@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y3K0: (2018-02-05 )
MTDLIKASKFFYHYLKRYKLSFFFIFITVIIATYLQVKAPQYIGEAFQELANYVGGLMQGVDDKSKFVSVIWKLLLFYVLASAANFIYSILFTQVVGKSTNRMRIGLFNKLEKLTIRFFDSHQDGEILSRFTSDLDNIQNSLNQALLQVITNAVLLVGILIMMFRQNVELAWATIASTPVAVLIAVLIIRKARKYVDLQQDEVGKLNGYMDEKISGQRVIITNGLQEETIEGFLEHNQSVREATFKGQAYSGLLFPMMQGMSLVNTAIVIFFGGWLALNGDLERSVALGLVVTFVQYSQQYYQPLMQISSGYSMIQLAITGARRLNEIFDEKDEVKPENGKAFDGVEKGLALQHVDFGYSPEKLVLKDVSINVDKGEMVALVGPTGSGKTTIMNLLNRFYDVNDGSVVIDGIDIRDYDLDALRRHVGIVLQESVLFSGTIKDNITFGKPDASDEEVINAAKQANIHDFIMTLEKGYDTEISEENNLFSTGQKQLISIARTIITNPSLLILDEATSNVDTVTEARIQKAMDEAIKGRTSFVIAHRLKTILNADRIVVLRDGEVIEEGSHHELLAENGFYAELYHNQFVFE
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70.--.......80..-......90.......--------.100.......110.......120.......130.......140.-------......150.......160.......170.......180.......190.......200.......210.......220-.......230.......240.......250.......260.......270.-...---...-280.......290..-.....300-........310.......320----........330.......--340.--........-350........-360.-------.--..-.....370.......380.......390.......400.......410.......420.......430.......440.....---..450-.-........460.......470.......480.......490.......500....-...510.......520.......530..--.....540.......550.......560.......570..-.....580.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
D
L
I
K
A
S
K
F
F
Y
H
Y
L
K
R
Y
K
L
S
F
F
F
I
F
I
T
V
I
I
A
T
Y
L
QVK
A
P
Q
Y
I
G
E
A
F
Q
E
L
A
N
Y
V
G
G
L
M
QGVD
D
K
S
K
F
V
S
V
I
W
--
K
L
L
L
F
Y
V
L
A
S
A
-
A
N
F
I
Y
S
I
L
F
T
Q
V
VGK--------STN
R
M
R
I
G
L
F
N
K
L
E
K
L
T
I
R
F
FDSHQD
G
E
I
L
S
R
F
T
S
D
L
D
N
I
Q
N
S
L
N
-------
Q
A
L
L
Q
V
I
T
N
A
V
L
L
V
G
I
L
I
M
M
F
RQNV
E
L
A
W
ATIAS
T
P
V
A
V
L
I
A
V
L
I
I
R
K
A
R
K
Y
VDLQQDEVGKLNGYMDEKISG
Q
R
V
I
I
T-NGL
Q
E
E
T
I
E
G
F
L
E
HN
Q
S
V
R
E
A
TFKGQAYS
G
L
L
F
P
M
M
Q
G
M
S
L
V
N
T
A
I
V
I
F
FG-
G
W
L
---
A
LN-G
D
L
E
R
S
V
A
L
G
L
V
V
T
F
-
V
Q
Y
S
Q
Q
Y
--
Y
Q
P
L
M
Q
ISSG
Y
S
M
I
Q
L
A
IT
G
-----
A
R
R
L
N
E
I
FDEKDEVKPEN--G--K--A
F
D
G
V
E
KG-
L
A
-
L
Q
HVDFGY-S--P-------E--
K
L
-
V
L
K
D
V
S
I
NVDKG
E
M
V
A
L
VGPTGS
G
K
T
T
I
M
N
L
L
N
R
FYDVNDG
S
V
V
I
D
G
I
D
IRDY
D
L
D
A
L
R
R
H
V
G
I
V
L
QES
V
L
F
S
G
TIKDNITFG---KPD---A-
S
D
E
E
V
I
N
A
A
K
QA
N
I
H
D
F
I
M
T
L
EKGYDTEISEENNLFST
G
Q
K
Q
L
I
S
I
A
R
T
IITNP
S
-
L
L
I
L
DEATSNV
D
T
V
T
E
A
R
I
Q
K
A
M
D
E
A
IK--GR
T
S
F
V
I
A
H
R
L
K
T
I
LNA
D
R
I
V
V
L
RDGEVIEEGSH
H
E
L
L
A
E-NG
F
Y
A
E
L
YH
N
Q
FVFE
155
HHSearch
85.14
40%
-141
- C2 -
-
3QF4
1
Y288_THEMA
B:
[24-591]
------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------
F
D
L
L
P
R
Y
M
L
--
I
L
G
T
I
Y
A
L
T
S
L
-
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
--------
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
-
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
-
D
----
I
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
--
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
-----
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
--
A
--
V
--
E
L
R
E
V
R
G
E
-
I
E
-
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
156
HHSearch
74.56
40%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[24-591]
------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------
F
D
L
L
P
R
Y
M
L
--
I
L
G
T
I
Y
A
L
T
S
L
-
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
--------
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
-
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
-
D
----
I
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
--
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
-----
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
--
A
--
V
--
E
L
R
E
V
R
G
E
-
I
E
-
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
9
PsiBlast_PDB
72.60
32%
-
- C2 -
-
3B5X
-
MSBA_VIBCH
A:
[14-580]
--------
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
----
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
-----
N
A
E
S
N
F
L
R
I
L
P
--
F
M
I
L
G
L
M
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
--------
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
-------
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
-
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
-
S
V
D
---
S
I
R
-
A
E
L
T
P
G
-------
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
G
L
M
D
L
--
E
T
E
R
D
N
--
G
--
K
Y
-
E
A
E
R
V
N
G
E
-
V
D
-
V
K
D
V
T
F
T
Y
Q
G
--
K
-------
E
--
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A--
E
G
E
---
Y
-
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
G
A
Y
A
Q
L
H
R
I
Q
F
---
3
PsiBlast_PDB
72.35
40%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[31-591]
-------------
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
----------------
F
V
P
R
R
F
--
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
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A
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L
L
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V
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F
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P
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R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
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V
T
L
A
G
A
V
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M
M
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L
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L
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N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
--
D
I
---
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
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Q
F
--
T
R
P
L
N
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L
S
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Q
F
N
M
I
Q
M
A
L
A
S
-----
A
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R
I
F
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I
L
D
L
E
E
E
K
D
D
P
D
--
A
--
V
--
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L
R
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V
R
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E
-
I
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-
F
K
N
V
W
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Y
-
D
--
K
-------
K
--
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-
V
L
K
D
I
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K
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A
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G
K
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L
L
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G
I
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L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
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E
I
K
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A
A
K
L
T
H
S
D
H
F
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Y
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L
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L
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A
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-
I
L
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A
M
W
K
L
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--
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K
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L
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N
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L
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H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
162
HHSearch
71.62
34%
-51
- C2 -
-
5MKK
-
?
A:
[11-591]
----
R
A
L
F
A
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
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V
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A
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L
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--
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W
V
G
Q
R
--------
V
L
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-------
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-
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F
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Y
Y
G
-
G
G
E
---
V
V
R
-
G
----
A
V
S
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G
L
L
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T
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-----
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--
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KGVEPTE
K
--
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V
L
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V
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V
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L
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V
L
D
N
L
R
L
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---
D
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S
---
V
-
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A
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--
G
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L
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I
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R
L
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T
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V
D
R
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R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
-
G
G
Y
Y
A
A
L
--------
157
HHSearch
70.91
31%
-
- C2 -
-
4Q4H
-
?
A:
[1-569]
-------
S
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--------
F
S
L
V
L
K
T
G
I
--
L
M
L
I
V
A
L
I
G
A
V
-
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
--------
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
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T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
-------
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
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M
A
V
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N
V
K
L
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S
V
L
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L
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L
L
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W
L
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K
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N
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V
N
R
V
V
R
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N
L
L
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V
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V
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R
A
-
F
R
R
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Y
E
N
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R
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I
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A
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S
L
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L
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F
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N
M
G
M
I
A
V
L
W
F
G
-
G
V
L
---
V
R
N
-
N
----
Q
M
E
I
G
S
I
M
A
Y
-
T
N
Y
L
M
Q
I
--
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
-----
A
K
R
V
L
E
V
L
N
E
K
P
A
I
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E
A
D
--
N
A
-
L
--
A
L
P
N
V
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G
S
-
V
S
-
F
E
N
V
E
F
R
Y
-
F
--
E
N------
T
--
D
P
-
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
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L
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G
S
G
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N
L
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R
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R
V
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V
D
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L
D
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L
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I
S
A
V
P
Q
E
T
V
L
F
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G
T
I
K
E
N
L
K
W
G
---
R
E
D
---
A
-
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
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P
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G
Y
D
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V
E
R
G
G
R
N
F
S
G
G
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K
Q
R
L
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A
R
A
L
V
K
K
P
K
-
V
L
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L
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D
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S
V
D
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R
I
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D
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L
K
R
Y
T
K
--
G
C
T
T
F
I
I
T
Q
K
I
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A
L
L
A
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K
I
L
V
L
H
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G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
-
C
K
P
Y
R
E
I
Y
E
S
Q
F
---
2
PsiBlast_PDB
68.19
40%
-22
- C2 -
-
4Q4A
1
Y288_THEMA
B:
[31-591]
-------------
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
----------------
F
V
P
R
R
F
--
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
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L
S
L
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L
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L
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T
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I
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S
Q
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Y
F
Y
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N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
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G
L
T
V
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K
L
-
F
T
R
E
E
K
E
M
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R
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N
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S
L
R
K
V
G
T
K
A
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I
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V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
--
D
I
---
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
--
T
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P
L
N
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N
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F
N
M
I
Q
M
A
L
A
S
-----
A
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R
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D
L
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D
D
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--
A
--
V
--
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L
R
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V
R
G
E
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I
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-
F
K
N
V
W
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Y
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--
K
-------
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L
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A
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T
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N
L
L
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I
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L
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D
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T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
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E
I
K
E
A
A
K
L
T
H
S
D
H
F
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H
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Y
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L
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G
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L
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Q
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L
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A
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L
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P
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-
I
L
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L
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V
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S
I
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A
A
M
W
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L
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--
G
K
T
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I
I
I
A
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R
L
N
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N
A
D
L
I
I
V
L
R
D
G
E
I
V
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M
G
K
H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
150
HHSearch
68.18
31%
-
- C2 -
-
3B5X
-
MSBA_VIBCH
A:
[10-580]
----
W
Q
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
--------
S
N
F
L
R
I
L
P
F
--
M
I
L
G
L
M
F
V
R
G
L
-
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
--------
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
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S
T
G
G
L
L
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V
A
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A
T
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-------
R
A
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A
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L
L
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W
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M
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A
M
G
H
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T
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S
A
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M
L
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V
V
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Y
G
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R
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R
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S
M
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A
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M
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A
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L
A
L
F
A
V
L
F
L
A
-
S
V
D
---
S
I
R
-
A
----
E
L
T
P
G
T
F
T
V
V
-
F
S
A
M
F
G
L
--
M
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A
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T
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F
Q
R
G
M
A
A
-----
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
D
N
G
K
--
Y
-----
E
A
E
R
V
N
G
E
-
V
D
-
V
K
D
V
T
F
T
Y
-
Q
--
G
K------
E
--
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
---
A
E
G
E--
Y
-
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
G
A
Y
A
Q
L
H
R
I
Q
F
---
1
PsiBlast_PDB
68.10
40%
-25
- C2 -
-
3QF4
1
Y288_THEMA
B:
[31-591]
-------------
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
----------------
F
V
P
R
R
F
--
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
-
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
--
D
I
---
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
--
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
-----
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
--
A
--
V
--
E
L
R
E
V
R
G
E
-
I
E
-
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
4
PsiBlast_PDB
67.53
40%
-32
- C2 -
-
4Q4J
-
Y288_THEMA
B:
[31-591]
-------------
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
----------------
F
V
P
R
R
F
--
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
-------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
-
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
---
A
L
K
--
D
I
---
I
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
--
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
-----
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
--
A
--
V
--
E
L
R
E
V
R
G
E
-
I
E
-
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
135
Fugue
67.50
30%
-39
- C2 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
----
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
--------
G
F
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
S
L
----
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
-----
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
P
G
--
R
-------
E
--
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
14
PsiBlast_PDB
66.80
31%
0
- C- -
-
4F4C
-
PGP1_CAEEL
A:
[136-703]
-------------------------------------------------------------------
M
N
V
V
W
--
S
Y
A
A
M
T
V
G
M
W
A
-
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
--------
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
-------
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
-
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
--------
L
T
T
F
-
S
S
V
M
--------
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
D
S
S
S
K
A
G
--
R
--
K
D
M
K
I
K
G
D
-
I
T
-
V
E
N
V
H
F
T
Y
-
P
SR
P
-------
D
--
V
P
-
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
---
K
E
G
---
I
-
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
--
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
-
Q
G
L
Y
Y
D
L
V
T
A
Q
----
149
HHSearch
66.79
26%
-66
- C2 -
-
5MKK
-
?
B:
[5-572]
---
A
A
P
L
L
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
-----------
G
F
G
V
Y
A
L
--
A
I
V
A
S
A
A
L
S
G
L
-
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
--------
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
-------
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
-
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
-
G
A
M
---
V
V
R
-
G
----
E
L
S
V
G
E
L
V
Q
F
-
N
A
Y
L
A
Q
L
--
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
-----
L
R
R
L
F
E
L
L
D
E
K
P
A
I
R
D
E
D
--
P
LP
L
--
A
L
E
D
L
S
G
E
-
V
R
-
F
E
G
V
G
L
K
R
-
D
--
G
----------
R
W
-
L
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
G
---
L
D
E
---
V
-
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
G
--
K
Q
T
T
L
L
I
S
H
R
T
A
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
-
G
G
L
Y
A
E
M
D
R
L
Q
----
145
HHSearch
66.54
30%
-40
- C2 -
-
3B60
2
MSBA_SALTY
D:
[10-581]
----
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--------
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
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I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
--
R
-----
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
R------
E
--
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
E--
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
154
HHSearch
65.71
33%
-37
- C2 -
-
4A82
-
Y1866_STAAM
B:
[3-576]
--------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
-
D
E
K
V
H
H
L
T
I
A
I
G
I
--
A
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
--------
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
-------
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
-
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
Y
L
---
A
I
S
-
G
----
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
L
E
L
L
--
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
-----
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
--
G
--
A
Q-
P
I
E
I
K
Q
G
R
-
I
D
-
I
D
H
V
S
F
Q
Y
-
N
--
D
N------
E
--
A
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
147
HHSearch
64.39
29%
-34
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[4-574]
----
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
-----
Y
S
D
N
L
T
R
L
C
L
--
G
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
--------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
-------
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
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N
L
A
T
F
V
L
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V
V
P
P
V
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I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
-
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
-
G
L
L
---
M
G
S
-
A
----
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
--
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
-----
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
--
G
--
V
I
L
N
E
K
S
F
Q
G
A
-
L
E
-
F
K
N
V
H
F
A
Y
-
P
--
A
-------
R
PE
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
---
A
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
-------------
22
PsiBlast_CBE
64.05
32%
-10
- C2 -
-
2HYD
2
Y1866_STAAM
B:
[3-576]
--------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
---
N
H
A
L
T
T
D
E
K
V
H
H
L
T
I
A
I
GI
A
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
--------
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
-------
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
-
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
Y
L
---
A
I
S
-
G
----
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
L
E
L
L
--
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
-----
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
--
G
--
A
--
Q
P
I
E
I
K
Q
G
R
I
D
-
I
D
H
V
S
F
Q
Y
-
N
--
D
N------
E
--
A
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
11
PsiBlast_PDB
63.90
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
30
PsiBlast_CBE
63.89
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
B:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
29
PsiBlast_CBE
63.88
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
C:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
32
PsiBlast_CBE
63.79
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
C:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
10
PsiBlast_PDB
63.79
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
A:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
33
PsiBlast_CBE
63.78
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
B:
[57-580]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
28
PsiBlast_CBE
63.21
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
D:
[57-579]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
----
31
PsiBlast_CBE
63.11
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
D:
[57-579]
-----------------------------------------------------------
G
K
T
D
R
S
V
L
L
W
M
P
L
--
V
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
--------
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
-------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
-
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-
S
F
P
---
S
V
M
-
D
----
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
--
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
-----
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
--
K
--
R
--
V
I
D
R
A
T
G
D
-
L
E
-
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
----
94
PsiBlast_CBE
33.31
37%
-5
- C2 -
-
2IXF
3
D:
[14-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-
L
V
K
F
Q
D
V
S
F
A
Y
-
P
NH
P
-------
N
--
V
Q
-
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L--
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
-
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
-
G
G
C
Y
R
S
M
--------
95
PsiBlast_CBE
30.97
37%
7
- C2 -
-
2IXF
3
TAP1_RAT
C:
[14-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-
L
V
K
F
Q
D
V
S
F
A
Y
-
P
NH
P
-------
N
--
V
Q
-
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
--
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
-
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
-
G
G
C
Y
R
S
M
--------
96
PsiBlast_CBE
30.39
37%
8
- C2 -
-
2IXF
3
TAP1_RAT
B:
[14-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-
L
V
K
F
Q
D
V
S
F
A
Y
-
P
NH
P
-------
N
--
V
Q
-
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L--
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
-
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
-
G
G
C
Y
R
S
M
--------
97
PsiBlast_CBE
29.80
37%
9
- C2 -
-
2IXF
4
TAP1_RAT
A:
[14-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-
L
V
K
F
Q
D
V
S
F
A
Y
-
P
NH
P
-------
N
--
V
Q
-
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L--
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
-
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
-
G
G
C
Y
R
S
M
--------
101
PsiBlast_CBE
28.64
36%
16
- C2 -
-
1JJ7
1
A:
[18-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
V
S
F
A
Y
-
P
NR
P
-------
D
--
V
L
-
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
LTQ
K
P
------
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
-
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
RY
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
-
K
G
C
Y
-----------