Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNPSISLIREIDALLPQTQCGLCGHRDGCLPYAKSIAEGEEANKCVPGGQPVADALAQLLNRPLLPAETSVWPVQADGRPQRMKAIIREDECIGCTKCINAC---PVDAIIGSGKLMHTILTDLCTGCELCIPPCP-VDCIDLVEDTQALPSEQQRFAEQNDLRQRYYAHIQREEKRRIHRKGPVVRAEIDTQLFAQFSQALDDLPSIQLIEKPKEVIVSDAKTTIELAKIRTQIKKLEKQLSVREDAKKRLQLDELQQQLIQLQEV 1H7X Chain:A ((942-1015)) --------------------------------------------------------------------------------EQVVAVIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIRMVSRTT--PYEPKR---------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1H7X.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 279 -26062 -93.41 -372.31 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : -93.41 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.576

(partial model without unconserved sides chains): PDB file : Tito_1H7X.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1H7X-query.scw PDB file : Tito_Scwrl_1H7X.pdb: