@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y3K1: (2018-02-05 )
MKLILRHAKKYKVAVFISLLSVAVMVAAALWQPKLLQQVLEAIITEDNDEMKTIGIYLISLALLGLAAGVTNTIFSAKVAQGVSADIREEAFRKIQTFSFGNIEQFSAGNLVVRLTNDITQIQNLVMISLQSLFRIPFLFIGAFILAMITMPQLWWIIVALIVTVFLITALSFTRMGKHFMIIQKLIDRVNSIAKENLLGIRVVKSFVQEENQLKSFSKVSEDLTKHNIIVGTLFSVMIPSFMLAANLAVVGAIFFVSDLVKDDPTLIGGIASFMNYLMQIMMAIIIGGMMMMMTSRAAVSLKRIAEILDAEPDLTYLDVPEQELTGSVTFDHVSFRYPGEDTDTLKDISFSIKPGEMVGIVGATGAGKSTLAQLIPRLFDPTEGKVEVGGVDLRQVNEKSLRQTVSFVLQKAILFSGTIAQNLRQGKKNATEKEMEHASSIAQAKEFIEKLSDRYEAPIEERSSNFSGGQKQRLSITRGVIGNPKILILDDSTSALDARSEKLVREALDRDLKGTTTIVIAQKIASVVKADRILVLDEGRLVGEGTHEELVAGNRVYQEIFETQKGTEE
Atome Classification :
(20 SA)
---.........10........20........30......-..40..--....-----------------------.-.--------.--------50..-.....-.60....-----....70.....---...80........90........100.......110.......120.......130.......140.......150...--....160-......-..170.......180.----...-...190.......200.......210.......220.......230.......240.......250......-.260..--.....270.......280.......290....---...300.......310...---....----320.......330......------.340-----...-.....350.......360.......370.......380.......390.......400.......410.......420.......430-.-....-....440.......450.......460.......470.......480....-.-..490.......500.......510.......520.......530.......540.......550....-...560.......570
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MK
L
I
L
R
HAKKY
K
V
A
V
F
I
S
L
L
S
V
A
V
M
V
A
A
A
LW
Q
P
K
L
L
Q
-
Q
V
L
-
E
A
--
I
ITE-----------------------D-N--------D--------EM
K
T
-
I
G
I
Y
L
-
I
S
L
A
L
L
G
-----
L
A
A
G
V
T
N
T
I
F
S
---
A
K
V
AQGV
S
A
D
I
R
E
E
A
F
R
K
I
QTFSFGNIEQFSAG
N
L
V
V
R
LTN
D
I
T
Q
I
Q
N
L
V
M
I
S
L
Q
S
L
F
R
I
P
F
L
F
I
G
A
F
I
L
A
M
I
T
M
P
Q
L
W
--
W
I
I
V
A
L
--
I
V
T
V
F
L
-
I
T
A
L
S
F
T
RMG
K
H
F
M
I
I
----
Q
K
L
-
I
D
R
V
N
S
I
A
K
E
N
L
L
G
I
R
V
V
K
S
F
V
Q
E
E
N
Q
L
K
S
F
S
K
V
S
E
D
L
T
KH
N
I
I
V
G
T
L
F
S
V
M
I
P
S
F
M
L
A
A
N
L
A
V
V
G
A
I
F
F
V
S
-
D
L
VKDD--P
T
L
I
G
G
I
A
S
F
M
N
Y
L
M
Q
I
M
M
A
I
I
I
G
G
M
M
M
M
M
T
S
---
R
A
A
V
S
L
K
R
I
A
E
I
LDAEPD
L
---
T
Y
LD----V
P
E
Q
ELTG
S
V
T
F
D
H
V
S
F
RY------PGE------DTD-T
L
K
D
I
S
F
SIKPG
E
M
V
G
I
VGATGA
G
K
S
T
L
A
Q
L
I
P
R
LFDPTEG
K
V
E
VGG
V
D
L
R
QV
N
E
K
S
L
R
Q
T
V
S
F
V
L
Q
K
A
I
LF
S
G
T
I
A
Q
N
L
R
QGKKN---A-
T
E
K
E
-
M
E
H
A
S
S
I
A
Q
A
K
E
F
I
E
K
L
S
D
R
YEA
P
I
E
E
RSSNFSGG
Q
K
Q
R
L
S
I
TRGVIGN
P
K
-
I
-
L
I
LDDSTSA
L
D
A
R
S
E
K
L
V
R
E
A
L
D
RDLKG
T
T
T
I
V
I
A
Q
K
I
A
S
V
V
KA
D
R
I
L
V
L
DEGRLVGEGT
H
E
E
L
VA
G
N
R
-
V
Y
Q
E
I
F
E
TQKGTEE
139
HHSearch
86.15
40%
-
- C1 -
-
4Q4H
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
-
R
I
V
-
D
E
--
G
I
A
R
-----------------------
G
D
F
--------
S
--------
L
V
L
K
-
T
G
I
L
M
-
L
I
V
A
L
I
G
-----
A
V
G
G
I
G
C
T
V
F
A
---
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
--
I
P
P
I
V
L
-
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
----
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
---
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
---
E
E
A
D
N
A
--
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
------
F
E
N
------
T
D
P
-
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
---
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
----
4
PsiBlast_PDB
84.94
40%
-
- C1 -
-
4Q4H
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
-
R
I
V
D
E
G
--
I
A
R
G
-----------------------
D
-
F
--------
S
--------
L
V
L
K
-
T
G
I
L
M
-
L
I
V
A
L
I
G
-----
A
V
G
G
I
G
C
T
V
F
A
---
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
--
I
P
P
I
V
L
-
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
----
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
---
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
---
E
E
A
D
N
A
L
A
L
P
N
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-------
F
E
------
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
---
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
----
3
PsiBlast_PDB
78.39
40%
-23
- C1 -
-
4Q4A
1
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
-
R
I
V
D
E
G
--
I
A
R
G
-----------------------
D
-
F
--------
S
--------
L
V
L
K
-
T
G
I
L
M
-
L
I
V
A
L
I
G
-----
A
V
G
G
I
G
C
T
V
F
A
---
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
--
I
P
P
I
V
L
-
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
----
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
---
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
---
E
E
A
D
N
A
L
A
L
P
N
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-------
F
E
------
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
---
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
----
2
PsiBlast_PDB
77.48
40%
-26
- C1 -
-
3QF4
1
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
-
R
I
V
D
E
G
--
I
A
R
G
-----------------------
D
-
F
--------
S
--------
L
V
L
K
-
T
G
I
L
M
-
L
I
V
A
L
I
G
-----
A
V
G
G
I
G
C
T
V
F
A
---
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
--
I
P
P
I
V
L
-
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
----
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
---
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
---
E
E
A
D
N
A
L
A
L
P
N
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-------
F
E
------
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
---
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
----
1
PsiBlast_PDB
75.76
40%
-27
- C1 -
-
4Q4J
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
-
R
I
V
D
E
G
--
I
A
R
G
-----------------------
D
-
F
--------
S
--------
L
V
L
K
-
T
G
I
L
M
-
L
I
V
A
L
I
G
-----
A
V
G
G
I
G
S
T
V
F
A
---
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
--
I
P
P
I
V
L
-
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
----
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
---
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
---
E
E
A
D
N
A
L
A
L
P
N
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-------
F
E
------
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
---
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
S
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
S
K
-
P
Y
R
E
I
Y
E
S
Q
F
----
14
PsiBlast_PDB
73.61
28%
0
- C- -
-
4F4C
1
PGP1_CAEEL
A:
[74-707]
--------------
K
L
L
L
F
I
G
T
L
-
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
-
Q
A
--
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
-
H
--------
D
--------
V
M
N
V
-
V
W
S
Y
A
-
A
M
T
V
G
M
W
-----
A
A
G
Q
I
T
V
T
C
Y
----
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
--
L
V
M
L
A
---
V
T
P
I
Q
A
-
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
----
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
-
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
--
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
---
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
DSS
S
K
A
G
----
R
K
D
M
K
I
K
G
D
I
T
V
E
N
V
H
F
T
Y
------
P
S
R
P-----
D
V
P
-
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
---
I
-
T
R
E
E
-
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
-
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
-
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
-
137
HHSearch
65.56
28%
-75
- C1 -
-
5MKK
-
?
B:
[10-572]
----
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
-
L
A
V
-
D
A
--
V
Q
A
G
----------------------------------
R
--------
G
F
G
V
-
Y
A
L
A
I
-
V
A
S
A
A
L
S
-----
G
L
L
S
Y
A
M
R
R
L
A
---
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
V
N
A
R
L
A
--
F
Y
L
T
L
I
--
L
P
G
I
F
L
-
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
----
Q
E
V
-
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
-
A
M
V
V
R
G
--
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
---
R
G
L
T
S
L
R
R
L
F
E
L
L
D
E
K
P
A
I
---
R
D
E
D
PLP-
L
A
L
E
D
L
S
G
E
V
R
F
E
G
V
G
L
K
R
------
D
G
--------
R
W
-
L
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
G
L
D
E
---
V
-
D
R
E
R
-
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
-
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
G
K
Q
T
T
L
L
I
S
H
R
T
A
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
G
G
-
L
Y
A
E
M
D
R
L
Q
-----
138
HHSearch
64.91
28%
-24
- C1 -
-
4A82
-
Y1866_STAAM
B:
[3-576]
----
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
-
Y
A
I
-
D
G
--
V
I
N
N
-----------------------
H
-
A
--------
L
TTDEKVHH
L
T
I
A
-
I
G
I
A
L
-
F
I
F
V
I
V
R
-----
P
P
I
E
F
I
R
Q
Y
L
A
---
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
--
L
A
A
L
F
I
--
F
P
F
Y
I
L
-
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
----
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
--
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
---
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
---
K
N
G
V
GA--
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
------
N
D
N
------
E
A
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
-----
145
HHSearch
64.43
30%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[27-590]
-----
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
-
K
T
I
-
D
V
--
V
F
V
P
-----------------------
R
R
F
--------
D
--------
L
L
P
R
-
Y
M
L
I
L
-
G
T
I
Y
A
L
T
-----
S
L
L
F
W
L
Q
G
K
I
M
---
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
--
L
V
T
L
S
I
--
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
----
Q
R
V
-
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
-
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
---
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
---
D
D
P
D
A---
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
------
D
K
K
-------
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
-
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
-
F
Y
Y
E
L
F
T
S
Q
-----
134
HHSearch
64.19
27%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[14-579]
----
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
-
P
L
L
-
D
E
--
G
F
G
N
-----------------------
A
E
S
--------
N
--------
F
L
R
I
-
L
P
F
M
I
-
L
G
L
M
F
V
R
-----
G
L
S
G
F
A
S
S
Y
C
L
---
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
--
L
V
L
I
V
V
--
A
P
V
V
A
F
-
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
----
Q
T
A
-
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
-
V
D
S
I
R
A
--
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
---
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
---
D
N
G
K
----
Y
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
------
Q
G
K
------
E
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
E--
Y
-
T
R
E
Q
-
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
G
-
A
Y
A
Q
L
H
R
I
Q
-----
15
PsiBlast_PDB
63.98
28%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[14-581]
----
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
-
P
L
L
D
E
G
--
F
G
N
A
-----------------------
E
-
S
--------
N
--------
F
L
R
I
-
L
P
F
M
I
-
L
G
L
M
F
V
R
-----
G
L
S
G
F
A
S
S
Y
C
L
---
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
-----
G
A
S
I
I
G
L
L
T
L
-
M
F
W
NS
W
Q
L
S
L
V
--
L
I
V
V
A
P
-
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
-
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
LT
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
------
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
---
D
N
G
K
----
Y
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
------
Q
G
K
------
E
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
---
E
Y
T
R
E
Q
-
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
G
-
A
Y
A
Q
L
H
R
I
Q
F
G
---
132
HHSearch
61.78
26%
-28
- C1 -
-
4AYX
6
ABCBA_HUMAN
A:
[8-574]
----
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
-
K
I
I
-
D
V
--
I
Y
T
N
-----------------------
P
-
T
VDY
S
----
D
--------
N
L
T
R
-
L
C
L
G
L
-
S
A
V
F
L
C
G
-----
A
A
A
N
A
I
R
V
Y
L
M
---
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
--
T
F
V
L
S
V
--
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
----
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
-
L
L
M
G
S
A
--
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
---
P
F
N
E
G
V
I
-
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
------
P
A
R
P-----
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
-
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
-
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G--------------
121
Fugue
61.22
27%
-25
- C1 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
-
P
L
L
-
D
D
--
G
F
G
K
-----------------------
T
-
D
--------
R
--------
S
V
L
L
W
M
P
L
V
V
-
I
G
L
M
I
L
R
-----
G
I
T
S
Y
I
S
S
Y
C
I
---
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
V
V
L
--
A
P
I
V
S
I
-
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
----
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
---
D
E
G
K
----
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
------
P
G
R
------
E
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
---
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
---
148
HHSearch
61.17
29%
-58
- C1 -
-
5MKK
-
?
A:
[16-590]
-----
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
-
W
A
I
-
D
L
--
A
L
V
P
-----------------------
T
-
E
PR
P
L
A
E
R
F
H
--------
L
L
L
W
-
I
S
L
G
F
-
L
A
V
R
A
V
H
-----
F
A
A
T
Y
G
E
T
Y
L
I
---
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
--
L
V
V
L
L
V
--
A
P
V
L
L
A
-
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
----
R
L
R
-
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
-
G
E
V
V
R
G
--
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
---
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
---
K
D
P
E
D
P
--
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
------
T
P
K
GVEPTE
K
D
W
-
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
D
P
S
---
V
-
P
P
E
R
-
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
-
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
G
-
Y
Y
A
A
----------
9
PsiBlast_PDB
60.63
29%
-56
- C1 -
-
5MKK
-
?
A:
[17-595]
------
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
-
W
A
I
-
D
L
A
L
V
P
T
E
-----------------------
P
-
R
--------
P
--------
L
A
E
R
-
F
H
L
L
L
W
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
---
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
--
L
V
V
L
L
V
--
A
P
V
L
L
A
-
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
----
R
L
R
-
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
-
G
E
V
V
R
G
--
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
---
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
---
K
D
P
E
D
P
--
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
TPKGVE
P
T
E
------
K
D
W
-
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
D
P
S
---
V
-
P
P
E
R
-
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
-
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
G
-
Y
Y
A
A
L
Y
R
L
Q
-----
144
HHSearch
59.94
30%
-32
- C1 -
-
3QF4
1
Y288_THEMA
B:
[27-590]
-----
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
-
K
T
I
-
D
V
--
V
F
V
P
-----------------------
R
R
F
--------
D
--------
L
L
P
R
-
Y
M
L
I
L
-
G
T
I
Y
A
L
T
-----
S
L
L
F
W
L
Q
G
K
I
M
---
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
--
L
V
T
L
S
I
--
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
----
Q
R
V
-
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
-
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
---
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
---
D
D
P
D
A---
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
------
D
K
K
-------
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
-
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
-
F
Y
Y
E
L
F
T
S
Q
-----
131
HHSearch
59.57
27%
-22
- C1 -
-
3B60
2
MSBA_SALTY
D:
[15-580]
-----
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
-
P
L
L
-
D
D
--
G
F
G
K
-----------------------
T
D
R
--------
S
--------
V
L
L
W
-
M
P
L
V
V
-
I
G
L
M
I
L
R
-----
G
I
T
S
Y
I
S
S
Y
C
I
---
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
V
V
L
--
A
P
I
V
S
I
-
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
----
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
---
D
E
G
K
----
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
------
P
G
R
------
E
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E--
Y
-
S
R
E
Q
-
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
----
133
HHSearch
59.14
26%
-30
- C1 -
-
4AYT
7
ABCBA_HUMAN
A:
[8-567]
----
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
-
K
I
I
-
D
V
--
I
Y
T
N
-----------------------
P
-
T
VDY
S
----
D
--------
N
L
T
R
-
L
C
L
G
L
-
S
A
V
F
L
C
G
-----
A
A
A
N
A
I
R
V
Y
L
M
---
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
--
T
F
V
L
S
V
--
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
----
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
-
L
L
M
G
S
A
--
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
---
P
F
N
E
G
V
I
-
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
------
P
A
R
P-----
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
-
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
-
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------
16
PsiBlast_PDB
58.51
30%
-
- C1 -
-
3B5W
-
MSBA_ECOLI
A:
[77-581]
---------------------------------------------------------------------------------------------------------------
L
R
G
-----
I
T
S
Y
V
S
S
Y
C
I
S
---
W
-
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
I
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
N
I
S
K
N
---
M
----
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
R
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
F
T
I
L
D
S
E
Q
E
K
---
D
E
G
K
----
R
V
I
E
R
A
T
G
D
V
E
F
R
N
V
T
F
T
Y
------
P
G
R
------
D
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
---
Q
-
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
K
A
D
E
I
V
V
V
E
D
G
V
I
V
E
R
G
T
H
N
D
L
L
E
H
R
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
---
18
PsiBlast_PDB
57.71
30%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[79-581]
--------------------------------------------------------------------------------------------------------------------------
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
---
M
----
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
---
D
E
G
K
----
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
------
P
G
R
------
E
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
---
E
-
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
---