
E
N
Y
N
S
T
L
Q
D
I
W
R
G
-
R
E
T
E
V
D
Y
I
H
G
K
I
V
E
Y
A
R
S
V
G
M
E
A
P
R
N
E
L
L
W
V
L
V
K
A
K
E
------
4
PsiBlast_PDB
63.22
56%
-20
- C2 -
-
2EW2
-
?
A:
[16-316]
------------
S
R
L
G
I
M
L
H
Q
G
G
N
D
V
T
L
I
D
Q
W
P
A
H
I
E
A
I
R
K
N
G
L
I
A
D
F
N
G
E
E
V
V
A
N
L
P
-
I
F
S
P
E
E
I
-
D
H
Q
N
E
Q
V
D
L
I
I
A
L
T
K
A
Q
Q
L
D
A
M
F
K
A
I
Q
P
M
I
T
E
K
T
Y
V
L
C
L
L
N
G
L
G
H
E
D
V
L
E
K
Y
V
P
K
E
N
I
L
V
G
I
T
M
W
T
A
G
L
E
G
P
G
R
V
K
L
L
G
D
G
E
I
E
L
E
N
I
D
P
S
G
K
K
F
A
L
E
V
V
D
V
F
Q
K
A
G
L
N
P
S
Y
S
S
N
V
R
Y
S
I
W
R
K
A
C
V
N
G
T
L
N
G
L
C
T
I
L
D
C
N
I
A
E
F
G
A
L
P
V
S
E
S
L
V
K
T
L
I
S
E
F
A
A
V
A
E
K
E
A
I
Y
L
D
Q
A
E
V
Y
T
H
I
V
Q
T
Y
D
P
-
N
G
I
G
L
H
Y
P
S
M
Y
Q
D
L
I
K
N
H
R
L
T
E
I
D
Y
I
N
G
A
V
W
R
K
G
Q
K
Y
N
V
A
T
P
F
C
A
M
L
T
Q
L
V
H
G
K
E
E
L
L
G
A
K